Research Topics
Species | Christian BenedictSummaryCountry: Germany Publications
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Detail Information
Publications
Intranasal insulin improves memory in humansChristian Benedict
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
Psychoneuroendocrinology 29:1326-34. 2004..These findings could be of relevance for the treatment of patients with memory disorders like in Alzheimer's disease...- Early morning rise in hypothalamic-pituitary-adrenal activity: a role for maintaining the brain's energy balanceChristian Benedict
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Psychoneuroendocrinology 34:455-62. 2009..Sleep is not critically involved in this glucose-glucocorticoid feedback loop but may reduce the brain's sensitivity to the anorexigenic effect of enhanced glucose supply... - Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulinChristian Benedict
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 23a, 23538 Lubeck, Germany
J Clin Endocrinol Metab 93:1339-44. 2008..Long-term administration of intranasal insulin reduces body weight in men, but not in women, while improving hippocampus-dependent memory processing in both genders... - Acute sleep deprivation reduces energy expenditure in healthy menChristian Benedict
Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
Am J Clin Nutr 93:1229-36. 2011..Epidemiologic evidence indicates that chronic sleep curtailment increases risk of developing obesity, but the mechanisms behind this relation are largely unknown... - Intranasal insulin to improve memory function in humansChristian Benedict
Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
Neuroendocrinology 86:136-42. 2007..e., declarative) memory. Intranasal administration of insulin provides an effective way of delivering the compound to the central nervous system, bypassing the blood-brain barrier and avoiding systemic side effects... - Sleep enhances serum interleukin-7 concentrations in humansChristian Benedict
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 23a, 23538 Lubeck, Germany
Brain Behav Immun 21:1058-62. 2007..The findings concur with the notion of a supportive influence of sleep on T cell function related to formation of T cell memory... - Intranasal insulin improves memory in humans: superiority of insulin aspartChristian Benedict
Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
Neuropsychopharmacology 32:239-43. 2007..This finding may be especially relevant for a potential clinical administration of intranasal insulin in the treatment of memory disorders like Alzheimer's disease... - Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy menChristian Benedict
Department of Neuroendocrinology, University of Lubeck, Germany
Diabetes 60:114-8. 2011..We determined the effect of intranasal insulin, which directly targets the brain, on glucose metabolism and energy expenditure in humans... - Immediate but not long-term intranasal administration of insulin raises blood pressure in human beingsChristian Benedict
Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
Metabolism 54:1356-61. 2005..However, the effect is not observed with prolonged administration of the hormone, suggesting the emergence of counterregulatory processes... - Gut protein uptake and mechanisms of meal-induced cortisol releaseChristian Benedict
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
J Clin Endocrinol Metab 90:1692-6. 2005..We conclude that the meal-related hypothalamo-pituitary-adrenal axis response to amino acids results from a signal that rather acts at the gastrointestinal mucosa than directly via the circulating blood... - Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disordersManfred Hallschmid
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Regul Pept 149:79-83. 2008..Our results may contribute to the future development of therapeutic strategies in disorders like obesity and cognitive impairments that derive from dysfunctions of central nervous neuropeptidergic pathways... - Intranasal insulin reduces body fat in men but not in womenManfred Hallschmid
Institute of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
Diabetes 53:3024-9. 2004..Our results provide a strong, first confirmation in humans that insulin acts as a negative feedback signal in the regulation of adiposity and point to a differential sensitivity to the catabolic effects of insulin based on sex... - Modulation of food intake by glucose in patients with type 2 diabetesBernd Schultes
Department of Internal Medicine I, Medical University Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
Diabetes Care 28:2884-9. 2005..On this background, we hypothesized that a short-term reduction of blood glucose concentration to normal values acutely increases food intake in type 2 diabetic patients... - Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memoryRosemarie Krug
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 50 1, 23538 Lubeck, Germany
J Clin Endocrinol Metab 95:E468-72. 2010.... - Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleepChristian Benedict
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
FASEB J 23:3629-36. 2009..01). Other types of memory were not affected. The ability of IL-6 to enhance sleep-associated emotional memory consolidation highlights an example of a functional interaction between the central nervous and immune system... - Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in manManfred Hallschmid
Institute of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
Physiol Behav 83:55-64. 2004..The results corroborate in humans the significance of all three messengers for the central nervous regulation of adiposity and might contribute to the future development of medical strategies against body-weight-related disorders... - Sleep enhances IL-6 trans-signaling in humansStoyan Dimitrov
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, Lubeck 23538, Germany
FASEB J 20:2174-6. 2006..The selective increase in sIL-6R implicates an enhanced trans-signaling capacity whereby sleep distinctly widens the profile of IL-6 actions, enabling an integrated influence on brain and peripheral organs... - Cortisol and epinephrine control opposing circadian rhythms in T cell subsetsStoyan Dimitrov
Departments of Neuroendocrinology, University of Lubeck, Germany
Blood 113:5134-43. 2009..Thus, activation of the major stress hormones during daytime favor immediate effector defense but diminish capabilities for initiating adaptive immune responses... - Circadian clocks in mouse and human CD4+ T cellsThomas Bollinger
Institute of Medical Microbiology and Hygiene, University of Lubeck, Lubeck, Germany
PLoS ONE 6:e29801. 2011..Collectively, these data demonstrate for the first time that CD4+ T cell responses are regulated by an intrinsic cellular circadian oscillator capable of driving rhythmic CD4+ T cell immune responses... - Targeting metabolic and cognitive pathways of the CNS by intranasal insulin administrationManfred Hallschmid
Expert Opin Drug Deliv 4:319-22. 2007..These results may fuel the future development of therapeutic strategies in disorders such as obesity and Alzheimer's disease that are promoted by dysfunctions of central nervous neuropeptidergic pathways...