Research Topics
| Siegfried AnsorgeSummaryCountry: Germany Publications
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Publications
Novel aspects of cellular action of dipeptidyl peptidase IV/CD26Siegfried Ansorge
IMTM GmbH, Department ImmunoPharm, Leipziger Str 44, D 39120 Magdeburg, Germany
Biol Chem 392:153-68. 2011..This finding suggests a crucial role of the immunosuppressive cytokine NPY in the function of DPIV in growth regulation...- Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-beta1 production of human immune cellsSiegfried Ansorge
Institute of Medical Technology Magdeburg, Germany
Z Naturforsch C 58:580-9. 2003..Thus, the bee product propolis can be considered as a powerful natural anti-inflammatory medicine influencing different types of immune-responses probably via immunoregulatory T cells... - Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammationDirk Reinhold
Institute of Immunology, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
Int Immunopharmacol 6:1935-42. 2006.... - Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functionsSiegfried Ansorge
IMTM GmbH, Magdeburg, Germany
Clin Chem Lab Med 47:253-61. 2009..The first active dual inhibitor, IP10.C8, has been developed by IMTM for the treatment of inflammatory skin diseases and has just entered the first phase II study... - Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout miceDirk Reinhold
Institute of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Magdeburg, Germany
Clin Chem Lab Med 47:268-74. 2009.... - Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiationAnja Thielitz
Department of Dermatology and Venereology, Otto von Guericke University Magdeburg, Magdeburg, Germany
J Invest Dermatol 127:1042-51. 2007.... - Synergistic action of DPIV and APN in the regulation of T cell functionUwe Lendeckel
Institute of Experimental Internal Medicine, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Adv Exp Med Biol 524:123-31. 2003..Therefore, the simultaneous inhibition of these enzymes represents a promising strategy for the pharmacological therapy of T cell mediated diseases such as autoimmune disease, inflammation, allergy, and allograft rejection... - Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)--a novel approach for the treatment of inflammatory bowel diseaseUte Bank
IMTM GmbH, Leipziger Str 44, 39120 Magdeburg, Germany
Int Immunopharmacol 6:1925-34. 2006..In summary our results strongly suggest that combined DPIV and APN inhibition by synthetic inhibitors represents a novel and efficient approach for the pharmacological therapy of IBD by triggering endogenous immunosuppressive mechanisms... - Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in miceUte Bank
IMTM GmbH, D 39120 Magdeburg, Germany
Int J Mol Med 20:483-92. 2007..We conclude that aminopeptidase inhibitors support the suppressive activity as well as TGF-beta1 and FoxP3 expression of natural regulatory T-cells... - Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effectsUte Bank
IMTM GmbH, Department ImmunoPharm, D 39120 Magdeburg, Germany
Biol Chem 392:169-87. 2011..In summary, in cells which do express DP4 on the surface, this archetypical member of the DP4 family is the most relevant peptidase in the regulation of cellular functions... - Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responsesDirk Reinhold
Institute of Immunology, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
Ann N Y Acad Sci 1110:402-9. 2007..This review summarizes the evidence for the role of both enzymes in T cell activation in vitro and in vivo and provides a rationale for using combined and dual peptidase inhibitors to treat autoimmune diseases like MS... - Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophreniaHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
J Psychiatr Res 43:1095-105. 2009..Furthermore, it might contribute to the altered metabolism of certain neuropeptides (IGF-I and IGF-II, beta-endorphin), in schizophrenia... - PETIR-001, a dual inhibitor of dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN), ameliorates experimental autoimmune encephalomyelitis in SJL/J miceDirk Reinhold
Institute of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, D 39120 Magdeburg, Germany
Biol Chem 392:233-7. 2011..Our results demonstrate that PETIR-001 exhibits a therapeutic effect on EAE in SJL/J mice. Thus, PETIR™ represents a novel and efficient therapeutic approach for immunotherapy of CNS inflammation... - Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblastsAnja Thielitz
University Clinic of Dermatology and Venereology, Otto von Guericke University, Magdeburg, Germany
J Invest Dermatol 128:855-66. 2008..Inhibition of DP IV-like enzymatic activity may therefore represent a promising therapeutic approach for the treatment of fibrotic skin disorders and keloids... - Inflammatory bowel diseases: multiple benefits from therapy with dipeptidyl- and alanyl-aminopeptidase inhibitorsUte Bank
IMTM GmbH, Department ImmunoPharm, Magdeburg, Germany
Front Biosci 13:3699-713. 2008.... - Assigning the phenotype of a natural regulatory T-cell to the human T-cell line, KARPAS-299Carmen Wolke
Institute of Experimental Internal Medicine, Otto-von-Guericke University, Magdeburg, Germany
Int J Mol Med 17:275-8. 2006.... - CD26/DP IV in T cell activation and autoimmunityVera Preller
Institute of Immunology Otto-von-Guericke University, Leipziger Str 44, D-39120 Magdeburg, Germany
Adv Exp Med Biol 575:187-93. 2006 - Inhibition of human leukocyte function, alanyl aminopeptidase (APN, CD13) and dipeptidylpeptidase IV (DP IV, CD26) enzymatic activities by aqueous extracts of Cistus incanus L. ssp. incanusUwe Lendeckel
Institute of Experimental Internal Medicine, Center of Internal Medicine, Otto von Guericke University Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
J Ethnopharmacol 79:221-7. 2002..Data are presented suggesting that the antiproliferative effects of CIT extracts are due to their strong cytotoxic activity... - Thiol-inducing and immunoregulatory effects of flavonoids in peripheral blood mononuclear cells from patients with end-stage diabetic nephropathyJörn Dietzmann
Division of Nephrology, Otto von Guericke University of Magdeburg, Magdeburg, Germany
Free Radic Biol Med 33:1347-54. 2002..These data provide the rational for clinical trials using flavonoids in ESDN to normalize immunoregulatory defects via restoration of the cellular thiol status... - Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokersCaroline Schmidt-Lucke
Department of Internal Medicine, Division of Cardiology, Angiology and Pneumology, Otto-von-Guericke University, Magdeburg, Germany
Int J Cardiol 100:207-12. 2005..VEGF, and not sFlt-1, may be related to the pathogenesis of endothelial dysfunction in healthy smoking individuals... - Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiationAnja Thielitz
Department of Dermatology and Venereology, IMTM, Leipziger Str 44, 39120 Magdeburg, Germany
Biochem Biophys Res Commun 321:795-801. 2004..Taken together, these data suggest that targeting alanyl aminopeptidases may be beneficial for psoriasis and other inflammatory skin disorders... - Extracellular cysteines define ectopeptidase (APN, CD13) expression and functionBeate Firla
Institute of Immunology, Otto von Guericke University of Magdeburg, Magdeburg, Germany
Free Radic Biol Med 32:584-95. 2002..This may relate to various disease processes such as inflammation or malignant transformation... - Increased concentrations of transforming growth factor beta1 and beta2 in the plasma of patients with glioblastomaThomas Schneider
Department of Neurosurgery, Otto von Guericke University, Leipziger Strasse 44, D 39120, Magdeburg, Germany
J Neurooncol 79:61-5. 2006..lt;6 ng/ml clearly correlates with a longer survival time. In conclusion, this study suggests that glioblastoma does secret TGF-beta2 in vivo and that TGF-beta2 may play an important role in glioblastoma patients... - Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitaryHans Gert Bernstein
HansDepartment of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
J Chem Neuroanat 35:216-24. 2008..Some immunolabeling was also present in the neurohypophysis. The putative importance of the distribution of the enzyme in brain and pituitary is discussed in relation to its main known substrates, insulin, Abeta, and beta-endorphin... - Changes of plasma concentrations of soluble vascular cell adhesion molecule-1 and vascular endothelial growth factor after increased perfusion of lower extremities in humansCaroline Schmidt-Lucke
Department of Internal Medicine, Division of Cardiology, Angiology and Pneumology, Otto von Guericke University, Magdeburg, Germany
Endothelium 10:159-65. 2003..Short acting suppression of VEGF and SVCAM-1 under physiological conditions may explain exercise-induced vascular protection and the lack of correlation of these cytokines with activity of atherosclerotic disease... - The ectopeptidases dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN) and their related enzymes as possible targets in the treatment of skin diseasesAnja Thielitz
University Clinic of Dermatology and Venereology, Otto von Guericke University Magdeburg, Germany
Front Biosci 13:2364-75. 2008..Targeting enzyme activity of DP IV and APN and their related molecules might be a novel approach for the treatment of acne, psoriasis or keloids... - DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosisDirk Reinhold
Institute of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Germany
Front Biosci 13:2356-63. 2008..In the following, we summarize the evidence for the role of both ectoenzymes in T cell activation in vitro and in vivo and provide a rationale for the use of combined or dual ectopeptidase inhibitors to treat autoimmune diseases like MS... - The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunityDirk Reinhold
Institute of Immunology, Otto von Gueircke University Magdeburg, Germany
Biol Chem 383:1133-8. 2002..A major focus of this review are clinical aspects of the function of CD26 on hematopoietic cells and the potential usage of synthetic DP IV inhibitors as therapeutics in inflammatory disorders... - New results on the conformations of potent DP IV (CD26) inhibitors bearing the N-terminal MWP structural motifCarmen Mrestani-Klaus
Department of Biochemistry/Biotechnology, Martin-Luther-University Halle-Wittenberg, Kurt-Mothes-Strsse 3, Halle, Germany
Adv Exp Med Biol 524:65-8. 2003 - TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26Vera Preller
Institute of Immunology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
J Immunol 178:4632-40. 2007..These results identify CD26/DP IV as a nonredundant inhibitory receptor controlling T cell activation and Th1-mediated autoimmunity, and may have important therapeutic implications for the treatment of autoimmune CNS disease... - Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammationAliza Biton
Department of Pathology, Faculty of Medicine, Hebrew University-Hadassah Medical School, POB 12272, 91120 Jerusalem, Israel
Adv Exp Med Biol 575:177-86. 2006 - Dipeptidylpeptidase IV (DPIV) and alanyl-aminopeptidases (AAPs) as a new target complex for treatment of autoimmune and inflammatory diseases-proof of concept in a mouse model of colitisUte Bank
IMTM 2 tto-von-Guericke-University Magdeburg, L 39120 Magdeburg, Germany
Adv Exp Med Biol 575:143-53. 2006 - Altered expression of ADAMs (A Disintegrin And Metalloproteinase) in fibrillating human atriaMarco Arndt
Institute of Experimental Internal Medicine, University Hospital Magdeburg, Germany
Circulation 105:720-5. 2002..The purpose of the present study was to determine whether structural remodeling of the atria during atrial fibrillation (AF) is associated with altered ADAM expression... - Calpains and cytokines in fibrillating human atriaAndreas Goette
Division of Cardiology, Department of Internal Medicine, University Hospital Magdeburg, 39120 Magdeburg, Germany
Am J Physiol Heart Circ Physiol 283:H264-72. 2002..In conclusion, atria of patients with permanent AF show evidence of calpain I activation that might contribute to structural remodeling and contractile dysfunction, whereas there is no evidence of activation of tissue cytokines... - Transcellular proteolysis demonstrated by novel cell surface-associated substrates of dipeptidyl peptidase IV (CD26)Susan Lorey
Department of Biochemistry and Biotechnology, Institute of Biochemistry, Martin Luther University Halle Wittenberg, Kurt Mothes Strasse 3, D 06120 Halle Saale, Germany
J Biol Chem 277:33170-7. 2002..These data demonstrate that ectopeptidases such as DP IV may be involved in communication between blood cells via proteolysis of cell-associated substrates... - Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cellsMatthew Cook
School of Biosciences, Cardiff University, P O Box 911, Cardiff CF10 3US, Wales, UK
Biochim Biophys Acta 1577:10-6. 2002.... - Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgeryChristine E Schneemilch
Department of Anesthesiology and Intensive Care Medicine, Otto von Guericke University, 39120 Magdeburg, Germany
J Clin Anesth 17:517-27. 2005.... - Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sitesSusan Lorey
Department of Biochemistry Biotechnology, Institute of Biochemistry, Martin Luther University Halle Wittenberg, Halle, Germany
Eur J Biochem 270:2147-56. 2003..These findings give new insights for the development of more potent and specific peptide-based DP IV inhibitors. Such inhibitors could be useful for the treatment of autoimmune and inflammatory diseases... - Possible role of DP IV inhibitors in acne therapyAnja Thielitz
Department of Dermatology and Venereology, Otto-von-Guericke University, Leipziger Str. 44, D-39120 Magdeburg, Germany
Adv Exp Med Biol 575:163-7. 2006