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Genomes and Genes | Ulrich CostabelSummaryAffiliation: Abteilung Pneumologie Country: Germany Publications
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Publications
Bronchoalveolar lavage in drug-induced lung diseaseUlrich Costabel
Ruhrlandklinik, Department Pneumology Allergy, Tueschener Weg 40, D 45239 Essen, Germany
Clin Chest Med 25:25-35. 2004..BAL also is helpful in the differential diagnosis, primarily in the exclusion of an infective cause and of involvement of the lungs by the underlying disease (eg, metastatic cancer or malignant lymphoma)...- Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trialJurgen Behr
Medizinische Klinik I, Klinikum Grosshadern der Ludwig Maximilians Universität, Munchen, Germany
Respir Res 10:101. 2009..To better understand the clinical implications of these findings we performed additional, explorative analyses of the IFGENIA data set... - Diagnosis of sarcoidosisUlrich Costabel
Department of Pneumology Allergy, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Essen, Germany
Curr Opin Pulm Med 14:455-61. 2008..To describe the recent advances in the diagnostic procedures for sarcoidosis and explore future directions... - Interleukin 12, interleukin 18, and tumor necrosis factor alpha release by alveolar macrophages: acute and chronic hypersensitivity pneumonitisQiao Ye
Department of Pneumology and Allergology, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Germany
Ann Allergy Asthma Immunol 102:149-54. 2009..The TH1-associated cytokines interleukin (IL) 12 and IL-18 and tumor necrosis factor alpha (TNF-alpha) may be involved in the pathogenesis of both the acute and chronic forms of HP... - Extrinsic allergic alveolitis: inhibitory effects of pentoxifylline on cytokine production by alveolar macrophagesZhaohui Tong
Department of Pneumology and Allergy, Ruhrlandklinik, Medical Faculty, University of Essen, Essen, Germany
Ann Allergy Asthma Immunol 92:234-9. 2004..CONCLUSION: Our results may be the basis for clinical trials to evaluate the role of pentoxifylline as an immunotherapeutic agent in the treatment of EAA... - Pulmonary alveolar proteinosis: New insights from a single-center cohort of 70 patientsFrancesco Bonella
Department of Pneumology Allergy, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Tueschener Weg 40, 45239 Essen, Germany
Respir Med 105:1908-16. 2011..The aim of the study is to describe the epidemiologic, clinical, physiologic, and laboratory features of PAP in a large single-center cohort of patients with PAP... - Production of soluble tumor necrosis factor receptors and tumor necrosis factor-alpha by alveolar macrophages in sarcoidosis and extrinsic allergic alveolitisHuaping Dai
Department of Penumology and Allergy, Ruhrlandklinik, Medical Faculty, University of Essen, Essen, Germany
Chest 127:251-6. 2005..The effects of TNF-alpha are mediated by membrane TNF receptor (mTNFR)-1 and mTNFR-2, and can be blocked by soluble TNF receptor (sTNFR)-1 and sTNFR-2... - Diagnostic modalities in sarcoidosis: BAL, EBUS, and PETUlrich Costabel
Medical Faculty, University of Duisburg Essen, Department of Pneumology Allergy, Ruhrlandklinik, Essen, Germany
Semin Respir Crit Care Med 31:404-8. 2010..These recent developments including novel biopsy procedures and novel imaging techniques could be of value to diagnosing sarcoidosis... - Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitisEsra Uzaslan
Department of Pneumology and Allergy, Ruhrlandklinik, Essen, Germany
Respiration 72:46-51. 2005..001). CONCLUSION: We conclude that cockade+ alveolar macrophages could play a role in the pathogenesis and differential diagnosis EAA... - Angiogenic and angiostatic chemokines in idiopathic pulmonary fibrosis and granulomatous lung diseaseAi Cui
Pneumology and Allergology, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Tueschener Weg 40, Essen, Germany
Respiration 80:372-8. 2010..Angiogenesis-angiostasis balance and leukocyte recruitment are influenced by different concentrations of distinct chemokines... - Production of IL-12, IL-18 and TNF-alpha by alveolar macrophages in hypersensitivity pneumonitisBaomin Chen
Department of Pneumology and Allergology, Ruhrlandklinik, Medical Faculty, University of Essen, Germany
Sarcoidosis Vasc Diffuse Lung Dis 21:199-203. 2004..72, p = 0.011), and negatively correlated with the percentage of macrophages (r = -0.88, p < 0.001). CONCLUSIONS: These observations suggest that IL-12, IL-18 and TNFalpha may be involved in the pathogenesis of HP... - Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosisShinichiro Ohshimo
University of Duisburg Essen, Department of Pneumology Allergy, Ruhrlandklinik Tueschener Weg 40, 45239 Essen, Germany
Am J Respir Crit Care Med 179:1043-7. 2009..Bronchoalveolar lavage (BAL) and/or transbronchial biopsy, one of four major criteria in the 2000 ATS/ERS IPF Statement, was no more essential in the diagnostic algorithm of 2002 ATS/ERS Consensus Classification... - Bronchoalveolar lavage in other interstitial lung diseasesUlrich Costabel
Department of Pneumology Allergy, Ruhrlandklinik, and University of Duisburg Essen, Essen, Germany
Semin Respir Crit Care Med 28:514-24. 2007..The same is true for radiation-induced lung injury... - Increased expression of tumor necrosis factor receptors in cryptogenic organizing pneumoniaQiao Ye
Department of Pneumology and Allergology, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Germany
Respir Med 105:292-7. 2011..Patients with cryptogenic organizing pneumonia (COP) usually respond well to corticosteroids, in contrast to those with idiopathic pulmonary fibrosis (IPF). This may be due to the different pathogenesis... - Comparison of serum KL-6 versus bronchoalveolar lavage neutrophilia for the diagnosis of bronchiolitis obliterans in lung transplantationShinichiro Ohshimo
Department of Pneumology Allergy, Ruhrlandklinik, University Hospital, Essen, Germany
J Heart Lung Transplant 30:1374-80. 2011..Our study compared the clinical utility of serum KL-6 level, a marker for pulmonary fibrosis, with that of neutrophilia in bronchoalveolar lavage fluid (BALF) for detecting BOS... - Systemic evaluation of a potential cutaneous sarcoidosis patientUlrich Costabel
Department of Pneumology Allergy, Ruhrlandklinik Essen, D 45239 Essen, Germany
Clin Dermatol 25:303-11. 2007..The evaluation leads to a wide number of organs being assessed by either history, physical examination or routine laboratory investigations. The major organs routinely assessed are the lungs, the eyes, the liver and the heart... - Alveolar extracellular 20S proteasome in patients with acute respiratory distress syndromeStephan Urs Sixt
Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstrasse 55, Essen, Germany
Am J Respir Crit Care Med 179:1098-106. 2009..Repair mechanisms resulting in alveolar protein degradation in acute respiratory distress syndrome (ARDS) are largely unknown... - Chronic hypersensitivity pneumonitisUlrich Costabel
Department of Pneumology Allergy, Ruhrlandklinik, University Hospital, Essen, Germany
Clin Chest Med 33:151-63. 2012..Additional research is needed to understand why the disease develops only in a minority of exposed individuals and why cases of chronic HP may progress without further antigen exposure... - CD4+CD25+ T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener's granulomatosisBenjamin Wilde
Department of Nephrology, University Duisburg Essen, Essen, Germany
Nephrol Dial Transplant 24:161-71. 2009..An increased CD4(+) CD25(+) T-cell population is observed in Wegener's granulomatosis (WG). This T-cell population is not well characterized yet and their contribution to the disease pathogenesis remains obscure... - Pulmonary alveolar proteinosis: a new autoimmune diseaseUlrich Costabel
Medical Faculty, University of Duisburg Essen, and Department of Pneumology Allergy, Ruhrlandklinik, Essen, Germany
Sarcoidosis Vasc Diffuse Lung Dis 22:S67-73. 2005..We report the studies that developed the concept that this disorder is an autoimmune disease caused by auto-antibodies against GM-CSF. The clinical management of the patients is also described... - Inhibition of cytokine release from alveolar macrophages in pulmonary sarcoidosis by pentoxifylline: comparison with dexamethasoneZhaohui Tong
Department of Pneumology and Allergy, Ruhrlandklinik, Medical Faculty, University of Essen, Essen, Germany
Chest 124:1526-32. 2003..However, the precise clinical value of POF in the treatment of sarcoidosis and other lung diseases will have to be determined in further clinical trials... - Rare infiltrative lung diseases: a challenge for cliniciansVenerino Poletti
Dipartimento di Malattie dell Apparato Respiratorio e del Torace, Ospedale GB Morgagni, IT 47100 Forlì, Italy
Respiration 71:431-43. 2004..The intent is, however, to emphasize that in this difficult field multidisciplinary expertise and the knowledge of the most recent pathogenetic mechanisms have the main role in diagnosis and treatment... - Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvementRobert P Baughman
University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
Am J Respir Crit Care Med 174:795-802. 2006..Evidence suggests that tumor necrosis factor (TNF)-alpha plays an important role in the pathophysiology of sarcoidosis... - [Current trends in pneumology 2002 -- Part 1]Claus Kroegel
Pneumologie and Allerologie/Immunologie, Medizinische Klinik IV, , Jena
Med Klin (Munich) 98:30-56. 2003 - Colpoplasty and acute pneumonitisUlrich Costabel
Respiration 70:31. 2003 - Idiopathic bronchiolitis mimicking diffuse panbronchiolitisVenerino Poletti
Dipartimento di Malattie dell Apparato Respiratorio e del Torace, Ospedale G B Morgagni, Forli, Italy
Sarcoidosis Vasc Diffuse Lung Dis 20:62-8. 2003..We suggest that diseases classified as IB in this study might be homogeneous entities which are clinically and radiologically similar to DPB... - Clinical features of recurrent and insidious chronic bird fancier's lungYoshio Ohtani
Pulmonary Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Ann Allergy Asthma Immunol 90:604-10. 2003..In contrast, the clinical findings of recurrent BFL are consistent with hypersensitivity pneumonitis induced by other antigens... - Clinical diagnosis of hypersensitivity pneumonitisYves Lacasse
Centre de Pneumologie, Hopital Laval, Universite Laval, Ste Foy, Quebec, Canada
Am J Respir Crit Care Med 168:952-8. 2003..The rule retained its accuracy when validated in a separate cohort of 261 patients. The diagnosis of HP can often be made or rejected with confidence, especially in areas of high or low prevalence, respectively, without BAL or biopsy... - [Inhibition of cytokine release from alveolar macrophages in pulmonary sarcoidosis by pentoxifylline]Zhao-hui Tong
Beijing Chaoyang Hospital-Beijing Institute of Respiratory Medicine, Beijing 100020, China
Zhonghua Jie He He Hu Xi Za Zhi 26:415-8. 2003..However, the precise clinical value of POF in the treatment of sarcoidosis and other lung diseases needs to be determined in further clinical trials... - [Preliminary study on effect of pentoxifylline in treatment of extrinsic allergic alveolitis]Zhao-hui Tong
Beijing Chao Yang Hospital-Beijing Institute of Respiratory Medicine, Beijing 100020, China
Zhonghua Yi Xue Za Zhi 84:482-5. 2004..001 or P < 0.01 or P < 0.05). CONCLUSION: Our results may be the basis for clinical trials to evaluate the role of POF as an immunotherapeutic agent in the treatment of EAA... - Reactive alveolar epithelium in chondroid hamartoma of the lungEsra Uzaslan
General and Experimental Pathology, University of Bochum, Bochum, Germany
Acta Cytol 49:154-6. 2005..This suggests that the alveolar epithelium found in chondroid hamartoma of the lung is a secondary reaction around the hamartoma and not a primary component of the lesion... - High-dose acetylcysteine in idiopathic pulmonary fibrosisMaurits Demedts
University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
N Engl J Med 353:2229-42. 2005..Idiopathic pulmonary fibrosis is a chronic progressive disorder with a poor prognosis...