J M Gaziano

..These data indicate that the risk of MI associated with treated hypertension may have a lipid mechanism involving high-density lipoprotein cholesterol and/or triglycerides...

..One advantage of the MDR method is that it provides an internal prediction error for validation. We summarize our use of this internal prediction error for model validation...

..Several case-control studies suggest an association between analgesic use and increased risk of chronic renal disease, but few cohort studies have examined this association...

..This study examined the relationship between light-to-moderate alcohol consumption and cause-specific mortality...

..To assess whether a similar association exists among diabetics, we examined the relation between light to moderate alcohol consumption and CHD in men with and without diabetes mellitus in a prospective cohort study...

..Moderate alcohol consumption decreases the risk of coronary heart disease, but its relation to peripheral arterial disease (PAD) is uncertain...

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..Clinicians may need to consider the previous pattern of DBP change when considering the risk associated with the current DBP level. These data require confirmation in other studies in which blood pressure is measured...

..Individuals who consume high amounts of alcohol (>5 drinks/d) have increased risks of ventricular arrhythmia and sudden cardiac death (SCD). However, the relationship is less clear for drinkers of light-to-moderate amounts...

..Few studies have examined the effects of paternal and maternal history of myocardial infarction (MI), including age at MI, on cardiovascular disease (CVD) risk, particularly among women...

..Few studies have examined whether changes in alcohol consumption influence future cardiovascular risk...

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..To evaluate which blood pressure measure is the best predictor of risk of total, ischemic, and hemorrhagic stroke...

..The results of epidemiologic studies of this hypothesis are inconclusive...

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..Recent data have shown an association between polymorphisms of prostaglandin-endoperoxide synthase-2 gene (PTGS2; alias COX-2), and prostaglandin-E receptor-2 gene (PTGER2) and risk of atherothrombotic disorders...

..To evaluate the association between Parkinson disease (PD) and mortality after adjustment for comorbidities...

..More widespread use of antithrombotic and thrombolytic therapies for acute myocardial infarction could prevent tens of thousands of premature deaths annually in the USA alone, and hundreds of thousands worldwide...

..Meta-analysis of 12 studies of rs266882 and overall prostate cancer risk was null...

..A high ratio of IGF-I to IGF-binding protein-3 (IGFBP-3) has been linked to an increased risk of colorectal cancer...

..63 (95% CI, 0.97-2.74; P for trend=0.13). Higher plasma homocysteine levels at baseline were associated with an increased but non-significant risk of incident hypertension that was minimally affected by multivariable adjustment...

..This manuscript reviews current evidence on dietary patterns, consumption of fat, whole grains, carbohydrate quality and quantity, and moderate alcohol consumption as they relate to metabolic syndrome...

..A study was undertaken to test the effect of 100 mg aspirin or placebo on alternate days on the risk of adult-onset asthma in the Women's Health Study...

..We sought to examine the association between nut consumption and the risk of DM...

..We examined the association between BMI and all-cause mortality according to pre-existing disease and smoking status in a large prospective cohort...

..All types of alcoholic beverage reduce the risk of cardiovascular disease, suggesting that ethanol is responsible for the protective effect...

..We investigated the relation among the ADH3 polymorphism, the level of alcohol consumption, and the risk of myocardial infarction in a nested case-control study based on data from the prospective Physicians' Health Study...

..06 mg/dl (-13.45 to 3.32 mg/dl)). These data are consistent with beneficial effects of dark chocolate/cocoa products on total and LDL cholesterol and no major effects on HDL and TG in short-term intervention trials...

..Although heart failure (HF) remains a major public health issue, limited data are available on the utility of parental information on the risk of HF in offspring...

..Migraine and headache in general have been associated with subsequent risk of stroke, primarily in retrospective case-control studies. Prospective data evaluating the association between specific headache forms and stroke are sparse...