Research Topics
Species | Marie Laure WelterSummaryCountry: France Publications
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Publications
Internal pallidal and thalamic stimulation in patients with Tourette syndromeMarie Laure Welter
National Institute of Health and Medical Research INSERM, Unit 679, Pierre et Marie Curie University Paris 6, France
Arch Neurol 65:952-7. 2008....
[Gait and balance disorders in patients with atypical parkinsonian syndromes]M L Welter
Département des Maladies du Système Nerveux, Hopital de la Pitie Salpetriere, Groupe Hospitalier Universitaire Est, Assistance Publique Hopitaux de Paris, 47, Boulevard de l Hopital, 75013 Paris, France
Rev Neurol (Paris) 166:188-95. 2010..Other symptomatic drug and surgical treatments have been proposed, but with generally disappointing results. Physiotherapeutic techniques targeting balance control can bring some temporary improvements...
Control of vertical components of gait during initiation of walking in normal adults and patients with progressive supranuclear palsyMarie Laure Welter
centre d investigation clinique, Fédération des Maladies du Système Nerveux, INSERM U679, Universite Pierre et Marie Curie Paris VI, France
Gait Posture 26:393-9. 2007..We hypothesize that the absence of active braking of the fall in the CG prior to foot-contact, observed in PSP patients, could contribute to the postural instability, characteristic of this disorder...
Gait and balance disorders in Parkinson's disease: impaired active braking of the fall of centre of gravityNathalie Chastan
Fédération des Maladies du Système Nerveux, centre d investigation clinique, Assistance Publique Hopitaux de Paris, Hopital Pitie Salpetriere, Paris, France
Mov Disord 24:188-95. 2009..The markedly decreased braking capacity observed in half the PD patients contributes to their gait disorders and postural instability, perhaps as a result of nondopaminergic lesions, possibly at the mesencephalic level...
Camptocormia and Parkinson's disease: MR imagingFabrice Bonneville
Service de Neuroradiologie, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
Eur Radiol 18:1710-9. 2008..009; R = -0.649) and sagittal pons area (P < 0.01; R = -0.642). The results suggest that PD with camptocormia may represent a selective form of PD in which a specific neuronal dysfunction possibly occurs within the brainstem...
Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutationsMichael Schüpbach
centre d investigation clinique, Hopital de la Pitie Salpetriere, AP HP, Paris, France
Mov Disord 22:119-22. 2007..Two patients with the G2019S LRRK2 mutation still benefited from STN stimulation, 9 and 10 years after surgery. Patients with LRRK2 mutations are, therefore, good candidates for STN stimulation...
Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behaviorLuc Mallet
Institut National de la Santé et de la Recherche Médicale AVENIR Group, Behavior, Emotion, and Basal Ganglia, 75013 Paris, France
Proc Natl Acad Sci U S A 104:10661-6. 2007....
Periodic leg movements and REM sleep without atonia in Parkinson's disease with camptocormiaSophie Lavault
Unité des pathologies du sommeil, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
Mov Disord 24:2419-23. 2009..Lesions causing this axial dystonia may spare the sleep systems but affect the control of movements during sleep...
Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia-choreoathetosis cerebral palsy: a prospective pilot studyMarie Vidailhet
AP HP, Groupe Hospitalier Pitie Salpetriere, Federation de Neurologie, Paris, F 75013, France
Lancet Neurol 8:709-17. 2009..Our aim was to test the effectiveness of BP-DBS in adults with dystonia-choreoathetosis CP...
Deep brain stimulation of the globus pallidus for generalized dystonia in GM1 Type 3 gangliosidosis: technical case reportEmmanuel Roze
Department of Neurology, Saint Antoine Hospital, Paris, France
Neurosurgery 59:E1340; discussion E1340. 2006..We performed bilateral pallidal stimulation in a patient with GM1 gangliosidosis and report the 12-month postoperative course...
Bilateral deep brain stimulation of the pallidum for myoclonus-dystonia due to ?-sarcoglycan mutations: a pilot studyJulie Azoulay-Zyss
Service de Neurologie, Groupe Hospitalier Paris Saint Joseph, Universite Paris 5, Paris, France
Arch Neurol 68:94-8. 2011..To assess the efficacy of bilateral deep brain stimulation of the internal pallidum in patients with myoclonus-dystonia due to genetically proved ?-sarcoglycan (SGCE-M-D) deficiency...
Subthalamic stimulation in Parkinson disease: behavior and social adaptationJean-Luc Houeto
Centre d'Investigations Cliniques, , , 75013 Paris, France
Arch Neurol 63:1090-5. 2006....
Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleusMichael W M Schüpbach
centre d investigation clinique, Fédération de Neurologie and National Institute of Health and Medical Research INSERM Unit 679 former Unit 289, Hopital de la Salpetriere, Paris, France
Mov Disord 22:257-61. 2007..6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1)...
Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14Giovanni Stevanin
INSERM U289, Institut Fédératif de Recherche en Neuroscience, Assistance Publique Hopitaux de Paris, Hôpital de al Salpêtrière, Paris, France
Arch Neurol 61:1242-8. 2004....
Deep brain stimulation for hyperkinetics disorders: dystonia, tardive dyskinesia, and ticsMarie Laure Welter
AP HP, Fédération des Maladies du Système Nerveux, Université Pierre et Marie Curie Paris, Groupe Hospitalier Pitie Salpetriere, Paris, France
Curr Opin Neurol 23:420-5. 2010..This review focuses on new insights in deep brain stimulation (DBS) for patients with hyperkinetic movement disorders: dystonia, tardive dyskinesia and Gille de la Tourette's syndrome, during the last 18 months...
Effects of high-frequency stimulation on subthalamic neuronal activity in parkinsonian patientsMarie-Laure Welter
Centre d'Investigation Clinique, , , , , 75013 Paris, France
Arch Neurol 61:89-96. 2004..CONCLUSION: The beneficial effects of high-frequency stimulation result from a change in the firing pattern of cellular discharge and a blockade of the spontaneous overactivity of STN neurons...
Subthalamic stimulation in Parkinson disease: intraoperative predictive factorsJean-Luc Houeto
Centre d'Investigation Clinique, , INSERM Unit 289, , Paris, France
Arch Neurol 60:690-4. 2003..CONCLUSION: The improvement of segmental akinesia and the observation of dyskinesias provoked by stimulation during the operation predict the best postoperative effects of bilateral STN stimulation on parkinsonian motor disability...
Compulsions, Parkinson's disease, and stimulationLuc Mallet
CNRS UMR 7593 and Service de Psychiatrie, Pavillon Clerambault, GH Pitié Salpétrière, Hopital de la Salpetriere, Assistance Publique Hôpital de Paris, 75651 Cedex 13, Paris, France
Lancet 360:1302-4. 2002..The improvements in these two patients suggest that high-frequency stimulation could improve function in the subcortical-limbic circuitry in patients with severe OCD...
Are parkin patients particularly suited for deep-brain stimulation?Ebba Lohmann
INSERM, U679, Paris, France
Mov Disord 23:740-3. 2008..Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results...
