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Genomes and GenesSpecies | Marie Helene VerlhacSummaryCountry: France Publications
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Publications
Interactions between chromosomes, microfilaments and microtubules revealed by the study of small GTPases in a big cell, the vertebrate oocyteMarie Helene Verlhac
Equipe Divisions Méiotiques chez la souris, CNRS Universite Pierre et Marie Curie, UMR7622, Bat C 5e, 9 quai Saint Bernard, 75005 Paris, France
Mol Cell Endocrinol 282:12-7. 2008..The present review summarizes these findings that shed light on the molecular mechanisms by which small GTPases control asymmetric cell divisions in vertebrate oocytes...- Actin filaments: key players in the control of asymmetric divisions in mouse oocytesJessica Azoury
UMR7622, CNRS UPMC University Paris 06, Paris, France
Biol Cell 101:69-76. 2009..In the present review, we will emphasize the role of the actin cytoskeleton in the control of spindle positioning, spindle anchoring to the cortex and cortical differentiation... - DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytesM Emilie Terret
UMR 7622, CNRS, Universite Paris VI, 9 quai Saint Bernard, Bat C, 75252 Paris, Cedex 05, France
Development 130:5169-77. 2003..Thus, the discovery of DOC1R, a substrate of MAPK that regulates microtubule organization of metaphase II mouse oocytes, reinforces the importance of this pathway in the control of spindle stability during the metaphase II arrest... - Symmetry breaking in mouse oocytes requires transient F-actin meshwork destabilizationJessica Azoury
UMR7622, CNRS UMPC, College de France, 9 quai Saint Bernard, Paris, France
Development 138:2903-8. 2011..Hence, the meshwork density drop at meiosis resumption is germane to the symmetry-breaking event required for successful asymmetric meiotic divisions... - p90Rsk is not involved in cytostatic factor arrest in mouse oocytesJulien Dumont
Equipe Divisions Méiotiques chez la souris, UMR7622, Centre National de la Recherche Scientifique Université Pierre et Marie Curie, Paris, France
J Cell Biol 169:227-31. 2005..Eventually, oocytes from the triple Rsk (1, 2, 3) knockout present a normal CSF arrest. We demonstrate that p90Rsk is not involved in the MII arrest of mouse oocytes... - Formin-2 is required for spindle migration and for the late steps of cytokinesis in mouse oocytesJulien Dumont
Equipe Divisions Méiotiques chez la souris, UMR7622, CNRS, Universite Pierre et Marie Curie Paris 6, Bat C, 5e, 9 Quai Saint Bernard 75005, Paris, France
Dev Biol 301:254-65. 2007..We show here that attempts of cytokinesis in these oocytes abort due to phospho-myosin II mislocalization... - HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cellsManuel Breuer
Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique Université Pierre et Marie Curie, 75005 Paris, France
J Cell Biol 191:1251-60. 2010..Furthermore, HURP is also required for the clustering of extra centrosomes before division, arguing for a shared molecular requirement of MTOC sorting in mammalian meiosis and cancer cell division... - A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytesJulien Dumont
UMR7622, Centre National de la Recherche Scientifique Université Pierre et Marie Curie, 75005 Paris, France
J Cell Biol 176:295-305. 2007..These findings suggest that a mechanism common to vertebrates promotes meiosis I spindle formation in the absence of chromatin-induced microtubule production and centriole-based microtubule organizing centers... - Control of the oocyte-to-embryo transition by the ubiquitin-proteolytic system in mouse and C. elegansMarie Helene Verlhac
UMR7622, CNRS Universite Pierre et Marie Curie, 9 Quai St Bernard, Bat C, 75005 Paris, France
Curr Opin Cell Biol 22:758-63. 2010..By following the chronological order of events, we update recent discoveries on the instrumental role of the cullin-RING and APC/C ubiquitin-ligases in promoting meiosis resumption and the oocyte-to-embryo transition... - Spindle positioning: going against the actin flowMarie Helene Verlhac
College de France, Center for Interdisciplinary Research in Biology, UMR CNRS7241 INSERM U1050, 11 place Marcelin Berthelot, 75005 Paris, France
Nat Cell Biol 13:1183-5. 2011..Arp2/3-nucleated actin filaments are now shown to flow away from the cortex overlying the spindle, resulting in cytoplasmic streaming, which maintains the spindle in its asymmetric position... - Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytesStephane Brunet
UMR7622, Université Pierre et Marie Curie CNRS, Bat C, 5e, 9 quai Saint Bernard, Paris, France
PLoS ONE 3:e3338. 2008..We show that meiotic spindle formation in vivo depends on the regulation of at least a target of Ran, TPX2, rather than on the regulation of the RanGTP gradient itself...