Odile Sergent

Summary

Country: France

Publications

  1. ncbi Ethanol induces oxidative stress in primary rat hepatocytes through the early involvement of lipid raft clustering
    Philippe Nourissat
    Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil UPRES EA 3891, Universite de Rennes 1, Rennes, France
    Hepatology 47:59-70. 2008
  2. ncbi Ximelagatran increases membrane fluidity and changes membrane lipid composition in primary human hepatocytes
    Odile Sergent
    UPRES EA SeRAIC, IFR 140, Universite Rennes 1, 2 av Prof Léon Bernard, 35043 Rennes Cedex, France
    Toxicol In Vitro 23:1305-10. 2009
  3. ncbi Role for membrane fluidity in ethanol-induced oxidative stress of primary rat hepatocytes
    Odile Sergent
    Laboratoire de Biologie Cellulaire et Vegetale, Faculte de Pharmacie, 2, av Pr Léon Bernard, 35043 Rennes Cedex, France
    J Pharmacol Exp Ther 313:104-11. 2005
  4. ncbi Physical and chemical modulation of lipid rafts by a dietary n-3 polyunsaturated fatty acid increases ethanol-induced oxidative stress
    Fatiha Aliche-Djoudi
    EA 4427 SeRAIC IRSET, IFR 140, UFR des Sciences Pharmaceutiques et Biologiques, Universite de Rennes 1, Rennes Cedex, France
    Free Radic Biol Med 51:2018-30. 2011
  5. ncbi Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis
    Xavier Tekpli
    EA 4427 SeRAIC, Equipe Labellisée Ligue contre le Cancer, Universite de Rennes 1, IFR 140, 35043 Rennes Cedex, France
    Toxicol Appl Pharmacol 243:68-76. 2010
  6. ncbi Importance of plasma membrane dynamics in chemical-induced carcinogenesis
    Xavier Tekpli
    EA 4427 SeRAIC IRSET, IFR 140, Universite de Rennes 1, 35043, Rennes, France
    Recent Pat Anticancer Drug Discov 6:347-53. 2011
  7. ncbi Combination of iron overload plus ethanol and ischemia alone give rise to the same endogenous free iron pool
    Odile Sergent
    Laboratoire de Biologie Cellulaire et Vegetale, UPRES 3891, UFR des Sciences Pharmaceutiques et Biologiques, University of Rennes 1, , CS, 34317 35043, Rennes Cedex, France
    Biometals 18:567-75. 2005
  8. ncbi A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells
    Morgane Gorria
    INSERM U620, Toxicity of polycyclic aromatic hydrocarbons group Equipe Labellisée Ligue contre le Cancer, Faculte de Pharmacie, Universite Rennes I, 2 Avenue Pr Léon Bernard, Rennes Cedex, France
    Toxicol Appl Pharmacol 228:212-24. 2008
  9. ncbi Identification of the couple GSK3?/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis
    Béatrice Dendelé
    EA SERAIC, Equipe Labellisée Ligue contre le Cancer, IRSET, Universite de Rennes 1, IFR 140, Rennes, France
    Toxicol In Vitro 26:94-101. 2012
  10. ncbi Glutathione depletion increases nitric oxide-induced oxidative stress in primary rat hepatocyte cultures: involvement of low-molecular-weight iron
    Sompadthana Sinbandhit-Tricot
    Laboratoire de Biologie Cellulaire et Vegetale, Pharmaceutiques et Biologiques, Rennes Cedex, France
    Free Radic Biol Med 34:1283-94. 2003

Collaborators

Detail Information

Publications15

  1. ncbi Ethanol induces oxidative stress in primary rat hepatocytes through the early involvement of lipid raft clustering
    Philippe Nourissat
    Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil UPRES EA 3891, Universite de Rennes 1, Rennes, France
    Hepatology 47:59-70. 2008
    ..Conclusion: Membrane structure, depicted as membrane fluidity and lipid rafts, plays a key role in ethanol-induced oxidative stress of the liver, and its modulation may be of therapeutic relevance...
  2. ncbi Ximelagatran increases membrane fluidity and changes membrane lipid composition in primary human hepatocytes
    Odile Sergent
    UPRES EA SeRAIC, IFR 140, Universite Rennes 1, 2 av Prof Léon Bernard, 35043 Rennes Cedex, France
    Toxicol In Vitro 23:1305-10. 2009
    ....
  3. ncbi Role for membrane fluidity in ethanol-induced oxidative stress of primary rat hepatocytes
    Odile Sergent
    Laboratoire de Biologie Cellulaire et Vegetale, Faculte de Pharmacie, 2, av Pr Léon Bernard, 35043 Rennes Cedex, France
    J Pharmacol Exp Ther 313:104-11. 2005
    ..In conclusion, the present findings clearly highlight the pivotal role of membrane fluidity in ethanol-induced oxidative stress and the potential therapeutic effect of membrane stabilizing compounds...
  4. ncbi Physical and chemical modulation of lipid rafts by a dietary n-3 polyunsaturated fatty acid increases ethanol-induced oxidative stress
    Fatiha Aliche-Djoudi
    EA 4427 SeRAIC IRSET, IFR 140, UFR des Sciences Pharmaceutiques et Biologiques, Universite de Rennes 1, Rennes Cedex, France
    Free Radic Biol Med 51:2018-30. 2011
    ..To conclude, the ability of EPA to modify lipid raft physical and chemical properties plays a key role in the enhancement, by this dietary n-3 PUFA, of ethanol-induced oxidative stress...
  5. ncbi Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis
    Xavier Tekpli
    EA 4427 SeRAIC, Equipe Labellisée Ligue contre le Cancer, Universite de Rennes 1, IFR 140, 35043 Rennes Cedex, France
    Toxicol Appl Pharmacol 243:68-76. 2010
    ..In F258 cells, the B[alpha]P-induced membrane remodeling was identified as an early apoptotic event leading to an intracellular alkalinization...
  6. ncbi Importance of plasma membrane dynamics in chemical-induced carcinogenesis
    Xavier Tekpli
    EA 4427 SeRAIC IRSET, IFR 140, Universite de Rennes 1, 35043, Rennes, France
    Recent Pat Anticancer Drug Discov 6:347-53. 2011
    ..Here, we review the effects of environmental toxicants on cellular plasma membrane structure and function, and further describe possible implication for health and disease...
  7. ncbi Combination of iron overload plus ethanol and ischemia alone give rise to the same endogenous free iron pool
    Odile Sergent
    Laboratoire de Biologie Cellulaire et Vegetale, UPRES 3891, UFR des Sciences Pharmaceutiques et Biologiques, University of Rennes 1, , CS, 34317 35043, Rennes Cedex, France
    Biometals 18:567-75. 2005
    ....
  8. ncbi A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells
    Morgane Gorria
    INSERM U620, Toxicity of polycyclic aromatic hydrocarbons group Equipe Labellisée Ligue contre le Cancer, Faculte de Pharmacie, Universite Rennes I, 2 Avenue Pr Léon Bernard, Rennes Cedex, France
    Toxicol Appl Pharmacol 228:212-24. 2008
    ....
  9. ncbi Identification of the couple GSK3?/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis
    Béatrice Dendelé
    EA SERAIC, Equipe Labellisée Ligue contre le Cancer, IRSET, Universite de Rennes 1, IFR 140, Rennes, France
    Toxicol In Vitro 26:94-101. 2012
    ..In conclusion, we show that the couple GSK3?/c-Myc plays a key role in B[a]P-induced early apoptotic cell signaling via HKII dysfunction...
  10. ncbi Glutathione depletion increases nitric oxide-induced oxidative stress in primary rat hepatocyte cultures: involvement of low-molecular-weight iron
    Sompadthana Sinbandhit-Tricot
    Laboratoire de Biologie Cellulaire et Vegetale, Pharmaceutiques et Biologiques, Rennes Cedex, France
    Free Radic Biol Med 34:1283-94. 2003
    ....
  11. ncbi Protective effect of monosialoganglioside GM1 against chemically induced apoptosis through targeting of mitochondrial function and iron transport
    Morgane Gorria
    INSERM U620, , , IFR140, , Rennes Cedex, France
    Biochem Pharmacol 72:1343-53. 2006
    ..In conclusion, our results indicate that exogenous GM1 partly prevents B[a]P-induced apoptosis by interfering with mitochondria-related intracellular acidification and iron transport...
  12. ncbi Membrane fluidity changes are associated with benzo[a]pyrene-induced apoptosis in F258 cells: protection by exogenous cholesterol
    Morgane Gorria
    INSERM U620, , , , Rennes Cedex, France
    Ann N Y Acad Sci 1090:108-12. 2006
    ....
  13. ncbi Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells
    Amelie Rebillard
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 620, Institut Fédératif de Recherche 140 Génétique Fonctionnelle Agronomie et Santé, France
    Cancer Res 67:7865-74. 2007
    ..These events are independent of cisplatin-induced DNA adducts formation. The membrane exchanger NHE1 may be another potential target of cisplatin, increasing cell sensitivity to this compound...
  14. ncbi Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells
    Sandrine Lacour
    , Dijon, France
    Cancer Res 64:3593-8. 2004
    ..Such redistribution contributes to cell death and sensitizes tumor cells to CD95-mediated apoptosis...
  15. ncbi Physical fitness and plasma non-enzymatic antioxidant status at rest and after a wingate test
    Carole Groussard
    Laboratoire de Physiologie et de Biomechanique de l'Exercice Musculataire, UFRAPS, University de Rennes 2, Rennes Cedex, France
    Can J Appl Physiol 28:79-92. 2003
    ....