Research Topics | Ali SaibSummaryCountry: France Publications
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Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to humansAugustin Mouinga-Ondeme
Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
Retrovirology 7:105. 2010..We evaluated the natural history of the virus in a free-ranging colony of mandrills and investigated possible transmission of mandrill SFV to humans...
Suppression of HIV-1 replication by microRNA effectorsChristine Chable-Bessia
Institut de Génétique Humaine CNRS UPR1142, Laboratoire de Virologie Moleculaire, Montpellier, France
Retrovirology 6:26. 2009..Interestingly, knockdown of RCK/p54 or DGCR8 resulted in virus reactivation in PBMCs isolated from HIV infected patients treated with suppressive HAART...
Endogenous Retroviruses: Thierry Heidmann wins the 2009 Retrovirology prizeAli Saib
Conservatoire National des Arts et Metiers, CNRS UMR7212 INSERM U944, Paris, France
Retrovirology 6:108. 2009..ABSTRACT: Thierry Heidmann wins the 2009 Retrovirology prize...
Integrase and integration: biochemical activities of HIV-1 integraseOlivier Delelis
LBPA, CNRS, Ecole Normale Superieure de Cachan, 61 Avenue du President Wilson, 94235 Cachan, France
Retrovirology 5:114. 2008..Taken together, these data underline the propensity of retroviral integrases for binding symmetrical sequences and give perspectives for targeting specific sequences used for gene therapy...
Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defectAlessia Zamborlini
CNRS UMR7212, INSERM U944, Institut Universitaire d Hématologie Université Paris7 Diderot, 75475 Paris, France
J Biol Chem 286:21013-22. 2011..Because SUMOylation-defective IN mutants retained WT catalytic activity, we hypothesize that SUMOylation might regulate the affinity of IN for co-factors, contributing to efficient HIV-1 replication...
Centrosomal pre-integration latency of HIV-1 in quiescent cellsAlessia Zamborlini
CNRS UMR7151, Universite Paris 7, Hopital Saint Louis, Paris, France
Retrovirology 4:63. 2007..Upon cell activation, viral replication resumes leading to viral gene expression. Thus, HIV-1 can persist in quiescent cells as a stable, centrosome-associated, pre-integration intermediate...
Centrosomal latency of incoming foamy viruses in resting cellsJacqueline Lehmann Che
Universite Paris 7, Paris, France
PLoS Pathog 3:e74. 2007..Incoming foamy retroviruses can stably persist at the centrosome, awaiting cell stimulation to initiate capsid cleavage, nuclear import, and viral gene expression...
Centrosome and retroviruses: the dangerous liaisonsPhilippe V Afonso
Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Departement de Virologie, Institut Pasteur, Paris, France
Retrovirology 4:27. 2007..Enthrallingly, HTLV-1 Tax expression also targets the functions of the centrosome, and this event is correlated with centrosome amplification, aneuploidy and transformation...
HIV-1 infection of primary effusion lymphoma cell line triggers Kaposi's sarcoma-associated herpesvirus (KSHV) reactivationRastine Merat
Policlinique de Dermatologie, Hopital Saint Louis, Paris, France
Int J Cancer 97:791-5. 2002..By showing that HIV-1 infection directly reactivates latent KSHV, our results suggest a direct role of HIV-1 in the onset of KS in coinfected individuals...
Characterization of reemerging chikungunya virusMarion Sourisseau
Department of Virology, Unité Virus et Immunite, Institut Pasteur, Paris, France
PLoS Pathog 3:e89. 2007..CHIKV was highly sensitive to the antiviral activity of type I and II interferons. These results provide a general insight into the interaction between CHIKV and its mammalian host...
