Research Topics
| Laurent RiouSummaryCountry: France Publications
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Detail Information
Publications
Assessment of non-reperfused and reperfused myocardial infarction using diffusible or deposited radiolabelled perfusion imaging agentsL M Riou
INSERM, U340 Radiopharmaceutiques Biocliniques Université de Grenoble, La Tronche, France
Eur J Nucl Med Mol Imaging 34:330-7. 2007..We compared the myocardial uptake of diffusible ((201)Tl) and deposited ((99m)TcN-NOET) perfusion imaging agents in the setting of experimental infarction...- The in vivo cardiac kinetics of Tc-99m N-NOET are accelerated in obese, hyperlipidemic Zucker ratsLaurent M Riou
INSERM 0340 Radiopharmaceutiques Biocliniques, Université de Grenoble, Grenoble, France
J Nucl Cardiol 13:75-82. 2006..We sought to determine whether the myocardial kinetics of Tc-99m N-NOET were affected by hyperlipidemia in a clinically relevant experimental model... - Differential effects of cyclodextrins and derivatives on the biological behavior of the myocardial perfusion imaging agent 99mTcN-NOETLaurent Riou
INSERM E0340 Radiopharmaceutiques Biocliniques, Faculte de Medecine de Grenoble, Domaine de la Merci, La Tronche, France
Eur J Pharm Biopharm 61:40-9. 2005..Moreover, the in vitro and ex vivo biological behavior of (99m)TcN-NOET was greatly affected depending on the CD used for inclusion of the tracer... - Pre-clinical and clinical evaluation of nuclear tracers for the molecular imaging of vulnerable atherosclerosis: an overviewL M Riou
INSERM, U877, Radiopharmaceutiques Biocliniques, Faculte de Medecine de Grenoble, F 38700, La Tronche, France
Curr Med Chem 16:1499-511. 2009..The experimental and pilot clinical studies reviewed in the present paper represent a fundamental step prior to the evaluation of the efficacy of any selected tracer for the early, non-invasive detection of vulnerable patients... - Chemical and biological evaluations of an (111)in-labeled RGD-peptide targeting integrin alpha(V) beta(3) in a preclinical tumor modelMitra Ahmadi
INSERM, Radiopharmaceutiques Biocliniques, La Tronche, France
Cancer Biother Radiopharm 23:691-700. 2008..Whole-body noninvasive planar imaging allowed tumor visualization from 1 hour postinjection. However, renal uptake must be reduced to increase the therapeutic potential of RAFT-RGD... - Verapamil does not inhibit 99mTcN-NOET uptake in situ in normal or ischemic canine myocardiumLaurent M Riou
Laboratoire d'Etude de Radiopharmaceutiques, University Hospital of Grenoble, Grenoble, France
J Nucl Med 44:981-7. 2003..These results suggest that verapamil should not affect (99m)TcN-NOET myocardial uptake in patients referred for myocardial perfusion imaging... - In vivo imaging of tumour angiogenesis in mice with the alpha(v)beta (3) integrin-targeted tracer 99mTc-RAFT-RGDLucie Sancey
INSERM U877, Radiopharmaceutiques Biocliniques, Faculte de Medecine, Université de Grenoble, La Tronche, France
Eur J Nucl Med Mol Imaging 34:2037-47. 2007..We evaluated the potential of the novel radiotracer (99m)Tc-RAFT-RGD for the non-invasive molecular imaging of alpha(v)beta(3) integrin expression in mice models of tumour development... - Intravenous administration of 99mTc-HMPAO-labeled human mesenchymal stem cells after stroke: in vivo imaging and biodistributionOlivier Detante
INSERM, U836, Grenoble Cedex 9, France
Cell Transplant 18:1369-79. 2009..After 20 h, more hMSC are found in the ischemic lesion than into the undamaged cerebral tissue. IV delivery of hMSC could be the initial route for a clinical trial of tolerance... - In vivo molecular imaging of myocardial angiogenesis using the alpha(v)beta3 integrin-targeted tracer 99mTc-RAFT-RGDJulien Dimastromatteo
INSERM U877, Radiopharmaceutiques Biocliniques, Faculte de Medecine de Grenoble, 38700 La Tronche, Grenoble, France
J Nucl Cardiol 17:435-43. 2010..99m)Tc-RAFT-RGD is a novel (99m)Tc-labeled tracer that targets the alpha(v)beta(3) integrin. Our objective was to determine whether this tracer was suitable for myocardial angiogenesis imaging... - Mapping elasticity moduli of atherosclerotic plaque in situ via atomic force microscopyPhilippe Tracqui
Laboratoire TIMC IMAG, Equipe DynaCell, CNRS UMR 5525, Institut de l Ingénierie et de l Information de Santé, Faculte de Medecine de Grenoble, 38706 La Tronche Cedex, France
J Struct Biol 174:115-23. 2011.... - Assessing low levels of mechanical stress in aortic atherosclerotic lesions from apolipoprotein E-/- mice--brief reportAlexis Broisat
INSERM U1039, Radiopharmaceutiques Biocliniques, Grenoble, France
Arterioscler Thromb Vasc Biol 31:1007-10. 2011.... - Organ biodistribution and myocardial uptake, washout, and redistribution kinetics of Tc-99m N-DBODC5 when injected during vasodilator stress in canine models of coronary stenosesKengo Hatada
Second Department of Internal Medicine, Cardiovascular Division, Kansai Medical University Takii Hospital Moriguchi City, Osaka, Japan
J Nucl Cardiol 13:779-90. 2006.... - Reduction of infarct size and postischemic inflammation from ATL-146e, a highly selective adenosine A2A receptor agonist, in reperfused canine myocardiumDavid K Glover
Department of Internal Medicine, Division of Cardiology, University of Virginia, PO Box 800500, UVA Health System, Cobb Hall, Rm 1010, Hospital Drive, Charlottesville, VA 22908 0500, USA
Am J Physiol Heart Circ Physiol 288:H1851-8. 2005..Such combination therapy may be beneficial clinically by potentiating cardioprotection after coronary reperfusion at doses far below those producing vasodilatation or side effects... - Effects of increased lipid concentration and hyperemic blood flow on the intrinsic myocardial washout kinetics of (99m)TcN-NOETLaurent M Riou
Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia 22908-0500, USA
J Nucl Med 44:1092-8. 2003..The potential impact of variations in circulating lipid levels among patients on clinical imaging with (99m)TcN-NOET requires further investigation... - Assessment of myocardial inflammation produced by experimental coronary occlusion and reperfusion with 99mTc-RP517, a new leukotriene B4 receptor antagonist that preferentially labels neutrophils in vivoLaurent M Riou
University of Virginia Health System, Charlottesville, VA 22908-0500, USA
Circulation 106:592-8. 2002..After reperfusion, 99mTc-RP517 uptake correlated with myeloperoxidase and was observed on ex vivo images, indicating that this tracer may have potential as an inflammation-imaging agent... - 99mTc-N-DBODC5, a new myocardial perfusion imaging agent with rapid liver clearance: comparison with 99mTc-sestamibi and 99mTc-tetrofosmin in ratsKengo Hatada
Experimental Cardiology Laboratory, Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
J Nucl Med 45:2095-101. 2004.... - Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A(2A)-receptor-mediated coronary vasodilationLaurent M Riou
Cardiovascular Division, University of Virginia Health System, Charlottesville, VA 22908-0500, USA
J Am Coll Cardiol 40:1687-94. 2002....