Research Topics
Species | Christian PagnouxSummaryCountry: France Publications
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Publications
Therapeutic strategies for systemic necrotizing vasculitidesLoic Guillevin
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, université Paris René Descartes, Paris, France
Allergol Int 56:105-11. 2007..Some of them have achieved promising positive effects, for example, anti-CD20 monoclonal antibodies, and are now being evaluated in prospective trials...- Peripheral neuropathy in systemic vasculitidesChristian Pagnoux
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris V, Paris, France
Curr Opin Rheumatol 17:41-8. 2005..However, it carries no poor prognostic value in vasculitides. Recent advances have been made in understanding the pathogenetic mechanisms of PNS involvement... - How can patient care be improved beyond medical treatment?Christian Pagnoux
Department of Internal Medicine, Hopital Cochin, 27 rue du Faubourg Saint Jacques, Universite Paris 5, AP HP, 75679 Paris Cedex 14, France
Best Pract Res Clin Rheumatol 19:337-44. 2005..A multifaceted and point-by-point approach to patient care is needed to further improve quality of life whenever possible... - [Treatment of systemic vasculitides]Lïc Guillevin
Service de Medecine Interne, Centre de référence maladies rares Vascularites et Sclérodermies systémiques, Hopital Cochin, université Paris V René Descartes, Paris
Rev Prat 58:541-4. 2008..The treatment duration of non-infectious vasculitides is typically 18 to 24 months. The improvement in prognosis is due to the treatment as well as to anti-infectious prophylaxis and careful management of potential complications... - Treatment of Churg-Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patientsCamillo Ribi
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Arthritis Rheum 58:586-94. 2008.... - Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group DatabaseChristian Pagnoux
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 62:616-26. 2010..This study was undertaken to describe the main characteristics of and long-term outcomes in patients with well-characterized PAN diagnoses... - [Treatment of ANCA-associated vascularitides]Loic Guillevin
Service de Medecine Interne, Centre de référence national, Plan maladies rares, vascularites et sclérodermie systémique, Hopital Cochin, AP HP, Universite Paris 5 Rene Descartes, Paris, France
Presse Med 36:922-7. 2007..These biologics must be prescribed extremely cautiously and only in trial settings, especially in view of the adverse effects, few but severe, recently been reported with them... - Azathioprine or methotrexate maintenance for ANCA-associated vasculitisChristian Pagnoux
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
N Engl J Med 359:2790-803. 2008..However, azathioprine and methotrexate have not been compared with regard to safety and efficacy... - Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: A prospective randomized study of one hundred twenty-four patientsCamillo Ribi
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 75679 Paris, France
Arthritis Rheum 62:1186-97. 2010.... - [Wegener's granulomatosis and microscopic polyangiitis]Christian Pagnoux
Centre de référence maladies auto immunes et maladies systémiques rares, vascularites nécrosantes et sclérodermie systémique, Pôle de médecine, Hopital Cochin, Universite Paris 5, Paris
Rev Prat 58:522-32. 2008..Ten-year survival rate now exceeds 80%, but relapses are frequent. The precise place of new biologics, such as rituximab, needs to be further defined... - Treatment of refractory and/or severe ANCA-associated systemic necrotizing vasculitidesLoic Guillevin
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris, Paris, France
Isr Med Assoc J 10:89-91. 2008..Some of them (e.g., anti-tumor necrosis factor-alpha and anti-CD20 monoclonal antibodies) have achieved promising results and are now often used to treat severe cases... - Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: comparison of two independent cohortsChristian Pagnoux
Hopital Cochin, AP HP, UNIVERSITE DE PARIS, Paris, France
Arthritis Rheum 58:2908-18. 2008..This study was undertaken to evaluate the applicability of those predictors in an independent cohort followed up by the French Vasculitis Study Group... - [Microscopic polyangiitis]Christian Pagnoux
Service de Medecine Interne, Centre de référence national, Plan maladies rares, vascularites nécrosantes et sclérodermie systémique, Hopital Cochin, AP HP, Universite Paris 5 Rene Descartes, Paris, France
Presse Med 36:895-901. 2007..Biological therapies are under evaluation. The remission rate is above 80% with these regimens, and the relapse rate is around 30% at 5 years, lower than for Wegener's granulomatosis... - [Classification of systemic vasculitides]Loic Guillevin
Service de Medecine Interne, Centre de référence maladies rares Vascularites et Sclérodermies systémiques, Hopital Cochin, université Paris V René Descartes, Paris
Rev Prat 58:480-6. 2008.... - The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohortLoic Guillevin
Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases Vasculitides and Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, UPRES 4058, Universite Paris Descartes, INSERM 1016, Paris, France loic guillevin cch aphp fr
Medicine (Baltimore) 90:19-27. 2011..The better WG prognosis for patients with ENT manifestations, even for patients with other visceral involvement, compared with the prognosis for those without ENT manifestations, probably reflects WG phenotype heterogeneity... - Intravenous immunoglobulins for relapses of systemic vasculitides associated with antineutrophil cytoplasmic autoantibodies: results of a multicenter, prospective, open-label study of twenty-two patientsValerie Martinez
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Arthritis Rheum 58:308-17. 2008.... - Churg-Strauss syndrome with poor-prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patientsPascal Cohen
Hopital Cochin, Assistance Publique Hopitaux de Paris, Université René Descartes Paris, Recherche Clinique et Thérapeutique, Paris, France
Arthritis Rheum 57:686-93. 2007..To compare long and short durations of adjunctive cyclophosphamide for the treatment of severe Churg-Strauss syndrome (CSS)... - Indication for plasma exchange for systemic necrotizing vasculiditiesLoic Guillevin
Department of Internal Medicine, Referral Center for Rare Diseases, Vasculitis and Scleroderma, Hopital Cochin, AP HP, Université de Paris René Descartes, 27, rue du Faubourg Saint Jacques, Paris, France
Transfus Apher Sci 36:179-85. 2007..Although PE does not improve survival, their adjunction to corticosteroids and immunosuppressants for patients with alveolar hemorrhage could also limit the severity of this severe manifestation... - Extraocular manifestations of birdshot chorioretinopathy in 118 French patientsChristian Pagnoux
Department of Internal Medicine, National referral center for Systemic necrotizing vasculitides and systemic scleroderma, Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, 75879 Paris cedex 14, France
Presse Med 39:e97-e102. 2010..Published studies on birdshot chorioretinopathy (BCR) did not provide definitive information on possibly associated extraocular manifestations... - Churg-strauss syndrome: clinical symptoms, complementary investigations, prognosis and outcome, and treatmentBertrand Dunogué
Department of Internal Medicine, National Referral Center for Rare Autoimmune and Systemic Diseases including Vasculitis, Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, France
Semin Respir Crit Care Med 32:298-309. 2011..Future therapies might reflect these differences more strongly... - Long-term outcome of 37 patients with Wegener's granulomatosis with renal involvementJacques Eric Gottenberg
Department of Internal Medicine, Nationale referral center for Vasculitides and Scleroderma, Hopital Cochin, AP HP, Universite Paris 5, Paris
Presse Med 36:771-8. 2007..This prospective study sought to assess the long-term outcome and identify prognostic factors of patients with kidney disease related to Wegener's granulomatosis (WG)... - Differences in patients with systemic sclerosis recruited from associations and tertiary care settingsCaroline Mestre-Stanislas
Universite Paris Descartes, Faculte de Medecine, Pôle de Médecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Presse Med 39:e205-9. 2010..To compare patients with systemic sclerosis (SSc) recruited from a patient association or a tertiary care setting... - Cardiac magnetic resonance imaging in Churg-Strauss-syndrome. Impact of immunosuppressants on outcome assessed in a prospective study on 8 patientsJulien Marmursztejn
Department of Cardiology, Hopital Cochin, UNIVERSITE DE PARIS, France
Clin Exp Rheumatol 28:8-13. 2010..To evaluate the effects of immunosuppressive therapy on cardiac abnormalities observed by cardiac magnetic resonance imaging (CMRI) in patients with Churg-Strauss syndrome (CSS)... - Treatment strategies and outcome of induction-refractory Wegener's granulomatosis or microscopic polyangiitis: analysis of 32 patients with first-line induction-refractory disease in the WEGENT trialRaphaele Seror
Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Ann Rheum Dis 69:2125-30. 2010.... - Wegener's granulomatosis strictly and persistently localized to one organ is rare: assessment of 16 patients from the French Vasculitis Study Group databaseChristian Pagnoux
Department of Internal Medicine, Hopital Cochin, 75879 Paris cedex 14, France
J Rheumatol 38:475-8. 2011..To study the frequency and characteristics of patients with Wegener's granulomatosis (WG) strictly and persistently localized to one organ... - [Classification of systemic vasculatides]Loic Guillevin
Centre de référence national, Plan maladies rares, vascularites et sclérodermie systémique, Hopital Cochin, AP HP, Universite Paris 5 Rene Descartes, Paris, France
Presse Med 36:845-53. 2007.... - Remittent non-destructive polysynovitis in P-ANCA-positive vasculitis patients with anti-CCP antibodiesChristian Pagnoux
Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75879 Paris cedex 14, France
Joint Bone Spine 77:604-7. 2010.... - Indications for biotherapy in systemic vasculitidesLoic Guillevin
Department of Internal Medicine, French Vasculitis Study Group, Centre de Référence Vascularites et Sclérodermie, Hopital Cochin, Universite Paris Descartes, Paris, France
Clin Rev Allergy Immunol 32:85-96. 2007..Results of international ongoing trials will determine whether the agents may also have a place as first-line treatment... - Analysis of Wegener's granulomatosis responses to rituximab: current evidence and therapeutic prospectsAchille Aouba
Department of Internal Medicine and the French Vasculitis Study Group, Assistance Publique Hopitaux de Paris, Universite Paris, 5 René Descartes, Hopital Cochin, 27, rue du Faubourg Saint Jacques, 75679, Paris Cedex 14, France
Clin Rev Allergy Immunol 34:65-73. 2008..This promising biotherapy opens the way for other therapeutic agents targeting B lymphocytes and to improve our understanding of the pathophysiology of ANCA-associated vasculitis... - Infliximab or rituximab for refractory Wegener's granulomatosis: long-term follow up. A prospective randomised multicentre study on 17 patientsMathilde de Menthon
Department of Internal Medicine, Hopital Cochin, University Paris Descartes, Paris, France
Clin Exp Rheumatol 29:S63-71. 2011..To compare efficacy and tolerance of infliximab versus rituximab to treat refractory Wegener's granulomatosis (WG), and clarify their respective indications... - Incidence and predictors of urotoxic adverse events in cyclophosphamide-treated patients with systemic necrotizing vasculitidesGuillaume Le Guenno
Hopital Cochin, Assistance Publique Hopitaux de Paris, and Université Paris 5, Paris, France
Arthritis Rheum 63:1435-45. 2011..To assess hemorrhagic cystitis and urinary tract cancer incidence and predictors in cyclophosphamide (CYC)-treated patients with systemic necrotizing vasculitis (SNV)... - Cerebral vasculopathy is associated with severe vascular manifestations in systemic sclerosisBenjamin Terrier
Descartes University, Faculty of Medicine, Department of Internal Medicine and French Reference Centre for Necrotizing Vasculitides and Systemic Sclerosis, Cochin Hospital, Assistance Publique Hopitaux de Paris AP HP, 75679 Paris Cedex 14, France
J Rheumatol 36:1486-94. 2009..To investigate brain involvement in patients with systemic sclerosis (SSc)... - Predictors at diagnosis of a first Wegener's granulomatosis relapse after obtaining complete remissionCarole Pierrot-Deseilligny Despujol
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 27, Paris, France
Rheumatology (Oxford) 49:2181-90. 2010..Although in most patients with WG, induction therapy leads to complete remission (CR), the high relapse rate remains a major problem. This study was undertaken to identify potential predictors of these relapses... - Reporting of corticosteroid use in systemic disease trials: evidence from a systematic review of the potential impact on treatment effectChristian Pagnoux
INSERM U738, Universite Paris Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Arthritis Care Res (Hoboken) 62:1002-8. 2010..To study how corticosteroid therapy is planned and described in reports of systemic disease trials and estimate the impact of the between-arm difference in corticosteroid dose on treatment effect... - [Periostitis in systemic necrotizing vasculitides: Study of the 4 cases identified among the 1762 patients of the FVSG database and review of the literature]Sophie Périchon
Pôle de Médecine Interne, centre de référence vascularites systémiques nécrosantes et sclérodermie systémique, Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, 75879 Paris cedex 14, France
Presse Med 39:e165-73. 2010..Periostitis (periosteal new bone formation) is a rare manifestation of systemic necrotizing vasculitis... - Churg-Strauss syndrome: evidence for disease subtypes?Christian Pagnoux
Department of Internal Medicine, French Vasculitis Study Group, National Referral Center for Necrotizing Vasculitides and Systemic Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Curr Opin Rheumatol 22:21-8. 2010..Conversely, physiopathogenetic mechanisms are not completely elucidated and clearly multiple, thereby suggesting the existence of different disease subtypes... - A paradigm of diagnostic criteria for polyarteritis nodosa: analysis of a series of 949 patients with vasculitidesCorneliu Henegar
Hopital Cochin, Paris 5 René Descartes University, Assistance Publique Hopitaux de Paris, France
Arthritis Rheum 58:1528-38. 2008..To establish a set of clinical and paraclinical criteria potentially useful as a diagnostic screening tool for polyarteritis nodosa (PAN)... - Deaths occurring during the first year after treatment onset for polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: a retrospective analysis of causes and factors predictive of mortality based on 595 patientsAnne Bourgarit
Department of Internal Medicine, , , France
Medicine (Baltimore) 84:323-30. 2005..Cyclophosphamide-induced cytopenia and infection were responsible for 2 deaths. Despite these iatrogenic complications, early deaths were more frequently the consequence of insufficient or inappropriate therapy... - [Wegener's granulomatosis]Christian Pagnoux
Service de Medecine Interne, Centre de référence national maladies rares, vascularites nécrosantes et sclérodermies, Hopital Cochin, AP HP, université Paris V René Descartes, Paris, France
Presse Med 36:860-74. 2007..Today, however, they are reserved for refractory cases... - [Pregnancy and vasculitides]Christian Pagnoux
Pôle de Médecine Interne, Centre de Référence Groupe I Maladies Rares, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris Cedex 14, France
Presse Med 37:1657-65. 2008.... - Rituximab maintenance therapy for granulomatosis with polyangiitis and microscopic polyangiitisClaire Roubaud-Baudron
Department of Internal Medicine, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
J Rheumatol 39:125-30. 2012.... - Encrusting cystitis due to Corynebacterium urealyticum in a patient with ANCA-associated vasculitis: case report and review of the literatureChristian Pagnoux
Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Semin Arthritis Rheum 41:297-300. 2011..The relevant literature on this infection is reviewed... - Pregnancies in systemic necrotizing vasculitides: report on 12 women and their 20 pregnanciesChristian Pagnoux
Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Universite Paris Descartes, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
Rheumatology (Oxford) 50:953-61. 2011..To describe pregnancies of women with systemic necrotizing vasculitides (SNVs), i.e. PAN, WG, Churg-Strauss syndrome (CSS) or microscopic polyangiitis (MPA), followed over the past 15 years at four French centres... - Patients with systemic inflammatory and autoimmune diseases are at risk of vaccine-preventable illnessesCecile Marchand-Janssen
Universite Paris Descartes, Faculte de Medecine, INSERM, CIC BT505, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Pôle de médecine, CIC de vaccinologie Cochin Pasteur, Paris, France
Rheumatology (Oxford) 50:1099-105. 2011..To evaluate vaccine coverage and humoral immunity to tetanus, diphtheria and poliomyelitis in adults followed for systemic inflammatory and/or autoimmune diseases (SIADs)... - [Antileukotrienes and Churg-Strauss syndrome]Philippe Guilpain
Service de Medecine Interne, AP HP, Hopital Cochin, Universite Paris V, Paris, France
Presse Med 36:890-4. 2007..The onset of Churg-Strauss syndrome in patients treated with LTRA usually requires that they stop this treatment. Prescription of LTRA In patients with Churg-Strauss syndrome should be discussed with specialists... - Rituximab reversed cardiac involvement of Wegener's granulomatosis: magnetic resonance imaging assessmentBenoit Brihaye
French Vasculitis Study Group, Department of Internal Medicine, AP HP, Hopital Cochin, Université Paris 5 Descartes, F 75679 Paris cedex 14, France
Presse Med 37:412-5. 2008..We report the disease course of a patient who received rituximab to treat cardiac involvement documented by contrast-enhanced cardiac magnetic resonance imaging (ceCMR)... - Pathogenic effects of antimyeloperoxidase antibodies in patients with microscopic polyangiitisPhilippe Guilpain
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 56:2455-63. 2007..The aim of this study was to investigate whether anti-MPO antibodies can activate MPO to generate an oxidative stress that is potentially deleterious to the endothelium... - Patient preference disability questionnaire in systemic sclerosis: a cross-sectional surveyLuc Mouthon
Paris Descartes University, UPRES EA 4058, and Assistance Publique Hopitaux de Paris, Cochin Hospital, Paris, France
Arthritis Rheum 59:968-73. 2008..To assess patient priorities concerning disability in systemic sclerosis (SSc)... - Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)Cécile Espy
Université Paris Descartes and Hôpital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 63:2105-15. 2011.... - Churg-Strauss syndromeChristian Pagnoux
Department of Internal Medicine, French Vasculitis Study Group, Centre de Référence Vascularites et Sclérodermies, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Curr Opin Rheumatol 19:25-32. 2007..The most recent clinical studies on its pathogenesis and therapeutic management are reviewed here... - Safety and efficacy of rituximab in systemic lupus erythematosus: results from 136 patients from the French AutoImmunity and Rituximab registryBenjamin Terrier
Bicetre Hospital, Assistance Publique Hopitaux de Paris, and Paris 11 University, Le Kremlin Bicetre, France
Arthritis Rheum 62:2458-66. 2010..However, in 2 recent randomized controlled trials (RCTs) of RTX, the primary end points were not met. We undertook this study to evaluate the safety and efficacy of RTX in off-trial patients with SLE seen in regular clinical practice... - Indications of plasma exchanges for systemic vasculitidesLoic Guillevin
Department of Internal Medicine, Hopital Avicenne, Universite Paris Nord, Assistance Publique Hopitaux de Paris, Bobigny, France
Ther Apher Dial 7:155-60. 2003..We review herein these indications of plasma exchanges in the light of the results of major trials... - Hepatitis B virus-associated polyarteritis nodosa: clinical characteristics, outcome, and impact of treatment in 115 patientsLoic Guillevin
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Medicine (Baltimore) 84:313-22. 2005..The major cause of death is gastrointestinal tract involvement. Importantly, the frequency of HBV-PAN has decreased in relation to improved blood safety and vaccination campaigns... - [Pregnancy and inflammatory myopathies]Dalia Dimitri
Service d Histologie, Centre de Référence des maladies Neuromusculaires, Garches Necker Mondor Hendaye, INSERM U841, CHU Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
Presse Med 37:1652-6. 2008..Maternal disease should be treated with corticosteroids, using the same dosage and regimen as for non-pregnant women and according to the disease activity and severity... - Seasonal variations in onset of Wegener's granulomatosis: increased in summer?Alfred Mahr
Department of Internal Medicine, Hopital Cochin, Universite Rene Descartes, Paris, France
J Rheumatol 33:1615-22. 2006..Investigators have reported significant seasonal variations of onset of Wegener's granulomatosis (WG), but those data were not confirmed by others. We reexamined the hypothesis of a seasonal pattern of onset of WG... - Atherosclerosis in ANCA-associated vasculitidesChristian Pagnoux
Department of Internal Medicine, French National Referral Center for Necrotizing Vasculitides and Systemic Sclerodermas, Hopital Cochin, Universite Paris 5 Rene Descartes, Paris, France
Ann N Y Acad Sci 1107:11-21. 2007..Until their precise identification, it remains important to take into consideration and treat, every time it is necessary and possible, the other well-known cardiovascular risk factors... - Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester diseaseAchille Aouba
Department of Internal Medicine, French National Referral Center for Langerhans Cell Histiocytosis, Hopital Cochin, Université de Paris Descartes, Assistance Publique Hopitaux de Paris AP HP, Paris, France
Blood 116:4070-6. 2010..Therefore, our results support a central role of the IL-1 network, which seemed to be overstimulated in ECD. Its specific blockade using anakinra thereby opens new pathophysiology and therapeutic perspectives in ECD... - Dorsal prevertebral lesions in Wegener granulomatosis: report on four casesPaulo Barreto
Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75879 Paris cedex 14, France
Joint Bone Spine 78:88-91. 2011..WG should be included in the differential diagnosis of fibrosing mediastinitis (with tuberculosis, neoplastic diseases, sarcoidosis, histiocytosis and inflammatory pseudotumor), which may have a similar radiological appearance... - Plasma exchange for systemic lupus erythematosusChristian Pagnoux
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Rene Descartes, Paris, 27, rue du Faubourg Saint Jacques, 75689 Paris Cedex 14, France
Transfus Apher Sci 36:187-93. 2007..The use of newer technologies, like immunoadsorption, possibly in combination with recent biologics, might, in the future, offer some new perspectives for extracorporeal therapy of systemic lupus erythematosus... - Presentation and outcome of gastrointestinal involvement in systemic necrotizing vasculitides: analysis of 62 patients with polyarteritis nodosa, microscopic polyangiitis, Wegener granulomatosis, Churg-Strauss syndrome, or rheumatoid arthritis-associated Christian Pagnoux
Hopital Cochin, Service de Medecine Interne, 27, rue du Faubourg Saint Jacques, Paris Cedex 14, France
Medicine (Baltimore) 84:115-28. 2005.... - Churg-Strauss syndrome: evolving conceptsChristian Pagnoux
Department of Internal Medicine, French Vasculitis Study Group, National Referral Center for Necrotizing Vasculitides and Systemic Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Discov Med 9:243-52. 2010..Hence, progress is needed in Churg-Strauss syndrome's therapeutic management, and better understanding of the complex disease mechanisms may aid such a quest... - Plasma exchange for rheumatoid arthritisRaphaele Seror
Department of Internal Medicine, Hopital Cochin, 27, rue du fauborg Saint Jacques, Universite Rene Descartes, Assistance Publique Hopitaux de Paris, 75679 Paris Cedex 14, France
Transfus Apher Sci 36:195-9. 2007..But, the emergence of effective biologics has clearly restrained their use and limited their indications to some rare patients with refractory and severe RA... - Marked efficacy of a therapeutic strategy associating prednisone and plasma exchange followed by rituximab in two patients with refractory myopathy associated with antibodies to the signal recognition particle (SRP)Jean-Benoit Arlet
Department of Internal Medicine, Faculty of Medicine, Cochin Hospital, Paris-Descartes University, , AP-HP, Paris, France
Neuromuscul Disord 16:334-6. 2006..A marked response was observed in both patients, with partial to complete recovery of muscle strength, which was sustained... - [Abdominal and digestive manifestations in systemic vasculitides]Christian Pagnoux
, , 27, rue du Faubourg-Saint-Jacques, 75679 Paris 14
Ann Med Interne (Paris) 154:457-67. 2003..Prompt surgical and medical care of these seriously ill patients has lowered mortality from nearly 100% twenty years ago to approximately 23 to 56% currently... - JC virus leukoencephalopathy complicating Wegener's granulomatosisChristian Pagnoux
Travail du Service de Rhumatologie, groupe hospitalier Bichat-Claude-Bernard, 46, rue Henri-Huchard, 75877 Paris Cedex 18, France
Joint Bone Spine 70:376-9. 2003..No specific or effective treatments are available. Immunosuppressant drugs should be discontinued if possible...