Research Topics
Genomes and Genes | Emeline NandrotSummaryAffiliation: Institut de la Vision Location: Paris, France URL: http://www.institut-vision.org/index.php?option=com_content&view=article&id=44%3Aequipe-de-nandrot&catid=17%3Afiches&Itemid=15&lang=en Publications
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Publications
Spatial and temporal mapping of c-kit and its ligand, stem cell factor expression during human embryonic haemopoiesisM Teyssier-Le Discorde
CEA DSV DRM SRHI Groupe de Recherche sur la Régulation et l Expression des Gènes, Hopital St Louis, Paris, France
Br J Haematol 107:247-53. 1999....- Three gene-targeted mouse models of RNA splicing factor RP show late-onset RPE and retinal degenerationJohn J Graziotto
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Invest Ophthalmol Vis Sci 52:190-8. 2011..The retinal ultrastructure of Prpf31-knockout mice was also investigated... - EYS is a major gene for rod-cone dystrophies in FranceIsabelle Audo
INSERM U968, Department of Genetics, Institut de la Vision, UPMC Univ Paris 06, 17 rue Moreau, Paris, France
Hum Mutat 31:E1406-35. 2010..With a prevalence of 12% or more we provide evidence that EYS is a major gene for RP in France and probably elsewhere... - Mertk in daily retinal phagocytosis: a history in the makingEmeline F Nandrot
Centre de Recherche Institut de la Vision, UPMC University of Paris 06, Paris, France
Adv Exp Med Biol 664:133-40. 2010..We now have a more precise picture of the sequence of molecular events governing retinal phagocytosis. However, requirement of MerTK ligands in vivo and linked signaling pathways still remain elusive so far... - TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindnessIsabelle Audo
INSERM, UMR_S968, F 75012, Paris, France
Am J Hum Genet 85:720-9. 2009..The mutation spectrum comprises missense, splice-site, deletion, and nonsense mutations. We propose that the cCSNB phenotype in these patients is due to the absence of functional TRPM1 in retinal ON bipolar cells... - Lack of alphavbeta5 integrin receptor or its ligand MFG-E8: distinct effects on retinal functionEmeline F Nandrot
Department of Ophthalmology, Dyson Vision Research Institute, New York, NY 10065, USA
Ophthalmic Res 40:120-3. 2008..We recently identified an important role for alphavbeta5 integrin receptors and their ligand Milk fat globule-EGF factor 8 (MFG-E8) in RPE phagocytosis... - Alphavbeta5 integrin receptors at the apical surface of the RPE: one receptor, two functionsEmeline F Nandrot
Margaret M. Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, Box 233, 1300 York Avenue, New York, NY 10021, USA
Adv Exp Med Biol 613:369-75. 2008 - Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosisEmeline F Nandrot
Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 104:12005-10. 2007..Thus, MFG-E8 stimulates rhythmic POS phagocytosis by ligating apical alphavbeta5 receptors of the RPE. These results identify MFG-E8 as the first extracellular ligand in the retina that is essential for diurnal POS phagocytosis... - MerTK activation during RPE phagocytosis in vivo requires alphaVbeta5 integrinSilvia C Finnemann
Department of Ophthalmology, Weill Medical College of Cornell University, Box 233, 1300 York Avenue, New York, NY 10021, USA
Adv Exp Med Biol 572:499-503. 2006 - Altered rhythm of photoreceptor outer segment phagocytosis in beta5 integrin knockout miceEmeline F Nandrot
Department of Ophthalmology, Weill Medical College of Cornell University, Box 233, 1300 York Avenue, New York, NY 10021, USA
Adv Exp Med Biol 572:119-23. 2006 - Novel role for alphavbeta5-integrin in retinal adhesion and its diurnal peakEmeline F Nandrot
Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
Am J Physiol Cell Physiol 290:C1256-62. 2006..Furthermore, they indicate that alpha(v)beta(5) receptors at the same apical plasma membrane domain of RPE cells fulfill two separate functions that are synchronized by different diurnal rhythms... - Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoterAlexis-Pierre Bemelmans
BioVectys, c/o laboratoire LGN, , Paris, France
J Gene Med 7:1367-74. 2005..CONCLUSIONS: Mokola-pseudotyped lentiviral vectors are effective for specific gene transfer to the RPE. Neither VSV- nor Mokola-pseudotyped lentiviral vectors are adequate for efficient gene transfer to photoreceptors of adult rats... - Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrinEmeline F Nandrot
Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
J Exp Med 200:1539-45. 2004..Furthermore, they identify the beta5-/- integrin mouse strain as a new animal model of age-related retinal dysfunction... - Identification of novel genes and altered signaling pathways in the retinal pigment epithelium during the Royal College of Surgeons rat retinal degenerationEric M Dufour
CERTO, , , , 156 rue de Vaugirard 75015 Paris, France
Neurobiol Dis 14:166-80. 2003..We also found differential levels of transcripts encoding proteins involved in phagocytosis, vesicle trafficking, the cytoskeleton, retinoic acid, and general metabolism... - Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataractsE Nandrot
Centre de Recherches Thérapeutiques en Ophtalmologie de la Faculté de Médecine Necker, EA No 2502 du Ministére de la Recherche et de l Enseignement Supérieur, Universite Rene Descartes, Paris, France
J Med Genet 40:262-7. 2003..Furthermore, this is the first report of a mutation in this gene resulting in autosomal dominant congenital cerulean cataracts... - Evidence of clinical and genetic heterogeneity in autosomal dominant congenital cerulean cataractsLatifa Hilal
, , , Morocco
Ophthalmic Genet 23:199-208. 2002..This finding confirms the clinical and genetic heterogeneity of autosomal dominant congenital cerulean cataracts... - Homozygous deletion in the coding sequence of the c-mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosisE Nandrot
Universite Rene Descartes, Centre de Recherches Thérapeutiques en Ophtalmologie, Paris, France
Neurobiol Dis 7:586-99. 2000..The c-mer gene contains characteristic motifs of neural cell adhesion. A ligand of the c-mer receptor, Gas6, exhibits antiapoptotic properties... - In vitro differentiation of retinal pigment epithelium from adult retinal stem cellsClaudia Aruta
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
Pigment Cell Melanoma Res 24:233-40. 2011..These data suggest that our protocol to differentiate RPE in vitro can provide a useful model for molecular and functional studies...