Research Topics
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Publications
Prediction of volume responsiveness in critically ill patients with spontaneous breathing activityJean Louis Teboul
Research Unit EA 4046, Bicêtre Teaching Hospital, Paris 11 University, Le Kremlin Bicetre, France
Curr Opin Crit Care 14:334-9. 2008..The aim of this review is to summarize the different tools that have been proposed to predict the hemodynamic response to fluid infusion in the presence of spontaneous breathing activity...- Esophageal Doppler monitoring predicts fluid responsiveness in critically ill ventilated patientsXavier Monnet
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Intensive Care Med 31:1195-201. 2005..CONCLUSIONS: The respiratory variation in aortic blood flow reliably predicts fluid responsiveness in patients with sinus rhythm and without breathing activity... - Volume responsivenessXavier Monnet
Medical Intensive Care Unit, Bicetre University Hospital, Paris 11 University, Le Kremlin Bicetre, France
Curr Opin Crit Care 13:549-53. 2007..We aim to summarize the methods available for predicting volume responsiveness, focusing on recent findings in patients with spontaneous breathing activity... - Effects of changes in vascular tone on the agreement between pulse contour and transpulmonary thermodilution cardiac output measurements within an up to 6-hour calibration-free periodOlfa Hamzaoui
Service de Reanimation Medicale, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, EA 4046, Université Paris 11, Le Kremlin Bicetre, France
Crit Care Med 36:434-40. 2008..To examine whether the agreement between pulse contour and transpulmonary thermodilution cardiac index (CI) measurements is altered by changes in vascular tone within an up to 6-hr calibration-free period... - Third-generation FloTrac/Vigileo does not reliably track changes in cardiac output induced by norepinephrine in critically ill patientsX Monnet
Hôpitaux Universitaires Paris Sud, Hopital de Bicetre, Service de Reanimation Medicale, 78, rue du General Leclerc, Le Kremlin Bicêtre F 94270, France
Br J Anaesth 108:615-22. 2012..The ability of the third-generation FloTrac/Vigileo software to track changes in cardiac index (CI) induced by volume expansion and norepinephrine in critically ill patients is unknown... - Detecting volume responsiveness and unresponsiveness in intensive care unit patients: two different problems, only one solutionJean Louis Teboul
Service de Reanimation Medicale, CHU Bicetre, AP HP, Le Kremlin Bicetre, F 94270, France
Crit Care 13:175. 2009..Measuring the short-term hemodynamic changes during passive leg raising can be reliably used for that purpose in both situations, even when patients are breathing spontaneously... - Early administration of norepinephrine increases cardiac preload and cardiac output in septic patients with life-threatening hypotensionOlfa Hamzaoui
Service de Reanimation Medicale, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, EA 4046, Universite Paris Sud, 78 rue du General Leclerc, 94 270 Le Kremlin Bicêtre, France
Crit Care 14:R142. 2010..We sought to examine the cardiac consequences of early administration of norepinephrine in severely hypotensive sepsis patients hospitalized in a medical intensive care unit of a university hospital... - Rapid and beneficial hemodynamic effects of activated protein C in septic shock patientsX Monnet
Service de Reanimation Medicale, CHU de Bicetre, Assistance Publique Hopitaux de Paris, Universite Paris XI, 78 rue du General Leclerc, 94270, Le Kremlin Bicetre, France
Intensive Care Med 31:1573-6. 2005..We tested whether rhAPC reduces the dose of norepinephrine required to maintain mean arterial pressure (MAP) in septic shock patients... - Passive leg raisingXavier Monnet
Service de Reanimation Medicale, Hopital de Bicetre, AP HP, 78 rue du General Leclerc, 94270, Le Kremlin Bicetre, France
Intensive Care Med 34:659-63. 2008..To assess whether the passive leg raising test can help in predicting fluid responsiveness... - [Field 6. Safety practices for haemodynamic procedures (administration of vasoactive drugs, vascular and cardiac catheterization). French-speaking Society of Intensive Care. French Society of Anesthesia and Resuscitation]X Monnet
Service de Reanimation Medicale, Hopital de Bicetre, AP HP, 78, rue du General Leclerc, 94270 Le Kremlin Bicetre, France
Ann Fr Anesth Reanim 27:e91-9. 2008..Concerning the pulmonary artery catheter, the balloon tip should be inflated with visual control of the pulmonary artery pressure. Its removal is recommended within the first five days... - Predicting volume responsiveness by using the end-expiratory occlusion in mechanically ventilated intensive care unit patientsXavier Monnet
AP HP, Hopital de Bicetre, Service de Reanimation Medicale, Le Kremlin Bicetre, France
Crit Care Med 37:951-6. 2009..We tested whether this could serve as a functional test for fluid responsiveness in patients with circulatory failure... - Critical care management and outcome of severe Pneumocystis pneumonia in patients with and without HIV infectionXavier Monnet
AP HP, Hopital de Bicetre, Service de Reanimation Medicale, 78, rue du General Leclerc, Le Kremlin Bicetre, F 94270, France
Crit Care 12:R28. 2008..Improved knowledge about the differential characteristics and management modalities could guide treatment based on HIV status... - Arterial pressure-based cardiac output in septic patients: different accuracy of pulse contour and uncalibrated pressure waveform devicesXavier Monnet
AP HP, Hopital de Bicetre, Service de Reanimation Medicale, 78 rue du General Leclerc, Le Kremlin Bicêtre F 94270, France
Crit Care 14:R109. 2010.... - Norepinephrine increases cardiac preload and reduces preload dependency assessed by passive leg raising in septic shock patientsXavier Monnet
AP HP, Hopital de Bicetre, Service de Reanimation Medicale, Le Kremlin Bicetre, France
Crit Care Med 39:689-94. 2011..To assess the effects of norepinephrine on cardiac preload, cardiac index, and preload dependency during septic shock... - Early fluid resuscitationXavier Monnet
Service de Reanimation Medicale, Hopital de Bicetre, 78, rue du General Leclerc, 94270, Le Kremlin Bicetre, France
Curr Infect Dis Rep 12:354-60. 2010..Finally, the risk of fluid overload must always be kept in mind, especially in case of lung injury... - Arterial pressure allows monitoring the changes in cardiac output induced by volume expansion but not by norepinephrineXavier Monnet
Service de Reanimation Medicale, Hopital de Bicetre, AP HP, Le Kremlin Bicetre, France
Crit Care Med 39:1394-9. 2011..To evaluate to which extent the systemic arterial pulse pressure could be used as a surrogate of cardiac output for assessing the effects of a fluid challenge and of norepinephrine... - Precision of the transpulmonary thermodilution measurementsXavier Monnet
AP HP, Hôpitaux Universitaires Paris Sud, Service de Reanimation Medicale, Le Kremlin Bicetre, F 94270 France
Crit Care 15:R204. 2011.... - Passive leg-raising and end-expiratory occlusion tests perform better than pulse pressure variation in patients with low respiratory system complianceXavier Monnet
AP HP, Hopital de Bicetre, Service de Reanimation Medicale, Le Kremlin Bicetre, France
Crit Care Med 40:152-7. 2012.... - Do hypooncotic fluids for shock increase the risk of late-onset acute respiratory distress syndrome?Frederique Schortgen
Service de Reanimation Medicale, AP HP, Groupe Hospitalier Albert Chenevier Henri Mondor, Creteil 94000, France
Intensive Care Med 36:1724-34. 2010..PARTICIPANT AND SETTINGS: International prospective cohort of consecutive adults who were free of ARDS on admission and who received fluid resuscitation for shock in 115 intensive care units (ICUs) during a 4-week period... - Cardiac filling pressures are not appropriate to predict hemodynamic response to volume challengeDavid Osman
Service de Reanimation Medicale, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, Universite Paris XI, Le Kremlin Bicetre, France
Crit Care Med 35:64-8. 2007..By analyzing a large number of volume challenges, our aim was to test the significance of the recommended target values in terms of prediction of volume responsiveness... - Passive leg raising predicts fluid responsiveness in the critically illXavier Monnet
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Crit Care Med 34:1402-7. 2006.... - Cardiac function index provided by transpulmonary thermodilution behaves as an indicator of left ventricular systolic functionJulien Jabot
AP HP, Hopital de Bicetre, Service de Reanimation Medicale, Paris Sud, Le Kremlin Bicetre, France
Crit Care Med 37:2913-8. 2009..The transpulmonary thermodilution calculates the cardiac function index, which is the ratio of cardiac output over global end-diastolic volume... - Pulse oximeter as a sensor of fluid responsiveness: do we have our finger on the best solution?Xavier Monnet
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Crit Care 9:429-30. 2005.... - Subendocardial viability index is related to the diastolic/systolic time ratio and left ventricular filling pressure, not to aortic pressure: an invasive study in resting humansDenis Chemla
Paris Sud University, Research Team EA4046, Le Kremlin Bicetre, France
Clin Exp Pharmacol Physiol 36:413-8. 2009..Although LVEDP accounted for only 13% of SVI variability, it should be taken into account in the non-invasive calculation of SVI in patients with known or suspected increases in LV filling pressure... - Subendocardial viability ratio estimated by arterial tonometry: a critical evaluation in elderly hypertensive patients with increased aortic stiffnessDenis Chemla
Paris Sud University, Research Team EA4046, Le Kremlin Bicetre, France
Clin Exp Pharmacol Physiol 35:909-15. 2008..4. The tonometric SEVR was not impaired in elderly hypertensive patients with increased aortic stiffness. In resting elderly and middle-aged individuals, the tonometric SEVR was mainly related to DT/ST ratio, not to aortic pressure... - Echocardiographic prediction of volume responsiveness in critically ill patients with spontaneously breathing activityBouchra Lamia
Service de Reanimation Medicale, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, EA 4046, Universite Paris Sud, 78 rue du General Leclerc, 94270, Le Kremlin Bicetre, France
Intensive Care Med 33:1125-32. 2007..We also examined whether common echocardiographic indices of cardiac filling status are valuable to predict volume responsiveness in this category of patients... - The risk associated with hyperoncotic colloids in patients with shockFrederique Schortgen
Réanimation Médicale, AP HP, Groupe Hospitalier Albert Chenevier, Henri Mondor, 94000 Creteil, France
Intensive Care Med 34:2157-68. 2008..This study assessed the risk of renal adverse events in patients with shock resuscitated using hypo-oncotic colloids, artificial hyperoncotic colloids, hyperoncotic albumin or crystalloids, according to physician's choice... - Hemodynamic impact of a positive end-expiratory pressure setting in acute respiratory distress syndrome: importance of the volume statusEmilie Fougères
AP HP, Hopital de Bicetre, Service de Reanimation Medicale, Le Kremlin Bicetre, France
Crit Care Med 38:802-7. 2010..Our aim was to evaluate the hemodynamic effect of increasing positive end-expiratory pressure when tidal volume and the plateau pressure are limited and to explore the underlying mechanisms... - Passive leg raising for predicting fluid responsiveness: importance of the postural changeJulien Jabot
Service de Reanimation Medicale, AP HP, Hopital de Bicetre, Centre Hospitalier Universitaire de Bicetre, 78, rue du General Leclerc, 94270, Le Kremlin Bicetre, France
Intensive Care Med 35:85-90. 2009..PLR(SUPINE) could have a lower hemodynamic impact than PLR(SEMIREC) since it should not recruit the splanchnic venous reservoir... - Incidence and prognostic value of right ventricular failure in acute respiratory distress syndromeDavid Osman
Service de Reanimation Medicale, Hopital de Bicetre, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, Université Paris 11 Sud, Le Kremlin Bicetre, France
Intensive Care Med 35:69-76. 2009..To analyse the incidence and the impact on outcome of right ventricular failure (RVF) in patients with acute respiratory distress syndrome (ARDS)... - Relationship between the tricuspid annular plane systolic excursion and right and left ventricular function in critically ill patientsBouchra Lamia
AP HP, Service de Reanimation Medicale, 94275 Le Kremlin Bicetre, France
Intensive Care Med 33:2143-9. 2007..The ability of TAPSE to reflect right ventricular function at baseline and to monitor acute changes in right ventricular function was tested in critically ill patients... - Cardiopulmonary interactions in patients with heart failureXavier Monnet
Service de Reanimation Medicale, Centre Hospitalier Universitaire de Bicetre, Assistance Publique Hopitaux de Paris, Université Paris 11, Le Kremlin Bicetre, France
Curr Opin Crit Care 13:6-11. 2007.... - Assessing pulmonary permeability by transpulmonary thermodilution allows differentiation of hydrostatic pulmonary edema from ALI/ARDSXavier Monnet
Service de Reanimation Medicale, Centre Hospitalier Universitaire de Bicetre, 78, rue du General Leclerc, 94 270, Le Kremlin Bicetre, France
Intensive Care Med 33:448-53. 2007..To test whether assessing pulmonary permeability by transpulmonary thermodilution enables to differentiate increased permeability pulmonary edema (ALI/ARDS) from hydrostatic pulmonary edema... - Increase in plasma protein concentration for diagnosing weaning-induced pulmonary oedemaNadia Anguel
Service de Reanimation Medicale, Centre Hospitalier Universitaire de Bicetre, AP HP, 94 270, Le Kremlin Bicetre, France
Intensive Care Med 34:1231-8. 2008..Thus, we tested whether the changes in plasma protein concentration during a weaning trial could diagnose weaning-induced pulmonary oedema... - Contribution of arterial stiffness and stroke volume to peripheral pulse pressure in ICU patients: an arterial tonometry studyBouchra Lamia
Universite Paris Sud 11, Equipe d Accueil EA4046, 94275 Le Kremlin Bicetre, France
Intensive Care Med 33:1931-7. 2007..Our aim was to test the respective influence of arterial stiffness, stroke volume, peripheral resistance, and various hemodynamic and demographic variables on peripheral pulse pressure in critically ill patients... - Invasive measures of left ventricular preloadXavier Monnet
Medical Intensive Care Unit, , Paris-11 University, , France
Curr Opin Crit Care 12:235-40. 2006..SUMMARY: The best prediction of the hemodynamic response to fluid therapy is afforded by functional evaluation of preload responsiveness rather than by static markers of preload... - Reduction in postsystolic wall thickening during late preconditioningXavier Monnet
Laboratoire de Pharmacologie, INSERM U660, Faculté de Médecine de Créteil, 8, rue Général Sarrail, 94010 Creteil Cedex, France
Am J Physiol Heart Circ Physiol 292:H158-64. 2007..e., the rate of wall thickening is enhanced and PWST is almost abolished. These phenotype adaptations represent potential approaches for characterizing stunning and late preconditioning with repetitive ischemia in humans... - Differential effects of heart rate reduction and beta-blockade on left ventricular relaxation during exercisePatrice Colin
, , , , France
Am J Physiol Heart Circ Physiol 282:H672-9. 2002..Thus, for a similar reduction in heart rate at rest and during exercise, ivabradine, in contrast with atenolol, does not exert any negative lusitropic effect... - Conversion of post-systolic wall thickening into ejectional thickening by selective heart rate reduction during myocardial stunningLaurence Lucats
INSERM, Unite 841, Creteil, F 94010, France
Eur Heart J 28:872-9. 2007..The effects of two heart rate reducing agents, i.e. the beta-blocker atenolol and the selective I(f) current inhibitor ivabradine, were compared on PSWT... - [Shock]Xavier Monnet
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Rev Prat 55:433-9. 2005 - Heart rate reduction during exercise-induced myocardial ischaemia and stunningXavier Monnet
Laboratoire de Pharmacologie, INSERM E 00.01, , Paris, France
Eur Heart J 25:579-86. 2004..Additional negative inotropism is protective against ischaemia but deleterious during stunning... - Contributions of heart rate and contractility to myocardial oxygen balance during exercisePatrice Colin
Laboratoire de Pharmacologie, INSERM E 00.01, , , France
Am J Physiol Heart Circ Physiol 284:H676-82. 2003..Thus HR reduction and negative inotropy equally contribute to the reduction in MVo(2) during exercise in the normal heart. The negative inotropy limits the increase in DT afforded by HR reduction... - Regional and temporal heterogeneity of postsystolic wall thickening is associated with left ventricular asynchrony in normal and experimental stunned myocardiumLaurence Lucats
Laboratoire de Pharmacologie, INSERM U 841 Equipe 03 Faculté de Médecine Université Paris 12, 8, rue du Général Sarrail, 94010, Creteil Cedex, France
Basic Res Cardiol 103:385-96. 2008..Postsystolic wall thickening (PSWT) occurs after aortic valve closure. We investigated the influence of ischemia location and wall interactions on PSWT in normal and stunned myocardium...