Research Topics
| Marc MichelSummaryCountry: France Publications
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Detail Information
Publications
[Characteristics of warm autoimmune hemolytic anemia and Evans syndrome in adults]Marc Michel
Service de Medecine Interne, Centre de référence sur les cytopénies auto immunes de l adulte, CHU Henri Mondor, F 94010 Créteil Cedex, France
Presse Med 37:1309-18. 2008..Its management is usually extrapolated from the standard of care for isolated wAIHA. Before the availability of rituximab, the overall prognosis was relatively poor for adults with both wAIHA and ES, with a mortality rate of 15 to 20%...- Characteristics and outcome of connective tissue diseases in patients with sickle-cell disease: report of 30 casesM Michel
Department of Internal Medicine, Henri Mondor University Hospital, Creteil, France
Semin Arthritis Rheum 38:228-40. 2008..To analyze the main characteristics of adults with sickle cell disease (SCD) and concurrent connective tissue disease (CTD)... - [Warm autoimmune hemolytic anemias and Evans syndrome in adults]M Michel
Service de Medecine Interne, centre de référence pour les cytopénies auto immunes de l adulte, CHU Henri Mondor, 52, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
Rev Med Interne 29:105-14. 2008..FUTURE PROSPECTS AND PROJECTS: A better knowledge of the mechanisms triggering AIHA and ES as well as therapeutic trials are needed in order to better stratify treatment taking into account the promising efficacy of rituximab... - The spectrum of Evans syndrome in adults: new insight into the disease based on the analysis of 68 casesMarc Michel
Department of Internal Medicine, Henri Mondor Hospital, Assistance Publique Hopitaux de Paris, Paris XII University, Creteil, France
Blood 114:3167-72. 2009..In conclusion, ES is a potentially life-threatening condition that may be associated with other underlying autoimmune or lymphoproliferative disorders... - [Autoimmune diseases: epidemiology, diagnosis and treatment]Marc Michel
, , CHU Henri-Mondor,
Rev Prat 58:909-16. 2008 - Reduced corticosteroid use in adult patients with primary immune thrombocytopenia receiving romiplostimMarc Michel
CHU Henri Mondor AP HP, Universite Paris, 51 Av du Mal de Lattre de Tassigny, Creteil, France
Hematology 16:274-7. 2011..Such reductions in corticosteroids may improve health-related quality of life in patients with primary immune thrombocytopenia... - Characteristics and outcome of immune thrombocytopenia in elderly: Results from a single center case-controlled studyMarc Michel
Department of Internal Medicine, national referral center for adult s immune cytopenias, Henri Mondor University Hospital, Assistance Publique Hopitaux de Paris, Université Paris Est Créteil, Creteil, France
Am J Hematol 86:980-4. 2011..In conclusion, this study confirms that at equivalent platelet count, ITP has a greater impact in elderly. Am. J. Hematol. 2011. © 2011 Wiley-Liss, Inc... - Classification and therapeutic approaches in autoimmune hemolytic anemia: an updateMarc Michel
Department of Internal Medicine, National Referral Center for Adults Immune Cytopenias, Henri Mondor University Hospital, Assistance Publique Hopitaux de Paris, Université Paris Est Créteil, Creteil, France
Expert Rev Hematol 4:607-18. 2011..In this article, the classification of AIHA and the recent progress in therapeutics are discussed... - Romiplostim safety and efficacy for immune thrombocytopenia in clinical practice: 2-year results of 72 adults in a romiplostim compassionate-use programMehdi Khellaf
Department of Internal Medicine, Centre Hospitalier Universitaire Henri Mondor, Assistance Publique Hopitaux de Paris, Université Paris Est Créteil, Creteil, France
Blood 118:4338-45. 2011..Our results confirmed that romiplostim use in clinical practice is effective and safe for severe chronic ITP. This trial was registered at www.clinicaltrials.gov as #NCT01013181... - Assessment of a therapeutic strategy for adults with severe autoimmune thrombocytopenic purpura based on a bleeding score rather than platelet countMehdi Khellaf
Service de Medecine Interne, Hopital Henri Mondor, 51 avenue de Lattre de Tassigny, 94010 Creteil Cedex, France
Haematologica 90:829-32. 2005.... - Efficacy and safety of rituximab in adults' warm antibody autoimmune haemolytic anemia: retrospective analysis of 27 casesGuillaume Bussone
Department of Internal Medicine, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris 12, Creteil, France
Am J Hematol 84:153-7. 2009..In conclusion, rituximab seems highly effective and relatively safe in adults with steroid-resistant or steroid-dependent wAIHA... - Antiphospholipid antibodies in adults with immune thrombocytopenic purpuraCarole Pierrot-Deseilligny Despujol
Centre de Référence National pour la Prise en Charge et la Recherche sur les Cytopénies Auto immunes de l Adulte, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris 12, Creteil, France
Br J Haematol 142:638-43. 2008..9; 95% CI: 2.3-43.4) or high IgG-aCL level (HR: 7.5; 95% CI; 1.8-31.5). Although the thrombosis rate was low, the significant associations between thrombosis and LA or high aCL level suggest that aPL should be tested at ITP diagnosis... - Costs of managing severe immune thrombocytopenia in adults: a retrospective analysisMehdi Khellaf
Service de Medecine Interne, Centre Hospitalier Universitaire, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris 12, Creteil, France
Ann Hematol 90:441-6. 2011..Management of adults with chronic ITP is costly in France, especially for patients with severe disease. IVIg use was a major cost driver... - Efficacy and safety of rituximab in common variable immunodeficiency-associated immune cytopenias: a retrospective multicentre study on 33 patientsDelphine Gobert
Department of Internal Medicine, Hopital Henri Mondor, Creteil, Paris, France
Br J Haematol 155:498-508. 2011..In conclusion, rituximab appears to be highly effective and relatively safe for the management of CVID-associated severe immune cytopenias... - [Treatment of systemic autoimmune and inflammatory diseases with rituximab]Guillaume Bussone
Universite Paris Descartes, Pôle de Médecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hopitaux de Paris, F 75679 Paris cedex 14, France
Presse Med 38:808-23. 2009..Relapses of the disease are common around six months after rituximab infusion. The response to retreatment with rituximab is usually the same that was obtained after the first course of treatment... - IgA-mediated human autoimmune hemolytic anemia as a result of hemagglutination in the spleen, but independent of complement activation and Fc?RIPhilippe Chadebech
Etablissement Français du Sang, Ile de France, Henri Mondor Hospital, Creteil, France
Blood 116:4141-7. 2010..These results, together with the efficacy of splenectomy 17 months after AIHA onset, suggest that the trapping and subsequent sequestration of agglutinated RBCs in the spleen are the principal pathogenic mechanisms of pIgA-mediated AIHA... - Association of sarcoidosis and immune thrombocytopenia: presentation and outcome in a series of 20 patientsMatthieu Mahevas
Department of Internal Medicine, Henri Mondor Hospital, Assistance Publique Hopitaux de Paris, Paris, France
Medicine (Baltimore) 90:269-78. 2011.... - Autoimmune thrombocytopenic Purpura and Helicobacter pylori infectionMarc Michel
Service de Medecine Interne, CHU Hopital Henri Mondor, 51 Av du Mal de Lattre de Tassigny, 94010 Creteil Cedex, France
Arch Intern Med 162:1033-6. 2002..We looked for an association between H pylori infection and AITP in adults... - Rituximab efficacy and safety in adult splenectomy candidates with chronic immune thrombocytopenic purpura: results of a prospective multicenter phase 2 studyBertrand Godeau
Medecine Interne, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris 12, Creteil, France
Blood 112:999-1004. 2008..Based on these results, rituximab was an apparently safe and effective splenectomy-avoiding option in some adults with chronic ITP. This trial is registered at http://clinicaltrials.gov as NCT00225875... - Autoimmune thrombocytopenic purpura and common variable immunodeficiency: analysis of 21 cases and review of the literatureMarc Michel
Department of Internal Medicine, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
Medicine (Baltimore) 83:254-63. 2004..Steroids and splenectomy seem to have the same efficacy as in idiopathic AITP, but the increased risk of severe infections must be taken into consideration... - Persistent multifocal pseudo-conduction blocks in vasculitic neuropathy without antiganglioside antibodiesRechdi Ahdab
Service de Physiologie Explorations Fonctionnelles, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, 51 avenue de Lattre de Tassigny, 94010, Creteil, France
Muscle Nerve 40:290-3. 2009..This condition should be distinguished from the occurrence of pseudo-CB in the acute phase of vasculitis or from superimposed immune-mediated demyelination. Muscle Nerve 40: 290-293, 2009... - Azathioprine or methotrexate maintenance for ANCA-associated vasculitisChristian Pagnoux
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
N Engl J Med 359:2790-803. 2008..However, azathioprine and methotrexate have not been compared with regard to safety and efficacy... - Vasculitis restricted to the lower limbs: a clinical and histopathological studyM Khellaf
Service de Medecine Interne, Hopital Henri Mondor, Universite Paris XII, France
Ann Rheum Dis 66:554-6. 2007..Rare cases of vasculitis restricted to the lower limbs have been reported, but the characteristics, outcome and response to treatment of this entity are not well known... - Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group DatabaseChristian Pagnoux
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 62:616-26. 2010..This study was undertaken to describe the main characteristics of and long-term outcomes in patients with well-characterized PAN diagnoses... - [Hemolytic anemia in adults: Main causes and diagnostic procedure]Valentine Loustau
CHU Henri Mondor, centre de référence pour les cytopénies auto immunes de l adulte, Service de Medecine Interne, 94010 Creteil Cedex, France
Presse Med 40:470-85. 2011..Based on these first data, the diagnosis procedure may then require more specific tests whose indications are discussed in this review... - Hemolytic anemia in adults: main causes and diagnostic proceduresConstance Guillaud
Department of Internal Medicine, National Referal Center for Adults Immune Cytopenias, Henri Mondor University Hospital, Assistance Publique Hopitaux de Paris, Université Paris Est Créteil, Creteil, France
Expert Rev Hematol 5:229-41. 2012..Based on these first data, the diagnostic procedure may then require more specific tests whose indications are discussed in this review... - A randomized, controlled clinical trial of ketoprofen for sickle-cell disease vaso-occlusive crises in adultsPablo Bartolucci
Service de Medecine Interne, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris 12, Creteil, France
Blood 114:3742-7. 2009..Thus, although ketoprofen was well-tolerated, it had no significant efficacy as treatment of VOC requiring hospitalization. These findings argue against its systematic use in this setting... - Psoas abscess: An unusual manifestation of Q feverGuillaume Breton
Department of Internal Medicine, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
Eur J Intern Med 18:66-8. 2007..We report two cases of psoas abscess due to Coxiella burnetii associated with lumbar osteomyelitis secondary to an aortic aneurysmal infection. Diagnosis was based on serology, and PCR detected C. burnetii DNA in an abscess sample... - Successful treatment with rituximab in a patient with an acquired factor V inhibitorAgnes Lebrun
Department of Internal Medicine, Henri Mondor University Hospital, Assistance Publique Hopitaux de Paris, Creteil, France
Am J Hematol 83:163-4. 2008..We report here a case of severe acquired factor V (FV) inhibitor deficiency due to FV inhibitor which has been dramatically improved after rituximab... - Fulminant hepatitis after infliximab in a patient with hepatitis B virus treated for an adult onset still's diseaseMarc Michel
Service de Medecine Interne, Hopital Henri Mondor, Creteil, France
J Rheumatol 30:1624-5. 2003..We report the case of a 28-year-old woman, with a positive hepatitis B virus surface antigen, who developed fulminant hepatitis 2 weeks after receiving a second infliximab infusion for a refractory adult onset Still's disease... - Rituximab for prevention of delayed hemolytic transfusion reaction in sickle cell diseaseF Noizat-Pirenne
Etablissement Français du Sang, Ile de France, Hopital Henri Mondor, Creteil, France
Haematologica 92:e132-5. 2007..DHTR recurrence was successfully prevented by rituximab administration prior transfusion, supporting the safe use of rituximab to prevent DHTR in SCD patients as a second line approach when other measures failed... - [Characteristics of autoimmune hemolytic anemia in adults: retrospective analysis of 83 cases]I Genty
, , 51, , , France
Rev Med Interne 23:901-9. 2002..Conversely, if no abnormalities are found, the relevance of a systematic MB at AIHA onset seems very low... - [Recurrent Kikuchi's disease in a patient with discoid lupus]S Lecoules
Service de Medecine Interne, Hopital Henri Mondor, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
Rev Med Interne 24:613-6. 2003..Recurrence is very rarely observed. KD may be associated with systemic lupus erythematosus, whereas the association with chronic discoid lupus has only been rarely reported... - Severe autoimmune type V hyperlipidemia preceding a systemic lupus erythematosus in a 15 year-old girlMarc Michel
Lupus 16:378-9. 2007 - Platelet autoantibodies and lupus-associated thrombocytopeniaMarc Michel
, EFS Ile de France, ,
Br J Haematol 119:354-8. 2002..In conclusion, the production of specific anti-platelet autoantibodies, mainly directed against GpIIb/IIIa, and their binding to platelet membrane plays an important role in the pathogenesis of SLE-associated thrombocytopenia...