Research Topics
| Fong Chi ChengSummaryAffiliation: MDS Pharma Services Country: France Publications
| Collaborators
|
Detail Information
Publications
Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor bindingFong Chi Cheng
MDS Pharma Services Taiwan Ltd, 158 Li Teh Road, Taipei 112, Taiwan, Republic of China
J Med Food 7:146-52. 2004..These results reveal potential pharmacological activities that, if confirmed by in vivo studies, might be exploited for the prevention or treatment of several serious pathologies, including inflammatory disease and cancer...- The neuroprotective effects of BNG-1: a new formulation of traditional Chinese medicines for strokeFong Chi Cheng
MDS Pharma Services Taiwan, Ltd, Taipei 112, Taiwan
Am J Chin Med 33:61-71. 2005..Moreover, the fundamental cellular mechanism underlying its therapeutic effects may result from phosphodiesterase inhibition... - Receptor binding activities of Chlorella on cysteinyl leukotriene CysLT, glutamate AMPA, ion channels, purinergic P 2Y, tachykinin NK2 receptors and adenosine transporterFong Chi Cheng
MDS Pharma Services Taiwan Ltd, 158 Li Teh Road, Peitou, Taipei, 112, Taiwan, ROC
Phytother Res 24:43-8. 2010..These results reveal important potential biochemical activities that might be exploited for the prevention or treatment of several pathologies. From these results, the possible therapeutic usage of the product is discussed... - Chlorella powder inhibits the activities of peptidase cathepsin S, PLA2, cyclooxygenase-2, thromboxane synthase, tyrosine phosphatases, tumor necrosis factor-alpha converting enzyme, calpain and kinasesFong Chi Cheng
MDS Pharma Services Taiwan, Ltd, Taipei, Taiwan, Republic of China
Int J Food Sci Nutr 60:89-98. 2009.... - Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channelsPeter J S Chiu
MDS Pharma Services, 22011 30th Drive SE, Bothell, WA 98021 4444, USA
J Pharmacol Sci 95:311-9. 2004..91, P<0.05). In conclusion, the [(3)H]astemizole binding assay is rapid and capable of detecting HERG inhibitors... - A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse modelsShiow-Lin Pan
Pharmacological Institutes, College of Medicine, National Taiwan University, Taipei
Thromb Haemost 93:940-8. 2005..It is suggested that YC-1 may be a potential agent for the therapeutic treatment of sepsis... - YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo modelsShiow-Lin Pan
Pharmacological Institute, College of Medicine, National Taiwan University, 1 Jen-Ai Road, Section 1, Taipei, Taiwan
J Pharmacol Exp Ther 314:35-42. 2005..YC-1 may be useful for treating angiogenesis-dependent human diseases such as cancer... - Design and synthesis of potent cystine-free cyclic hexapeptide agonists at the human urotensin receptorShane Foister
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Org Lett 8:1799-802. 2006..Further development led to a hexapeptide agonist with nanomolar affinity (2.8 nM)... - An in vivo analysis of the herbal compound essiacBlair J N Leonard
Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Anticancer Res 26:3057-63. 2006..CONCLUSION: Essiac, administered in established in vivo experimental models, did not significantly demonstrate its purported physiological modifying effects... - Identification of a novel competitive inhibitor of p38alpha MAPK by a human PBMC screenYu Chih Liu
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
Biochem Biophys Res Commun 352:656-61. 2007..13 and 0.55 microM, respectively. Further characterization of enzyme kinetics showed the binding mode of MT4 was competitive with the ATP substrate-binding site of p38alpha MAPK... - Design, synthesis, and binding affinities of pyrrolinone-based somatostatin mimeticsAmos B Smith
Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Org Lett 7:399-402. 2005..Binding affinities at two somatostatin receptor subtypes (hsst 4 and 5) reveal micromolar activity, demonstrating that the d,l-mixed pyrrolinone scaffold can be employed to generate functional mimetics of peptide beta-turns... - Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanolSanthosh Neelamkavil
Department of Chemistry, University of Pennsylvania, Philadelphia, 19104, USA
J Med Chem 48:4025-30. 2005..Finally, the chirality of Trp(8) was unexpectedly found to have a striking effect on NMR spectra in methanol, especially at lower temperatures...