Michel Marre

Summary

Country: France

Publications

  1. ncbi Effects of perindopril in hypertensive patients with or without type 2 diabetes mellitus, and with altered insulin sensitivity
    Michel Marre
    Service d Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat Claude Bernard, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Diab Vasc Dis Res 4:163-73. 2007
  2. ncbi Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus
    YaoMin Hu
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    BMC Med Genomics 2:41. 2009
  3. ncbi Insulin detemir improves glycaemic control with less hypoglycaemia and no weight gain: 52-week data from the PREDICTIVE study in a cohort of French patients with type 1 or type 2 diabetes
    M Marre
    Department of Endocrinology, Diabetology and Nutrition, Bichat Claude Bernard Hospital, Paris Cedex 18, France
    Diabetes Metab 35:469-75. 2009
  4. ncbi [Prevention of cardiovascular risk in diabetes]
    Michel Marre
    Service d Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat Claude Bernard, Paris
    Rev Prat 57:1423-30. 2007
  5. ncbi GLP-1 receptor agonists today
    Michel Marre
    Department of Endocrinology, Diabetology and Nutrition, Bichat Hospital, Assistance Publique des Hopitaux de Paris, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Diabetes Res Clin Pract 93:317-27. 2011
  6. ncbi [Diabetes complications. Strict blood glucose controls and beyond]
    Michel Marre
    , groupe hospitalier Bichat-Claude-Bernard, Paris
    Rev Prat 57:1409-10. 2007
  7. ncbi Association of ADIPOQ genetic variants and plasma adiponectin isoforms with the risk of incident renal events in type 2 diabetes
    Riphed Jaziri
    INSERM, U695, Genetic Determinants for Type 2 Diabetes and Its Vascular Complications, Paris, France
    Nephrol Dial Transplant 25:2231-7. 2010
  8. ncbi Hyperadiponectinemia is independent of kidney function, diabetes duration, and control in type 1 diabetic patients without microangiopathy
    Charbel Abi Khalil
    Service de Diabétologie Endocrinologie Nutrition, Hopital Bichat, Assistance Publique des Hopitaux de Paris, 75877 Paris, France
    J Clin Endocrinol Metab 96:E485-7. 2011
  9. ncbi Allelic variations in superoxide dismutase-1 (SOD1) gene are associated with increased risk of diabetic nephropathy in type 1 diabetic subjects
    Kamel Mohammedi
    INSERM, Research Unit 695, Paris, France
    Mol Genet Metab 104:654-60. 2011
  10. ncbi Associations of the -344 T>C and the 3097 G>A polymorphisms of CYP11B2 gene with hypertension, type 2 diabetes, and metabolic syndrome in a French population
    Naïma Muñoz Bellili
    Institut National de la Santé et de la Recherche Médicale INSERM U695, Déterminants Génétiques du Diabète de Type 2 et de ses Complications Cardiovasculaires, Faculte Xavier Bichat, Universite Denis Diderot Paris 7, Paris, France
    Am J Hypertens 23:660-7. 2010

Detail Information

Publications67

  1. ncbi Effects of perindopril in hypertensive patients with or without type 2 diabetes mellitus, and with altered insulin sensitivity
    Michel Marre
    Service d Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat Claude Bernard, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Diab Vasc Dis Res 4:163-73. 2007
    ....
  2. ncbi Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus
    YaoMin Hu
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    BMC Med Genomics 2:41. 2009
    ....
  3. ncbi Insulin detemir improves glycaemic control with less hypoglycaemia and no weight gain: 52-week data from the PREDICTIVE study in a cohort of French patients with type 1 or type 2 diabetes
    M Marre
    Department of Endocrinology, Diabetology and Nutrition, Bichat Claude Bernard Hospital, Paris Cedex 18, France
    Diabetes Metab 35:469-75. 2009
    ..Here, we report on long-term (52-week) data from a French cohort of patients (n=1772), comprising 643 with type 1 diabetes and 1129 with type 2 diabetes...
  4. ncbi [Prevention of cardiovascular risk in diabetes]
    Michel Marre
    Service d Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat Claude Bernard, Paris
    Rev Prat 57:1423-30. 2007
    ..A multiple intervention strategy was shown to be effective in type 2 diabetic subjects with microalbuminuria. Clinical trials aimed at normalizing blood glucose to reduce CV events will be available within 5 years...
  5. ncbi GLP-1 receptor agonists today
    Michel Marre
    Department of Endocrinology, Diabetology and Nutrition, Bichat Hospital, Assistance Publique des Hopitaux de Paris, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Diabetes Res Clin Pract 93:317-27. 2011
    ..It also concentrates on the physiological basis for early use of GLP-1 receptor agonists, their use as an alternative to insulin therapy, the rationale for combining them with insulin and their cost-effectiveness...
  6. ncbi [Diabetes complications. Strict blood glucose controls and beyond]
    Michel Marre
    , groupe hospitalier Bichat-Claude-Bernard, Paris
    Rev Prat 57:1409-10. 2007
  7. ncbi Association of ADIPOQ genetic variants and plasma adiponectin isoforms with the risk of incident renal events in type 2 diabetes
    Riphed Jaziri
    INSERM, U695, Genetic Determinants for Type 2 Diabetes and Its Vascular Complications, Paris, France
    Nephrol Dial Transplant 25:2231-7. 2010
    ..We investigated the possible association of polymorphisms in the adiponectin gene and baseline adiponectin levels with the incidence of renal events in subjects with type 2 diabetes...
  8. ncbi Hyperadiponectinemia is independent of kidney function, diabetes duration, and control in type 1 diabetic patients without microangiopathy
    Charbel Abi Khalil
    Service de Diabétologie Endocrinologie Nutrition, Hopital Bichat, Assistance Publique des Hopitaux de Paris, 75877 Paris, France
    J Clin Endocrinol Metab 96:E485-7. 2011
    ..We studied whether ADPN and its specific isoforms were elevated in T1D without microangiopathy and whether they were related to kidney function...
  9. ncbi Allelic variations in superoxide dismutase-1 (SOD1) gene are associated with increased risk of diabetic nephropathy in type 1 diabetic subjects
    Kamel Mohammedi
    INSERM, Research Unit 695, Paris, France
    Mol Genet Metab 104:654-60. 2011
    ..We investigated associations of allelic variations in SOD1 gene with nephropathy in patients with type 1 diabetes...
  10. ncbi Associations of the -344 T>C and the 3097 G>A polymorphisms of CYP11B2 gene with hypertension, type 2 diabetes, and metabolic syndrome in a French population
    Naïma Muñoz Bellili
    Institut National de la Santé et de la Recherche Médicale INSERM U695, Déterminants Génétiques du Diabète de Type 2 et de ses Complications Cardiovasculaires, Faculte Xavier Bichat, Universite Denis Diderot Paris 7, Paris, France
    Am J Hypertens 23:660-7. 2010
    ..We assessed the association of two polymorphisms -344 T>C and the 3097 G>A in the aldosterone synthase gene (CYP11B2) with prevalent and incident hypertension (HT), type 2 diabetes (T2D), and the metabolic syndrome (MetS)...
  11. ncbi Dairy consumption and the incidence of hyperglycemia and the metabolic syndrome: results from a french prospective study, Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Frederic Fumeron
    1INSERM U695, Paris, France
    Diabetes Care 34:813-7. 2011
    ..We assess the influence of dairy products on 9-year incident MetS and on impaired fasting glycemia and/or type 2 diabetes (IFG/T2D)...
  12. ncbi G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes
    David Alexandre Tregouet
    INSERM, Paris, France, and Pierre and Marie Curie Paris VI University, Paris, France
    Diabetes 57:2843-50. 2008
    ..The objective of the European Rational Approach for the Genetics of Diabetic Complications (EURAGEDIC) study is to identify nephropathy susceptibility genes. We report molecular genetic studies for 127 candidate genes for nephropathy...
  13. ncbi Association of common variants in NPPA and NPPB with blood pressure does not translate into kidney damage in a general population study
    Suliya Maimaitiming
    INSERM, U695, Paris, France
    J Hypertens 28:1230-3. 2010
    ....
  14. ncbi The common -866G>A variant in the promoter of UCP2 is associated with decreased risk of coronary artery disease in type 2 diabetic men
    Nadir Cheurfa
    Institut National de la Sante et de la Recherche Medicale, Research Unit 695, Paris, France
    Diabetes 57:1063-8. 2008
    ..We investigated association of this variant with coronary artery disease (CAD) in two cohorts of type 2 diabetic subjects...
  15. ncbi The CETP TaqIB polymorphism is associated with the risk of sudden death in type 2 diabetic patients
    Isabelle Porchay-Baldérelli
    Institut National de la Sante et de la Recherche Medicale, U695, Genetic Determinants for Type 2 Diabetes and Its Vascular Complications, Paris, France
    Diabetes Care 30:2863-7. 2007
    ..We investigated the association of the CETP TaqIB polymorphism with CHD, and sudden death in particular, in a prospective cohort of type 2 diabetic patients...
  16. ncbi ABCA1 single nucleotide polymorphisms on high-density lipoprotein-cholesterol and overweight: the D.E.S.I.R. study
    Isabelle Porchay
    Institut National de la Sante et de la Recherche Medicale, Unité 695, Xavier Bichat School of Medicine, Paris, France
    Obesity (Silver Spring) 14:1874-9. 2006
    ..This study suggests that ABCA1 gene polymorphisms modulate HDL-C concentrations, in interaction with BMI, and, thus, they might influence cardiovascular risk in the general population...
  17. ncbi Fetal exposure to maternal type 1 diabetes is associated with renal dysfunction at adult age
    Charbel Abi Khalil
    Diabetes Department, Groupe Hospitalier Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Diabetes 59:2631-6. 2010
    ..We tested whether this observation translates into renal dysfunction in humans by studying renal functional reserve in adult offspring exposed in utero to maternal type 1 diabetes...
  18. ncbi Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR Study
    Michel Marre
    Hopital Bichat, Service de Diabétologie et d Endocrinologie, Paris, France
    J Hypertens 22:1613-22. 2004
    ....
  19. ncbi Reducing cardiovascular risk in diabetes
    Michel Marre
    Groupe Hospitalier Bichat Claude Bernard, , Paris, France
    J Hypertens Suppl 25:S19-22. 2007
    ..This new understanding of the pathophysiology of cardiovascular disease in patients with diabetes may help in addressing the underlying processes at an earlier stage of disease...
  20. ncbi Low water intake and risk for new-onset hyperglycemia
    Ronan Roussel
    Universite Paris Diderot, Paris 7, Paris, France
    Diabetes Care 34:2551-4. 2011
    ..Water intake alters vasopressin secretion. Recent findings reveal an independent association between plasma copeptin, a surrogate for vasopressin, and risk of diabetes...
  21. ncbi Hemoglobin A1c and fasting plasma glucose levels as predictors of retinopathy at 10 years: the French DESIR study
    Pascale Massin
    Ophthalmology Department, Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Paris, France
    Arch Ophthalmol 129:188-95. 2011
    ..To evaluate the predictive values of hemoglobin A(1c) (HbA(1c)) and fasting plasma glucose (FPG) for retinopathy 10 years after the baseline examination...
  22. ncbi Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study
    Bénédicte Fontaine-Bisson
    INSERM, UMR_S 937, 75013, Paris, France
    J Mol Med (Berl) 88:193-201. 2010
    ..No robust interaction between SNPs located in different genes on the risk of MS was identified. In conclusion, we did not observe any convincing evidence that common polymorphisms of the lamina pathway could modulate the risk of MS...
  23. ncbi Investigation of the human ANP gene in type 1 diabetic nephropathy: case-control and follow-up studies
    Ronan Roussel
    Diabetologie, Hopital Bichat, Assistance Publique Hopitaux de Paris, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Diabetes 53:1394-8. 2004
    ..93, 95% CI 1.15-3.24; P = 0.012) was further confirmed by the haplotype analysis, suggesting that the 2238C allele of PND may affect the course of nephropathy in inadequately controlled type 1 diabetic patients...
  24. ncbi Metformin use and mortality among patients with diabetes and atherothrombosis
    Ronan Roussel
    INSERM, Department of Diabetology, Bichat Hospital, Paris, France
    Arch Intern Med 170:1892-9. 2010
    ..However, metformin is often not considered in patients with cardiovascular conditions because of concerns about its safety...
  25. ncbi Improved glycaemic control with metformin-glibenclamide combined tablet therapy (Glucovance) in Type 2 diabetic patients inadequately controlled on metformin
    Michel Marre
    Diabetology-Endocrinology-Metabolism Unit, Hospital of Xavier Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Diabet Med 19:673-80. 2002
    ....
  26. ncbi Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study
    Frederic Fumeron
    EA 3516, Interactions Gènes Environnement dans les Pathologies Métaboliques à Risque Cardiovasculaire, Faculte Xavier Bichat, Paris, France
    Diabetes 53:1150-7. 2004
    ..Adiponectin gene SNPs may have several phenotypic effects that co-occur with the development of the metabolic syndrome...
  27. ncbi Kallikrein protects against microalbuminuria in experimental type I diabetes
    Sophie Bodin
    INSERM UMR 872, Centre de Recherche des Cordeliers, Paris, France
    Kidney Int 76:395-403. 2009
    ....
  28. ncbi Type B insulin resistance syndrome associated with an immune reconstitution inflammatory syndrome in an HIV-infected woman
    Kamel Mohammedi
    Groupe Hospitalier Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Service d endocrinologie, Diabetologie, et Nutrition, 46 rue Henri Huchard, 75877 Paris, France
    J Clin Endocrinol Metab 96:E653-7. 2011
    ..Type B insulin resistance syndrome is a rare condition characterized by the presence of autoantibodies directed against the insulin receptor. It has been reported in association with autoimmune diseases such as systemic lupus erythematosus...
  29. ncbi Assessment of patients' and physicians' compliance to an ACE inhibitor treatment based on urinary N-acetyl Ser-Asp-Lys-Pro determination in the Noninsulin-Dependent Diabetes, Hypertension, Microalbuminuria, Proteinuria, Cardiovascular Events, and Ramipril
    Michel Azizi
    Centre d Investigations Cliniques, Hopital Europeen Georges Pompidou, 20 40 rue Leblanc, 75908 Paris Cedex 15, France
    Diabetes Care 29:1331-6. 2006
    ..25 mg o.d.) with placebo in 4,912 patients with type 2 diabetes and microalbuminuria/proteinuria...
  30. ncbi Development of a phenotypic method for detection of fecal carriage of OXA-48-producing enterobacteriaceae after incidental detection from clinical specimen
    Etienne Ruppe
    Centre National de Référence Associé Résistance dans les Flores Commensales, Laboratoire de Bacteriologie, Hopital Bichat Claude Bernard, AP HP, Paris, France
    J Clin Microbiol 49:2761-2. 2011
    ....
  31. ncbi Transforming growth factor-beta 1 production is correlated with genetically determined ACE expression in congenic rats: a possible link between ACE genotype and diabetic nephropathy
    Maria E Pueyo
    INSERM U460, and Service de Diabetologie, CHU Bichat, Paris, France
    Diabetes 53:1111-8. 2004
    ..These results show that TGF-beta 1 expression is correlated with ACE expression and suggest that this growth factor could be a link between ACE gene polymorphism and diabetic vascular complications...
  32. ncbi Effects of low dose ramipril on cardiovascular and renal outcomes in patients with type 2 diabetes and raised excretion of urinary albumin: randomised, double blind, placebo controlled trial (the DIABHYCAR study)
    Michel Marre
    Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat Claude Bernard, Assistance Publique des Hopitaux de Paris, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    BMJ 328:495. 2004
    ..To investigate whether a low dose of the angiotensin converting enzyme (ACE) inhibitor ramipril lowers cardiovascular and renal events in patients with type 2 diabetes who have microalbuminuria or proteinuria...
  33. ncbi Nephropathy in type 1 diabetes
    Michel Marre
    Service d Endocrinologie Diabétologie Métabolisme Nutrition, Centre Hospitalier Universitaire Bichat Claude Bernard, Paris, France
    Semin Vasc Med 2:97-107. 2002
    ..Blocking the course of nephropathy by blockers of the renin-angiotensin system relies on solid pathophysiological hypotheses and has proved to be efficacious for improving the prognosis of type 1 diabetes nephropathy...
  34. ncbi Reducing cardiovascular risk in diabetes
    Michel Marre
    Groupe Hospitalier Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    J Hypertens Suppl 25:S19-22. 2007
    ..This new understanding of the pathophysiology of cardiovascular disease in patients with diabetes may help in addressing the underlying processes at an earlier stage of disease...
  35. ncbi Hyperglycemia-induced defects in angiogenesis in the chicken chorioallantoic membrane model
    Etienne Larger
    INSERM U36, Chaire de Médecine Expérimentale, College de France, Paris, France
    Diabetes 53:752-61. 2004
    ..Hyperglycemia can therefore impair angiogenesis without altering the expression level of vascular growth factors through induction of apoptosis and decreased proliferation of endothelial cells...
  36. ncbi Vasopressin increases urinary albumin excretion in rats and humans: involvement of V2 receptors and the renin-angiotensin system
    Pascale Bardoux
    , , Paris, France
    Nephrol Dial Transplant 18:497-506. 2003
    ..These results bring additional support for an involvement of vasopressin in the albuminuria observed in pathological states such as diabetes mellitus or hypertension...
  37. ncbi Urinary albumin excretion is a risk factor for diabetes mellitus in men, independently of initial metabolic profile and development of insulin resistance. The DESIR Study
    Jean Michel Halimi
    Francois Rabelais University, CHRU Tours, Service de néphrologie immunologie clinique, Tours, France
    J Hypertens 26:2198-206. 2008
    ..Whether UAE predicts the development of diabetes mellitus, independently of the presence or the development of the metabolic syndrome, is unclear, in particular, in women...
  38. ncbi Efficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetes
    Juan Garcia Puig
    Servicio de Medicina Interna, Hospital La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain
    Am J Hypertens 20:90-7. 2007
    ....
  39. ncbi Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial
    Anne Katrin Sjølie
    Department of Ophthalmology, Odense University Hospital, Odense, Denmark
    Lancet 372:1385-93. 2008
    ..Diabetic retinopathy remains a leading cause of visual loss in people of working age. We examined whether candesartan treatment could slow the progression and, secondly, induce regression of retinopathy in people with type 2 diabetes...
  40. ncbi TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study
    Stephane Cauchi
    Imperial College, Section of Genomic Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Diabetes 55:3189-92. 2006
    ..We conclude that the TCF7L2 T at-risk allele variation (rs7903146) predicts hyperglycemia incidence in a general French population, possibly through a deleterious effect on insulin secretion...
  41. ncbi Ferritin and transferrin are both predictive of the onset of hyperglycemia in men and women over 3 years: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study
    Frederic Fumeron
    INSERM U695, Xavier Bichat Medical School, BP 416, 16 rue Henri Huchard, 75870 Paris Cedex 18, France
    Diabetes Care 29:2090-4. 2006
    ....
  42. ncbi Modulation of the renal response to ACE inhibition by ACE insertion/deletion polymorphism during hyperglycemia in normotensive, normoalbuminuric type 1 diabetic patients
    Laurent Weekers
    Department of Medicine, Centre Hospitalier Universitaire du Sart Tilman, Liege, Belgium
    Diabetes 54:2961-7. 2005
    ..018; MAP, 0.018; and total renal resistances, 0.055). These results provide a basis to different renal responses to ACE inhibition according to ACE genotype in type 1 diabetes...
  43. ncbi Different patterns of insulin resistance in relatives of type 1 diabetic patients with retinopathy or nephropathy: the Genesis France-Belgium Study
    Samy Hadjadj
    Department of Endocrinology and Diabetology, University Hospital, Poitiers, France
    Diabetes Care 27:2661-8. 2004
    ..CONCLUSIONS: Familial insulin resistance segregates with diabetic complications: lipid disorders and obesity segregate with diabetic nephropathy, whereas arterial hypertension and obesity segregate with diabetic retinopathy...
  44. ncbi [New trails in diabetology]
    Michel Marre
    Med Sci (Paris) 19:771-2. 2003
  45. ncbi The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population
    Martine Vaxillaire
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Diabetes 57:2253-7. 2008
    ..We evaluated, in a general French population, the contribution of the GCKR rs1260326-P446L polymorphism to quantitative metabolic parameters and to dyslipidemia and hyperglycemia risk...
  46. ncbi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
    ..5% yielded a 10% relative reduction in the combined outcome of major macrovascular and microvascular events, primarily as a consequence of a 21% relative reduction in nephropathy. (ClinicalTrials.gov number, NCT00145925.)..
  47. ncbi The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies
    Stephane Cauchi
    CNRS UMR8090, Institut de Biologie de Lille, Génomique et Physiologie Moléculaire des Maladies Métaboliques, Lille, France
    BMC Med Genet 9:45. 2008
    ....
  48. ncbi Retinal vascular lesions in patients of Caucasian and Asian origin with type 2 diabetes: baseline results from the ADVANCE Retinal Measurements (AdRem) study
    Ronald P Stolk
    Department of Epidemiology, University Medical Center Groningen, P O Box 30 001, 9700RB Groningen, The Netherlands
    Diabetes Care 31:708-13. 2008
    ....
  49. ncbi Does PERISCOPE provide a new perspective on diabetic treatment?
    Philippe Gabriel Steg
    JAMA 299:1603-4. 2008
  50. ncbi Evaluating the association of common PBX1 variants with type 2 diabetes
    Konsta Duesing
    Genomic Medicine, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 0NN, UK
    BMC Med Genet 9:14. 2008
    ..PBX1 is a biological candidate gene for type 2 diabetes at the 1q21-q24 susceptibility locus. The aim of this study was to evaluate the association of common PBX1 variants with type 2 diabetes in French Caucasian subjects...
  51. ncbi Effects of TCF7L2 polymorphisms on obesity in European populations
    Stephane Cauchi
    Centre National de la Recherche Scientifique 8090, Institute of Biology, Pasteur Institute, Lille, France
    Obesity (Silver Spring) 16:476-82. 2008
    ..Furthermore, our data suggest that the rs7903146 T allele may be possibly functional and associated with a nominal decrease in TCF7L2 expression in adipose tissue of individuals under calorie restriction...
  52. ncbi Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study
    Stephane Cauchi
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    J Mol Med (Berl) 86:341-8. 2008
    ..E.S.I.R. prospective cohort. However, in contrast to TCF7L2, the contribution of novel loci to T2D incidence seems only modest in the general middle-aged French population and should be replicated in larger cohorts...
  53. ncbi Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Istvan S Vari
    Institut National de la Sante et de la Recherche Medicale, unité 780 IFR69, Epidemiological and Biostatistical Research, Villejuif, France
    Diabetes Care 30:1795-801. 2007
    ..The aim of this work was to study cross-sectional and longitudinal relations between iron stocks (ferritin) and the iron transport protein (transferrin) with the metabolic syndrome and its abnormalities...
  54. ncbi Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity
    Nabila Bouatia-Naji
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    BMC Med Genet 8:44. 2007
    ..The aim of this study is to analyze associations of SGNE1 genetic variation with obesity and metabolism related quantitative traits...
  55. ncbi Analysis of KLF transcription factor family gene variants in type 2 diabetes
    Ruth Gutierrez-Aguilar
    UMR8090, CNRS, Institute of Biologie Institute Pasteur de Lille, Lille, France
    BMC Med Genet 8:53. 2007
    ..Moreover, several of these proteins have been implicated in glucose homeostasis, making them candidate genes for involvement in type 2 diabetes (T2D)...
  56. ncbi The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance
    Riphed Jaziri
    INSERM, U695, Xavier Bichat Medical School, BP 416, 16 rue Henri Huchard, 75870 Paris Cedex 18, France
    Diabetes 55:1157-62. 2006
    ..Cumulative rather than synergistic effects of PPARG Pro12Ala and APM1 SNPs on diabetes risk are suggested...
  57. ncbi Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population
    Claire Cheyssac
    CNRS UMR 8090, Institut de Biologie de Lille, Institut Pasteur, 59019 Lille, France
    BMC Med Genet 7:44. 2006
    ....
  58. ncbi Waist circumference and the metabolic syndrome predict the development of elevated albuminuria in non-diabetic subjects: the DESIR Study
    Fabrice Bonnet
    Department of Diabetology Endocrinology, CRNH, Hospital Edouard Herriot, INSERM U 449, Lyon, France
    J Hypertens 24:1157-63. 2006
    ..We investigated in both sexes whether an elevated waist circumference (WC) or the presence of the metabolic syndrome (MetS) predict the development of elevated albuminuria at 6 years...
  59. ncbi NMR-based prediction of cardiovascular risk in diabetes
    Ronan Roussel
    Nat Med 13:399-400. 2007
  60. ncbi Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials
    Nish Chaturvedi
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK
    Lancet 372:1394-402. 2008
    ..We therefore designed the DIabetic REtinopathy Candesartan Trials (DIRECT) Programme to assess whether candesartan could reduce the incidence and progression of retinopathy in type 1 diabetes...
  61. ncbi Prognostic value of the insertion/deletion polymorphism of the ACE gene in type 2 diabetic subjects: results from the Non-insulin-dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR), Diabete d
    Samy Hadjadj
    Centre Hospitalier Universitaire Poitiers, Endocrinology, Diabetology, Poitiers, France
    Diabetes Care 31:1847-52. 2008
    ..We tested whether determination of the ACE insertion/deletion polymorphism is useful for renal and cardiovascular prognoses of type 2 diabetic subjects...
  62. ncbi Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
    Stephane Cauchi
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    PLoS ONE 3:e2031. 2008
    ..Our aims were to validate these markers in other European and non-European populations, then to assess their combined effect in a large French study comparing T2D and normal glucose tolerant (NGT) individuals...
  63. ncbi A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels
    Nabila Bouatia-Naji
    CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Santé University, 59019 Lille, France
    Science 320:1085-8. 2008
    ..We speculate that G6PC2 regulates FPG by modulating the set point for glucose-stimulated insulin secretion in pancreatic beta cells...
  64. ncbi Analysis of 14 candidate genes for diabetic nephropathy on chromosome 3q in European populations: strongest evidence for association with a variant in the promoter region of the adiponectin gene
    Nathalie Vionnet
    INSERM U525, Centre National de Genotypage, 2, rue Gaston Crémieux, 91006 Evry Cedex, France
    Diabetes 55:3166-74. 2006
    ..50 [0.27-0.92], P = 0.026). The overall significance for this variant (nominal P = 0.011) suggests that ADIPOQ might be involved in the development of diabetic nephropathy...
  65. ncbi Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians
    Konsta Duesing
    Section of Genomic Medicine, Imperial College London, Hammersmith Campus, London, U K
    Diabetes 57:1992-6. 2008
    ....
  66. ncbi Implications of diabetes in patients with acute coronary syndromes. The Global Registry of Acute Coronary Events
    Kristen Franklin
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    Arch Intern Med 164:1457-63. 2004
    ..There are limited data describing the presenting characteristics, management, and outcomes of diabetic and nondiabetic patients with an acute coronary syndrome (ACS)...
  67. ncbi Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study
    Martine Vaxillaire
    UMR8090 and Institute of Biology, Lille 2 University, CNRS and Pasteur Institute, Lille, France
    Diabetes 57:244-54. 2008
    ..However, the relevance of these genes for disease prediction has not been extensively tested...