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Genomes and Genes | Vincent LaudetSummaryCountry: France Publications
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Publications
The fate of the duplicated androgen receptor in fishes: a late neofunctionalization event?Veronique Douard
INRA SCRIBE IFR 140, Campus de Beaulieu, 35042 Rennes Cedex, France
BMC Evol Biol 8:336. 2008..It has been proposed that this event might have facilitated the evolutionary radiation and the phenotypic diversification of the teleost fish, notably by allowing the sub- or neo-functionalization of many duplicated genes...- The origins and evolution of vertebrate metamorphosisVincent Laudet
Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Superieure de Lyon, CNRS UMR 5242, Universite Lyon 1, Universite de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
Curr Biol 21:R726-37. 2011..According to this view, metamorphosis of the anurans is an extreme example of a widespread life history transition... - Bisphenol A induces otolith malformations during vertebrate embryogenesisYann Gibert
Institut de Génomique Fonctionnelle de Lyon Université de Lyon Université Lyon 1 CNRS INRA Ecole Normale Supérieure de Lyon 46 allée d Italie, 69364 Lyon Cedex 07, France
BMC Dev Biol 11:4. 2011..Here, we investigated BPA effects during embryonic development using the zebrafish and Xenopus models... - Adaptive diversity: hormones and metabolism in freshwatersVincent Laudet
Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, France
Curr Biol 20:R1016-8. 2010..Genes underlying the evolution of morphological traits have recently been identified in a number of model species. In the stickleback, the metabolic adaptations to a freshwater habitat have now been linked to a well-known hormonal system... - OTX5 regulates pineal expression of the zebrafish REV-ERB alpha through a new DNA binding siteShin ichi Nishio
Universite de Lyon, Institut de Génomique Fonctionnelle de Lyon, Unité Mixte de Recherche 5242 du Centre National de la Recherche Scientifique, 69364 Lyon Cedex 07, France
Mol Endocrinol 22:23-32. 2008..Our data establish that PERE is a novel cis-acting element contributing to pineal-specific gene expression and to Otx target gene regulation... - The phytoestrogen genistein affects zebrafish development through two different pathwaysSana Sassi-Messai
Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon, France
PLoS ONE 4:e4935. 2009..The phytoestrogen, genistein (4', 5, 7-trihydroxy-isoflavone), is a naturally occurring compound found in soy products. Genistein has been the subject of numerous studies because of its known estrogenic activity... - Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expressionStephanie Bertrand
Molecular Zoology, Institut de Génomique Fonctionelle de Lyon UMR 5242 du CNRS, INRA, IFR128 Biosciences Lyon Gerland, Universite de Lyon, UCB Ecole Normale Supérieure de Lyon, France
PLoS Genet 3:e188. 2007..Altogether, this expression database of NRs provides novel routes for leading investigation into the biological function of each individual NR as well as for the study of their combinatorial regulatory circuitry within the superfamily... - An amphioxus orthologue of the estrogen receptor that does not bind estradiol: insights into estrogen receptor evolutionMathilde Paris
Institut de Génomique Fonctionnelle de Lyon, Molecular Zoology Team, Universite de Lyon, Ecole Normale Superieure de Lyon, Universite Lyon 1, CNRS, INRA, Institut Fédératif 128 Biosciences Gerland Lyon Sud, France
BMC Evol Biol 8:219. 2008.... - Rev-erbalpha2 mRNA encodes a stable protein with a potential role in circadian clock regulationJuliette Rambaud
Molecular Zoology Group, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, Universite Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, Lyon, France
Mol Endocrinol 23:630-9. 2009..We propose that the relative expression levels of the two REV-ERBalpha variants fine-tune the circadian period length by regulating REV-ERBalpha half-life... - Formation of oral and pharyngeal dentition in teleosts depends on differential recruitment of retinoic acid signalingYann Gibert
Molecular Zoology Group, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, UCB Lyon 1, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
FASEB J 24:3298-309. 2010..The loss of pharyngeal teeth in this group was cancelled out through a shift in aldh1a2 expression, while oral teeth might have been lost ultimately due to deficient RA signaling in the oral cavity... - Expression of estrogen-receptor related receptors in amphioxus and zebrafish: implications for the evolution of posterior brain segmentation at the invertebrate-to-vertebrate transitionPierre Luc Bardet
Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5161, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69007 Lyon, France
Evol Dev 7:223-33. 2005.... - Nuclear hormone receptor signaling in amphioxusMichael Schubert
CNRS UMR5242 INRA 1288 ENS UCBL, Institut de Génomique Fonctionnelle de Lyon, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
Dev Genes Evol 218:651-65. 2008.... - The amphioxus genome enlightens the evolution of the thyroid hormone signaling pathwayMathilde Paris
Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242 INRA 1288 ENS UCBL, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
Dev Genes Evol 218:667-80. 2008.... - Amphioxus postembryonic development reveals the homology of chordate metamorphosisMathilde Paris
Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, UCB Lyon 1, IFR128 Lyon Biosciences, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
Curr Biol 18:825-30. 2008..Therefore, TH-regulated metamorphosis, mediated by TR, is an ancestral feature of all chordates. This conservation of a regulatory network supports the homology of metamorphosis in the chordate lineage... - Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal developmentSophie Pantalacci
Molecular Zoology, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon, France
BMC Dev Biol 8:116. 2008..However, rugae could be useful as landmarks to monitor anterior/posterior (A/P) palatal growth, and they provide a simple model of mesenchymal-epithelial structures arranged in a serial pattern... - Independent elaboration of steroid hormone signaling pathways in metazoansGabriel V Markov
Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Université Lyon 1 and Centre National de Recherche Scientifique, Institut National de Recherche Agronomique, Ecole Normale Superieure de Lyon, Lyon Cedex 07, France
Proc Natl Acad Sci U S A 106:11913-8. 2009..Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics... - Netrin-4 acts as a pro-angiogenic factor during zebrafish developmentElise Lambert
Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Universite de Lyon, 28 rue Laennec, Lyon 69008, France
J Biol Chem 287:3987-99. 2012..Together these data underscore the crucial role of Netrin-4 in blood vessel formation and the involvement of protein kinases activation in Netrin-4-induced biological effects related to vascular development... - From carrot to clinic: an overview of the retinoic acid signaling pathwayMaria Theodosiou
Institut de Génomique Fonctionnelle de Lyon, Université de Lyon Université Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
Cell Mol Life Sci 67:1423-45. 2010..Moreover, we discuss the origin and diversification of the retinoid pathway, which are important factors for understanding the evolution of ligand-specificity among retinoid receptors... - Evolutionary trends of the pharyngeal dentition in Cypriniformes (Actinopterygii: Ostariophysi)Emmanuel Pasco-Viel
Evo devo of Vertebrate Dentition, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon, France
PLoS ONE 5:e11293. 2010..Here we provide a further description of this diversity using X-ray microtomography and we map the resulting dental characters on a phylogenetic tree to explore evolutionary trends... - Origin and evolution of the ligand-binding ability of nuclear receptorsGabriel V Markov
Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Ecole Normale Superieure de Lyon, Universite Lyon 1, CNRS, INRA, Institut Fédératif 128 Biosciences Gerland Lyon Sud, France
Mol Cell Endocrinol 334:21-30. 2011.... - The history of a developmental stage: metamorphosis in chordatesMathilde Paris
Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, UCB Lyon 1, IFR128 Lyon Biosciences, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
Genesis 46:657-72. 2008..The intensity and the nature of the morphological remodeling varies extensively among taxa, from drastic remodeling like in some ascidians or amphibians to more subtle events, as in mammals... - Conserved features and evolutionary shifts of the EDA signaling pathway involved in vertebrate skin appendage developmentSophie Pantalacci
Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Institut Fédératif Biosciences 128 Gerland Lyon Sud, CNRS, INRA, Universite Claude Bernard Lyon 1, 69364 Lyon Cedex 07, France
Mol Biol Evol 25:912-28. 2008.... - Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesisMarie Castets
Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
Dev Cell 16:614-20. 2009..Thus, the proapoptotic effect of unbound UNC5B and the survival effect of netrin-1 on endothelial cells finely tune the angiogenic process... - Thyroid hormone receptor expression in the obligatory paedomorphic salamander Necturus maculosusVirginie Vlaeminck-Guillem
Laboratorie de Biologie Moléculaire de la Cellule, CNRS UMR 5161, INRA LA1237, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69394 Lyon cedex 07, France
Int J Dev Biol 50:553-60. 2006..Our results thus indicate that, in contrast to previously held hypotheses, Necturus tissues are TH responsive... - Gene loss and evolutionary rates following whole-genome duplication in teleost fishesFrédéric G Brunet
Laboratoire de Biologie Moleculaire de la Cellule, INRA LA 1237, CNRS UMR5161, IFR 128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon, France
Mol Biol Evol 23:1808-16. 2006..These results show that similar mechanisms are at work in fishes as in yeast or plants and provide a framework for future investigation of the consequences of duplication in fishes and other animals... - Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognitaPierre Abad
INRA, UMR 1301, 400 Route des Chappes, F 06903 Sophia Antipolis, France
Nat Biotechnol 26:909-15. 2008..Our results provide insights into the adaptations required by metazoans to successfully parasitize immunocompetent plants, and open the way for discovering new antiparasitic strategies... - A retinoic acid-Hox hierarchy controls both anterior/posterior patterning and neuronal specification in the developing central nervous system of the cephalochordate amphioxusMichael Schubert
, CNRS UMR5161/INRA UMR1237/ENS Lyon, IFR128 BioSciences Lyon-Gerland, , , 69364 Lyon Cedex 07, France
Dev Biol 296:190-202. 2006.... - Amphioxus and tunicates as evolutionary model systemsMichael Schubert
, CNRS-UMR5161, INRA LA 1237, IFR 128 BioSciences Lyon-Gerland, , , 69364 Lyon Cedex 07, France
Trends Ecol Evol 21:269-77. 2006..We also review the two major groups of invertebrate chordates and compare relative advantages (and disadvantages) of each as model systems for elucidating the origin of the vertebrates... - Annotation of Tribolium nuclear receptors reveals an increase in evolutionary rate of a network controlling the ecdysone cascadeFrançois Bonneton
Universite de Lyon, Universite Lyon 1, IFR Gerland Lyon Sud, IGFL, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon Cedex 07, France
Insect Biochem Mol Biol 38:416-29. 2008..We suggest that coevolution occurred within a network of regulators that control the ecdysone cascade. The advent of Tribolium as a powerful model should allow a better understanding of this evolutionary event... - Cloning and developmental expression of five estrogen-receptor related genes in the zebrafishPierre Luc Bardet
Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5161, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364, Lyon Cedex 07, France
Dev Genes Evol 214:240-9. 2004..Our analysis also points to tissues in which err expression is conserved through evolution, such as slow muscles that specifically express erralpha, suggesting important functions in these tissues... - The nuclear receptor superfamilyMarc Robinson-Rechavi
, UMR CNRS 5665, , , 69364 Lyon Cedex 07, France
J Cell Sci 116:585-6. 2003 - Neofunctionalization in vertebrates: the example of retinoic acid receptorsHector Escriva
Structure and Evolution of Nuclear Hormone Receptors, UMR 5161 du CNRS, INRA LA 1237, , IFR128 BioSciences Lyon-Gerland, , Lyon, France
PLoS Genet 2:e102. 2006..We thus suggest that neofunctionalization occurred at both the expression and the functional levels to shape RAR roles during development in vertebrates... - The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinaseCéline Guenebeaud
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
Mol Cell 40:863-76. 2010..Thus we show here that, in the absence of netrin-1, recruitment of PP2A to UNC5H2/B allows the activation of DAPk via a PP2A-mediated dephosphorylation and that this mechanism is involved in angiogenesis regulation... - Pedomorphosis revisited: thyroid hormone receptors are functional in Necturus maculosusRachid Safi
CNRS UMR 5161, INRA LA 913, Laboratoire de Biologie Moleculaire de la Cellule, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, France
Evol Dev 8:284-92. 2006..Rather, the absence of metamorphosis may be due to the loss of TH-dependent control of key genes required for tissue transformation... - Retinoic acid signaling in development: tissue-specific functions and evolutionary originsFlorent Campo-Paysaa
Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242 INRA 1288 ENS UCBL, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon, France
Genesis 46:640-56. 2008..On the basis of this hypothesis, we conclude by proposing a scenario for the evolution of RA functions during development, which highlights functional gains and lineage-specific losses during metazoan diversification... - Heterochronic shifts explain variations in a sequentially developing repeated pattern: palatal ridges of muroid rodentsSophie Pantalacci
Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
Evol Dev 11:422-33. 2009..We also interpret our results in the light of developmental constraints specifically linked to this kind of process... - Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erbalphaTomoko Kakizawa
Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5161, INRA LA 1237, IFR 128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon Cedex, France
J Mol Endocrinol 38:555-68. 2007..Together, these data suggest that ZfP1 is orthologous to the mammalian P1 promoter, whereas zebrafish ZfP2 has no mammalian ortholog and does not function like ZfP1 to control Rev-erbalpha expression... - NUREBASE: database of nuclear hormone receptorsJorge Duarte
, CNRS UMR 5665, , , 69364 Lyon Cedex 07, France
Nucleic Acids Res 30:364-8. 2002..NUREBASE sequence data is also accessible through a World Wide Web server, allowing complex queries. All information on accessing and installing NUREBASE may be found at http://www.ens-lyon.fr/LBMC/laudet/nurebase.html... - Bioinformatics of nuclear receptorsMarc Robinson-Rechavi
, UMR CNRS 5665, , , 69364 Lyon, France
Methods Enzymol 364:95-118. 2003 - Molecular cloning and developmental expression patterns of thyroid hormone receptors and T3 target genes in the turbot (Scophtalmus maximus) during post-embryonic developmentOriane Marchand
CNRS UMR 5665, , , , 69364, 07, France
Gen Comp Endocrinol 135:345-57. 2004..The fact that TH regulates metamorphosis in amphibian and teleost fishes suggests that TH-regulated metamorphosis is a post-embryonic process conserved in most vertebrates... - Analysis of lamprey and hagfish genes reveals a complex history of gene duplications during early vertebrate evolutionHector Escriva
CNRS UMR 5665, , , Lyon Cedex, France
Mol Biol Evol 19:1440-50. 2002..Thus, the complexity of all the paralogy groups present in vertebrates should be explained by the contribution of genome duplications (2R hypothesis), extra gene duplications, and gene losses... - Amphioxus spawning behavior in an artificial seawater facilityMaria Theodosiou
Institut de Génomique Fonctionnelle de Lyon, Universite Lyon 1, CNRS UMR5242, INRA 1288, Ecole Normale Superieure de Lyon, Lyon, France
J Exp Zool B Mol Dev Evol 316:263-75. 2011..Taken together, this work represents an important step toward further establishing amphioxus as a laboratory animal making it more amenable to experimental research, and hence assists the coming of age of this emerging model... - Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodesMarc Robinson-Rechavi
Laboratoire de Biologie Moleculaire de la Cellule, UMR CNRS 5161, Ecole Normale Superieure de Lyon, France
J Mol Evol 60:577-86. 2005..Our results provide a framework to study nuclear receptors in nematodes, as well as to consider the functional and evolutionary consequences of lineage-specific duplications... - The ERRalpha orphan nuclear receptor controls morphogenetic movements during zebrafish gastrulationPierre Luc Bardet
Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5161, IFR 128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
Dev Biol 281:102-11. 2005..Altogether, these results propose ERRalpha as a new regulator of morphogenetic movement during gastrulation, independently of cell fate determination... - Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systemsStephanie Bertrand
Laboratoire de Biologie Moleculaire de la Cellule, Ecole Normale Superieure de Lyon, Lyon, France
Mol Biol Evol 21:1923-37. 2004..Our results imply that the genes for major receptors such as steroid receptors or thyroid hormone receptors were present in Urbilateria... - The axolotl (Ambystoma mexicanum), a neotenic amphibian, expresses functional thyroid hormone receptorsRachid Safi
Centre National de la Recherche Scientifique, , , , , 69364 Lyon Cedex 07, France
Endocrinology 145:760-72. 2004..Taken together, these results suggest that axolotl TRs are functional and that the molecular basis of neoteny in the axolotl is not linked to a major defect in TH response in peripheral tissues... - Retinoic acid influences anteroposterior positioning of epidermal sensory neurons and their gene expression in a developing chordate (amphioxus)Michael Schubert
, Centre National de la Recherche Scientifique, , and Institut National de la Recherche Agronomique, , 69364 Lyon, France
Proc Natl Acad Sci U S A 101:10320-5. 2004.... - The cephalochordate amphioxus: a key to reveal the secrets of nuclear receptor evolutionClaire Lecroisey
Institut de Génomique Fonctionnelle de Lyon, UCBL, CNRS UMR, ENSL, INRA, Ecole Normale Superieure de Lyon, France
Brief Funct Genomics 11:156-66. 2012.... - Developmental constraints revealed by co-variation within and among molar rows in two murine rodentsSabrina Renaud
Paléoenvironnements et Paléobiosphère, UMR 5125, CNRS, Universite Lyon 1, 69622 Villeurbanne, France
Evol Dev 11:590-602. 2009..These patterns of co-variation are furthermore conserved between the house mouse and the wood mouse that diverged >10 Ma, suggesting that they may constitute long-running constraints to the diversification of the murine rodent dentition... - Phylogenetic dating and characterization of gene duplications in vertebrates: the cartilaginous fish referenceMarc Robinson-Rechavi
Laboratoire de Biologie Moleculaire de la Cellule, UMR CNRS5161, Ecole Normale Superieure de Lyon, Lyon, France
Mol Biol Evol 21:580-6. 2004..Our results support rounds of gene or genome duplications during a limited period of early vertebrate evolution and allow a better characterization of these events... - Update of NUREBASE: nuclear hormone receptor functional genomicsDavid Ruau
, CNRS UMR 5161, , , 69364 Lyon Cedex 07, France
Nucleic Acids Res 32:D165-7. 2004..The core of NUREBASE is reviewed, and it is completed by NUREBASE_DAILY, automatically updated every 24 h. All information on accessing and installing NUREBASE may be found at http://www. ens-lyon.fr/LBMC/laudet/nurebase/nurebase.html... - The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemakerGerard Triqueneaux
Laboratoire de Biologie Moleculaire et Cellulaire, CNRS UMR 5161, Ecole Normale Supérieur de Lyon, 46 allee d Italie, 69364 Lyon Cedex, France
J Mol Endocrinol 33:585-608. 2004..Together these data demonstrate that CLOCK is a critical regulator of Rev-erbalpha circadian gene expression in evolutionarily distant vertebrates and suggest a role for Rev-erbalpha in the circadian clock output... - Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1Stephanie Bertrand
UMR 5161 CNRS, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
Biochim Biophys Acta 1678:57-66. 2004....