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Genomes and Genes | R LalondeSummaryCountry: France Publications
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Motor performance and regional brain metabolism of spontaneous murine mutations with cerebellar atrophyR Lalonde
Laboratoire de Neurobiologie de l Apprentissage, Universite de Rouen, Faculte des Sciences, UPRES PSY CO EA 1780, 76821 Mont Saint Aignan Cedex, France
Behav Brain Res 125:103-8. 2001..Altered CO activity in cerebellar-related pathways was linearly correlated with motor performance, indicating that the activity of this enzyme is associated not only with neuronal activity but also with motor performance...
Motor coordination in mice with hotfoot, Lurcher, and double mutations of the Grid2 gene encoding the delta-2 excitatory amino acid receptorR Lalonde
Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 bld Gambetta, Bâtiment de Recherche, EMI INSERM 9906, IFRMP 23, 76183 Rouen, France
Physiol Behav 80:333-9. 2003..These results indicate a deleterious effect of the Lc mutation on Grid2-deficient mice...
Immobility responses in Lurcher mutant miceR Lalonde
Universite de Rouen, Faculte des Sciences, Mont Saint Alignan, France
Behav Genet 28:309-14. 1998..Moreover, the mutants are able to improve with practice during a task requiring equilibrium that can be solved by the absence of movement, although terminal performance was not so high as that of controls...
Neurobehavioral evaluation of Reln-rl-orl mutant mice and correlations with cytochrome oxidase activityR Lalonde
Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 bld Gambetta, INSERM EMI 9906, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
Neurosci Res 49:297-305. 2004..Conversely, elevated CO activity in the polymorphic layer of primary somatosensory cortex was congruent with higher latencies before falling from the same apparatus, indicating functional compensation...
Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 miceR Lalonde
Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 bld Gambetta, INSERM U614, IFRMP 23, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
Neurosci Lett 369:156-61. 2004..No mouse displayed neurological signs, such as pathological reflexes, myoclonus, or convulsions. The results in the elevated plus-maze test are akin to the loss of inhibitory control observed in some patients with Alzheimer's disease...
Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screenR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, IFRMP23, Bâtiment de Recherche, 76183 Rouen Cedex, France
Behav Brain Res 157:91-8. 2005..Despite the neurologic signs, APP23 transgenic mice were not deficient in stationary beam, coat-hanger, and rotorod tests, indicating intact motor coordination abilities...
The neurobiological basis of spontaneous alternationRobert Lalonde
Equipe Neurobiologie de l Apprentissage, Faculte des Sciences, Universite de Rouen, PSY CO EA 1780, 76821 Mont Saint Aignan Cedex, France
Neurosci Biobehav Rev 26:91-104. 2002..In addition to the delineation of interactions between neurotransmitters, the spontaneous alternation test is sensitive to the consequences of normal and pathological aging...
Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordinationR Lalonde
Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 Boulevard Gambetta, INSERM EMI 9906, IFRMP 23, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
Brain Res 977:38-45. 2003..These measures may be added to cognitive dysfunctions as testing ground for Abeta vaccination and other attempts at experimental therapies...
Mice with the deleted neurofilament of low molecular weight (Nefl) gene: 2. Effects on motor functions and spatial orientationM Dubois
Faculte des Sciences, Universite de Rouen, UPRES PSY CO EA 1780, Mont Saint Aignan, France
J Neurosci Res 80:751-8. 2005..These results indicate that, as early as 6 months, depletion of the NFL protein is sufficient to cause mild sensorimotor dysfunctions and spatial deficits, but without overt signs of paresis...
Primary neurologic screening and motor coordination of Dstdt-J mutant mice (dystonia musculorum) with spinocerebellar atrophyR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, Bâtiment de Recherche, Salle 1D18, France
Physiol Behav 86:46-51. 2005..The neurologic screening battery delineated the functional integrity of some sensorimotor pathways in a spinocerebellar mutant whose severe phenotype prevents a more elaborate evaluation...
Motor coordination, exploration, and spatial learning in a natural mouse mutation (nervous) with Purkinje cell degenerationR Lalonde
Universite de Rouen, Faculté des Sciences PSY CO EA 1780, Laboratoire de Neurobiologie de l Apprentissage, 76821 Mont Saint Aignan, Cedex France
Behav Genet 33:59-66. 2003..The deficit in spontaneous alternation rates seen in nervous mutants is accountable by reduced motivation, disinhibition, or spatial disorientation...
Regional acetylcholinesterase activity and its correlation with behavioral performances in 15-month old transgenic mice expressing the human C99 fragment of APPM Dumont
, , INSERM U614, Rouen, France
J Neural Transm 113:1225-41. 2006..Because of some similarities in terms of neurochemistry and behavior, this mouse model may be of use for studying prodromal AD...
Brain regions and genes affecting postural controlR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, IFRMP, 76183 Rouen Cedex
Prog Neurobiol 81:45-60. 2007..In addition, transgenic mouse models of the synucleinopathies and of Huntington's disease cause deficiencies of motor coordination resembling those of patients with basal ganglia damage...
Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordinationR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 bld Gambetta, INSERM EPI 9906, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
Behav Brain Res 138:71-9. 2003..These results indicate that elevated Abeta(42) levels were insufficient for causing spatial defects but caused disinhibition, psychomotor slowing, and loss of motor skills in this model of familial Alzheimer's disease...
Exploratory activity and motor coordination in wild-type SOD1/SOD1 transgenic miceR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, Bâtiment de Recherche, 22 bld Gambetta, Salle 1D18, 76183 Rouen Cedex, France
Brain Res Bull 66:155-62. 2005....
Exploratory activity, motor coordination, and spatial learning in Mchr1 knockout miceR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 bld Gambetta, Bâtiment de Recherche, INSERM U614, IFRMP, 76183 Rouen Cedex, France
Behav Brain Res 178:293-304. 2007..Null mutants were lighter than C57BL/6J controls but heavier than 129/SvEv controls, attributable to interactions with strain-dependent genes...
Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutationM Dumont
Universite de Rouen, INSERM U614, IFRMP23, Faculte de Medecine et de Pharmacie, 22 bld Gambetta, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
Brain Res 1024:113-21. 2004..These results indicate that hyperactivity and impaired learning abilities characterize this mouse model of Alzheimer's disease and cerebral angiopathy...
Transgenic mice expressing the human C99 terminal fragment of betaAPP: effects on spatial learning, exploration, anxiety, and motor coordinationR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 blvd Gambetta, INSERM EPI 9906, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
Exp Gerontol 37:1401-12. 2002....
NFH-LacZ transgenic mice: regional brain activity of cytochrome oxidaseC Strazielle
Universite de Rouen, Faculte des Sciences, Laboratoire de Neurobiologie de l Apprentissage, UPRES PSY CO EA 1780, 76821, Mont Saint Aignan Cedex, France
Exp Neurol 177:521-30. 2002..These results indicate regional and age-selective deficits of brain metabolism in a transgenic model with neurofilament maldistribution...
Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutationR Lalonde
INSERM EPI 9906, Salle 1D18, Bâtiment de Recherche, Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 blvd Gambetta, 76183 Rouen Cedex, France
Brain Res 956:36-44. 2002..These results indicate that a learning deficit and hypoactivity, concordant with the early stages of Alzheimer's disease, characterize this mouse model with Abeta accumulation...
Neurobehavioral characteristics of mice with modified intermediate filament genesR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM, Rouen, France
Rev Neurosci 14:369-85. 2003..In addition, spatial learning was impaired in transgenic mice expressing transgenes for NFH and NFM, similar to the memory deficits reported in patients with ALS...
PS1 knockin mice with the Japanese I213T mutation: effects on exploratory activity, motor coordination, and spatial learningR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 bld Gambetta, Bâtiment de Recherche, INSERM U614, Salle 1D18, 76183 Rouen Cedex, France
Behav Brain Res 162:182-90. 2005..The dissociation between hidden and visible platform versions in the water maze is consistent with the hypothesis that elevated Abeta42 concentrations cause cognitive disturbances...
Motor coordination and spatial orientation are affected by neurofilament maldistribution: correlations with regional brain activity of cytochrome oxidaseR Lalonde
Universite de Rouen, Faculte des Sciences, UPRES PSY CO 1780, Laboratoire de Neurobiologie de l Apprentissage, Mont Saint Aignan, France
Exp Brain Res 126:223-34. 1999..The dramatic cytoskeletal perturbation characterizing NFH-LacZ mice affects only selective neuronal populations and results in selective behavioral deficits, which can be correlated with regional brain metabolic activity...
Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistryR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, 76183 Rouen Cedex, France
Brain Res 1140:51-74. 2007..We describe neurochemical characteristics of these mutants with respect to regional brain metabolism as well as amino acid and biogenic amine concentrations, uptake sites, and receptors...
Sensorimotor learning in Dab1(scm) (scrambler) mutant miceR Lalonde
Universite de Rouen, Faculte des Sciences, Dept Psychologie, 76821 Mont Saint Aignan, France
Behav Brain Res 218:350-2. 2011....
Mice with the deleted neurofilament of low-molecular-weight (Nefl) gene: 1. Effects on regional brain metabolismM Dubois
Faculte des Sciences, UPRES PSY CO EA 1780, Universite de Rouen, Mont Saint Aignan, France
J Neurosci Res 80:741-50. 2005..NFL-disrupted mice displayed functional alterations in brainstem sensorimotor regions affected in amyotrophic lateral sclerosis...
Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaquesR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 bld Gambetta, INSERM U614, IFRMP 23, Bâtiment de Recherche, 76183 Rouen Cedex, France
Neurosci Lett 390:87-92. 2005..These results indicate a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology...
Characterization of hemizygous SOD1/wild-type transgenic mice with the SHIRPA primary screen and tests of sensorimotor function and anxietyR Lalonde
Faculte de Medecine et de Pharmacie, Universite de Rouen, INSERM U614, Bâtiment de Recherche, 22 bld Gambetta, Salle 1D18, 76183 Rouen, Cedex, France
Brain Res Bull 64:251-8. 2004..These results indicate mild deficits in sensorimotor responsiveness in a mouse model expressing human SOD1 and that the overexpressed gene may be responsible for some Down symptoms...
Regional variations of cytochrome oxidase activity in the central auditory system of Relnrl-Orl (reeler) mutant miceK Hayzoun
Universite de Rouen, UPRES PSY CO EA 1780 and INSERM U614, France
Neurosci Res 58:378-85. 2007..These metabolic variations are discussed in terms of their possible relation to morphologic anomalies observed in the mutant...
Early development of synchronized walking on the rotorod in rats. Effects of training and handlingP Chapillon
Universite de Rouen, Faculte des Sciences, Laboratoire de Neurobiologie de l Apprentissage, Mont Saint Aignan, France
Behav Brain Res 93:77-81. 1998..These results indicate that the emergence of this postural sensorimotor skill is more dependent on the maturation of sensorimotor brain region than on previous training on the apparatus...
Event-related potentials for category-specific information during passive viewing of faces and objectsM Rebai
Universite de Rouen, Faculte des Sciences, Labo PSY CO EA 1780, 76821 Mont Saint Aignan Cedex France
Int J Neurosci 106:209-26. 2001..These results are concordant with the hypothesis of category-specific processing during the recognition of faces and objects...
Electrophysiological correlates of the visual after effect by means of visual evoked potentialsS Poiroux
Laboratoire PSY CO E A 1780, Equipe de Neurobiologie de l Apprentissage, Faculte des Sciences et Techniques, Universite de Rouen, 76821, Mont Saint Aignan, Cedex, France
Int J Neurosci 106:227-38. 2001..In view of these results, the hypothesis that the after effect represents a short term storage of the temporal characteristics of the stimulus is evoked...
Can time production predict cognitive decline?Robert Lalonde
Universite de Rouen, Departement de Psychologie, 76821 Mont Saint Aignan, Cedex, France
Med Hypotheses 75:525-7. 2010..Nevertheless, time production of a brief interval was correlated with verbal learning scores. These results may be due to age-related changes in prefrontal cortex...
Sensitivity of N170 and late positive components to social categorization and emotional valenceB Montalan
Universite de Rouen, Faculte des Sciences, Laboratoire de Psychologie et Neurosciences de la Cognition et de l Affectivité PSY NCA EA 4306, 76821 Mont Saint Aignan Cedex, France
Brain Res 1233:120-8. 2008....
Timed active avoidance learning in lurcher mutant miceV Monfort
Universite de Rouen, Faculte des Sciences, Laboratoire de Neurobiologie de l Apprentissage, Mont Saint Aignan, France
Behav Brain Res 91:165-72. 1998..An alternative explanation is that the cerebellar mutant animals had persevering tendencies acquired during performance of the one-way avoidance task...
Relations between open-field, elevated plus-maze, and emergence tests in C57BL/6JIco and BALB/cAnN@Ico mice injected with ethanolR Lalonde
Universite de Rouen, Dept de Psychologie, 76821 Mont Saint Aignan Cedex, France
Fundam Clin Pharmacol 26:271-8. 2012..The strain-specific effects may be attributable to differences in GABA(A) -related receptor binding or catalase activity...
Brain regions and genes affecting limb-clasping responsesR Lalonde
Universite de Rouen, Faculte des Sciences, Dept Psychologie, 76821 Mont Saint Aignan Cedex, France
Brain Res Rev 67:252-9. 2011..The underlying mechanism appears to include cerebello-cortico-reticular and cortico-striato-pallido-reticular pathways, possibly triggered by changes in noradrenaline and serotonin transmission...
A prefrontal ERP involved in decision making during visual duration and size discrimination tasksEmilie Gontier
Universite de Rouen, Faculte des Sciences, Laboratoire de Psychologie et Neurosciences de la Cognition EA1780, Mont Saint Aignan Rouen Cedex, France
Int J Neurosci 118:149-62. 2008..These results indicate that the LPCt is not specific to temporal discrimination but can reflect more general decision-making processes...
Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genesStéphane Thifault
Centre de Recherche, Centre hospitalier de l Université de Montréal Technopôle Angus, Montreal, Quebec, Canada
Hum Mol Genet 17:331-44. 2008..Functional polymorphisms in regulatory elements of candidate genes of the CV/inflammatory/immune systems support the hypothesis of genetically-altered environmental susceptibility in CV disease development...
Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse modelKen Ichiro Fukuchi
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Box 1649, Peoria, IL 61656, USA
Biochem Biophys Res Commun 344:79-86. 2006..Because scFvs lack the Fc portion of the immunoglobulin molecule, human scFvs against Abeta may be useful to treat AD patients without eliciting brain inflammation...
Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Abeta1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's diseaseHong Duck Kim
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, PO Box 1649, Peoria, IL 61656, USA
J Gene Med 9:88-98. 2007....
Anti-Abeta single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's diseaseKen Ichiro Fukuchi
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, PO Box 1649, Peoria, IL 61656, USA
Neurobiol Dis 23:502-11. 2006..Because the scFv lacks the Fc portion of the immunoglobulin molecule, this modality may be a feasible solution for AD without eliciting inflammation...
ERPs associated with familiarity and degree of familiarity during face recognitionStéphanie Caharel
Universite de Rouen, Faculte des Sciences, Labo PSY CO EA 1780, 76821 Mont Saint Aignan, France
Int J Neurosci 112:1499-512. 2002..Moreover, these results confirm the hypothesis that N170 is sensitive to face versus, object discriminations and to the discrimination among faces...
Event-related potentials in the frontal lobe during performance of a visual duration discrimination taskIsabelle Paul
, , Laboratoire Psychologie et Neurosciences de la Cognition, Rouen Cedex, France
J Clin Neurophysiol 20:351-60. 2003..These results indicate that the LPCt may reflect successful decision-making or retrieval during time estimation as a result of neuronal activity in the PFC...
ERPs associated with visual duration discriminations in prefrontal and parietal cortexChristophe Le Dantec
Universite de Rouen, Faculte des Sciences, Laboratoire de Psychologie et Neurosciences de la Cognition EA1780, 76821 Mont Saint Aignan, Rouen Cedex, France
Acta Psychol (Amst) 125:85-98. 2007..The results indicate that recorded activity at prefrontal and parietal association cortices is tightly linked to task parameters and behavioral performances...
Regional variations of 5HT concentrations in Rorasg (staggerer) mutantsRobert Lalonde
, , , 22 bld Gambetta, INSERM U614, IFRMP 23, Salle 1B10, 76183, Rouen Cedex, France
Neurochem Res 31:921-4. 2006..These results indicate that 5HT turnover decreased in cerebellum of an ataxic mutant, perhaps indicative of presynaptic accumulation and compromised neurotransmission and susceptible to be modified by 5HT pharmacotherapy...
Orthographic transparency and grapheme-phoneme conversion: An ERP study in Arabic and French readersGregory Simon
Groupe d Imagerie Neurofonctionnelle, UMR 6194, GIP Cyceron, BP 5229, 14074, CNRS CEA Universities of Caen and Paris 5, France
Brain Res 1104:141-52. 2006..The implications of these results on bilinguism and visual word recognition models are discussed...
