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Genomes and Genes | Alain KrolSummaryCountry: France Publications
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Publications
Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursorsPerrine Castets
INSERM, U582, F 75013 Paris, France
BMC Dev Biol 9:46. 2009..Using qRT-PCR, Western blot and whole mount in situ hybridization, we characterized in detail the spatio-temporal expression pattern of the murine Sepn1 gene during development, focusing particularly on skeletal muscles...- Evolutionarily different RNA motifs and RNA-protein complexes to achieve selenoprotein synthesisAlain Krol
Unité Propre de Recherche 9002 du CNRS Université Louis Pasteur, Institut de Biologie Moleculaire et Cellulaire, 15, rue René Descartes, 67084 Strasbourg Cedex, France
Biochimie 84:765-74. 2002..The scope of this review is to bring a sharper focus on the SECIS RNA structures and SECIS RNA-protein complexes involved. Obviously, the examples described here highlight once again the versatility in form and function of RNA... - Characterization of snRNA and snRNA-type genes in the pufferfish Fugu rubripesEvelyne Myslinski
UPR 9002 du CNRS, Structure des Macromolecules Biologiques et Mecanismes de Reconnaissance, Institut de Biologie Moléculaire et Cellulaire 15, rue René Descartes, 67084 Strasbourg Cedex, France
Gene 330:149-58. 2004..Also striking was the observation that the tRNA(Sec), and the snRNA genes that are tandemly repeated, are transcribed from promoter-less DSEs. Evolutionary implications of these results are discussed... - The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA bindingChristine Allmang
Unité Propre de Recherche 9002 du Centre National de la Recherche Scientifique Université Louis Pasteur, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
RNA 8:1308-18. 2002..In addition to identifying key amino acids for SECIS recognition by SBP2, our findings led to the proposal that some of the recognition principles governing the 15.5 kD-U4 snRNA interaction must be similar in the SBP2-SECIS RNA complex... - Protein factors mediating selenoprotein synthesisAlain Lescure
, , , 67084 Strasbourg Cedex, France
Curr Protein Pept Sci 3:143-51. 2002..In this review, we will focus on the structural and functional aspects of the SelB and SBP2 factors in selenoprotein synthesis... - A genome scale location analysis of human Staf/ZNF143-binding sites suggests a widespread role for human Staf/ZNF143 in mammalian promotersEvelyne Myslinski
Institut de Biologie Moleculaire et Cellulaire, UPR CNRS Architecture et Réactivité de l ARN, Universite Louis Pasteur, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
J Biol Chem 281:39953-62. 2006..Furthermore, we demonstrated that the presence of the SBS alone is sufficient to direct expression of a luciferase reporter gene, suggesting that hStaf/ZNF143 can recruit per se the transcription machinery... - Selenoprotein function and muscle diseaseAlain Lescure
Architecture et Reactivite de l ARN, Universite de Strasbourg, CNRS, IBMC F 67084 Strasbourg, France
Biochim Biophys Acta 1790:1569-74. 2009..Importantly, the conclusions of these experiments have opened new avenues of investigations that provide grounds for the development of therapeutic approaches... - Molecular basis for the role of selenium in muscle development and functionAlain Lescure
, , CNRS, , F-67084 Strasbourg
Chem Biodivers 5:408-13. 2008 - The selenium to selenoprotein pathway in eukaryotes: more molecular partners than anticipatedChristine Allmang
Architecture et Réactivité de l ARN Université de Strasbourg, Centre National de la Recherche Scientifique, Institut de Biologie Moleculaire et Cellulaire, 67084 Strasbourg, France
Biochim Biophys Acta 1790:1415-23. 2009..Particularly striking is the higher than originally envisaged number of factors necessary to synthesize Sec and selenoproteins. Clearly, selenoprotein synthesis is an exciting and very active field of research... - cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2Alain Lescure
UPR 9002 du Centre National de la Recherche Scientifique, Institut de Biologie Moleculaire et Cellulaire, 15, rue René Descartes, 67084 Strasbourg Cedex, France
Gene 291:279-85. 2002..Interestingly, we could show that the binding of human SBP2 to the SECIS RNA is stimulated by the selenoprotein-specialized elongation translation factor mSelB/eEFsec... - Novel selenoproteins identified from genomic sequence dataAlain Lescure
, , 67084 Strasbourg, France
Methods Enzymol 347:57-70. 2002 - The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinerySéverine Boulon
Institute of Molecular Genetics of Montpellier, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5535, Montpellier Cedex 5, France
J Cell Biol 180:579-95. 2008..Thus, Hsp90 may control the folding of these proteins during the formation of new RNPs. This suggests that Hsp90 functions as a master regulator of cell proliferation by allowing simultaneous control of cell signaling and cell growth... - Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distributionSergi Castellano
Grup de Recerca en Informàtica Biomèdica, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Dr Aiguader 80, 08003 Barcelona, Catalonia, Spain
EMBO Rep 5:71-7. 2004..Our data indicate a scattered evolutionary distribution of selenoproteins in eukaryotes, and suggest that, contrary to the picture emerging from data available so far, other taxa-specific selenoproteins probably exist... - Selenoprotein N: an endoplasmic reticulum glycoprotein with an early developmental expression patternNathalie Petit
INSERM U582, Institut de Myologie, GH Pitié Salpétrière, Paris, France
Hum Mol Genet 12:1045-53. 2003..Its high expression in cultured myoblasts is also down-regulated in differentiating myotubes, suggesting a role for SEPN1 in early development and in cell proliferation or regeneration... - Distinctive structures between chimpanzee and human in a brain noncoding RNAArtemy Beniaminov
RNA 14:1270-5. 2008..Thus, the rapid evolutionary changes resulted in a profound rearrangement of HAR1 RNA structure. Altogether, our results provide a structural context for elucidating HAR1 RNA function... - A single homozygous point mutation in a 3'untranslated region motif of selenoprotein N mRNA causes SEPN1-related myopathyValérie Allamand
Institut National de la Sante et de la Recherche Medicale, U582, Institut de Myologie, IFR 14, Groupe Hospitalier Pitie Salpetriere, Paris, France
EMBO Rep 7:450-4. 2006..The identification of this mutation affecting a conserved base in the SECIS functional motif thereby reveals the structural basis for a novel pathological mechanism leading to SEPN1-related myopathy... - Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafishChristine Thisse
Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 1 rue Laurent Fries, BP 10142, CU de Strasbourg, 67404 Illkirch, France
Gene Expr Patterns 3:525-32. 2003..Therefore, tissue- and development-specific expression patterns provided new information for selenoproteins of unknown function...