Research Topics
Genomes and Genes | Sandrina KinetSummaryCountry: France Publications
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Publications
The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesisNicolas Manel
Institut de Genetique Moleculaire de Montpellier, CNRS UMR 5535 IFR 24, F 34293 Montpellier cedex 5, France
Blood 101:1913-8. 2003..Up-regulation of the HTLV receptor, via signals transmitted through the IL-7 cytokine receptor as well as the TCR, is likely to contribute to the mother-to-infant transmission and spreading of HTLV-1...
Homeostasis of naive and memory CD4+ T cells: IL-2 and IL-7 differentially regulate the balance between proliferation and Fas-mediated apoptosisSara Jaleco
Institut de Genetique Moleculaire de Montpellier, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5535 Institut Fédératif de Recherche 122, Montpellier, France
J Immunol 171:61-8. 2003..Thus, IL-2 and IL-7 regulate homeostasis by modulating the equilibrium between proliferation and apoptotic cell death in RTE and mature naive and memory T cell subsets...
Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind Glut-1 on activated CD4+ and CD8+ T cellsSandrina Kinet
Institut de Genetique Moleculaire de Montpellier, Montpellier Cedex 5, France
Retrovirology 4:31. 2007..It was therefore of significant interest to thoroughly assess Glut-1 expression on CD4 and CD8 T cells, and its association with HTLV-1 and -2 envelope binding...
Cell surface expression of the bovine leukemia virus-binding receptor on B and T lymphocytes is induced by receptor engagementMadakasira Lavanya
Institut de Genetique Moleculaire de Montpellier, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5535 IFR 24, Université Montpellier I and II, Montpellier, France
J Immunol 181:891-8. 2008..Thus, expression of the BLV-binding receptor is a marker of enhanced metabolic activity in B cells, T cells, and thymocytes...
HTLV envelopes and their receptor GLUT1, the ubiquitous glucose transporter: a new vision on HTLV infection?Nicolas Manel
Institut de Genetique Moleculaire de Montpellier, CNRS UMR 5535/IFR 122, F-34293 Montpellier Cedex 5, France
Front Biosci 9:3218-41. 2004..Finally, we review the potential use of HTLV Env-derived constructs as tools for labeling GLUT1 in vivo and inhibiting GLUT1 transport in tumor cells...
The ubiquitous glucose transporter GLUT-1 is a receptor for HTLVNicolas Manel
Institut de Genetique Moleculaire de Montpellier, CNRS UMR 5535 IFR 122, F 34293 Montpellier cedex 5, France
Cell 115:449-59. 2003..Therefore, GLUT-1 is a receptor for HTLV. Perturbations in glucose metabolism resulting from interactions of HTLV envelope glycoproteins with GLUT-1 are likely to contribute to HTLV-associated disorders...
Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin CAmélie Montel-Hagen
Institut de Genetique Moleculaire de Montpellier, CNRS, Université Montpellier I and II, Montpellier, France
Cell 132:1039-48. 2008..Thus, erythrocyte-specific coexpression of Glut1 with stomatin constitutes a compensatory mechanism in mammals that are unable to synthesize vitamin C...
IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathwayLouise Swainson
Institut de Genetique Moleculaire de Montpellier, France
Blood 109:1034-42. 2007..Our finding that the survival and proliferation of RTEs are differentially modulated by the dose and kinetics of exogenous IL-7 has important implications for the clinical use of this cytokine...
Molecular and cellular basis of T cell lineage commitmentRita Vicente
Institut de Genetique Moleculaire de Montpellier, CNRS UMR 5535 IFR 122, 34293 Montpellier Cedex 5, France
Semin Immunol 22:270-5. 2010..Recent advances in our understanding of the mechanisms regulating precursor entry and their maintenance in the thymus will also be presented...
Ex vivo isolation protocols differentially affect the phenotype of human CD4+ T cellsFrederic Bernard
Institut de Genetique Moleculaire de Montpellier, UMR 5535 IFR 22, 1919 Route de Mende, F34293 Montpellier, Cedex 5, France
J Immunol Methods 271:99-106. 2002..Thus, it is essential to establish the parameters influenced by the isolation protocol in order to fully interpret T cell responses to antigens, chemokines, and cytokines...
gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytesSandrina Kinet
Institut de Genetique Moleculaire de Montpellier, Centre National de Recherche Scientifique CNRS UMR 5535 IFR 22, Montpellier, France
Blood 100:2546-53. 2002..These studies reveal a mechanism via which gp120 may differentially modulate the fate of activated and quiescent T cells in vivo...
Glucose transporter 1 expression identifies a population of cycling CD4+ CD8+ human thymocytes with high CXCR4-induced chemotaxisLouise Swainson
Institut de Genetique Moleculaire, Unite Mixte de Recherche 5535, Montpellier, Cedex 5, France
Proc Natl Acad Sci U S A 102:12867-72. 2005..Thus, during human thymopoiesis, GLUT1 is up-regulated after beta-selection, and these immature DP cells constitute a population with distinct metabolic and chemotactic properties...
IL-7 and CD4+ T-cell proliferationSara Jaleco
Blood 100:4676-7; author reply 4677-8. 2002
[GLUT-1 is the receptor of retrovirus HTLV]Nicolas Manel
Med Sci (Paris) 20:277-9. 2004
