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Genomes and GenesSpecies | A KahanSummaryCountry: France Publications
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Publications
Enhanced late-outgrowth circulating endothelial progenitor cell levels in rheumatoid arthritis and correlation with disease activityVanina Jodon de Villeroché
INSERM U781, Paris Descartes University, Necker Hospital, 149 rue de Sevres, 75015 Paris, France
Arthritis Res Ther 12:R27. 2010..Contradictory results have been published regarding circulating endothelial progenitor cells (EPCs) in RA. We herein investigated late outgrowth EPC sub-population using recent recommendations in patients with RA and healthy controls...
Cardiac complications of systemic sclerosisA Kahan
Department of Rheumatology A, Cochin Hospital, University of Paris Descartes, AP HP, Paris, France
Rheumatology (Oxford) 48:iii45-8. 2009..However, it remains to be seen if early intervention can limit the progression of these life-threatening complications...
[Primary scleroderma myocardial disease]Andre Kahan
Rhumatologie A, Hopital Cochin, AP HP, 27 rue du Faubourg Saint Jacques, 75014 Paris, Universite Paris Descartes, France
Bull Acad Natl Med 195:69-76; discussion 76-7. 2011....
Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trialAndre Kahan
University of Paris Descartes, and Cochin Hospital, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 60:524-33. 2009..To assess the long-term effects of chondroitins 4 and 6 sulfate (CS) on the radiographic progression of, and symptom changes associated with, knee osteoarthritis (OA)...
Primary myocardial involvement in systemic sclerosisA Kahan
Paris 5 René Descartes University, Department of Rheumatology A, Cochin Hospital, AP HP, Paris, France
Rheumatology (Oxford) 45:iv14-7. 2006..Vasodilators, such as calcium channel blockers and angiotensin converting enzyme inhibitors, improve both myocardial perfusion and function abnormalities...
Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosisP Dieude
Universite Paris 7, and Hôpital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 60:225-33. 2009..The aim of this study was to determine whether the IRF5 rs2004640 single-nucleotide polymorphism is associated with SSc...
BANK1 is a genetic risk factor for diffuse cutaneous systemic sclerosis and has additive effects with IRF5 and STAT4P Dieude
Universite Paris 7 Denis Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris AP HP, Paris, France
Arthritis Rheum 60:3447-54. 2009....
High N-terminal pro-brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosisY Allanore
Rene Descartes University, Cochin Hospital, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 58:284-91. 2008..To evaluate predictors of pulmonary arterial hypertension (PAH) in a prospective cohort of patients with systemic sclerosis (SSc)...
Association of hypoxia-inducible factor 1A (HIF1A) gene polymorphisms with systemic sclerosis in a French European Caucasian populationJ Wipff
Rene Descartes University, Department of Rheumatology A, Cochin Hospital, Paris
Scand J Rheumatol 38:291-4. 2009..The aim of this study was to determine whether polymorphisms of the hypoxia-inducible factor 1A gene (HIF1A) affects susceptibility to SSc in a large French European Caucasian population...
Myopathies related to systemic sclerosis: a case-control study of associated clinical and immunological featuresB Ranque
Department of Internal Medicine, French National Reference Center for Systemic Sclerosis and Necrotizing Vasculitides, Cochin Hospital, Faculty of Medicine, Paris Descartes University, the Public Assistance Hospitals of Paris AH HP, France
Scand J Rheumatol 39:498-505. 2010..Little is known about systemic sclerosis (SSc)-related myopathy. We aimed to compare the clinical and immunological features of SSc patients with or without associated myopathy...
STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosisP Dieude
Université Paris 7 and Service de Rhumatologie, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 60:2472-9. 2009..The aim of this study was to determine whether the STAT4 rs7574865 single-nucleotide polymorphism is associated with SSc, and whether it interacts with IRF5...
Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditionsJ Avouac
Université Paris Descartes and Hôpital Cochin, Assistance Publique Hopitaux de Paris, Paris, and INSERM U781, Hopital Necker, Paris, France
Arthritis Rheum 58:3550-61. 2008..To assess angiogenesis and explore the expression and regulation of vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGFR-1), and VEGFR-2, the leading mediators of angiogenesis, in SSc patients and controls...
The PTPN22 620W allele confers susceptibility to systemic sclerosis: findings of a large case-control study of European Caucasians and a meta-analysisP Dieude
Universite Paris 7, Paris, France
Arthritis Rheum 58:2183-8. 2008..We then conducted a meta-analysis of the most recent studies of SSc in order to verify the association or lack of association between the PTPN22 1858C>T variant and SSc...
Disturbed angiogenesis in systemic sclerosis: high levels of soluble endoglinJ Wipff
Department of Rheumatology A, Paris Descartes University, Medical Faculty, Cochin Hospital, Paris, France
Rheumatology (Oxford) 47:972-5. 2008..The aim of this study was to investigate, in a cross-sectional study, sENG levels together with other serum vascular markers...
Association of a KCNA5 gene polymorphism with systemic sclerosis-associated pulmonary arterial hypertension in the European Caucasian populationJ Wipff
Universite Paris Descartes, INSERM U781, Hopital Necker, and Hôpital Cochin, Paris, France
Arthritis Rheum 62:3093-100. 2010..We undertook this study to determine whether KCNA5 polymorphisms confer susceptibility to SSc and its vascular phenotype, including PAH...
Levels of circulating endothelial progenitor cells in systemic sclerosisY Allanore
Rheumatology A and Immunology departments, Rene Descartes University, Medical School, Cochin Hospital, Assistance Publique Hopitaux de Paris, France
Clin Exp Rheumatol 25:60-6. 2007..Our aim was to investigate bone marrow-derived circulating endothelial precursors (EPCs) and activated circulating endothelial cells (CECs) in SSc patients...
N-terminal pro-brain natriuretic peptide in systemic sclerosis: a new cornerstone of cardiovascular assessment?Y Allanore
Department of Rheumatology A, Paris Descartes University, Cochin Hospital, APHP, 75014 Paris, France
Ann Rheum Dis 68:1885-9. 2009..Cardiac involvement, a common and often fatal complication of systemic sclerosis (SSc), is currently detected by standard echocardiography enhanced by tissue Doppler echocardiography (TDE)...
Prevalence and factors associated with left ventricular dysfunction in the EULAR Scleroderma Trial and Research group (EUSTAR) database of patients with systemic sclerosisY Allanore
Service de Rhumatologie A, Hopital Cochin, Universite Paris Descartes, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
Ann Rheum Dis 69:218-21. 2010..To measure the prevalence of, and factors associated with, left ventricular (LV) dysfunction in systemic sclerosis (SSc)...
Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesisP Dieude
Universite Paris Diderot, Hopital Bichat Claude Bernard, Paris, France
Arthritis Rheum 63:1097-105. 2011..The purpose of this study was to test for association of the CD226 rs763361 polymorphism with systemic sclerosis (SSc) in European Caucasian populations...
Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imagingY Allanore
Service de Rhumatologie A, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
Ann Rheum Dis 65:249-52. 2006..Cardiac involvement in idiopathic inflammatory myopathy has been recognised as an important prognostic factor, but treatment remains empirical...
Association between an endoglin gene polymorphism and systemic sclerosis-related pulmonary arterial hypertensionJ Wipff
Rene Descartes University, Medical Faculty, Rheumatology A Department, Cochin Hospital, AP HP, Paris, France
Rheumatology (Oxford) 46:622-5. 2007..A 6-base insertion in intron 7 (6bINS) of ENG has been reported to be associated with microvascular disturbance...
Tetracyclines inhibit nitrosothiol production by cytokine-stimulated osteoarthritic synovial cellsD Borderie
Laboratoire de Biochimie A, Hopital Cochin, Paris, France
Inflamm Res 50:409-14. 2001..To evaluate the capacity of doxycycline and minocycline to inhibit NO production and N-nitrosation reactions in vitro...
Circulating endothelial progenitor cells in systemic sclerosis: association with disease severityJ Avouac
Paris Descartes University, Rheumatology A Department, Cochin Hospital, APHP, Paris, France
Ann Rheum Dis 67:1455-60. 2008..Heterogeneous data have been reported regarding the detection and number of circulating endothelial progenitor cells (EPCs) in systemic sclerosis (SSc)...
Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: Association with the functional IRAK1 196Phe/532Ser haplotypeP Dieude
Paris Diderot University, AP HP, INSERM U699, and Hôpital Bichat Claude Bernard, Paris, France
Arthritis Rheum 63:3979-87. 2011..This study was undertaken to test for an association between SSc and the IRAK1 SLE risk haplotype...
Predictive factors of hand radiographic lesions in systemic sclerosis: a prospective studyJ Avouac
Hopital Cochin, Service de Rhumatologie A, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
Ann Rheum Dis 70:630-3. 2011..To examine the outcomes of hand radiographic x-rays in patients with systemic sclerosis (SSc) and to identify risk factors for the progression of hand radiographic lesions in a prospective cohort...
Radiological hand involvement in systemic sclerosisJ Avouac
Service de Rhumatologie A, , 27 rue du Faubourg Saint Jacques, 75014 Paris, France
Ann Rheum Dis 65:1088-92. 2006..Calcinosis and acro-osteolysis were both associated with vascular complications, highlighting a potential role of vascular injury in such lesions...
Prognostic factors for lung function in systemic sclerosis: prospective study of 105 casesM Gilson
Dept of Rheumatology A, Paris Descartes University, Cochin Hospital, Paris, France
Eur Respir J 35:112-7. 2010..Only diffuse SSc was predictive of a decrease in pulmonary function in this early-SSc cohort. This does not support preliminary data suggestive of a causative role of oesophageal involvement...
Evaluation of the effect of nifedipine upon myocardial perfusion and contractility using cardiac magnetic resonance imaging and tissue Doppler echocardiography in systemic sclerosisO Vignaux
Services de Radiologie A, , AP-HP, , 75014 Paris, France
Ann Rheum Dis 64:1268-73. 2005..2 (1.6) v 3.0 (1.2) at baseline, p = 0.0003, respectively). CONCLUSION: Fourteen days of treatment with nifedipine simultaneously improves myocardial perfusion and function, as evaluated by highly sensitive and quantitative methods...
Prevalence of antiphospholipid antibodies in systemic sclerosis and association with primitive pulmonary arterial hypertension and endothelial injuryN Assous
Department of Rheumatology A, Paris 5 University, , Cochin Hospital, Paris, France
Clin Exp Rheumatol 23:199-204. 2005..005). CONCLUSION: We found that the prevalence of antiphospholipid antibodies in SSc patients was low. However, aCL antibodies were associated with PAH and endothelial injury...
Serum protein oxidation in patients with rheumatoid arthritis and effects of infliximab therapyH Lemarechal
Department of Biochemistry A, , Cochin Hospital, 75014 Paris, France
Clin Chim Acta 372:147-53. 2006..02) and increased thiol (231.2+/-48.7 micromol/L, p=0.02) levels. CONCLUSION: Our results highlight free radical protein damage in RA and a link with inflammation, as underlined by the beneficial effects of infliximab...
Outcome measures for heart involvement in systemic sclerosisY Allanore
Department of Rheumatology A, Paris Descartes University, Cochin Hospital, AP HP, Paris, France
Rheumatology (Oxford) 47:v51-3. 2008..Their predictive value should also be investigated when there is primary heart involvement...
Lack of association between three vascular endothelial growth factor gene polymorphisms and systemic sclerosis: results from a multicenter EUSTAR study of European Caucasian patientsY Allanore
Hopital Cochin, Service de Rhumatologie A, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
Ann Rheum Dis 66:257-9. 2007..Systemic sclerosis (SSc) is characterised by disturbed vessel morphology and an overproduction of vascular endothelial growth factor (VEGF). The VEGF gene located on chromosome 6p21.3 has several polymorphisms...
Low levels of nitric oxide (NO) in systemic sclerosis: inducible NO synthase production is decreased in cultured peripheral blood monocyte/macrophage cellsY Allanore
Department of Rheumatology A, Cochin Hospital, , Paris 75014, France
Rheumatology (Oxford) 40:1089-96. 2001..Low levels of NO, a vasodilator, may be involved in vasospasm, which is critical in SSc. This may have therapeutic implications...
Hand vascular involvement assessed by magnetic resonance angiography in systemic sclerosisY Allanore
Rene Descartes University, and Service de Rheumatologie A, Hopital Cochin, 27 rue du Faubourg St Jacques, 75014 Paris, France
Arthritis Rheum 56:2747-54. 2007..Magnetic resonance angiography (MRA) has improved the assessment of vascular lesions of the hand. The aim of this study was to evaluate vascular abnormalities in the hands of patients with SSc, using MRA...
Effects of oral treatments on exercise capacity in systemic sclerosis related pulmonary arterial hypertension: a meta-analysis of randomised controlled trialsJ Avouac
Paris Descartes University, Rheumatology A Department, Cochin Hospital, APHP, Paris, France
Ann Rheum Dis 67:808-14. 2008....
Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian populationJ Wipff
Rheumatology A Department, Cochin Hospital, Paris, France
Ann Rheum Dis 65:1230-2. 2006..38). The PTPN22*620W allele was also not associated with autoantibody patterns. Thus, the PTPN22*R620W polymorphism cannot be regarded as a genetic susceptibility factor for SSc in the French Caucasian population...
Chronic recurrent multifocal osteomyelitis: five-year outcomes in 14 pediatric casesC Job-Deslandre
Service de Rhumatologie A, Hĵpital Cochin, Paris, France
Joint Bone Spine 68:245-51. 2001..To determine the clinical presentation and outcomes of chronic recurrent multifocal osteomyelitis (CRMO) in pediatric patients...
[Spondylarthropathies and anti-TNFalpha drugs]S Pavy
Service de Rhumatologie A, , , 27, rue du Faubourg-Saint-Jacques, AP-HP, 75014 Paris, France
Rev Med Interne 26:717-24. 2005..Long-term follow-up in large populations of patients with spondylarthropathies is necessary to better define the benefit/risk/cost ratio of anti-TNFalpha drugs...
A descriptive and prognostic study of systemic sclerosis-associated myopathiesB Ranque
Universite Paris Descartes, UPRES EA 4058, Department of Internal Medicine, French National Reference Center for Systemic Sclerosis and Necrotizing Vasculitides, Hopital Cochin, Assistance Publique des Hopitaux de Paris, Paris, France
Ann Rheum Dis 68:1474-7. 2009..To describe the clinical characteristics and muscle pathological features of patients with systemic sclerosis (SSc) and myopathy and analyse their impact on muscle outcome...
[Watermelon stomach in systemic sclerosis]K Laoubi
Service de Rhumatologie A, Hopital Cochin, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
J Mal Vasc 35:250-3. 2010..Indeed, specific local treatment must be delivered and is usually efficient despite frequent recurrent events...
DHEA in bone and joint diseasesC Cormier
Rheumatology Department A, , AP-HP, Paris, France
Joint Bone Spine 68:588-94. 2001..DHEA cannot be recommended as a treatment for osteoporosis at present given the absence of studies evaluating possible efficacy in reducing the fracture rate and possible long-term side effects...
[Treatment of systemic scleroderma: update]Y Allanore
Service de Rhumatologie A, , , , , 75014 Paris
Ann Dermatol Venereol 133:286-91. 2006
NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesisP Dieude
Service de Rhumatologie, Paris Diderot University, INSERM U699, Hopital Bichat Claude Bernard, 46 rue Henri Huchard, 75018 Paris, France
Ann Rheum Dis 70:668-74. 2011..NLRP1 provides a scaffold for the assembly of the inflammasome that promotes the processing and maturation of pro-IL-1?. In addition, NLRP1 variants were found to confer susceptibility to autoimmune disorders...
N-terminal pro-brain natriuretic peptide as a diagnostic marker of early pulmonary artery hypertension in patients with systemic sclerosis and effects of calcium-channel blockersY Allanore
Paris V University, Assistance Publique Hopitaux de Paris, Hopital Cochin, Paris, France
Arthritis Rheum 48:3503-8. 2003....
Induction of autoantibodies in refractory rheumatoid arthritis treated by infliximabY Allanore
Rheumatology A Department, Paris V University, Cochin Hospital, AP HP Paris, France
Clin Exp Rheumatol 22:756-8. 2004..To investigate autoantibody induction in rheumatoid arthritis (RA) patients treated with infliximab...
Refractory multicentric reticulohistiocytosis treated by infliximab: two casesJ Sellam
, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France
Clin Exp Rheumatol 23:97-9. 2005..A switch to etanercept did not improve polyarthritis in the second patient. Some data suggest that TNFalpha is involved in MRH, but based on our cases anti-TNFalpha therapy needs further evaluation in patients with refractory MRH...
Increased prevalence of ocular glaucomatous abnormalities in systemic sclerosisY Allanore
Hopital Cochin, Service de Rhumatologie A, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
Ann Rheum Dis 63:1276-8. 2004..Cardiovascular diseases, vasospasm, and dysimmunity have been implicated in normal tension glaucoma (NTG)...
Prevalence of Barrett's esophagus in systemic sclerosisJ Wipff
Cochin Hospital, AP-HP Paris 5 University, Paris, France
Arthritis Rheum 52:2882-8. 2005..Long-term prospective studies are warranted to determine the phenotype of SSc patients at high risk of developing dysplasia or esophageal adenocarcinoma...
Lack of effect of phenobarbital on ex vivo leukocyte oxidative metabolism in healthy volunteersJ L Pinquier
ECLIMED, , , Paris, France
Fundam Clin Pharmacol 7:311-7. 1993..This study suggests that human polymorphonuclears cytochrome P450 leukotriene B4 omega-hydroxylase and procainamide metabolism is not a useful method to study cytochrome P450 induction in clinical pharmacology...
169Erbium-citrate synoviorthesis after failure of local corticosteroid injections to treat rheumatoid arthritis-affected finger jointsA Kahan
Paris V University, Rheumatology A Department, Hopital Cochin, AP HP, Paris, France
Clin Exp Rheumatol 22:722-6. 2004..However, its efficacy in corticosteroid-resistant rheumatoid arthritis-affected joints has not been clearly demonstrated...
[Hyperparathyroidism and osteoporosis]C Cormier
Service de Rhumatologie A, Hopital Cochin, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
Rev Med Interne 25:S560-7. 2004..Parathyroidectomy remains the treatment of choice given the low mortality associated with this procedure and the absence of pharmacological alternatives suitable for long-term use...
Brachial plexopathy associated with systemic sclerosisY Allanore
Cochin Hospital, Assistance Publique Hopitaux de Paris, Rene Descartes University, France
Clin Rheumatol 21:401-2. 2002..We report a third case of brachial plexopathy, presumably related to vasculitis, in a patient with systemic sclerosis, which improved after cyclophosphamide therapy...
Sacral inflammatory pseudotumor revealed by paraneoplastic syndromeY Allanore
Department of Rheumatology, Assistance Publique Hopitaux de Paris, Rene Descartes University, Paris, France
Rheumatol Int 24:166-8. 2004..All clinical symptoms disappeared within a few days after surgery, which is suggestive of a paraneoplastic syndrome. No relapse has occurred after 4 years...
Evaluation of cardiac abnormalities by Doppler echocardiography in a large nationwide multicentric cohort of patients with systemic sclerosisP de Groote
Hopital Cardiologique, Service de Cardiologie C, Boulevard du Professeur Leclercq, CHRU, 59037 Lille Cedex, France
Ann Rheum Dis 67:31-6. 2008..However, previous studies have generally been conducted in small populations. The aims of this study were to prospectively screen for PAH and to describe echocardiographic parameters in a large group of SSc patients...
[Myocardial microvascularization in scleroderma]A Kahan
Service de Rhumatologie, , Paris
Arch Mal Coeur Vaiss 81:495-500. 1988..Finally, the preliminary results of long-term studies suggest that some coronary vasodilators may be beneficial in the long-term treatment of myocardial perfusion abnormalities in systemic sclerosis...
Increased plasma soluble CD40 ligand concentrations in systemic sclerosis and association with pulmonary arterial hypertension and digital ulcersY Allanore
Rheumatology A, Paris V University, , France
Ann Rheum Dis 64:481-3. 2005..41; p = 0.005). CONCLUSIONS: The soluble form of CD40L is increased in plasma in systemic sclerosis and may be associated with vascular complications of the disease...
Efficacy of rituximab in patients with rheumatoid arthritis refractory or with contra-indication to anti-tumor necrosis factor-alpha drugs in daily practice: an open label observational studyN Assous
Clin Exp Rheumatol 25:504. 2007
Predominant primitive right ventricular involvement in systemic sclerosisC Meune
Clin Exp Rheumatol 25:658. 2007
Systemic sclerosis-associated Sjögren's syndrome and relationship to the limited cutaneous subtype: results of a prospective study of sicca syndrome in 133 consecutive patientsJ Avouac
, Medical Faculty, , France
Arthritis Rheum 54:2243-9. 2006..The prevalence of secondary SS, as defined by the American-European Consensus Group criteria, was 14% and was markedly associated with lcSSc. We believe that lcSSc should be regarded as a specific autoimmune subgroup of SSc...
Progressive osseous heteroplasia: a rare case of late onsetR Seror
Rheumatology (Oxford) 46:716-7. 2007
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trialJosef S Smolen
Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
Lancet 371:987-97. 2008..Our aim was to assess the therapeutic effects of blocking interleukin 6 by inhibition of the interleukin-6 receptor with tocilizumab in patients with rheumatoid arthritis...
Fatal exacerbation of fibrosing alveolitis associated with systemic sclerosis in a patient treated with adalimumabY Allanore
Ann Rheum Dis 65:834-5. 2006
[Pulmonary arterial hypertension in systemic sclerosis: definition of a screening algorithm for early detection (the ItinérAIR-Sclérodermie Study)]E Hachulla
Service de Medecine Interne, CHRU Claude Huriez, Place de Verdun, 59037 Lille Cedex, France
Rev Med Interne 25:340-7. 2004..Its prevalence varies from 5% to 35% in the literature. A systematic yearly screening is recommended for early detection and management of PAH, but no precise algorithm is yet available...
Total joint replacement of hip or knee as an outcome measure for structure modifying trials in osteoarthritisR D Altman
Rheumatology and Immunology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Osteoarthritis Cartilage 13:13-9. 2005..g., >0.3-0.7 mm) combined with a lack of clinically relevant improvement in symptoms (e.g., >/=20-25%) for 'failure' of a secondary outcome in structure modifying trials of the hip and knee...
