Research Topics
| Christian JorgensenSummaryCountry: France Publications
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Detail Information
Publications
Systems medicine and integrated care to combat chronic noncommunicable diseasesJean Bousquet
Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
Genome Med 3:43. 2011..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...- [Mesenchymal stem cells: A therapeutic update]Christian Jorgensen
Unité Inserm U844, Montpellier, France
Med Sci (Paris) 27:275-84. 2011.... - Prospects for gene therapy in inflammatory arthritisChristian Jorgensen
INSERM, U844, Montpellier, F 34091 France
Best Pract Res Clin Rheumatol 24:541-52. 2010..We also discuss the currently used gene therapy clinical trials and define optimal strategies for success... - Mesenchymal stem cells immunosuppressive properties: is it specific to bone marrow-derived cells?Christian Jorgensen
INSERM, U 844, Hopital Saint Eloi, Montpellier, F 34295 France
Stem Cell Res Ther 1:15. 2010..All of these biological effects are probably shared by all stromal cells, including fibroblasts and stem cells isolated from exfoliated deciduous teeth. The therapeutical implications are discussed... - Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-dependent mechanismFarida Djouad
Institut National de la Sante et de la Recherche Medicale, U 844, Hopital Saint Eloi, Bât INM, 80 avenue Augustin Fliche, Montpellier, France
Stem Cells 25:2025-32. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytesFarida Djouad
INSERM, U 844, 80 avenue Augustin Fliche, Montpellier, F 34091 France
Arthritis Res Ther 9:R33. 2007..Our data suggest that crosstalk between ECM components of the microenvironment and MSCs within the cartilage is responsible for the differentiation of MSCs into chondrocytes... - Peripheral blood T4 cell surface CCR5 density as a marker of activity in rheumatoid arthritis treated with anti-CD20 monoclonal antibodyPierre Portales
Laboratoire d Immunologie de l Hôpital Saint Eloi, Montpellier, France
Immunology 128:e738-45. 2009..Thus, peripheral blood T4 cell surface CCR5 density is a good surrogate marker of RA activity and of the efficiency of anti-CD20 therapy... - Antitumoral activity and osteogenic potential of mesenchymal stem cells expressing the urokinase-type plasminogen antagonist amino-terminal fragment in a murine model of osteolytic tumorVanessa Fritz
Institut National de la Santé et de la Recherche Médicale U844, Montpellier, France
Stem Cells 26:2981-90. 2008..Disclosure of potential conflicts of interest is found at the end of this article... - Gene expression profile of multipotent mesenchymal stromal cells: Identification of pathways common to TGFbeta3/BMP2-induced chondrogenesisDominique Mrugala
INSERM, Montpellier, France
Cloning Stem Cells 11:61-76. 2009..Indeed, these data propose new pathways to understand the complexity of MSC differentiation to chondrocytes... - Transcriptomic analysis identifies Foxo3A as a novel transcription factor regulating mesenchymal stem cell chrondrogenic differentiationFarida Djouad
INSERM, U 844, Montpellier, F 34091 France
Cloning Stem Cells 11:407-16. 2009..Therefore, our findings suggest that upregulation of Foxo3A over the course of chondrogenic differentiation plays a dual role, mainly inhibiting the differentiation process toward hypertrophy and promoting cell apoptosis... - Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritisMaroun Khoury
INSERM, U844, Hopital Saint Eloi, and Université Montpellier I, Montpellier, France
Arthritis Rheum 62:765-70. 2010.... - Comparative proteomic analysis of human mesenchymal and embryonic stem cells: towards the definition of a mesenchymal stem cell proteomic signatureStephane Roche
CNRS, Institut de Genetique Humaine, UPR1142, Montpellier, France
Proteomics 9:223-32. 2009..Based on these proteomic data, we could propose a panel of proteins which were the basis for the definition of a mesenchymal stem cell proteomic signature... - Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexesMaroun Khoury
INSERM, U 844, INM, Hopital St Eloi, and Université Montpellier 1, UFR de Medecine, Montpellier, France
Arthritis Rheum 58:2356-67. 2008..As proof of concept, we tested the efficiency of an RNA interference (RNAi)-based intervention that targets proinflammatory cytokines in suppressing murine collagen-induced arthritis (CIA)... - Skin fibroblasts are potent suppressors of inflammation in experimental arthritisCarine Bouffi
INSERM U844, Hopital Saint Eloi, Montpellier, France
Ann Rheum Dis 70:1671-6. 2011..This study explored whether fibroblasts isolated from skin may suppress the host immune response in a model of autoimmune disorder... - IL-6-dependent PGE2 secretion by mesenchymal stem cells inhibits local inflammation in experimental arthritisCarine Bouffi
INSERM, Unité 844, Montpellier, France
PLoS ONE 5:e14247. 2010.... - Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseasesFarida Djouad
INSERM, U844, Montpellier, France
Nat Rev Rheumatol 5:392-9. 2009..These unique properties of MSCs confer on them the potential to be used for therapeutic applications in rheumatic diseases, including rheumatoid arthritis, osteoarthritis, genetic bone and cartilage disorders as well as bone metastasis... - Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapyClaire Vinatier
INSERM, U 791, LIOAD, Nantes, F 44042, France
Curr Stem Cell Res Ther 4:318-29. 2009..Finally, some of the major obstacles generally encountered in cartilage engineering are discussed as well as future trends to overcome these limiting issues for clinical applications... - Adoptive transfer of IL-10-secreting CD4+CD49b+ regulatory T cells suppresses ongoing arthritisLouis Marie Charbonnier
INSERM, U844, Montpellier, F 34295, France Université MONTPELLIER1, Montpellier, F 34000, France
J Autoimmun 34:390-9. 2010.... - In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cellsGabriel Courties
INSERM U844, INM, Hopital Saint Eloi, 80 rue Augustin Fliche, Montpellier, France
Blood 116:3505-16. 2010..Finally, in vitro inhibition of TAK1 in myeloid cells decreases interferon-?-producing T cells, suggesting that a delivery system able to target MPS cells and to silence TAK1 impacts on pathogenic T effector cells in autoimmunity... - Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentialsDaniele Noel
INSERM U844, Montpellier, F 34091 France
Exp Cell Res 314:1575-84. 2008..In summary, our observations indicate that ADSC and MSC are fundamentally different cell types and differently committed cells... - Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cellsFarida Djouad
INSERM Unit 475, Montpellier, France
Arthritis Res Ther 7:R1304-15. 2005.... - The role of pharmacologically active microcarriers releasing TGF-beta3 in cartilage formation in vivo by mesenchymal stem cellsCarine Bouffi
INSERM, U 844, Hopital Saint Eloi, 80 avenue Augustin Fliche, Montpellier F 34295, France
Biomaterials 31:6485-93. 2010.... - Tripartite siRNA micelles as controlled delivery systems for primary dendritic cellsAriane Boudier
Institut Charles Gerhardt Montpellier, UMR 5253 CNRS ENSCM UM2 UM1, Montpellier, France
Drug Dev Ind Pharm 35:950-8. 2009..Our results underscore the potential of pH-sensitive polyion complex micelles to formulate therapeutic siRNA for DC engineering in order to maintain the homeostasis of the immune response... - Earlier onset of syngeneic tumors in the presence of mesenchymal stem cellsFarida Djouad
INSERM U475, Montpellier, France
Transplantation 82:1060-6. 2006..An important finding of this study is that a low but relevant amount of MSC may induce tumor rejection... - Multipotent mesenchymal stromal cells and immune toleranceDaniele Noel
Universite Montpellier 1, Montpellier, France
Leuk Lymphoma 48:1283-9. 2007..Finally, the data obtained from in vivo experimentation in various animal models as well as potential therapeutic applications will be presented... - Engineered mesenchymal stem cells for cartilage repairFarida Djouad
INSERM, U 475, 99 rue Puech Villa, 34197 Montpellier Cedex 5, France
Regen Med 1:529-37. 2006..Here, we focus on the potential of MSCs to repair cartilage with an emphasis on the factors that are known to be required in inducing chondrogenesis... - [Multipotent stromal cells: controversial impact on tumor development and metastasis]Florence Apparailly
INSERM, U844, INM, , 80 rue Augustin Fliche, 34295 Montpellier Cedex 5, France
Med Sci (Paris) 24:359-60. 2008 - Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cellsLouis-Marie Charbonnier
, Montpellier, France
J Immunol 177:3806-13. 2006..Thus, together these data demonstrate that iDCs can expand and activate a novel regulatory population of CD49b+ T cells, with high immunosuppressive potential able to mediate protection against a systemic autoimmune disease... - Cell surface CCR5 density determines the intensity of T cell migration towards rheumatoid arthritis synoviocytesCaroline Desmetz
Institut de Génétique Humaine du CNRS UPR1142, Montpellier, F 34000, France
Clin Immunol 123:148-54. 2007..The CCR5 density on T cell surface, which is constant over time for a given individual, but varies drastically from one individual to another, might thus be a factor determining the intensity of joint inflammation in the course of RA... - MicroRNAs as new player in rheumatoid arthritisIsabelle Duroux-Richard
INSERM, U844, CHU Saint Eloi, bâtiment INM, 80, rue Augustin Fliche, 34295 Montpellier Cedex 5, France
Joint Bone Spine 78:17-22. 2011..Here, we provide an overview of the state-of-the-art on miRNAs in RA, focusing on both systemic and local features of the pathology... - Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor alpha in experimental arthritisMaroun Khoury
INSERM U475 and University of Montpellier I, Montpellier, France
Arthritis Rheum 54:1867-77. 2006..The aim of this study was to determine the therapeutic effect of systemic administration of TNFalpha siRNA in an experimental model of RA, optimizing its delivery using new liposome formulations... - RNA interference-based gene therapy for successful treatment of rheumatoid arthritisGabriel Courties
INSERM, U844, Universite Montpellier 1, CHU Lapeyronie, Montpellier, France
Expert Opin Biol Ther 9:535-8. 2009..For clinical development, however, the use of RNAi-based therapeutics has to overcome major obstacles, mainly targeted delivery and safety issues... - Cartilage engineering: a crucial combination of cells, biomaterials and biofactorsClaire Vinatier
INSERM, U 791, LIOAD, Nantes, F 44042, France
Trends Biotechnol 27:307-14. 2009..Finally, some of the major obstacles encountered in cartilage engineering are discussed, as well as future trends in clinical applications... - Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cellsBruno Delorme
INSERM, Equipe ESPRI EA 3855, Faculty of Medicine, University Francois Rabelais, 10 boulevard Tonnelle, Tours, France
Blood 111:2631-5. 2008..In addition, the expression of CD73, CD146, and CD200 was down-regulated in differentiated cells. The new marker CD200, because of its specificity and immunomodulatory properties, deserves further in-depth studies... - Two dimensional gel electrophoresis analysis of mesenchymal stem cellsMonique Provansal
CNRS, Institut de Génétique Humaine UPR1142, Montpellier, France
Methods Mol Biol 698:431-42. 2011..In this chapter, we detail these protocols which can be used not only for MSC but also for other cells in culture... - Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor alpha in collagen-induced arthritisFarida Djouad
INSERM U475, Montpellier, France
Arthritis Rheum 52:1595-603. 2005..CONCLUSION: Our data suggest that environmental parameters, in particular those related to inflammation, may influence the immunosuppressive properties of MSCs... - Immunosuppression by mesenchymal stem cells: mechanisms and clinical applicationsSoufiane Ghannam
INSERM, U844, Montpellier F 34091, France
Stem Cell Res Ther 1:2. 2010.... - Concise review: adult multipotent stromal cells and cancer: risk or benefit?Gwendal Lazennec
Institut National de la Sante et de la Recherche Medicale, Montpellier, France
Stem Cells 26:1387-94. 2008..Disclosure of potential conflicts of interest is found at the end of this article... - Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritisFlorence Apparailly
Unité de Recherche en Immunopathologie des Maladies Tumorales et Autoimmunes, INSERM U475, France
Hum Gene Ther 13:1179-88. 2002..Our results supported, for the first time, the utility of AAV-tetON-vIL10 as a therapeutic tool for gene therapy in RA... - RNAi in arthritis: prospects of a future antisense therapy in inflammationMaroun Khoury
Inserm U 844, INM Hôpital Saint Eloi, BP 74103, 80 rue Augustin Fliche, 34091 Montpellier Cedex 5, France
Curr Opin Mol Ther 9:483-9. 2007..In addition, RNAi and current biotherapies used in the clinic are compared and contrasted... - Mesenchymal stem cells: an emerging tool for cancer targeting and therapyVanessa Fritz
INSERM U844, CHU Hôpital Saint Eloi Bâtiment INM, BP74103, 80 rue Augustin Fliche, 34091 Montpellier Cedex 5, France
Curr Stem Cell Res Ther 3:32-42. 2008..This review highlights recent works and potential clinical applications of MSCs in this field... - Multipotent mesenchymal stromal cells in articular diseasesChristian Jorgensen
INSERM U844, CHU Saint Eloi, bâtiment INM, 80 avenue Augustin Fliche, Montpellier F 34091, France
Best Pract Res Clin Rheumatol 22:269-84. 2008..This chapter focuses on the potential of MSC to repair cartilage, with an emphasis on the factors that are known to be required in inducing chondrogenesis and on their immunosuppressive potential... - Tissue engineering through autologous mesenchymal stem cellsChristian Jorgensen
Service d Immuno Rhumatologie, Hopital Lapeyronie, 34295 Montpellier, Cedex 5, France
Curr Opin Biotechnol 15:406-10. 2004..The long-term behavior of MSCs associated with biomaterials and implanted in pathological joints remains to be investigated before clinical application in osteoarthritis or rheumatoid arthritis... - Micro-CT combined with bioluminescence imaging: a dynamic approach to detect early tumor-bone interaction in a tumor osteolysis murine modelVanessa Fritz
INSERM U844, CHU Saint Eloi, 80 rue Augustin Fliche, 34091 Montpellier Cedex 5, France
Bone 40:1032-40. 2007..This model will help to assess new therapeutic approaches targeting intraosseous tumor growth or tumor/osteoclast crosstalk... - miRNAs and rheumatoid arthritis - promising novel biomarkersIsabelle Duroux-Richard
INSERM U844, CHU Saint Eloi, bâtiment INM, 80 rue Augustin Fliche, 34295 Montpellier Cedex 5, France
Swiss Med Wkly 141:w13175. 2011..As a growing body of evidences reveals abnormal expression of specific miRNAs in RA tissues, the use of a blood-based miRNA signature for optimal diagnosis and treatment becomes a realistic option... - Cellular Senescence is a Common Characteristic Shared by Preneoplasic and Osteo-Arthritic TissueJean Marc Brondello
INSERM, U844, Montpellier, F 34295, France
Open Rheumatol J 4:10-4. 2010.... - Primary cutaneous Nocardia otitidiscaviarum infection in a patient with rheumatoid arthritis treated with infliximabSylvie Fabre
Department of Immuno-Rheumatology, Centre Hospitalier Universitaire Lapeyronie, Montpellier, France
J Rheumatol 32:2432-3. 2005..We describe a patient receiving infliximab who developed a primary cutaneous Nocardia otitidiscaviarum infection after a skin injury... - Interleukin-8 expression is regulated by histone deacetylases through the nuclear factor-kappaB pathway in breast cancerCarine Chavey
Institut National de la Santé et de la Recherche Mé dicale, U844, University of Montpellier I, 34091 Montpellier Cedex 5, France
Mol Pharmacol 74:1359-66. 2008..TSA increased binding of acetylated histone 3 to the IL-8 gene promoter. In summary, our results demonstrate that NF-kappaB pathway repression by HDAC is responsible for the low expression of IL-8 in ERalpha-positive breast cancer cells... - Short-term BMP-2 expression is sufficient for in vivo osteochondral differentiation of mesenchymal stem cellsDaniele Noel
INSERM U475, Montpellier, France
Stem Cells 22:74-85. 2004.... - Mesenchymal stem cell-based therapies in regenerative medicine: applications in rheumatologyMarie Maumus
INSERM, U844, Montpellier, F 34091 France
Stem Cell Res Ther 2:14. 2011....