Research Topics
| S WalrandSummaryAffiliation: Institut National de la Recherche Agronomique Country: France Publications
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Detail Information
Publications
Ornithine alpha-ketoglutarate: could it be a new therapeutic option for sarcopenia?S Walrand
INRA, UMR1019, Unite de Nutrition Humaine, Clermont Ferrand, F 63000, France
J Nutr Health Aging 14:570-7. 2010..Therefore, OKG may be of a potential interest to modulate muscle protein metabolism and to maintain muscle mass during aging...- Insulin differentially regulates monocyte and polymorphonuclear neutrophil functions in healthy young and elderly humansStephane Walrand
Unité du Métabolisme Protéino Energétique, Laboratoire de Nutrition Humaine, BP 321, 58 rue Montalembert, 63009 Clermont Ferrand cedex 1, France
J Clin Endocrinol Metab 91:2738-48. 2006..Insulin can regulate immune cell function. Aging is associated with various degrees of insulin resistance together with reduced immune cell activity... - Insulin regulates protein synthesis rate in leukocytes from young and elderly healthy humansStephane Walrand
Unité du Métabolisme Protéino Energétique, UMR Université d Auvergne INRA, Centre de Recherche en Nutrition Humaine, CHU de Clermont Ferrand, Clermont Ferrand, France
Clin Nutr 24:1089-98. 2005..55+/-0.28%/d) period or after insulin infusion (PBMCs: 6.86+/-0.69%/d, PMNs: 2.76+/-0.47%/d). We conclude that insulin is able to stimulate protein synthesis in leukocyte populations independently of the age of the subjects... - Optimizing protein intake in agingStephane Walrand
UMR Université d Auvergne INRA, Centre de Recherche en Nutrition Humaine, CHU, Clermont Ferrand, France
Curr Opin Clin Nutr Metab Care 8:89-94. 2005.... - In vivo evidences that insulin regulates human polymorphonuclear neutrophil functionsS Walrand
Unité du Métabolisme Protéino Energétique, UMR Université d Auvergne INRA CHU de Clermont Ferrand Cedex 1, France
J Leukoc Biol 76:1104-10. 2004..05). Therefore, insulin treatment may modulate PMN functions not only by attainment of a better metabolic control, as suggested by in vivo studies in diabetic patients, but also through a direct effect of insulin... - Protein synthesis rates of human PBMC and PMN can be determined simultaneously in vivo by using small blood samplesStephane Walrand
Unité du Métabolisme Protéino Energétique, UMR Université d Auvergne Insitut National de la Recherche Agronomique, Centre de Recherche en Nutrition Humain, centre hospitalier universitaire de Clermont Ferrand, France
Am J Physiol Cell Physiol 286:C1474-8. 2004..In conclusion, it is possible to assess immune cell metabolism in vivo in humans by using small blood samples to directly indicate their metabolic activity in various clinical situations and in response to regulating factors... - Aging: a barrier to renutrition? Nutritional and immunologic evidence in ratsS Walrand
Laboratoire de Biochimie, Biologie Moléculaire et Nutrition, Faculte de Pharmacie, Centre de Recherche en Nutrition Humaine, Clermont Ferrand, France
Am J Clin Nutr 72:816-24. 2000..Previous reports suggest that correcting the malnourished state is more difficult in elderly people than in younger ones and that protein requirements may be higher in elderly than in younger adults... - Specific and nonspecific immune responses to fasting and refeeding differ in healthy young adult and elderly personsS Walrand
Laboratoire de Biochimie, Biologie Moléculaire et Nutrition, Faculte de Pharmacie, Centre de Recherche en Nutrition Humaine, Clermont Ferrand, France
Am J Clin Nutr 74:670-8. 2001..Undernutrition is a main cause of immunodeficiency. Many confounding factors limit the interpretation of immune function in hospitalized elderly patients... - Involvement of glutamine, arginine, and polyamines in the action of ornithine alpha-ketoglutarate on macrophage functions in stressed ratsC Moinard
Laboratoire de Biochimie, Biologie Moléculaire et Nutrition, Faculte de Pharmacie, Centre de Recherche en Nutrition Humaine, Clermont Ferrand, France
J Leukoc Biol 67:834-40. 2000..Our results underline the complexity of the mechanism of action of OKG, which can differ according to the functions of even a single cell type... - A pancreatic extract-enriched diet improves the nutritional status of aged ratsC Chambon-Savanovitch
Laboratory of Biochemistry, Molecular Biology and Nutrition, Pharmacy School, EA 2416, Human Nutrition Research Center, Clermont Ferrand, France
J Nutr 131:813-9. 2001..7 +/- 4.7 vs. CH2, 8.7 +/- 2.3, P: < 0.05) were improved in rats fed PE2. A pancreatic extract could improve the efficiency of realimentation in malnourished aged rats... - Impact of energy and casein or whey protein intake on bone status in a rat model of age-related bone lossJ Mardon
Unité de Nutrition Humaine UMR1019, INRA Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
Br J Nutr 99:764-72. 2008..Moreover, it seems that impaired bone status could not be significantly prevented by modulating the amount and quality of dietary proteins... - Centrifugation-based isolation of myosin for measurement of its synthesis rate in small muscle samplesA Zangarelli
, , Centre de Recherche en Nutrition Humaine, CHU de Clermont-Ferrand, 63009 Clermont-Ferrand, France
Anal Biochem 327:55-60. 2004..029%/h, respectively (p not significant). In conclusion, the centrifugation method is a useful and reproducible procedure that results in sufficient amounts of pure myosin for reliable determinations of its own synthesis rate in vivo...