Sylvain Perruche

Summary

Affiliation: Institut de Veille Sanitaire
Country: France

Publications

  1. ncbi Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity
    Eric Toussirot
    Department of Rheumatology, University Hospital Jean Minjoz, Boulevard Fleming, Besancon Cedex, France
    Arthritis Res Ther 11:R101. 2009
  2. ncbi Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Convent Drive, Bethesda, MD 20892, USA
    Arthritis Res Ther 11:R104. 2009
  3. ncbi Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:953-61. 2009
  4. ncbi CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research NIDCR, US National Institutes of Health NIH, 30 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Med 14:528-35. 2008

Collaborators

  • Wanjun Chen
  • Philippe Saas
  • Eric Toussirot
  • Pierre Tiberghien
  • Daniel Wendling
  • Marina Deschamps
  • Fabienne Pouthier
  • Jacqueline Chabod
  • Lucille Perrot

Detail Information

Publications4

  1. ncbi Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity
    Eric Toussirot
    Department of Rheumatology, University Hospital Jean Minjoz, Boulevard Fleming, Besancon Cedex, France
    Arthritis Res Ther 11:R101. 2009
    ..Here, we evaluated circulating levels of sCTLA-4 as a marker of immune dysregulation in SpA. Intracellular CTLA-4 and levels of CTLA-4 transcript expression in peripheral blood lymphocytes (PBL) were also studied...
  2. ncbi Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Convent Drive, Bethesda, MD 20892, USA
    Arthritis Res Ther 11:R104. 2009
    ..Therefore we evaluated the potential of apoptotic cell injection to influence the course of inflammation in SCW-induced arthritis in rats...
  3. ncbi Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:953-61. 2009
    ..The study may also provide a novel molecular mechanism explaining the early death in TGF-beta1(-/-) mice...
  4. ncbi CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research NIDCR, US National Institutes of Health NIH, 30 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Med 14:528-35. 2008
    ..Thus, CD3-specific antibody-induced immune tolerance is associated with TGF-beta production in phagocytes involved in clearing apoptotic T cells, which suggests that apoptosis is linked to active suppression in immune tolerance...