Georges Herbein

Summary

Country: France

Publications

  1. ncbi The macrophage in HIV-1 infection: from activation to deactivation?
    Georges Herbein
    Department of Virology, UPRES EA 4266 Pathogens and Inflammation, IFR 133 Inserm, Franche Comte University, CHU Besancon, Besancon, France
    Retrovirology 7:33. 2010
  2. ncbi Epigenetic regulation of HIV-1 transcription
    Manoj Kumar Tripathy
    Department of Virology, University of Franche Comte, EA4266, IFR133 INSERM, CHU Besancon, Besancon, France
    Epigenomics 3:487-502. 2011
  3. ncbi Increased HCMV seroprevalence in patients with hepatocellular carcinoma
    Quentin Lepiller
    Department of Virology, University of Franche Comte, EA 4266, IFR 133 Inserm, CHU Besancon, F 25030 Besancon, France
    Virol J 8:485. 2011
  4. ncbi Macrophage signaling in HIV-1 infection
    Georges Herbein
    Department of Virology, UPRES 4266 Pathogens and Inflammation, IFR 133 Inserm, University of Franche Comte, CHU Besancon, F 25030 Besancon, France
    Retrovirology 7:34. 2010
  5. ncbi Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages
    Audrey Varin
    Department of Virology, EA3186, IFR133, Franche Comte University, F 25030 Besancon, France
    J Biol Chem 280:42557-67. 2005
  6. ncbi Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages
    Georges Herbein
    Department of Virology, University of Franche Comte, Besancon, France
    Curr HIV Res 6:117-29. 2008
  7. ncbi Increased nuclear factor-kappaB activation in peripheral blood monocytes of patients with rheumatoid arthritis is mediated primarily by tumor necrosis factor-alpha
    Isabelle Dichamp
    Department of Virology, CHU Besancon, Franche Comte University, Besancon, France
    J Rheumatol 34:1976-83. 2007
  8. ncbi Bcl-3-regulated transcription from major immediate-early promoter of human cytomegalovirus in monocyte-derived macrophages
    Kashif Aziz Khan
    Department of Virology, Institut Fédératif de Recherche 133, Equipe d Accueil 3186, Franche Comte University, Centre Hospitalier Universitaire de Besancon, Besancon, France
    J Immunol 182:7784-94. 2009
  9. ncbi HIV and inflammation
    Anne Zelie Decrion
    Department of Virology, EA3186, IFR133, Franche-Comte University, Besancon, France
    Curr HIV Res 3:243-59. 2005
  10. ncbi Is HIV infection a TNF receptor signalling-driven disease?
    Georges Herbein
    Department of Virology, EA3186, IFR133, Franche Comte University, Hopital Saint Jacques, Besancon Cedex, France
    Trends Immunol 29:61-7. 2008

Collaborators

Detail Information

Publications16

  1. ncbi The macrophage in HIV-1 infection: from activation to deactivation?
    Georges Herbein
    Department of Virology, UPRES EA 4266 Pathogens and Inflammation, IFR 133 Inserm, Franche Comte University, CHU Besancon, Besancon, France
    Retrovirology 7:33. 2010
    ..Finally IL-10 deactivation of macrophages will lead to immune failure observed at the very late stages of the HIV-1 disease...
  2. ncbi Epigenetic regulation of HIV-1 transcription
    Manoj Kumar Tripathy
    Department of Virology, University of Franche Comte, EA4266, IFR133 INSERM, CHU Besancon, Besancon, France
    Epigenomics 3:487-502. 2011
    ..Understanding the molecular mechanisms underlying HIV-1 transcriptional silencing and activation is thus a major challenge in the fight against AIDS and will certainly lead to new therapeutic tools...
  3. ncbi Increased HCMV seroprevalence in patients with hepatocellular carcinoma
    Quentin Lepiller
    Department of Virology, University of Franche Comte, EA 4266, IFR 133 Inserm, CHU Besancon, F 25030 Besancon, France
    Virol J 8:485. 2011
    ..The goal of the present study was to determine a potential correlation between HCMV infection and the appearance of HCC...
  4. ncbi Macrophage signaling in HIV-1 infection
    Georges Herbein
    Department of Virology, UPRES 4266 Pathogens and Inflammation, IFR 133 Inserm, University of Franche Comte, CHU Besancon, F 25030 Besancon, France
    Retrovirology 7:34. 2010
    ..The role of HIV-1 proteins in the modulation of macrophage signaling will be discussed in regard to the formation of viral reservoirs and macrophage-mediated T cell apoptosis during HIV-1 infection...
  5. ncbi Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages
    Audrey Varin
    Department of Virology, EA3186, IFR133, Franche Comte University, F 25030 Besancon, France
    J Biol Chem 280:42557-67. 2005
    ..Therefore, our results suggest that extracellular Vpr could fuel the progression of AIDS via stimulation of HIV-1 provirus present in such cellular reservoirs as mononuclear phagocytes in HIV-infected patients...
  6. ncbi Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages
    Georges Herbein
    Department of Virology, University of Franche Comte, Besancon, France
    Curr HIV Res 6:117-29. 2008
    ....
  7. ncbi Increased nuclear factor-kappaB activation in peripheral blood monocytes of patients with rheumatoid arthritis is mediated primarily by tumor necrosis factor-alpha
    Isabelle Dichamp
    Department of Virology, CHU Besancon, Franche Comte University, Besancon, France
    J Rheumatol 34:1976-83. 2007
    ..We assessed NF-kappaB activation in peripheral blood mononuclear cells (PBMC), peripheral blood lymphocytes (PBL), and monocytes from patients with RA, patients with ankylosing spondylitis (AS), and healthy subjects...
  8. ncbi Bcl-3-regulated transcription from major immediate-early promoter of human cytomegalovirus in monocyte-derived macrophages
    Kashif Aziz Khan
    Department of Virology, Institut Fédératif de Recherche 133, Equipe d Accueil 3186, Franche Comte University, Centre Hospitalier Universitaire de Besancon, Besancon, France
    J Immunol 182:7784-94. 2009
    ..Thus, activation of p52/Bcl-3 complexes in MDMs and p50/p65 heterodimers in fibroblasts in response to HCMV infection might explain the low-level growth of the virus in MDMs vs efficient growth in fibroblasts...
  9. ncbi HIV and inflammation
    Anne Zelie Decrion
    Department of Virology, EA3186, IFR133, Franche-Comte University, Besancon, France
    Curr HIV Res 3:243-59. 2005
    ..Understanding the role of inflammation in HIV infection could lead to new therapeutic strategies that could ultimately enhance immune restoration and limit the formation of viral reservoirs in HIV-infected patients...
  10. ncbi Is HIV infection a TNF receptor signalling-driven disease?
    Georges Herbein
    Department of Virology, EA3186, IFR133, Franche Comte University, Hopital Saint Jacques, Besancon Cedex, France
    Trends Immunol 29:61-7. 2008
    ..This article proposes a model that highlights the role of HIV proteins in the modulation of TNF receptor signalling and could explain both immune suppression and the formation of viral reservoirs during HIV infection...
  11. ncbi A subset of functional effector-memory CD8+ T lymphocytes in human immunodeficiency virus-infected patients
    Anne Zelie Decrion
    Department of Virology, Franche Comte School of Medicine, Besancon, France
    Immunology 121:405-15. 2007
    ..These findings indicate that a subset of functional effector-memory CD8(+) T cells specific for HIV, CMV and EBV antigens may contribute to an efficient immune response in HIV-infected subjects...
  12. ncbi In vitro and in vivo effects of zinc on cytokine signalling in human T cells
    Audrey Varin
    Department of Virology, EA 3186 IFR 133, Franche Comte University, Hopital Saint Jacques, Besancon Cedex, France
    Exp Gerontol 43:472-82. 2008
    ..Our results suggest that zinc can have a potent immunomodulatory effect via the modulation of cytokine signalling and AICD, however this effect depends on the function and the activation status of the T cells...
  13. ncbi Mixed cytomegalovirus glycoprotein B genotypes in immunocompromised patients
    Alain Coaquette
    Department of Virology, Franche-Comte University School of Medicine, , France
    Clin Infect Dis 39:155-61. 2004
    ..The presence of multiple gB genotypes, rather than the presence of a single gB genotype, could be a critical factor associated with severe clinical manifestations in immunocompromised patients...
  14. ncbi NF-kappaB, AP-1, Zinc-deficiency and aging
    Georges Herbein
    Department of Virology, IFR 133, EA 3186, Franche Comte University, F 25030, Besancon, France
    Biogerontology 7:409-19. 2006
    ..In this review we summarize our present knowledge on NF-kappaB and AP-1 activation and underline the role of Zn in this process, especially in the context of Zn deficiency observed in aged persons leading to immunosenescence...
  15. ncbi Cytomegalovirus and tumors: two players for one goal-immune escape
    Quentin Lepiller
    Department of Virology, University of Franche Comte, UPRES EA 4266, IFR 133, CHU Besancon, F 25030 Besanon, France
    Open Virol J 5:60-9. 2011
    ..In return CMV, by acting directly on the cancer cell and/or on the tumor microenvironment, provides the tumor cell the ways to promote its immune escape and development of immune tolerance...
  16. ncbi Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis
    Audrey Varin
    Department of Virology and Institut d Etude et de Transfert de Gènes, Franche Comte University, F 25030 Besancon, France
    J Biol Chem 278:2219-27. 2003
    ..Therefore, our results suggest that exogenous Nef could fuel the progression of the disease via stimulation of HIV-1 provirus present in such cellular reservoirs as mononuclear phagocytes in HIV-infected patients...