Research Topics
Species | Jean Michel HalimiSummaryCountry: France Publications
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Publications
Effects of current smoking and smoking discontinuation on renal function and proteinuria in the general populationJ M Halimi
Center de Recherche Clinique, Faculte de Medecine, and Service de Néphrologie Immunologie Clinique, Hopital Bretonneau, Tours, France
Kidney Int 58:1285-92. 2000..Smoking may adversely affect the progression of renal diseases. However, it is unknown whether smoking affects renal function in subjects without nephropathy...- Urinary albumin excretion and the risk of graft loss and death in proteinuric and non-proteinuric renal transplant recipientsJ M Halimi
Francois Rabelais University, Department of Nephrology and Clinical Immunology, CHU Tours, Tours, France
Am J Transplant 7:618-25. 2007..Whether microalbuminuria (especially in non-proteinuric patients) and macroalbuminuria constitute risk factors for graft loss and death is presently unknown in renal transplantation... - Enalapril/amlodipine combination in cyclosporine-treated renal transplant recipients: a prospective randomized trialJean Michel Halimi
Department of Nephrology and Clinical Immunology, Francois Rabelais University, CHRU Bretonneau, Tours, France
Clin Transplant 21:277-84. 2007..Most hypertensive renal transplant recipients require two or more antihypertensive medications to achieve blood pressure control. However, which medications must be combined is still a matter of debate... - Microalbuminuria and urinary albumin excretion: French clinical practice guidelinesJ M Halimi
Service de néphrologie immunologie clinique, CHU de Tours, 37044 Tours Cedex, France
Diabetes Metab 33:303-9. 2007.... - [Vascular and renal effects of anti-angiogenic therapy]Jean Michel Halimi
Universite Francois Rabelais, CHU Tours, Tours, France
Nephrol Ther 4:602-15. 2008..has-sante.fr/); (5) optimal care is best achieved within a network of professionals including general practitioners, oncologists, cardiologists and nephrologists... - [Microalbuminuria and urinary albumin excretion: clinical practice guidelines]Jean Michel Halimi
Service de néphrologie immunologie clinique, CHU de Tours, 37044 Tours Cedex, France
Nephrol Ther 3:384-91. 2007.... - Respective predictive role of urinary albumin excretion and nonalbumin proteinuria on graft loss and death in renal transplant recipientsJean Michel Halimi
Department of Nephrology and Clinical Immunology, Francois Rabelais University, CHU Tours, Tours, France
Am J Transplant 7:2775-81. 2007..12 [1.65-10.29], p = 0.0024) were risk factors for death. Proteinuria is made of various proportions of UAE and NAP in renal transplantation; these two parameters provide different information on graft/patient survival... - Urinary albumin excretion is a risk factor for diabetes mellitus in men, independently of initial metabolic profile and development of insulin resistance. The DESIR StudyJean Michel Halimi
Francois Rabelais University, CHRU Tours, Service de néphrologie immunologie clinique, Tours, France
J Hypertens 26:2198-206. 2008..Whether UAE predicts the development of diabetes mellitus, independently of the presence or the development of the metabolic syndrome, is unclear, in particular, in women... - [Microalbuminuria and urinary albumin excretion: French guidelines]J M Halimi
Service de néphrologie immunologie clinique, CHU de Tours, France
Ann Biol Clin (Paris) 66:277-84. 2008.... - Early proteinuria is a strong indicator of donor renal lesions, ischemia-reperfusion injury and immunological aggressionJ Halimi
Francois Rabelais University, Department of Nephrology and Clinical Immunology, Hopital Bretonneau, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
Transplant Proc 38:2319-20. 2006..Early proteinuria is associated with reduced long-term graft survival. However, the determinants and mechanisms of proteinuria early after transplantation have not been identified... - [Renal artery stenosis : atheromatous disease and fibromuscular dysplasia]Jean Michel Halimi
Service de néphrologie immunologie clinique, Hopital Bretonneau, Universite Francois Rabelais, CHU Tours, F 37044 Tours, France
Presse Med 38:621-6. 2009..Patients with atheromatous renal artery disease are at very high renal and cardiovascular risk : aggressive management of cardiovascular risk factors is crucial... - Early low-grade proteinuria: causes, short-term evolution and long-term consequences in renal transplantationJean Michel Halimi
Department of Nephrology and Clinical Immunology, Francois Rabelais University, Tours, France
Am J Transplant 5:2281-8. 2005..Early low-grade proteinuria due to pre-transplant renal lesions, ischemia-reperfusion and immunologic injuries is a potent predictor of graft loss. Short-term reduction in proteinuria is associated with improved long-term graft survival... - Optimal nephroprotection: use, misuse and misconceptions about blockade of the renin-angiotensin system. Lessons from the ONTARGET and other recent trialsJ M Halimi
Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU de Tours, Francois Rabelais University, Tours Cedex, France
Diabetes Metab 35:425-30. 2009..In recent trials, lowering blood pressure towards values recommended by the current guidelines (130/80mmHg) has reduced microvascular (lower levels of urinary albumin excretion) and macrovascular events in diabetic patients... - [The kidney and diabetes]J-M Halimi
, , 2, boulevard Tonnell, 37044 Tours, France
Rev Med Interne 25:S339-41. 2004 - The risk of hypertension in men: direct and indirect effects of chronic smokingJean Michel Halimi
Centre de Recherche Clinique, Faculte de Medecine, Tours, France
J Hypertens 20:187-93. 2002..To assess the risk of hypertension associated with smoking status... - Autosomal dominant polycystic kidney disease: risk factor for nonmelanoma skin cancer following kidney transplantationAnne Bretagnol
Department of Nephrology and Clinical Immunology, CHRU Tours, Universite Francois Rabelais, Tours, France
Transpl Int 23:878-86. 2010..96; P = 0.89). Our findings suggest that ADPKD is an independent risk factor for developing NMSC after kidney transplantation... - Immunosuppressive medications, clinical and metabolic parameters in new-onset diabetes mellitus after kidney transplantationMélanie Roland
Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU Tours, Tours, France
Transpl Int 21:523-30. 2008..However, main independent risk factors were age, BMI, initial glucose and triglycerides... - Doubling of serum creatinine in clinical trials, cost-effectiveness studies, and individual patients: adequate use in renal transplantationPhilippe Gatault
Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU Tours, France
Transplantation 92:1012-7. 2011..The predictive value of doubling of serum creatinine (DSC) has never been assessed in renal transplantation. We evaluated it in terms of its use for clinical trials, cost-effectiveness studies, and individual patients... - Association of donor TNFRSF6 (FAS) gene polymorphism with acute rejection in renal transplant patients: a case-control studySandrine Cappellesso
UPRES EA 3249 Cellules Hématopoïétiques, Hémostase et Greffe, Universite de Tours, Faculte de Medecine, and Laboratoire d Immunologie and Service de Néphrologie et Immunologie Clinique, CHRU de Tours, Tours Cedex, France
Nephrol Dial Transplant 19:439-43. 2004.... - Association between a polymorphism in the human programmed death-1 (PD-1) gene and cytomegalovirus infection after kidney transplantationThomas W Hoffmann
Universite Francois Rabelais de Tours, EA 4245 Cellules Dendritiques Immunomodulation et Greffes, UFR de Medecine, Tours, France
J Med Genet 47:54-8. 2010..3, has recently been reported to be clinically relevant in several immune disorders. However, its association with CMV infection has never been reported... - Living with a functioning kidney transplant at 74 yr or older: a national epidemiological studyMatthias Buchler
Department of Nephrology and Clinical Immunology, CHU Bretonneau, Tours, France
Clin Transplant 18:681-5. 2004..Renal function in this group of patients was good and quality of life seemed excellent. Cardiovascular disease and malignancies were the main co-morbid conditions... - Kidney transplant with multiple renal artery grafts from deceased donors: are long-term graft and patient survival compromised?Inass Laouad
University Francois Rabelais, Tours, France
Prog Transplant 22:102-9. 2012..Kidneys with multiple arteries are often transplanted. However, the long-term outcome of such kidneys recovered exclusively from deceased donors is not clear... - Effect of the heme oxygenase inducer hemin on blood haemostasis measured by high-frequency ultrasoundGael Y Rochefort
LAB PART EA3852 IFR135, Francois Rabelais University, Faculty of Medicine, Tours, France
Clin Exp Pharmacol Physiol 34:1272-5. 2007..3. Further investigations are required to explore the effects of hemin in thrombosis models, because it could be a promising 'old drug' for the treatment of venous thrombosis in patients... - Center effect on ankle-brachial index measurement when using the reference method (Doppler and manometer): results from a large cohort studyEmilie Vierron
INSERM, CIC 202, Tours, France
Am J Hypertens 22:718-22. 2009..We aimed to assess, in a French multicenter cohort, the center effect associated with arterial pressure (AP) and ABI measurements using the reference method and using a semiautomatic device... - Renal resistive index as a new independent risk factor for new-onset diabetes mellitus after kidney transplantationPrisca Mutinelli-Szymanski
Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU Tours, Tours, France
Transpl Int 25:464-70. 2012..27), P<0.0001] and 12months [HR per 0.1:1.74 (1.33-2.27), P<0.0001] after transplantation. High RI early after renal transplantation is a long-term risk factor for NODAT, and could be used to refine the individual risk of NODAT... - Variability in creatinine excretion in adult diabetic, overweight men and women: consequences on creatinine-based classification of renal diseaseDavid Jacobi
CHRU de Tours, Service de Medecine interne et nutrition, France
Diabetes Res Clin Pract 80:102-7. 2008..It is crucial to estimate renal function in diabetic patients. However, formulas are inadequate in this population whereas creatinine clearance (C(cr)) on a 24-h urine collection may be valuable only if we can improve its reproducibility... - Intravascular ultrasound allows a hyperplasia diagnosis in vivo in rat as accurate as histomorphometryGael Y Rochefort
Laboratoire de Physiologie de la Paroi Artérielle LABPART EA 3852 IFR135, Universite Francois Rabelais, Tours Cedex 1, France
Ultrasonics 49:145-8. 2009..This result is of major importance since it will allow this device to be used for restenosis drug testing in rat model of carotid angioplasty... - Tolerance of low-frequency ultrasound sonophoresis: a double-blind randomized study on humansAnnabel Maruani
University François Rabelais Tours, Inserm U930 Tours, Service de Dermatologie, CHRU Tours, FranceUniversity François Rabelais Tours, INSERM CIC 202, CHRU Tours, FranceTransderma Systems, Tours, France
Skin Res Technol 18:151-6. 2012..Conclusion: Such data demonstrating good tolerance of sonophoresis can be useful before the initiation of a clinical trial of the therapeutic use of low-frequency sonophoresis in humans... - Heme oxygenase-1 inducer hemin attenuates the progression of remnant kidney modelNicolas Desbuards
LABPART, EA 3852, IFR135, Universite Francois Rabelais, FR 37032 Tours, France
Nephron Exp Nephrol 113:e35-44. 2009..The purpose of this study was to evaluate the impact of a treatment with the HO-1 inducer hemin on the progression of chronic kidney disease in nephrectomized rats versus the AT1 receptor antagonist losartan... - Association between a polymorphism in the IL-12p40 gene and cytomegalovirus reactivation after kidney transplantationThomas W Hoffmann
JE2448 Cellules Dendritiques et Greffes, UFR de Medecine, Universite Francois Rabelais, Tours, France
Transplantation 85:1406-11. 2008..However, the impact of this single nucleotide polymorphism on events after organ transplantation has never been reported... - Urinary elimination of coproporphyrins is dependent on ABCC2 polymorphisms and represents a potential biomarker of MRP2 activity in humansIsabelle Benz-de Bretagne
CHRU de Tours, Laboratoire de Biochimie et Biologie Moleculaire, Tours, France
J Biomed Biotechnol 2011:498757. 2011..This study provides a proof of concept that UCP I/(I + III) ratio can be used as a biomarker of MRP2 function in clinical studies as it provides quantitative information about the in vivo activity of MRP2 in a given patient... - Recipient age and mycophenolate mofetil as the main determinants of outcome after steroid withdrawal: analysis of long-term follow-up in renal transplantationInass Laouad
Department of Nephrology and Clinical Immunology, Tours University Hospital, Tours, France
Transplantation 80:872-4. 2005..1%). Our findings indicate that late steroid withdrawal results in excellent long-term outcome in most low-risk patients, but it should be attempted with caution in younger patients and when MMF is not used... - Waist circumference and the metabolic syndrome predict the development of elevated albuminuria in non-diabetic subjects: the DESIR StudyFabrice Bonnet
Department of Diabetology Endocrinology, CRNH, Hospital Edouard Herriot, INSERM U 449, Lyon, France
J Hypertens 24:1157-63. 2006..We investigated in both sexes whether an elevated waist circumference (WC) or the presence of the metabolic syndrome (MetS) predict the development of elevated albuminuria at 6 years... - Renal arterial resistance indexBruno Giraudeau
N Engl J Med 349:1573-4; author reply 1573-4. 2003 - Heme oxygenase-1 inducer hemin prevents vascular thrombosisNicolas Desbuards
LABPART EA 3852 IFR135 Université François Rabelais, Tours Cedex 1, France
Thromb Haemost 98:614-20. 2007..In conclusion, hemin by inducing HO-1 expression may be a preventive agent against clinical disorders associated to an increased risk of thrombosis events and may limit haemorrhagic risks...