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Genomes and GenesSpecies | Yves GruelSummaryCountry: France Publications
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Publications
[Heparin-induced thrombocytopenia. Pathogenesis, diagnosis and treatment]Y Gruel
Service d Hématologie Hémostase, Hopital Trousseau, Centre Hospitalier Universitaire de Tours, 37044 Tours, France
Rev Med Interne 25:35-45. 2004....- [Heparin-induced thrombocytopenia]Yves Gruel
Service d Hématologie Hémostase, Hopital Trousseau, Centre Hospitalier Universitaire de Tours, 37044 Tours, France
Rev Prat 56:710-8. 2006.... - [Specificities of neonatal hemostasis and implications in pathologic situations]Y Gruel
Service d Hématologie Hémostase, Hopital Trousseau, 37044 Tours cedex 9, France
Arch Pediatr 17:S93-100. 2010..This review will discuss about the foetal development of haemostasis until birth, and some implications regarding the pathophysiology, the diagnosis and the treatment of bleeding disorders in the human neonate... - The homozygous FcgammaRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexesYves Gruel
Department of Hematology Hemostasis, Centre Hospitalier Universitaire Tours, Institut National de la Santé et de la Recherche Médicale U618, Tours, France
Blood 104:2791-3. 2004..01). Since anti-H/PF4 Abs are mainly IgG1 and IgG3, clearance of sensitized platelets may be increased in patients homozygous for the FcgammaRIIIa-158V allotype, thus contributing to the development of thrombocytopenia... - Usefulness of pretest clinical score (4Ts) combined with immunoassay for the diagnosis of heparin-induced thrombocytopeniaYves Gruel
Department of Hematology Hemostasis, France
Curr Opin Pulm Med 14:397-402. 2008..This review addresses the clinical and biological strategy to be applied for the diagnosis of heparin-induced thrombocytopenia... - Biological and clinical features of low-molecular-weight heparin-induced thrombocytopeniaYves Gruel
Tours Laboratoire d hématologie hémostase, France
Br J Haematol 121:786-92. 2003..LMW-HIT is potentially severe and may be observed after longer heparin treatment compared with UF-HIT. It is highly recommended, therefore, that platelet counts be monitored carefully whenever LMWH is administered... - [Accidents caused by anticoagulants]Yves Gruel
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Rev Prat 52:1929-35. 2002 - Changes in platelet count after cardiac surgery can effectively predict the development of pathogenic heparin-dependent antibodiesClaire Pouplard
Haematology-Haemostasis, , 37044 Tours, France
Br J Haematol 128:837-41. 2005..Careful follow-up of PC after CPB makes it possible to predict with high specificity (99%) for those patients who develop pathogenic HIT antibodies... - Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell linesSebastien Roger
INSERM, E0211, Tours, F 37000, France
Int J Biochem Cell Biol 39:774-86. 2007..These channels could serve both as novel markers of the metastatic phenotype and as potential new therapeutic targets... - Increased prevalence of factor V Leiden in patients with retinal vein occlusion and under 60 years of ageSophie Arsene
Laboratoire d Hemostase, Hopital Trousseau, CHU de Tours, 37044 Tours Cedex 1, France
Thromb Haemost 94:101-6. 2005..027). In conclusion, this study suggests a role of FV Leiden in the occurrence of RVO in patients younger than 60 years who exhibit fewer acquired vascular risk factors than in older patients... - High frequency ultrasound device to investigate the acoustic properties of whole blood during coagulationRachel Libgot-Callé
Université François Rabelais Tours, Laboratoire Ultrasons Signaux Instrumentation, CNRS FRE 2448, Tours, France
Ultrasound Med Biol 34:252-64. 2008..Intra- and inter-individual dispersion of these parameters were also measured and discussed... - Transient RNA silencing of tissue factor pathway inhibitor-2 modulates lung cancer cell invasionSophie Iochmann
INSERM U618, Protéases et Vectorisation Pulmonaires, Faculte de Medecine, Universite Francois Rabelais, IFR 135, 10 boulevard Tonnelle, 37032, Tours Cedex, France
Clin Exp Metastasis 26:457-67. 2009..In conclusion, this study confirms that TFPI-2 downregulation can contribute to tumour invasion of lung cancer cells... - Demonstration of inducible TFPI-2 mRNA synthesis in BeWo and JEG-3 trophoblast cells using a competitive RT-PCRSophie Iochmann
Laboratoire d Hématologie Hémostase, EA 3249 Cellules Hématopoïétiques, Hémostase et Greffe, Faculte de Medecine, 2 bis Boulevard Tonnelle, 37032 Cedex Tours, France
Thromb Res 105:217-23. 2002..JEG-3 and BeWo are thus two cell lines that could be used to study TFPI-2 gene regulation and to investigate the role of TF, TFPI-1, and TFPI-2 during trophoblast differentiation... - Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopeniaClaire Pouplard
Department of Hematology Hemostasis, University Hospital of Tours, France
Thromb Res 129:465-9. 2012.... - Bullous hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin: three casesAdeline Perrinaud
Department of Dermatology, , University Hospital of Tours, Tours, France
J Am Acad Dermatol 54:S5-7. 2006..A causative link is suggested by a temporal relationship between heparin introduction and onset of disease as well as exclusion of other causes, but the mechanism remains unknown... - Ischaemic strokes and homozygosity for the alpha2 807T allele of the platelet collagen receptor in young monozygotic twinsAbdullah Maakaroun
Department of Haematology Haemostasis, University Hospital, Tours, France
Blood Coagul Fibrinolysis 14:83-5. 2003..Further prospective studies are needed to evaluate whether screening for this polymorphism should be considered in young patients with unexplained stroke, particularly when a positive family history was found... - Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTENSandra Regina
Department of Hematology Hemostasis, Trousseau Hospital and François Rabelais University, Tours, France
Clin Chem 55:1834-42. 2009..Heparanase (HPSE) gene expression was also measured because this endo-beta-D-glucuronidase was recently shown to enhance TF gene expression... - Induction of monocyte tissue factor expression by antibodies to heparin-platelet factor 4 complexes developed in heparin-induced thrombocytopeniaC Pouplard
Department of Hematology, , Tours, and Hyphen Biomed, Andresy, France
Blood 97:3300-2. 2001.... - Heparin-induced thrombocytopenia: a frequent complication after cardiac surgeryC Pouplard
Departments of Hematology Hemostasis and Cardiac Surgery, Hopital Trousseau, and INSERM U618, CHU de Tours, 37044 Tours Cedex, France
Arch Mal Coeur Vaiss 100:563-8. 2007..The risk of HIT will probably soon decrease due to the wider use of fondaparinux, which does not interact in vitro with PF4, but it could remain significant in patients undergoing cardiac surgery with CPB... - Plasma therapy in von Willebrand factor protease deficiencyGeorges Deschenes
Unité de Néphrologie Pédiatrique, hôpital Gatien de Clocheville, 49 Boulevard Beranger, 37044 Tours, France
Pediatr Nephrol 17:867-70. 2002..Long-term treatment with fresh-frozen plasma exchanges prevented recurrence of HUS, cerebrovascular attacks, and early loss of the graft... - Prospective evaluation of the '4Ts' score and particle gel immunoassay specific to heparin/PF4 for the diagnosis of heparin-induced thrombocytopeniaC Pouplard
Department of Hematology, CHRU de Tours, Tours, France
J Thromb Haemost 5:1373-9. 2007..A clinical scoring system, the '4Ts' score, has been proposed to estimate its probability before laboratory testing, and a particle gel immunoassay (H/PF4 PaGIA) has also been developed for rapid detection of HIT antibodies... - Diagnosis and management of heparin-induced thrombocytopeniaEmmanuel de Maistre
Laboratoire d Hématologie Hémostase, CHU Dijon, BP 77 908, 21 079 Dijon Cedex, France
Can J Anaesth 53:S123-34. 2006..To review recent developments in the pathogenesis, clinical features, laboratory testing and treatment of heparin-induced thrombocytopenia (HIT)... - Demonstration of a tissue factor pathway inhibitor 2 messenger RNA synthesis by pure villous cytotrophoblast cells isolated from term human placentasFlorent Hube
Laboratoire d Hemostase, EA 3249 Hématopoïetiques, Hémostase et Greffe, Faculte de Medicine, 37032 Tours Cedex, France
Biol Reprod 68:1888-94. 2003.... - Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudinBernard Tardy
Institut National de la Santé et de la Recherche Médicale Inserm Centre d Investigation Clinique Epidémiologique 3 CIC E3, Service d Urgence et de Réanimation Médicales Hôpital Bellevue, Saint Etienne, France
Blood 108:1492-6. 2006..Overall, these results suggest that the recommended dose of lepirudin in patients with HIT is too high; the use of reduced doses may be safer with regard to bleeding risk and does not compromise antithrombotic efficacy... - Platelet activation induced by human antibodies to interleukin-8Veronique Regnault
, , Nancy, France
Blood 101:1419-21. 2003..This is another example of potentially pathogenic platelet activation by antibodies... - Skin necrosis is a clinical manifestation of low-molecular weight heparin-induced thrombocytopeniaPierre Fontana
Division of Angiology and Hemostasis, Geneva University Hospital, 24, rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
Thromb Haemost 91:196-7. 2004 - Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled studyGuy Meyer
Department of Respiratory and Critical Care Medicine, Hopital Europeen Georges Pompidou, Paris V University, France
Arch Intern Med 162:1729-35. 2002..The use of low-molecular-weight heparin sodium for secondary prevention of venous thromboembolism in cancer patients may reduce the complication rate... - Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancerJerome Rollin
INSERM, U618, Tours F 37000, France
Lung Cancer 56:273-80. 2007..6-fold in -735CC patients (p=0.045; 95% CI=1.0-6.7). The results of this study suggest that the -735C/T MMP-2 polymorphism might be an independent prognostic marker in NSCLC, but this should be confirmed in a larger cohort of patients... - Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutationSandra Regina
Department of Haematology Haemostasis, Hôpital Trousseau and Université François Rabelais, Cedex, France
J Thorac Oncol 3:689-97. 2008..Tissue factor (TF) is the physiological trigger of blood coagulation, but it could also have an important role in cancer by regulating VEGF expression and angiogenesis... - Fibrinogen Aalpha-Thr312Ala and factor XIII-A Val34Leu polymorphisms in idiopathic venous thromboembolismGregoire Le Gal
EA 3878, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
Thromb Res 121:333-8. 2007..However, clinical studies have yielded conflicting results on their possible association with venous thromboembolism (VTE)... - Effect of fondaparinux on platelet activation in the presence of heparin-dependent antibodies: a blinded comparative multicenter study with unfractionated heparinPierre Savi
Cardiovascular Thrombosis Research Department, Sanofi Synthelabo Recherche, Toulouse, France
Blood 105:139-44. 2005..Together, these results suggest that fondaparinux is nonreactive to HIT sera and raise the possibility that the drug may be used for prophylaxis and treatment of thrombosis in patients with a history of HIT...