Carole Giraud

Summary

Country: France

Publications

  1. ncbi Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes
    Carole Giraud
    Centre de Recherche Clinique Paris Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Site Hôpital Tarnier, 75006 Paris, France
    J Clin Pharmacol 50:226-30. 2010
  2. ncbi High levels of P-glycoprotein activity in human lymphocytes in the first 6 months of life
    C Giraud
    Universite Paris Descartes, Paris, France
    Clin Pharmacol Ther 85:289-95. 2009
  3. ncbi High levels and safety of oseltamivir carboxylate plasma concentrations after nasogastric administration in critically ill children in a pediatric intensive care unit
    Carole Giraud
    Groupe Hospitalier Broca Cochin Hôtel Dieu, Assistance Publique Hopitaux de Paris, Unite de recherche clinique, Paris, France
    Antimicrob Agents Chemother 55:433-5. 2011
  4. ncbi ABC transporters in human lymphocytes: expression, activity and role, modulating factors and consequences for antiretroviral therapies
    Carole Giraud
    Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Centre de Recherche Clinique Paris Descartes, Site Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
    Expert Opin Drug Metab Toxicol 6:571-89. 2010
  5. ncbi Expression and induction by dexamethasone of ABC transporters and nuclear receptors in a human T-lymphocyte cell line
    Sandra Manceau
    EA 3620, Universite Paris Descartes, Paris, France
    J Chemother 24:48-55. 2012
  6. ncbi Developmental pharmacokinetics of etoposide in 67 children: lack of dexamethasone effect
    Saik Urien
    CIC 0901 Inserm Necker Cochin and EA 3620, Paris, France
    Cancer Chemother Pharmacol 67:597-603. 2011
  7. ncbi Lopinavir/ritonavir population pharmacokinetics in neonates and infants
    Saik Urien
    EA 3620, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 71:956-60. 2011
  8. ncbi Length of the treatment and number of doses per day as major determinants of child adherence to acute treatment
    H Chappuy
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Acta Paediatr 99:433-7. 2010
  9. ncbi Transplacental transfer of oseltamivir and its metabolite using the human perfused placental cotyledon model
    Paul Berveiller
    Clinical Research Unit, Institut National de la Sante et de la Recherche Medicale, Cochin Teaching Hospital, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, France
    Am J Obstet Gynecol 206:92.e1-6. 2012
  10. ncbi Comparison of a morphine and midazolam combination with morphine alone for paediatric displaced fractures: a randomized study
    Chrystèle Wille-Ledon
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, France
    Acta Paediatr 100:e203-7. 2011

Collaborators

Detail Information

Publications12

  1. ncbi Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes
    Carole Giraud
    Centre de Recherche Clinique Paris Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Site Hôpital Tarnier, 75006 Paris, France
    J Clin Pharmacol 50:226-30. 2010
    ..Neither HIV infection nor antiretroviral therapies modulated the gene expression profiles of ABC transporters. In conclusion, drugs that are substrates of BCRP and MRP4, like zidovudine, may have an altered efficacy in newborns...
  2. ncbi High levels of P-glycoprotein activity in human lymphocytes in the first 6 months of life
    C Giraud
    Universite Paris Descartes, Paris, France
    Clin Pharmacol Ther 85:289-95. 2009
    ..MDR1 gene expression was not influenced by age, nor was it correlated with P-gp activity. The high levels of P-gp activity observed in the lymphocytes of children ~6 months of age may affect the efficacy of intracellular drugs...
  3. ncbi High levels and safety of oseltamivir carboxylate plasma concentrations after nasogastric administration in critically ill children in a pediatric intensive care unit
    Carole Giraud
    Groupe Hospitalier Broca Cochin Hôtel Dieu, Assistance Publique Hopitaux de Paris, Unite de recherche clinique, Paris, France
    Antimicrob Agents Chemother 55:433-5. 2011
    ..5 and 6.8 mg/kg of body weight. High OC concentrations were found, with a mean level of 678 ± 535 ?g/liter. The mean OP concentration was 27 ± 52 ?g/liter. No marked side effect was reported...
  4. ncbi ABC transporters in human lymphocytes: expression, activity and role, modulating factors and consequences for antiretroviral therapies
    Carole Giraud
    Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Centre de Recherche Clinique Paris Descartes, Site Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
    Expert Opin Drug Metab Toxicol 6:571-89. 2010
    ..This variability may affect the intracellular concentrations and efficacy of drugs acting within lymphocytes, such as antiretroviral drugs...
  5. ncbi Expression and induction by dexamethasone of ABC transporters and nuclear receptors in a human T-lymphocyte cell line
    Sandra Manceau
    EA 3620, Universite Paris Descartes, Paris, France
    J Chemother 24:48-55. 2012
    ..ABCB1 induction by DEX in CCRF-CEM cells suggests a potential risk of interaction in lymphocytes when associating DEX to ABCB1 substrates in antiretroviral multitherapies in vivo...
  6. ncbi Developmental pharmacokinetics of etoposide in 67 children: lack of dexamethasone effect
    Saik Urien
    CIC 0901 Inserm Necker Cochin and EA 3620, Paris, France
    Cancer Chemother Pharmacol 67:597-603. 2011
    ....
  7. ncbi Lopinavir/ritonavir population pharmacokinetics in neonates and infants
    Saik Urien
    EA 3620, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 71:956-60. 2011
    ..WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: • Lopinavir/ritonavir pharmacokinetics have been fully investigated in adults and children...
  8. ncbi Length of the treatment and number of doses per day as major determinants of child adherence to acute treatment
    H Chappuy
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Acta Paediatr 99:433-7. 2010
    ..To determine the rate of aftercare adherence to prescriptions from a paediatric emergency department and to identify predictors for nonadherence...
  9. ncbi Transplacental transfer of oseltamivir and its metabolite using the human perfused placental cotyledon model
    Paul Berveiller
    Clinical Research Unit, Institut National de la Sante et de la Recherche Medicale, Cochin Teaching Hospital, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, France
    Am J Obstet Gynecol 206:92.e1-6. 2012
    ....
  10. ncbi Comparison of a morphine and midazolam combination with morphine alone for paediatric displaced fractures: a randomized study
    Chrystèle Wille-Ledon
    Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, France
    Acta Paediatr 100:e203-7. 2011
    ..To compare the efficacy of sublingual midazolam with oral morphine versus that of oral morphine with placebo in a paediatric population attending an emergency department (ED) with acute long-bone fractures...
  11. ncbi Readability of the written study information in pediatric research in France
    Véronique Ménoni
    Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    PLoS ONE 6:e18484. 2011
    ..The aim was to evaluate the readability of research information leaflets (RIL) for minors asked to participate in biomedical research studies and to assess the factors influencing this readability...
  12. ncbi Lack of P-glycoprotein induction by rifampicin and phenobarbital in human lymphocytes
    S Manceau
    EA3620, Universite Paris Descartes, Paris, France
    Int J Pharm 395:98-103. 2010
    ..The very weak PXR and CAR mRNA expression levels in these cells could partly explain these results. Therefore, P-gp induction by rifampicin and phenobarbital may play a negligible role in drug interactions occurring within lymphocytes...