Lluis Fajas

Summary

Country: France

Publications

  1. ncbi The CDK4-pRB-E2F1 pathway : A new modulator of insulin secretion
    Lluis Fajas
    Institut de Recherche en Cancérologie de Montpellier, France
    Islets 2:51-3. 2010
  2. ncbi CDK4, pRB and E2F1: connected to insulin
    Lluis Fajas
    IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F 34298, France
    Cell Div 5:6. 2010
  3. ncbi E2F transcription factor-1 regulates oxidative metabolism
    Emilie Blanchet
    IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier F 34298, France
    Nat Cell Biol 13:1146-52. 2011
  4. ncbi Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis
    Emilie Blanchet
    UMR866 Dynamique Musculaire et Métabolisme, Universite Montpellier 1, Montpellier, France
    FASEB J 26:40-50. 2012
  5. ncbi Cyclin G2 regulates adipogenesis through PPAR gamma coactivation
    Victor Aguilar
    Institut de Recherche en Cancérologie de Montpellier, CRLC Val d Aurelle, Parc Euromedecine, F 34298, Montpellier Cedex 5, France
    Endocrinology 151:5247-54. 2010
  6. ncbi Adipogenesis: a cross-talk between cell proliferation and cell differentiation
    Lluis Fajas
    Department of Endocrinologie Moléculaire et Cellulaire des Cancers, INSERM U540, 60 rue Navacelles, FR 34090 Montpellier, France
    Ann Med 35:79-85. 2003
  7. ncbi Cell cycle regulators in the control of metabolism
    Emilie Blanchet
    INSERM U896 and IRCM, Institut de Recherche en Cancérologie de Montpellier and University Montpellier 1, Montpellier, France
    Cell Cycle 8:4029-31. 2009
  8. ncbi The CDK4-pRB-E2F1 pathway controls insulin secretion
    Jean Sebastien Annicotte
    INSERM, U834, Montpellier, F 34298, France
    Nat Cell Biol 11:1017-23. 2009
  9. ncbi Cycling through metabolism
    Victor Aguilar
    IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM, U896, Université de Montpellier1, CRLC Val d Aurelle Paul Lamarque, Montpellier, France
    EMBO Mol Med 2:338-48. 2010
  10. ncbi Downregulation of protein tyrosine phosphatase PTP-BL represses adipogenesis
    Murielle Glondu-Lassis
    IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F 34298, France
    Int J Biochem Cell Biol 41:2173-80. 2009

Collaborators

  • Francois Casas
  • Christine Feillet-Coudray
  • Joan Vendrell
  • Dominique Langin
  • Said Assou
  • Safia Costes
  • Vincent Cavailles
  • Jacob B Hansen
  • Jean Sebastien Annicotte
  • Emilie Blanchet
  • Carine Chavey
  • Victor Aguilar
  • Irena Iankova
  • Murielle Glondu-Lassis
  • Jacques Teyssier
  • Jonathan Levin
  • Gilles Fouret
  • Christelle Bertrand
  • Audrey Schlernitzauer
  • Chantal Wrutniak-Cabello
  • Gérard Cabello
  • Laurence Pessemesse
  • Beatrice Bonafos
  • Vanessa Fritz
  • Johan Auwerx
  • Florence Apparailly
  • Cyrielle Clapé
  • Sylviane Lagarrigue
  • Xavier Escote
  • Claude Sardet
  • Wiljan Hendriks
  • Mathilde Dromard
  • Gilles Freiss
  • Stephane Dalle
  • Carole Puech
  • Monsef Benkirane
  • Karsten Kristiansen
  • Rasmus K Petersen
  • David Sarruf
  • Irina Kratchmarova
  • Gwendal Lazennec
  • Nadège Servant
  • Eric Badia
  • Anne Licznar
  • Thierry Maudelonde
  • Pascal Pujol
  • Françoise Vignon
  • Aurélie Bardin

Detail Information

Publications13

  1. ncbi The CDK4-pRB-E2F1 pathway : A new modulator of insulin secretion
    Lluis Fajas
    Institut de Recherche en Cancérologie de Montpellier, France
    Islets 2:51-3. 2010
    ..Altogether our data unravel a new function for these factors in the control of insulin secretion and open up new avenues for the treatment of diabetes...
  2. ncbi CDK4, pRB and E2F1: connected to insulin
    Lluis Fajas
    IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F 34298, France
    Cell Div 5:6. 2010
    ..In our recent study we decipher a new function for these factors in the control of insulin secretion and open up new avenues for the treatment of metabolic diseases, in particular type 2 diabetes...
  3. ncbi E2F transcription factor-1 regulates oxidative metabolism
    Emilie Blanchet
    IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier F 34298, France
    Nat Cell Biol 13:1146-52. 2011
    ..Thus, E2F1 represents a metabolic switch from oxidative to glycolytic metabolism that responds to stressful conditions...
  4. ncbi Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis
    Emilie Blanchet
    UMR866 Dynamique Musculaire et Métabolisme, Universite Montpellier 1, Montpellier, France
    FASEB J 26:40-50. 2012
    ..Our findings establish that p43 is an important regulator of glucose homeostasis and pancreatic ?-cell function and provide evidence for the first time of a physiological role for a mitochondrial endocrine receptor...
  5. ncbi Cyclin G2 regulates adipogenesis through PPAR gamma coactivation
    Victor Aguilar
    Institut de Recherche en Cancérologie de Montpellier, CRLC Val d Aurelle, Parc Euromedecine, F 34298, Montpellier Cedex 5, France
    Endocrinology 151:5247-54. 2010
    ..The role of cyclin G2 in adipogenesis is further underscored by its increased expression in mice fed a high-fat diet. Taken together, our results demonstrate a novel role for cyclin G2 in the regulation of adipogenesis...
  6. ncbi Adipogenesis: a cross-talk between cell proliferation and cell differentiation
    Lluis Fajas
    Department of Endocrinologie Moléculaire et Cellulaire des Cancers, INSERM U540, 60 rue Navacelles, FR 34090 Montpellier, France
    Ann Med 35:79-85. 2003
    ..I will focus this review on the influence of the proliferative phase of preadipocytes in the adipocyte differentiation process...
  7. ncbi Cell cycle regulators in the control of metabolism
    Emilie Blanchet
    INSERM U896 and IRCM, Institut de Recherche en Cancérologie de Montpellier and University Montpellier 1, Montpellier, France
    Cell Cycle 8:4029-31. 2009
    ..There is enough evidence to indicate that the CDK4-pRB-E2F1 regulatory pathway is involved in general glucose homeostasis, and metabolism. In this article we discuss which are the metabolic implications of these findings...
  8. ncbi The CDK4-pRB-E2F1 pathway controls insulin secretion
    Jean Sebastien Annicotte
    INSERM, U834, Montpellier, F 34298, France
    Nat Cell Biol 11:1017-23. 2009
    ..2. In summary we provide evidence that the CDK4-pRB-E2F1 regulatory pathway is involved in glucose homeostasis, defining a new link between cell proliferation and metabolism...
  9. ncbi Cycling through metabolism
    Victor Aguilar
    IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM, U896, Université de Montpellier1, CRLC Val d Aurelle Paul Lamarque, Montpellier, France
    EMBO Mol Med 2:338-48. 2010
    ..Furthermore, we will discuss the possible relevance of these findings in the context of metabolic disorders such as obesity or diabetes...
  10. ncbi Downregulation of protein tyrosine phosphatase PTP-BL represses adipogenesis
    Murielle Glondu-Lassis
    IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F 34298, France
    Int J Biochem Cell Biol 41:2173-80. 2009
    ..These findings demonstrate a key role for PTP-BL in 3T3-L1 and MEF-derived adipocyte differentiation that is independent of its enzymatic activity...
  11. ncbi CXCL5 drives obesity to diabetes, and further
    Carine Chavey
    IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F 34298, France
    Aging (Albany NY) 1:674-7. 2009
    ..Finally we propose to analyze the CXCL5 gene to find particular polymorphisms that could predict the development of type II diabetes in obese subjects...
  12. ncbi Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis
    Irena Iankova
    Institut National de la Sante et de la Recherche Medicale, Equipe Avenir, Unité 540, 60 rue de Navacelles, Montpellier, France
    Mol Endocrinol 20:1494-505. 2006
    ..PPARgamma-cdk9 interaction results in increased transcriptional activity of PPARgamma and therefore increased adipogenesis...
  13. ncbi The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene
    Jean Sebastien Annicotte
    INSERM Equipe Avenir, U540, 60 rue de Navacelles, Montpellier, France
    Oncogene 24:8167-75. 2005
    ..Altogether, these data demonstrate that LRH-1 is transcriptionally regulated by the ER alpha and reinforce the hypothesis that LRH-1 could exert potential oncogenic effects during breast cancer formation...