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Publications
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and high-performance liquid chromatography study of quantitative and qualitative variation in tarantula spider venomsPierre Escoubas
Suntory Institute for Bioorganic Research, Mishima gun, Shimamoto cho, Wakayamadai 1 1 1, Osaka 618 8503, Japan
Rapid Commun Mass Spectrom 16:403-13. 2002....- Venomics: unravelling the complexity of animal venoms with mass spectrometryP Escoubas
Universite de Nice Sophia Antipolis, Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR6097, 06560 Valbonne, France
J Mass Spectrom 43:279-95. 2008..This approach now serves as the basis for the full investigation of complex spider venom proteomes, in combination with cDNA analysis... - ArachnoServer: a database of protein toxins from spidersDavid L A Wood
Queensland Facility for Advanced Bioinformatics, The University of Queensland, St Lucia, QLD 4072, Australia
BMC Genomics 10:375. 2009..However, at present, there are no databases dedicated to spider toxins and hence it is difficult to realise their full potential as drugs, insecticides, and pharmacological probes... - Venom landscapes: mining the complexity of spider venoms via a combined cDNA and mass spectrometric approachPierre Escoubas
Institut de Pharmacologie Moléculaire et Cellulaire CNRS, 660 route des Lucioles, Valbonne 06560, France
Toxicon 47:650-63. 2006..We propose that these venom landscapes might have predictive value for the discovery of various groups of pharmacologically distinct toxins in complex venoms... - Tarantulas: eight-legged pharmacists and combinatorial chemistsPierre Escoubas
Institut de Pharmacologie Moléculaire et Cellulaire CNRS, 660 route des Lucioles, Valbonne 06560, France
Toxicon 43:555-74. 2004..Tarantulas appear to be a good model for the discovery of novel compounds with important therapeutic potential, and for the study of the molecular evolution of peptide toxins... - Molecular diversification in spider venoms: a web of combinatorial peptide librariesPierre Escoubas
Institut de Pharmacologie Moléculaire et Cellulaire IPMC CNRS UMR 6097, 660 route des Lucioles, Valbonne, France
Mol Divers 10:545-54. 2006..Post-translational modifications, fine structural variations and new molecular scaffolds are other potential mechanisms of toxin diversification, leading to the pharmacologically complex cocktails used for predation and defense... - Isolation, synthesis and pharmacological characterization of delta-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae)G Corzo
Suntory Institute for Bioorganic Research, Osaka, Japan Laboratoire de Neurophysiologie, Universite d Angers, France
Eur J Biochem 267:5783-95. 2000.... - Sequence and electrophysiological characterization of two insect-selective excitatory toxins from the venom of the Chinese scorpion Buthus martensiP Escoubas
Suntory Institute for Bioorganic Research, Wakayamadai, Osaka, Japan
FEBS Lett 483:175-80. 2000..Increased Na(+) conductance at negative potential values is responsible for axonal hyperexcitability and the contractive paralysis of insect prey... - Peptides inhibitors of acid-sensing ion channelsS Diochot
Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Sophia Antipolis, 660 route des Lucioles, 06560 Valbonne, France
Toxicon 49:271-84. 2007..Nevertheless, APETx2 structure is related to other sea anemone peptides, which act as gating modifiers on Nav and Kv channels... - Pharmacologically active spider peptide toxinsG Corzo
Suntory Institute for Bioorganic Research, Mishima gun, Shimamoto cho, Wakayamadai 1 1 1, Osaka 618 8503, Japan
Cell Mol Life Sci 60:2409-26. 2003..Their high insecticidal potency can also make them useful probes for the discovery of novel insecticide targets in the insect nervous system or for the development of genetically engineered microbial pesticides... - Isolation of a tarantula toxin specific for a class of proton-gated Na+ channelsP Escoubas
Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Sophia Antipolis, Valbonne, France
J Biol Chem 275:25116-21. 2000..The new toxin is the first high affinity and highly selective pharmacological agent for this novel class of ionic channels. It will be important for future studies of their physiological and physio-pathological roles... - A comparison of matrix-assisted laser desorption/ionization time-of-flight and liquid chromatography electrospray ionization mass spectrometry methods for the analysis of crude tarantula venoms in the Pterinochilus groupP Escoubas
Suntory Institute for Bioorganic Research, Mishima gun, Shimamoto cho, Wakayamadai 1 1 1, Osaka 618, Japan
Rapid Commun Mass Spectrom 13:1861-8. 1999.... - Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperatorG Corzo
Suntory Institute for Bioorganic Research, Mishima gun, Shimamoto cho, Wakayamadai 1 1 1, Osaka 618 8503, Japan
Biochem J 359:35-45. 2001..Their presence brings new insights into the mode of action of scorpion venom and also opens new avenues for the discovery of novel antibiotic molecules from arthropod venoms... - Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypesFrank Bosmans
, Valbonne, France
Mol Pharmacol 69:419-29. 2006..Furthermore, an evolutionary trace analysis of these toxins and other structurally related three-disulfide spider toxins provides clues for the exploration of toxin-channel interaction and future structure-function research... - Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamiliesPierre Escoubas
, , Sophia-Antipolis, Valbonne, France
Mol Pharmacol 62:48-57. 2002..HmTx1 is the first described peptide effector of the Kv4.1 subtype. Those novel toxins are new tools for the investigation of the physiological role of the different potassium channel subunits in cellular physiology... - Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channelsPierre Escoubas
, CNRS UMR 6097, Sophia-Antipolis, 06560 Valbonne, France
Protein Sci 12:1332-43. 2003.... - Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activityMorgane Rouault
, CNRS-UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
Biochemistry 45:5800-16. 2006.... - The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1aMiguel Salinas
, , UMR-6097, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
J Physiol 570:339-54. 2006..The linker domain between CRDI and CRDII is important for their correct spatial positioning to form the PcTx1 binding site. These results will be useful for the future identification or design of new molecules acting on ASICs... - A spider toxin that induces a typical effect of scorpion alpha-toxins but competes with beta-toxins on binding to insect sodium channelsGerardo Corzo
Suntory Institute for Bioorganic Research, Mishima gun, Shimamoto cho, Wakayamadai 1 1 1, Osaka 618 8503, Japan
Biochemistry 44:1542-9. 2005..Yet, their different mode of channel modulation provides a novel perspective about the structural relatedness of receptor sites 3 and 4, which until now have been considered topologically distinct... - A tarantula peptide against pain via ASIC1a channels and opioid mechanismsMichel Mazzuca
Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique CNRS, Institut Paul Hamel, Universite de Nice Sophia Antipolis, 660 Route des Lucioles 06560 Valbonne, France
Nat Neurosci 10:943-5. 2007..The analgesic properties of the peptide are suppressed by antagonists of the mu and delta-opioid receptors and are lost in Penk1-/- mice... - Intersexual variations in Northern (Missulena pruinosa) and Eastern (M. bradleyi) mouse spider venomVolker Herzig
Monash Venom Group, Department of Pharmacology, Monash University, Victoria, Australia
Toxicon 51:1167-77. 2008..bradleyi venom in vertebrates. These findings are consistent with clinical reports that mouse spiders, particularly species other than male M. bradleyi, do not appear to be a major medical problem in humans... - A rational nomenclature for naming peptide toxins from spiders and other venomous animalsGlenn F King
Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road, St Lucia, QLD 4072, Australia
Toxicon 52:264-76. 2008..In this article, we introduce a rational nomenclature that can be applied to the naming of peptide toxins from spiders and other venomous animals... - AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channelsGuillaume Sandoz
Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR6097, Institut Paul Hamel, 660 route des Lucioles, 06560 Valbonne, France
EMBO J 25:5864-72. 2006..The association of AKAP150 with TREK channels integrates them into a postsynaptic scaffold where both G-protein-coupled membrane receptors (as demonstrated here for beta2AR) and TREK-1 dock simultaneously... - Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratusBenjamin Chagot
, Centre National de la Recherche Scientifique, , 13402 Marseille 20, France
Protein Sci 13:1197-208. 2004.... - Mass spectrometry in toxinology: a 21st-century technology for the study of biopolymers from venomsPierre Escoubas
Toxicon 47:609-13. 2006.... - Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channelsBenjamin Chagot
, Centre National de le Recherche Scientifique, , , Marseille Cedex 20, France
Protein Sci 14:2003-10. 2005..An additional region made of the type II'-beta turn connecting beta-strands I and II could also play a role in the specificity observed for these different ion effectors...