Research Topics
| Francois DurandSummaryCountry: France Publications
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Detail Information
Publications
Liver transplantation for hepatocellular carcinoma: role of biopsyFrancois Durand
Pôle des Maladies de l Appareil Digestif, Hepatology, Hospital Beaujon, Clichy, France
Liver Transpl 13:S17-23. 2007..Negative biopsy findings do not exclude the presence of HCC. Patients with negative biopsy findings should either undergo a second biopsy or an enhanced surveillance protocol...
Hot-topic debate on kidney function: renal-sparing approaches are beneficialFrancois Durand
Department of Hepatology and Liver Intensive Care, Beaujon Hospital, and Bichat Beaujon Center of Biomedical Research National Institute of Health and Medical Research Unit 773, University of Paris VII, Clichy, France
Liver Transpl 17:S43-9. 2011..New immunosuppressive agents without intrinsic nephrotoxicity are currently under development for solid organ transplantation. These agents could help to reduce the burden of impaired renal function in transplantation in the near future...
Wilson's disease: an old disease keeps its old secretsFrancois Durand
Service d Hepatologie, Universite Denis Diderot, Hospital Beaujon, Clichy, France
Eur J Gastroenterol Hepatol 19:97-9. 2007..Overall, the authors failed to document any genotype-phenotype correlation suggesting that non genetical factors are involved in the clinical variability of the disease...
Assessment of prognosis of cirrhosisFrancois Durand
Pôle des Maladies del Appareil Digestif, Service d Hepatologie, Universite Paris VII, INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Hopital Beaujon, Clichy, France
Semin Liver Dis 28:110-22. 2008..However, MELD is not a universal prognostic marker of cirrhosis and several MELD exceptions require more specific approaches...
Inaccuracies of creatinine and creatinine-based equations in candidates for liver transplantation with low creatinine: impact on the model for end-stage liver disease scoreClaire Francoz
Hepatology and Liver Intensive Care Unit, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3
Liver Transpl 16:1169-77. 2010..True GFR seems to have a better prognostic value than creatinine and creatinine-based equations. Specific equations are needed in patients with cirrhosis to improve prognostic scores...
Living donor liver transplantation in high-risk vs. low-risk patients: optimization using statistical modelsFrancois Durand
Hepatology INSERM U481, Hospital Beaujon, Clichy, France
Liver Transpl 12:231-9. 2006..On an individual basis, the sickest patients are those who derive the most important benefit from LDLT. This study provides incentives for considering LDLT in high-risk patients...
Extended liver resection for polycystic liver disease can challenge liver transplantationBeatrice Aussilhou
Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France
Ann Surg 252:735-43. 2010....
Microbial epidemiology and outcome of bloodstream infections in liver transplant recipients: an analysis of 259 episodesFrederic Bert
Department of Microbiology, APHP, Beaujon Hospital, Clichy, France
Liver Transpl 16:393-401. 2010..47). In conclusion, BSIs are frequent and early complications after liver transplantation and are mostly caused by gram-negative bacilli. A BSI in the first posttransplant month is a significant predictor of 1-year survival...
The spectrum of renal lesions in patients with cirrhosis: a clinicopathological studyJean Marie Trawalé
Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
Liver Int 30:725-32. 2010..This retrospective, one-point-in-time study aimed to report the results of the analysis of renal biopsy specimens obtained in patients with cirrhosis...
Model for end-stage liver disease exceptions in the context of the French model for end-stage liver disease score-based liver allocation systemClaire Francoz
Departments of Hepatology, Beaujon Hospital, Clichy, France
Liver Transpl 17:1137-51. 2011..MELD exceptions were discussed in an attempt to reconcile the concepts of transparency, equity, justice, and utility...
Beta-blockers cause paracentesis-induced circulatory dysfunction in patients with cirrhosis and refractory ascites: a cross-over studyThomas Sersté
INSERM, U773, Centre de Recherche Biomédicale Bichat Beaujon CRB3 Clichy, Paris, France
J Hepatol 55:794-9. 2011..The aim of this study was to investigate the incidence of PICD before and after discontinuation of beta-blockers in patients with cirrhosis and refractory ascites. A self control cross-over study was performed...
A randomized study comparing IGL-1 to the University of Wisconsin preservation solution in liver transplantationFederica Dondero
Beaujon Hospital, Assistance Publique Hopitaux de Paris, Clichy, France
Ann Transplant 15:7-14. 2010..These characteristics which improve liver preservation lead us to evaluate clinical effects of IGL-1 in a randomized controlled study with UW...
Obliterative portal venopathy: portal hypertension is not always present at diagnosisDominique Cazals-Hatem
Service d Anatomie Pathologique, Hôpital Beaujon AP HP, Clichy and Institut National de la Santé et de la Recherche Médicale U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Denis Diderot Paris 7, France
J Hepatol 54:455-61. 2011..Previous studies on obliterative portal venopathy (OPV) have been biased due to the selection of patients with non-cirrhotic portal hypertension. The aim of this study was to clarify the characteristics of OVP diagnosed by liver biopsy...
Detection of bacterial DNA in serum and ascitic fluid of asymptomatic outpatients with cirrhosis and non-neutrocytic ascitesThomas Sersté
Service d Hepatologie, Hôpital AP HP Beaujon, Clichy, France
Liver Int 31:494-8. 2011..The aim of this prospective study was to investigate the presence of bactDNA in AF and serum among cirrhotic outpatients with non-neutrocytic ascites...
Harvesting the middle hepatic vein with a right hepatectomy does not increase the risk for the donorOlivier Scatton
Department of Hepatobiliary Surgery, Hospital Beaujon, Clichy, France
Liver Transpl 10:71-6. 2004..05). The results of this comparative study show that right hepatectomy with the MHV neither affects morbidity nor impairs early liver function and regeneration in donors...
Autophagy in liver diseasesPierre Emmanuel Rautou
Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
J Hepatol 53:1123-34. 2010..This decrease in autophagy contributes to the formation of Mallory-Denk bodies and to liver cell death. Hepatic autophagy is defective in the liver in obesity and its upregulation improves insulin sensitivity...
The impact of preoperative hepatic hydrothorax on the outcome of adult liver transplantationThomas Sersté
Hepatology and Liver Intensive Care, Hospital Beaujon, Clichy, France
Eur J Gastroenterol Hepatol 22:207-12. 2010..Orthotopic liver transplantation (OLT) is the best option in case of end-stage liver disease. The impact of hepatic hydrothorax on pre-transplant and post-transplant courses has not been clearly investigated...
Benefit of initial resection of hepatocellular carcinoma followed by transplantation in case of recurrence: an intention-to-treat analysisDavid Fuks
Department of Hepato pancreato biliary Surgery, Assistance Publique Hopitaux de Paris, Clichy, France Université Denis Didero, Paris 7, France
Hepatology 55:132-40. 2012..12]). CONCLUSION: The high risk of failure of ST after initial LR for HCC within MC suggests the use of tissue analysis as a selection criterion. The salvage LT strategy should be restricted to patients with favorable oncological factors...
Risk factors for Staphylococcus aureus infection in liver transplant recipientsFrederic Bert
Services de Microbiologie, Hopital Beaujon, Clichy, France
Liver Transpl 11:1093-9. 2005..aureus infection in liver transplant recipients. The infection is most often of endogenous origin. Alcoholic cirrhosis and the severity of liver failure are also associated with a high risk of infection...
Amanita phalloides poisoning: reassessment of prognostic factors and indications for emergency liver transplantationLuc Escudie
Hepatology Unit and INSERM U773, Hospital Beaujon, Clichy, France
J Hepatol 46:466-73. 2007..Amanita phalloides poisoning is an uncommon cause of acute liver failure with an especially rapid course. The aim of this study was to re-assess transplantation criteria in patients with mushroom poisoning...
Auxiliary liver transplantation for fulminant hepatitis B: results from a series of six patients with special emphasis on regeneration and recurrence of hepatitis BFrancois Durand
Service d Hépatologie and INSERM U481, Hopital Beaujon, Clichy, France
Liver Transpl 8:701-7. 2002..Finally, the remnant part of the native liver does not compromise immunization against HBV...
Indications of liver transplantation in patients with complications of cirrhosisClaire Francoz
Service d Hepatologie, INSERM, Bichat Beaujon, Clichy, France
Best Pract Res Clin Gastroenterol 21:175-90. 2007..However, transplantation should be limited to patients with small tumours. HIV infection no longer represents a definitive contraindication...
Levels and initial course of serum alanine aminotransferase can predict outcome of patients with Budd-Chiari syndromePierre Emmanuel Rautou
Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
Clin Gastroenterol Hepatol 7:1230-5. 2009..An increased level of serum alanine aminotransferase (ALT) is an objective marker for acute liver injury. We analyzed the significance of changes in ALT levels in Budd-Chiari syndrome patients...
Criteria for liver transplantation for hepatocellular carcinoma: what is an acceptable outcome?Jacques Belghiti
Department of Hepato pancreato biliary and Transplantation Surgery, Beaujon Hospital, Assistance Publique Hopitaux de Paris, Clichy, France
Liver Int 31:161-3. 2011..More precise predictors of negative prognostic factors including elevated ?-feto protein level, poor differentiation and molecular techniques should be considered in order to optimize the use of grafts and achieve zero recurrence...
Risk factors for Enterobacteriaceae bacteremia after liver transplantationClaire Bellier
Department of Internal Medicine, Beaujon Hospital, Assistance Publique Hopitaux de Paris, Clichy, France
Transpl Int 21:755-63. 2008..Patients grafted for a posthepatitic cirrhosis, with a severe pretransplantation status, with a positive bile culture and those undergoing reoperation have a high risk of developing EB...
Role of replicative senescence in the progression of fibrosis in hepatitis C virus (HCV) recurrence after liver transplantationViviane Trak-Smayra
Service d'Anatomie Pathologique, , Clichy, France
Transplantation 77:1755-60. 2004..05). CONCLUSIONS: These data show that RS has a significant impact upon the course of liver transplantation, especially in the long-term progression of fibrosis observed in HCV-infected patients...
Aiming at minimal invasiveness as a therapeutic strategy for Budd-Chiari syndromeAurelie Plessier
Service d Hepatologie, Hopital Beaujon, Universite Paris VII, France
Hepatology 44:1308-16. 2006....
Resection prior to liver transplantation for hepatocellular carcinomaJacques Belghiti
Department of Surgery, Hospital Beaujon, 100 Boulevard du General Leclerc, 92118 Clichy Cedex, France
Ann Surg 238:885-92; discussion 892-3. 2003..To evaluate the feasibility and postoperative course of liver transplantation (LT) in cirrhotic patients who underwent liver resection prior to LT for HCC...
Severe sepsis in cirrhosisThierry Gustot
INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, Paris 75018, France
Hepatology 50:2022-33. 2009....
Arterial and portal circulation and parenchymal changes in Budd-Chiari syndrome: a study in 17 explanted liversDominique Cazals-Hatem
Service d Anatomie Pathologique, laboratoire d hématologie et d immunologie, Hopital Beaujon, Clichy, France
Hepatology 37:510-9. 2003..This pathologic situation offers an interesting vascular model to further understand the parenchymal response to changes in hepatic blood flow...
Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagyPierre Emmanuel Rautou
Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
Gastroenterology 135:840-8, 848.e1-3. 2008..Acute liver insufficiency is a rare complication of anorexia nervosa. The mechanisms for this complication are unclear. The aim of this study was to describe patient characteristics and clarify the mechanisms involved...
Hepatocellular carcinoma in patients with nonalcoholic fatty liver disease: helical CT and MR imaging findings with clinical-pathologic comparisonRiccardo Iannaccone
Department of Radiology, Hopital Beaujon, Clichy, France
Radiology 243:422-30. 2007..To retrospectively evaluate the clinical, pathologic, and helical computed tomographic (CT) and magnetic resonance (MR) imaging findings of hepatocellular carcinoma (HCC) in patients with nonalcoholic fatty liver disease (NAFLD)...
Comparison of outcome in patients with cirrhosis and ascites following treatment with albumin or a synthetic colloid: a randomised controlled pilot trailRichard Moreau
Service d Hépatologie and INSERM Unité 481, Hopital Beaujon, Clichy, France
Liver Int 26:46-54. 2006..The question of which colloid (albumin or synthetic colloids) used for plasma expansion following paracentesis or other complications requiring fluid loading in patients with cirrhosis remains controversial...
Impact of tumour differentiation to select patients before liver transplantation for hepatocellular carcinomaThomas Decaens
AP HP, Department of Hepatology, Groupe Henri Mondor Albert Chenevier, Creteil, France
Liver Int 31:792-801. 2011..To generate a new score with improved accuracy compared with Milan criteria to select patients...
[Hepatitis C and liver transplantation: fibrosis progression and treatment. Or how to improve management]Tarik Asselah
Service d Hépatologie et Unité INSERM CRB3, Universite Paris VII
Gastroenterol Clin Biol 30:1281-95. 2006..In this article we present a comprehensive review of post-transplant hepatitis C virus infection; in particular fibrosis progression and the major challenges according to treatment...
Erythromycin infusion or gastric lavage for upper gastrointestinal bleeding: a multicenter randomized controlled trialDominique Pateron
Emergency Department, Saint Antoine Hospital, Assistance Publique Hopitaux de Paris, Pierre et Marie Curie Paris 6 University, Paris, France
Ann Emerg Med 57:582-9. 2011..We determine whether in acute upper gastrointestinal bleeding the frequency of satisfactory stomach visualization was different after intravenous erythromycin, a nasogastric tube with gastric lavage, or both...
Pulmonary hemodynamics and gas exchange after liver transplantation in patients with cirrhosisEmmanuel Rassiat
, INSERM U-481, , Clichy, France
Dig Dis Sci 47:746-9. 2002..Moreover, it has no major effect on gas exchange in patients with cirrhosis without hypoxemia...
The evaluation of renal function and disease in patients with cirrhosisClaire Francoz
Hepatology and Liver Intensive Care Unit, Hospital Beaujon, Clichy, France
J Hepatol 52:605-13. 2010..In candidates for transplantation, attention should therefore be focused on vascular lesions which may represent a risk factor for nephrotoxicities induced by calcineurin-inhibitors...
[Liver transplantation in adults]Francois Durand
Service d Hépatologie et Inserm U 481, Hopital Beaujon, 100, boulevard du General Leclerc, 92110 Clichy, France
Med Sci (Paris) 21:89-94. 2005..Education for organ donation in the general population still remains a priority...
Report of the Paris consensus meeting on expanded criteria donors in liver transplantationFrancois Durand
Hepatology and Liver Intensive Care, Hospital Beaujon, University Paris 7, Clichy, France
Liver Transpl 14:1694-707. 2008..Updated data concerning the risks associated with different donor variables in different recipient populations are given. Recommendations on how to safely expand donor selection criteria are proposed...
Herbal medicines in acute viral hepatitis: a ticket for more troubleJacques Raymond Bernuau
Hopital Beaujon, Center of Digestive Tract Diseases, Clichy, France
Eur J Gastroenterol Hepatol 20:161-3. 2008....
Prevalence, molecular epidemiology, and clinical significance of heterogeneous glycopeptide-intermediate Staphylococcus aureus in liver transplant recipientsFrederic Bert
Department of Microbiology, Hospital Beaujon, Clichy, France
J Clin Microbiol 41:5147-52. 2003..These results suggest that the high prevalence of hGISA among our patients was due to the clonal spread of a multiresistant strain...
Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: results of a multicenter studyJean Marc Regimbeau
, Paris, France
J Surg Oncol 85:36-41. 2004..CONCLUSIONS: These findings enable identification of patients with HCC who are at high risk for early death due to recurrence following potentially curative resection who might be candidates for adjuvant therapy trials...
Respiratory complications: a major concern after right hepatectomy in living liver donorsFederica Dondero
, , Clichy, France
Transplantation 81:181-6. 2006..These complications are mainly observed after right hepatectomy. The particular prevalence of pulmonary embolism should lead to focus on its early diagnosis and prevention...
Diagnosis of portopulmonary hypertension in candidates for liver transplantation: a prospective studyIsabelle O Colle
, , Clichy, France
Hepatology 37:401-9. 2003..In addition, the absence of portopulmonary hypertension at evaluation does not exclude the occasional occurrence of acquired portopulmonary hypertension profile after listing...
Obesity and diabetes as a risk factor for hepatocellular carcinomaJean M Regimbeau
, Department of Surgery, Hospital Beaujon, , University Paris VII, Paris, France
Liver Transpl 10:S69-73. 2004..Whether HCC is primarily related to obesity and diabetes mellitus or secondarily to a NAFLD-like parenchymal lesions remains to be clarified...
Terlipressin in patients with cirrhosis and type 1 hepatorenal syndrome: a retrospective multicenter studyRichard Moreau
INSERM U 481 et Service d Hépatologie, Hopital Beaujon, Clichy, France
Gastroenterology 122:923-30. 2002..Although the administration of terlipressin improves renal function, its effect on survival is unknown. This study investigated predictive factors of survival in patients with type 1 HRS treated with terlipressin...
Feasibility and effectiveness of using coronary stents in the treatment of hepatic artery stenoses after orthotopic liver transplantation: preliminary reportAlban L Denys
Department of Radiology, , , 92118, Clichy, France
AJR Am J Roentgenol 178:1175-9. 2002..CONCLUSION: Hepatic artery stenosis after liver transplantation can be treated using coronary stents. The low rate of complication, high technical success, and 1-year patency rates are encouraging...
Multifactorial aetiology of hepatic infarction: a case report with literature reviewSven Francque
, , Clichy, France
Eur J Gastroenterol Hepatol 16:411-5. 2004..Because hepatic infarction is usually explained by the concurrence of several factors impairing the hepatic blood supply, an extensive search for associated conditions is necessary even when a conspicuous cause is present...
