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Genomes and Genes | Thierry CouffinhalSummaryCountry: France Publications
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Publications
Adherence with statins in a real-life setting is better when associated cardiovascular risk factors increase: a cohort studyPhilippe Latry
Univ de Bordeaux, Bordeaux, France
BMC Cardiovasc Disord 11:46. 2011..While the factors for poor adherence for treatment with statins have been highlighted, the impact of their combination on adherence is not clear...- Mouse models to study angiogenesis in the context of cardiovascular diseasesThierry Couffinhal
Institut National de la Sante et de la Recherche Medicale, INSERM U828, Pessac, France Universite Victor Segalen Bordeaux 2, Bordeaux, France
Front Biosci 14:3310-25. 2009..We will also discuss quantitative techniques for assessing angiogenesis in these assays... - Micro computed tomography for vascular explorationLyubomir Zagorchev
INSERM U828, Plateforme d Innovation Biotechnologique de Xavier Arnozan, , Pessac, France
J Angiogenes Res 2:7. 2010..This review highlights the capabilities of micro-CT for vascular exploration, describes the current state of imaging protocols, and offers guidelines and suggestions aimed at making micro-CT more accurate, replicable, and robust... - FrzA/sFRP-1, a secreted antagonist of the Wnt-Frizzled pathway, controls vascular cell proliferation in vitro and in vivoJerome Ezan
INSERM U441, Avenue du Haut Leveque, 33 600 Pessac, France, and Université Victor Segalen Bordeaux 2, rue Leo Saignat, 33 000 Bordeaux, France
Cardiovasc Res 63:731-8. 2004..In this study, we aimed to examine the mechanisms by which FrzA exerts its antiproliferative effect on vascular cells in vitro and its potential effect in vivo... - Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzALaurent Barandon
Department of Cardiovascular Surgery and Cardiology, Hopital Haut Leveque, Pessac, France
Circulation 108:2282-9. 2003..FrzA is involved in cell cycle control of vascular cells and angiogenesis. We assessed the hypothesis that FrzA could control the healing process after myocardial infarction (MI)... - Involvement of FrzA/sFRP-1 and the Wnt/frizzled pathway in ischemic preconditioningLaurent Barandon
Department of Cardiovascular Surgery, , Pessac, France
Circ Res 96:1299-306. 2005..This study demonstrates for the first time that disruption of a beta-catenin independent Wnt/Frizzled pathway induces the activation of GSK-3beta and reverses the benefit of preconditioning... - Mapping 3-dimensional neovessel organization steps using micro-computed tomography in a murine model of hindlimb ischemia-brief reportPierre Oses
INSERM U828, Pessac, Universite Victor Segalen, Bordeaux, France
Arterioscler Thromb Vasc Biol 29:2090-2. 2009..We sought to evaluate the contribution of the microcomputed tomography (mCT) providing high-resolution 3-dimensional (3D) structural data, to a better comprehension of the well-studied mouse hindlimb postischemic neovascularization... - Secreted frizzled-related protein-1 improves postinfarction scar formation through a modulation of inflammatory responseLaurent Barandon
Universite de Bordeaux, Adaptation Cardiovasculaire à l ischémie, U1034, Pessac, France
Arterioscler Thromb Vasc Biol 31:e80-7. 2011..We aimed to further elucidate the role of sFRP-1 in the postischemic inflammatory process... - Secreted frizzled-related protein-1 enhances mesenchymal stem cell function in angiogenesis and contributes to neovessel maturationPascale Dufourcq
Institut National de la Santé et de la Recherche Médicale U828, Universite Victor Segalen, Bordeaux2, Pessac, France
Stem Cells 26:2991-3001. 2008..Disclosure of potential conflicts of interest is found at the end of this article... - Repair of myocardial infarction by epicardial deposition of bone-marrow-cell-coated muscle patch in a murine modelLaurent Barandon
Department of Cardiovascular Surgery and Cardiology, Haut Leveque Hospital, Pessac, France
Ann Thorac Surg 78:1409-17. 2004..Myocardial infarction results in irreversible myocyte loss. In a murine model, we tested the feasibility of a novel repair technique combining bone marrow cell (BMC) transplantation and cardiomyoplasty... - Hypoxia preconditioned mesenchymal stem cells improve vascular and skeletal muscle fiber regeneration after ischemia through a Wnt4-dependent pathwayLionel Leroux
INSERM U828, Universite Victor Segalen, Pessac, France
Mol Ther 18:1545-52. 2010.... - Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formationPascale Dufourcq
INSERM U828, Av du haut lévèque, 33600 Pessac, France
Am J Pathol 172:37-49. 2008..This study illustrates a regulated pathway by sFRP-1 involving GSK-3beta and Rac-1 in endothelial cell cytoskeletal reorganization and in neovessel formation... - FrzA, a secreted frizzled related protein, induced angiogenic responsePascale Dufourcq
INSERM U441, Pessac, France
Circulation 106:3097-103. 2002.... - GSK-3? at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathwaysFrançois Vigneron
Inserm Unit 828, Pessac, France
Cardiovasc Res 90:49-56. 2011..Here, we investigate whether the mTOR pathway is involved in cardioprotection... - Gene therapy for chronic peripheral arterial disease: what role for the vascular surgeon?Laurent Barandon
Department of Cardiovascular Surgery, Haut Leveque Hospital, Pessac, France
Ann Vasc Surg 18:758-65. 2004..Therapeutic angiogenesis should be viewed as an adjunct to rather than as a competitor of current surgical revascularization techniques... - Osteopontin expression in cardiomyocytes induces dilated cardiomyopathyMarie Ange Renault
INSERM U828, Ave du Haut Lévêque, Pessac, France
Circ Heart Fail 3:431-9. 2010..However, its role in the development of heart diseases is not known... - [Metabolic syndrome with a predisposition to coronary diseases and type 2 diabetes]Thierry Couffinhal
Centre d exploration, de prévention et de traitement de l athérosclérose, Hopital Cardiologique du Haut Leveque, Avenue de Magellan, 33604 Pessac, France
Nephrol Ther 2:S39-48. 2006.... - Clinical outcome after a negative spiral CT pulmonary angiographic finding in an inpatient population from cardiology and pneumology wardsKatia Bourriot
Service de cardiologie, , Pessac, France
Chest 123:359-65. 2003..8% and 4.9%. SCT angiography can be used confidently to rule out significant PE, and may prevent further investigations and unnecessary treatment in an inpatient population with cardiac and/or respiratory diseases... - The -308 G/A tumor necrosis factor-alpha gene dimorphism: a risk factor for unstable anginaVirginie Bernard
Institut Fédératif de Recherche no 4 Heart Lung Vessel Thrombosis, Institut National de la Santé et de la Recherche Médicale U441, Pessac, France
Clin Chem Lab Med 41:511-6. 2003..On the other hand, mechanisms controlling myocardial infarction appear more complex and heterogeneous... - Postprandial recurrent hemiplegiaKarim Farid
Department of Nuclear Medicine, CHU de Bordeaux, Bordeaux, France
Clin Nucl Med 35:80-2. 2010..Postprandial hemodynamic disturbances have been previously described. We report a case of postprandial transient ischemic attacks... - Prevalence of metabolic syndrome after acute coronary syndrome and its prognostic significanceCarine Boulon
, Bordeaux, France
Am J Cardiol 98:1429-34. 2006..In conclusion, MS was highly prevalent after an ACS, notably in young patients, and was not associated with a specific ACS presentation... - Vitronectin is up-regulated after vascular injury and vitronectin blockade prevents neointima formationPascale Dufourcq
Institut National de la Sante et de la Recherche Medicale, INSERM Unité 441, Athéroclérose, Avenue du Haut Leveque, 33600 Pessac, France
Cardiovasc Res 53:952-62. 2002..We investigated the expression and the functional role of vitronectin (VN) in the response after vascular injury...