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Genomes and Genes | Sebastien GibotSummaryAffiliation: CHU de Nancy Country: France Publications
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Publications
TREM-1 promotes survival during septic shock in miceSebastien Gibot
Réanimation Médicale, Hopital Central, Nancy, France
Eur J Immunol 37:456-66. 2007..These data highlight the crucial role of the TREM-1 pathway in mounting an adequate inflammatory and cytotoxic response to polymicrobial sepsis, and both the therapeutic promise and potential risks of its modulation...- Urine sTREM-1 assessment in diagnosing sepsis and sepsis-related acute kidney injuryMarc Derive
Service de Reanimation Medicale, Hopital Central, 54035 Nancy Cedex, France
Crit Care 15:1013. 2011..If these results were to be confirmed by larger studies, urinary soluble TREM-1 would possibly become a new biomarker for sepsis-associated AKI... - Metformin-associated lactic acidosis in an intensive care unitNicolas Peters
Service de Nephrologie, CHU Brabois Vandoeuvre les Nancy, 54500, France
Crit Care 12:R149. 2008..We aimed to assess the prevalence of MALA in a 16-bed, university-affiliated, intensive care unit (ICU), and the effect of dialysis on patient outcome... - Modulation of the triggering receptor expressed on myeloid cells-1 pathway during pneumonia in ratsSebastien Gibot
Service de Reanimation Medicale, Hopital Central, 54035 Nancy, France
J Infect Dis 194:975-83. 2006..The aim of the present study was to investigate the effect of the modulation of the TREM-1 pathway during experimental pneumonia in rats... - Growth arrest-specific protein 6 plasma concentrations during septic shockSebastien Gibot
Service de Reanimation Medicale, Avenue du Marechal de Lattre de Tassigny, Hopital Central, Nancy, France
Crit Care 11:R8. 2007..Our purpose was to investigate plasma Gas6 concentration and its relation to organ dysfunction in patients with septic shock... - High-mobility group box 1 protein plasma concentrations during septic shockSebastien Gibot
Hopital Central, Service de Reanimation Medicale, 29 Avenue du Marechal de Lattre de Tassigny, 54000, Nancy, France
Intensive Care Med 33:1347-53. 2007..To investigate plasma high-mobility group box 1 protein (HMGB1) concentration and its relationship with organ dysfunction and outcome in septic shock patients... - Combined measurement of procalcitonin and soluble TREM-1 in the diagnosis of nosocomial sepsisSebastien Gibot
Service de Reanimation Medicale, Hopital Central, Nancy, France
Scand J Infect Dis 39:604-8. 2007..We therefore concluded that the combined measurement of serum PCT and BAL sTREM-1 concentrations could be of interest in detecting the presence of a nosocomial sepsis and in discriminating VAP versus extrapulmonary infection... - Effects of the TREM-1 pathway modulation during mesenteric ischemia-reperfusion in ratsSebastien Gibot
Groupe CHOC, Contrat AVENIR INSERM, U684, Faculte de Medecine, Nancy Universite, Nancy, France
Crit Care Med 36:504-10. 2008.... - Effects of the TREM 1 pathway modulation during hemorrhagic shock in ratsSebastien Gibot
Groupe CHOC, Contrat AVENIR INSERM, Faculte de Medecine, Nancy Universite, Nancy, France
Shock 32:633-7. 2009..Finally, LP17 improved survival. Thus, the early modulation of the TREM-1 pathway by means of a synthetic peptide may be useful during severe hemorrhagic shock in rats in preventing organ dysfunction and improving survival... - The therapeutic potential of TREM-1 modulation in the treatment of sepsis and beyondSebastien Gibot
Service de Réanimation Médicale Hôpital Central, 29 Avenue du Marechal de Lattre de Tassigny, 54035 Nancy Cedex, France
Curr Opin Investig Drugs 7:438-42. 2006.... - Modulation of the triggering receptor expressed on the myeloid cell type 1 pathway in murine septic shockSebastien Gibot
Service de Reanimation Medicale, 29 bld du Maréchal de Lattre de Tassigny, Hopital Central, 54035 Nancy, France
Infect Immun 74:2823-30. 2006..These data suggest that in vivo modulation of TREM-1 might be a suitable therapeutic tool for the treatment of sepsis... - Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia and severe sepsisSebastien Gibot
Service de Reanimation Medicale, Hopital Central, Nancy Cedex, France
Semin Respir Crit Care Med 27:29-33. 2006..Moreover, the evolutionary pattern of TREM-1 may be interesting during the follow-up of septic patients... - Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumoniaSebastien Gibot
Service de Reanimation Medicale, Hopital Central, Nancy, France
N Engl J Med 350:451-8. 2004..The presence of soluble TREM-1 (sTREM-1) in bronchoalveolar-lavage fluid from patients receiving mechanical ventilation may be an indicator of pneumonia... - A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsisSebastien Gibot
Réanimation Médicale, Hopital Central, 29 Avenue du Marechal de Lattre de Tassigny, 54035 Nancy Cedex, France
J Exp Med 200:1419-26. 2004..These data suggest that in vivo modulation of TREM-1 by sTREM peptide might be a suitable therapeutic tool for the treatment of sepsis... - Surface triggering receptor expressed on myeloid cells 1 expression patterns in septic shockSebastien Gibot
Réanimation Médicale, Hopital Central, 54000 Nancy, France
Intensive Care Med 31:594-7. 2005..To analyze the pattern of cell-surface expression of the triggering receptor expressed on myeloid cells (TREM) 1 during septic shock... - Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infectionSebastien Gibot
Service de Reanimation Medicale, Nancy, France
Clin Med Res 2:181-7. 2004..Here we report on the potential usefulness of assessing the soluble form of TREM-1 (sTREM-1) in biological fluids for the diagnosis of microbial infection... - Surface and soluble triggering receptor expressed on myeloid cells-1: expression patterns in murine sepsisSebastien Gibot
Department of Intensive Care and Experimental Physiology, Hopital Central, Nancy Cedex, France
Crit Care Med 33:1787-93. 2005..To examine the expression patterns of the triggering receptor expressed on myeloid cells (TREM)-1 during experimental septic shock... - Clinical review: role of triggering receptor expressed on myeloid cells-1 during sepsisSebastien Gibot
Service de Reanimation Medicale, 29 Avenue du Marechal de Lattre de Tassigny, Hopital Central, Nancy, France
Crit Care 9:485-9. 2005..Modulation of the TREM-1 signalling pathway by the use of small synthetic peptides confers interesting survival advantages during experimental septic shock in mice, even when this teatment is administered late after the onset of sepsis... - The relationship between CD4+CD25+CD127- regulatory T cells and inflammatory response and outcome during shock statesFrançois Hein
Service de Reanimation Medicale, Hopital Central, CHU de Nancy, 29 Bld du Mal de Lattre de Tassigny, Nancy, 54000, France
Crit Care 14:R19. 2010.... - Increased aerobic glycolysis through beta2 stimulation is a common mechanism involved in lactate formation during shock statesBruno Levy
Groupe CHOC, Contrat AVENIR INSERM 2006, Faculte de Medecine, Nancy Universite, Vandoeuvre les Nancy, France
Shock 30:417-21. 2008..In shock state associated with a reduced or maintained blood flow, an important proportion of muscle lactate release is regulated by a beta2 receptor stimulation and not secondary to a reduced oxygen availability... - Activated protein C improves lipopolysaccharide-induced cardiovascular dysfunction by decreasing tissular inflammation and oxidative stressNacira Sennoun
Groupe CHOC, Equipe Avenir Inserm, Nancy Universite, Faculte de Medecine, 54500 Vandoeuvre les Nancy, France
Crit Care Med 37:246-55. 2009..The hemodynamic effects of APC on arterial pressure and cardiac function are now well established in animal models. However, the specific effects of APC on heart and vessels have never been studied... - Comparative effects of recombinant human activated protein C and dexamethasone in experimental septic shockYoucef Bouazza
Groupe CHOC, Contrat AVENIR INSERM, Faculte de Medecine, Nancy Universite, Nancy, France
Intensive Care Med 37:1857-64. 2011..The effects of treatments on major cellular pathways likely implicated were also studied... - Probiotics in the critically ill patient: a double blind, randomized, placebo-controlled trialDamien Barraud
Service de Reanimation Medicale, Hopital Central, CHU Nancy, 29 Avenue du Marechal de Lattre de Tassigny, 54035, Nancy Cedex, France
Intensive Care Med 36:1540-7. 2010..The aim of this study was to assess the effects of prophylactic probiotic administration in patients ventilated for up to 2 days... - Early increase in arterial lactate concentration under epinephrine infusion is associated with a better prognosis during shockYann Wutrich
Services de Réanimation Médicale, Hôpital Central et CHU Nancy Brabois, Faculte de Medecine, Nancy Universite, Nancy, France
Shock 34:4-9. 2010..7% when Deltalactate was less than 100 (log-rank test, P = 0.0002). An adapted response (lactate production) to a pharmacological trigger (epinephrine) is associated with better prognosis during shock of various etiologies... - Triggering receptor expressed on myeloid cell 1Damien Barraud
Medical ICU, University Hospital of Nancy, avenue de Lattre de Tassigny, 54000 Nancy, France
Crit Care Clin 27:265-79. 2011..Its expression is upregulated on phagocytic cells in the presence of bacteria or fungi. This article reports on the potential usefulness of the assessment of the soluble form of TREM-1 in biologic fluids in the diagnosis of infection... - Comparative effects of early versus delayed use of norepinephrine in resuscitated endotoxic shockNacira Sennoun
Equipe Avenir Inserm, U684, Shock Research Group, Nancy Universite, Nancy, France
Crit Care Med 35:1736-40. 2007.... - Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shockBruno Levy
Coordination Circulation UHP INSERM, Groupe CHOC, Faculte de Medecine, Universite Henri Poincare Nancy 1, Nancy, France
Intensive Care Med 33:495-502. 2007.... - Increased muscle-to-serum lactate gradient predicts progression towards septic shock in septic patientsBruno Levy
Groupe CHOC, Contrat AVENIR INSERM, Faculte de Medecine, Nancy Universite, Vandoeuvre Nancy Cedex, France
Intensive Care Med 36:1703-9. 2010..Thus, in sepsis patients, we investigated (1) whether muscle produces lactate and pyruvate, and (2) whether muscle lactate production is linked to epinephrine levels and the severity of the patient's condition... - [Patients' perception of their experience in the intensive care unit]Cecile Cazorla
Service de Reanimation Medicale, Hopital Central, CHU, Nancy 54
Presse Med 36:211-6. 2007..To analyze patients' assessment of quality of care in our intensive care unit... - Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective studyBruno Levy
Service de Reanimation Medicale, Hopital Central, 54035 Nancy, France
Lancet 365:871-5. 2005..Muscles can generate lactate under aerobic conditions in a process linking glycolytic ATP supply to stimulation of Na+K+ ATPase. Using in-vivo microdialysis, we tested whether inhibition of Na+K+ ATPase can reduce muscle lactate... - Cardiovascular response to dopamine and early prediction of outcome in septic shock: a prospective multiple-center studyBruno Levy
, , Nancy Cedex, France
Crit Care Med 33:2172-7. 2005..CONCLUSIONS: Dopamine sensitivity is associated with decreased mortality rate. Early recognition of dopamine resistant septic shock could allow for better screening of patients with an ominous prognosis... - Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rateSebastien Gibot
Service de Reanimation Medicale, Hopital Central, Nancy, France
Crit Care Med 30:969-73. 2002..We evaluated the frequency of a recently discovered CD14 promoter gene polymorphism (C to T transition at base pair -159) among patients with septic shock compared with those in a control group...