Victor de Ledinghen

Summary

Affiliation: CHU de Bordeaux
Country: France

Publications

  1. ncbi Transient elastography for the diagnosis of liver fibrosis
    Victor de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, 33604 Pessac Cedex, France
    Expert Rev Med Devices 7:811-23. 2010
  2. ncbi Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    Dig Liver Dis 44:413-8. 2012
  3. ncbi Diagnosis of liver fibrosis and cirrhosis using liver stiffness measurement: comparison between M and XL probe of FibroScan®
    Victor de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Centre Hospitalier Universitaire CHU de Bordeaux, Hopital Haut Leveque, France
    J Hepatol 56:833-9. 2012
  4. ncbi Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease
    Thierry Poynard
    Hepato Gastroenterology, AP HP Groupe Hospitalier Pitié Salpétrière, Paris, France
    BMC Gastroenterol 6:34. 2006
  5. ncbi Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease
    Vlad Ratziu
    Hepato Gastroenterology, AP HP Groupe Hospitalier Pitié Salpétrière, Paris, France
    BMC Gastroenterol 6:6. 2006
  6. ncbi Transient elastography (FibroScan)
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, Pessac, France INSERM U889, Universite Victor Segalen, Bordeaux, France
    Gastroenterol Clin Biol 32:58-67. 2008
  7. ncbi Diagnostic and predictive factors of significant liver fibrosis and minimal lesions in patients with persistent unexplained elevated transaminases. A prospective multicenter study
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital du Haut leveque, Pessac, France
    J Hepatol 45:592-9. 2006
  8. ncbi Outbreak of hepatitis C virus infection during sclerotherapy of varicose veins: long-term follow-up of 196 patients (4535 patient-years)
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    J Hepatol 46:19-25. 2007
  9. ncbi [Non-invasive evaluation of liver fibrosis in hepatitis C]
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, CHU Bordeaux, Hopital du Haut leveque, 1, Avenue de Magellan, 33604 Pessac, France
    Gastroenterol Clin Biol 32:S90-5. 2008
  10. ncbi Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than HIV-negative patients despite antiretroviral therapy
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    J Viral Hepat 15:427-33. 2008

Detail Information

Publications43

  1. ncbi Transient elastography for the diagnosis of liver fibrosis
    Victor de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, 33604 Pessac Cedex, France
    Expert Rev Med Devices 7:811-23. 2010
    ..FibroScan evaluates liver stiffness, which is related to fibrosis, but also inflammation and portal hypertension. Therefore, FibroScan values have to be interpreted according to clinical, biological and morphological data...
  2. ncbi Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    Dig Liver Dis 44:413-8. 2012
    ..Patients with diabetes are at risk for nonalcoholic fatty liver disease leading to cirrhosis. Existing guidelines do not advocate screening for liver related complications amongst persons with diabetes...
  3. ncbi Diagnosis of liver fibrosis and cirrhosis using liver stiffness measurement: comparison between M and XL probe of FibroScan®
    Victor de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Centre Hospitalier Universitaire CHU de Bordeaux, Hopital Haut Leveque, France
    J Hepatol 56:833-9. 2012
    ..The aim of this study was to evaluate the accuracy of liver stiffness measurement using M and XL probes of Fibroscan® for the diagnosis of fibrosis and cirrhosis in a large cohort of patients...
  4. ncbi Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease
    Thierry Poynard
    Hepato Gastroenterology, AP HP Groupe Hospitalier Pitié Salpétrière, Paris, France
    BMC Gastroenterol 6:34. 2006
    ..The aim was to develop and validate a new biomarker of non alcoholic steato hepatitis (NASH) the NashTest (NT) in patients with NAFLD...
  5. ncbi Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease
    Vlad Ratziu
    Hepato Gastroenterology, AP HP Groupe Hospitalier Pitié Salpétrière, Paris, France
    BMC Gastroenterol 6:6. 2006
    ..The aim of this study was to determine the diagnostic utility of non-invasive markers of fibrosis, validated in chronic viral hepatitis and alcoholic liver disease (FibroTest, FT), in patients with NAFLD...
  6. ncbi Transient elastography (FibroScan)
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, Pessac, France INSERM U889, Universite Victor Segalen, Bordeaux, France
    Gastroenterol Clin Biol 32:58-67. 2008
    ..Therefore, FibroScan values have to be interpreted according to clinical, biological and morphological data...
  7. ncbi Diagnostic and predictive factors of significant liver fibrosis and minimal lesions in patients with persistent unexplained elevated transaminases. A prospective multicenter study
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital du Haut leveque, Pessac, France
    J Hepatol 45:592-9. 2006
    ..The aim of this prospective study was to identify diagnosis and clinical and biological factors associated with significant (bridging) fibrosis and minimal lesions of the liver in patients with persistent unexplained elevated ALT levels...
  8. ncbi Outbreak of hepatitis C virus infection during sclerotherapy of varicose veins: long-term follow-up of 196 patients (4535 patient-years)
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    J Hepatol 46:19-25. 2007
    ....
  9. ncbi [Non-invasive evaluation of liver fibrosis in hepatitis C]
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, CHU Bordeaux, Hopital du Haut leveque, 1, Avenue de Magellan, 33604 Pessac, France
    Gastroenterol Clin Biol 32:S90-5. 2008
    ..However, their performances are excellent for the diagnosis of severe fibrosis or cirrhosis compared to moderate fibrosis...
  10. ncbi Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than HIV-negative patients despite antiretroviral therapy
    V de Ledinghen
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    J Viral Hepat 15:427-33. 2008
    ..HIV/HCV-coinfected patients have more advanced liver fibrosis than HCV-monoinfected patients despite the immunologic benefit of HAART...
  11. ncbi Feasibility of liver transient elastography with FibroScan using a new probe for obese patients
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Pessac, France
    Liver Int 30:1043-8. 2010
    ..The aim of this prospective study was to assess the feasibility of LSM when using a new XL probe on patients with a body mass index (BMI) > or =30 kg/m(2)...
  12. ncbi Detection of nodules in liver cirrhosis: spiral computed tomography or magnetic resonance imaging? A prospective study of 88 nodules in 34 patients
    Victor de Ledinghen
    Unite de Transplantation Hepatique, Hopital Pellegrin, Bordeaux, France
    Eur J Gastroenterol Hepatol 14:159-65. 2002
    ..However, tumour size is always a restricting factor for these two techniques, which are unable to detect small HCC in more than 60% of cases...
  13. ncbi Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy
    Victor de Ledinghen
    INSERM, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    J Pediatr Gastroenterol Nutr 45:443-50. 2007
    ....
  14. ncbi Should a liver biopsy be done in patients with subclinical chronically elevated transaminases?
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Centre Hospitalier Universitaire, Hopital du Haut leveque, Pessac, France
    Eur J Gastroenterol Hepatol 16:879-83. 2004
    ..Since the risk of F > or = 2 fibrosis is significantly increased in patients with AST > N and/or ALT > 2N, liver biopsy should be performed only in patients with AST > N or ALT > 2N...
  15. ncbi Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire CHU de Bordeaux, Pessac, France
    J Hepatol 50:59-68. 2009
    ....
  16. ncbi Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C
    Julien Vergniol
    Centre d Investigation de la Fibrose hépatique, Hopital Haut Leveque, CHU Bordeaux, Pessac, France
    Gastroenterology 140:1970-9, 1979.e1-3. 2011
    ..We evaluated the abilities of liver stiffness, results from noninvasive tests for fibrosis, and liver biopsy analyses to predict overall survival or survival without liver-related death with a 5-year period...
  17. ncbi Assessment of liver fibrosis using transient elastography in patients with alcoholic liver disease
    Pierre Nahon
    AP HP, Service d Hepato Gastroenterologie, Hopital Jean Verdier, Avenue du 14 Juillet, 93143 Bondy, France
    J Hepatol 49:1062-8. 2008
    ..The aim of this study was to assess the accuracy of liver stiffness measurement (LSM) for the diagnosis of extensive fibrosis and cirrhosis in patients with alcoholic liver disease (ALD)...
  18. ncbi Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, C H U Bordeaux, Pessac, France
    Gastroenterology 128:343-50. 2005
    ....
  19. ncbi Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire C H U de Bordeaux, Pessac, France
    J Hepatol 52:191-8. 2010
    ..The aim of this prospective study was to compare the performance of these two algorithms for diagnosing significant fibrosis and cirrhosis in 302 CHC patients...
  20. ncbi A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C
    Jérôme Boursier
    Service d Hepato Gastroenterologie, CHU, Angers, France
    Am J Gastroenterol 106:1255-63. 2011
    ..Our aim was to develop a new and more accurate fibrosis stage classification by using new scores combining non-invasive fibrosis tests...
  21. ncbi Usefulness of noninvasive tests in nodular regenerative hyperplasia of the liver
    David Laharie
    INSERM U853, Universite Victor Segalen Bordeaux 2, France
    Eur J Gastroenterol Hepatol 22:487-93. 2010
    ..The only way to diagnose nodular regenerative hyperplasia (NRH) is liver biopsy...
  22. ncbi Psychological impact of chronic hepatitis C: comparison with other stressful life events and chronic diseases
    Laurent Castera
    Service d Hepato Gastroenterologie, Centre Hospitalier Universitaire de Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    World J Gastroenterol 12:1545-50. 2006
    ..To examine the psychological impact of chronic hepatitis C (CHC) diagnosis in a large cohort of CHC patients as compared with other stressful life events and chronic diseases carrying a risk of life-threatening complications...
  23. ncbi [Transient elastography (FibroScan): a new tool in hepatology]
    Julien Vergniol
    Centre d Investigation de la Fibrose hépatique, Service d Hepato gastro enterologie, Hopital Haut Leveque, F 33604 PESSAC, France
    Presse Med 38:1516-25. 2009
    ..Liver stiffness is strongly correlated with the severity of portal hypertension and of cirrhosis...
  24. ncbi Meta-analyses of FibroTest diagnostic value in chronic liver disease
    Thierry Poynard
    Service d Hepato Gastroenterologie, Groupe Hospitalier Pitie Salpetriere, Universite Paris VI, CNRS ESA 8067 Paris, France
    BMC Gastroenterol 7:40. 2007
    ....
  25. ncbi Predictive value of early HCV RNA quantitation for sustained response in nonresponders receiving daily interferon and ribavirin therapy
    Pascale Trimoulet
    Laboratoire de Virologie, Centre Hospitalier Universitaire, Hopital Pellegrin, Bordeaux Cedex, France
    J Med Virol 72:46-51. 2004
    ..Nonresponse can be predicted as early as week 4 or week 12 in nonresponders treated with daily IFN and ribavirin...
  26. ncbi Validation and comparison of simple noninvasive indexes for predicting liver fibrosis in HIV-HCV-coinfected patients: ANRS CO3 Aquitaine cohort
    Marc Arthur Loko
    INSERM, U593, Bordeaux, France
    Am J Gastroenterol 103:1973-80. 2008
    ..Although an increasing number of noninvasive fibrosis markers are available in HCV-monoinfected patients, data on the performance of these tests in HIV-HCV-coinfected patients are lacking...
  27. ncbi Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations
    Laurent Castera
    Services d Hépato gastroentérologie, Centre Hospitalo Universitaire de Bordeaux, Hopital Haut Leveque, Avenue Magellan, 33604 Pessac, France
    Hepatology 51:828-35. 2010
    ..These results emphasize the need for adequate operator training and for technological improvements in specific patient subpopulations...
  28. ncbi Psychosocial factors associated with perceived disease severity in patients with chronic hepatitis C: relationship with information sources and attentional coping styles
    Aymery Constant
    Laboratoire de Psychologie de la Santé EA 3662, Universite Victor Segalen Bordeaux 2, France
    Psychosomatics 46:25-33. 2005
    ..These results suggest that information processing and psychological features play a key role in the way patients with chronic hepatitis C perceive their disease...
  29. ncbi Diagnosis of hepatic fibrosis and cirrhosis by transient elastography in HIV/hepatitis C virus-coinfected patients
    Victor de Ledinghen
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Bordeaux, France
    J Acquir Immune Defic Syndr 41:175-9. 2006
    ....
  30. ncbi Gastric variceal bleeding uncovering a rare association of CREST syndrome, primary biliary cirrhosis, nodular regenerative hyperplasia and pulmonary hypertension
    Etienne Riviere
    Service d Hepato Gastroenterologie, Hopital du Haut leveque, 33604 Pessac Cedex, France
    Eur J Gastroenterol Hepatol 22:1145-8. 2010
    ..This case shows the association of PBC and NRH with porto pulmonary hypertension in CREST syndrome...
  31. ncbi Lamivudine therapy of chronic hepatitis B in three groups of patients: non transplanted patients, liver recipients, and kidney recipients
    Evelyne Schvoerer
    Laboratoire de Virologie, , Bordeaux, France
    Gastroenterol Clin Biol 26:62-6. 2002
    ..CONCLUSION: The poor response to lamivudine in liver recipients requires further studies...
  32. ncbi Optimization and robustness of blood tests for liver fibrosis and cirrhosis
    Paul Cales
    Service d Hepato Gastroenterologie, CHU, Angers, France
    Clin Biochem 43:1315-22. 2010
    ..To optimize the performance and feasibility of fibrosis blood tests and evaluate their robustness...
  33. ncbi [Managing comorbidities in hepatology: toward a more holistic medicine]
    Patrice Couzigou
    Service Hépato gastroentérologie, Hopital du Haut leveque, F 33604 PESSAC, France
    Presse Med 37:1274-80. 2008
    ..In this more holistic approach, the physician treats a person with liver disease, rather than just a diseased liver...
  34. ncbi [Brief intervention about alcohol use]
    Patrice Couzigou
    Service d Hepato gastro enterologie, Hôpital Haut Lévêque Pessac, F 33600 Bordeaux, France
    Presse Med 38:1126-33. 2009
    ..This efficacy has been demonstrated for a duration of at least 4 years. Given that evidence also supports the behavioral changes, these findings should be taken into account by healthcare providers...
  35. ncbi Hepatitis B virus genotypes: a retrospective survey in Southwestern France, 1999-2004
    Pascale Trimoulet
    Laboratoire de virologie Hôpital Pellegrin, 33076 Bordeaux Cedex
    Gastroenterol Clin Biol 31:1088-94. 2007
    ..To determine the prevalence of HBV genotypes in Southwestern France and the association between HBV genotypes and patients characteristics...
  36. ncbi Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients
    Nathalie Salles
    INSERM ERI 10, Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, Bat 2B RDC Zone Nord, 33076 Bordeaux Cedex, France
    J Gerontol A Biol Sci Med Sci 61:1144-50. 2006
    ..34; p = .018). The negative association between ghrelin and H. pylori infection may be related to a higher prevalence of atrophy and raises the possibility that H. pylori may be contributing to undernutrition in some older people...
  37. ncbi Prevalence and factors associated with failure of liver stiffness measurement using FibroScan in a prospective study of 2114 examinations
    Juliette Foucher
    , , , Pessac, France
    Eur J Gastroenterol Hepatol 18:411-2. 2006
    ..Other non-invasive methods such as biochemical methods or liver biopsy could therefore be used only in patients with failure of FibroScan examination...
  38. ncbi Paroxysmal nocturnal hemoglobinuria and Budd-Chiari syndrome: therapeutic challenge with bone marrow transplantation, transjugular intrahepatic portosystemic shunt, and vena cava stent
    Julien Vergniol
    , , CHU Bordeaux, France
    Eur J Gastroenterol Hepatol 17:453-6. 2005
    ..This case report confirms that TIPS is a good treatment for BCS, but stenosis of inferior vena cava can occur after such a treatment...