Research Topics
| L A Bruins SlotSummaryAffiliation: Centre de Recherche Pierre Fabre Country: France Publications
|
Detail Information
Publications
Effects of antipsychotics and reference monoaminergic ligands on marble burying behavior in miceLiesbeth A Bruins Slot
Department of Cellular and Molecular Biology bDivision of Neurobiology 2, Pierre Fabre Research Centre, Castres Cedex, France
Behav Pharmacol 19:145-52. 2008..Inhibition of marble burying behavior may result from the interplay of several receptor systems, including 5-HT2 receptor blockade, dopamine D2 partial agonism and serotonin 5-HT1A agonism...- Sign-reversal during persistent activation in mu-opioid signal transductionL A Bruins Slot
Centre de Recherche Pierre Fabre 17, avenue Jean Moulin, Castres Cedex, F81106, France
J Theor Biol 215:169-82. 2002..The findings indicate that with opioid signaling systems, transduction mechanisms operate that may cause the sign of the effect to reverse not only when activation is discontinued but also whilst it is maintained at a constant magnitude... - Experimental conditions for the continuous subcutaneous infusion of four central analgesics in ratsL A Bruins Slot
Centre de Recherche Pierre Fabre 17, avenue Jean Moulin, 81106 Castres Cedex, France
Pharmacol Biochem Behav 72:943-51. 2002..The conditions identified here appear appropriate for future studies of these four compounds in rat models of chronic pain and neuropathic allodynia... - Action of novel antipsychotics at human dopamine D3 receptors coupled to G protein and ERK1/2 activationLiesbeth A Bruins Slot
Department of Cellular and Molecular Biology, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres Cedex, France
Neuropharmacology 53:232-41. 2007..In summary, these findings underline the differences of dopamine D(3) properties of new generation antipsychotics which may need to be considered in understanding their diverse therapeutic actions... - Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinaseLiesbeth A Bruins Slot
Department of Cellular and Molecular Biology, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres Cedex, France
Eur J Pharmacol 534:63-70. 2006..Thus, antipsychotics display varying efficacies at serotonin 5-HT1A and dopamine D2S receptors which may play a major role in their differential functional profiles in blocking the diverse symptoms of schizophrenia... - Effects of novel antipsychotics with mixed D(2) antagonist/5-HT(1A) agonist properties on PCP-induced social interaction deficits in the ratLiesbeth A Bruins Slot
Department of Cellular and Molecular Biology, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, F 81106 Castres Cedex, France
Neuropharmacology 49:996-1006. 2005.... - Memory of an operant response and of depressed mood retained in activation states of 5-HT(1A) receptors: evidence from rodent modelsF C Colpaert
Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Cedex, Castres, France
Behav Brain Res 117:41-51. 2000..It is suggested that depression may in part be acquired in the course of ontogeny and may be available for retrieval in the same but not in other states; various biological rhythms conceivably define such states... - Opiate self-administration as a measure of chronic nociceptive pain in arthritic ratsF C Colpaert
Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Cedex, Castres, France
Pain 91:33-45. 2001..Paralleling patient-controlled analgesic drug intake, FSA offers a specific measure allowing the dynamic effects of neurobiological agents to be studied in this unique animal model of persistent nociceptive pain... - F15063, a potential antipsychotic with dopamine D(2)/D(3) receptor antagonist and 5-HT(1A) receptor agonist properties: influence on immediate-early gene expression in rat prefrontal cortex and striatumLiesbeth A Bruins Slot
Department of Cellular and Molecular Biology, Centre de Recherche Pierre Fabre, Castres Cedex, France
Eur J Pharmacol 620:27-35. 2009..Furthermore, the substantial F15063-induced expression of IEGs such as c-fos in striatum is not related to cataleptogenic activity and may act more as a marker of efficacious dopamine D(2) receptor blockade... - Ethanol state dependence involving a lever press response requirement in ratsL A Bruins Slot
Centre de Recherche Pierre Fabre, Castres, France
Behav Pharmacol 10:229-33. 1999..Extensive parametric studies are needed to unravel the apparently subtle conditions that govern the occurrence and features of the state dependence produced by various CNS compounds... - Evidence that mnesic states govern normal and disordered memoryF C Colpaert
Centre de Recherche Pierre Fabre, Castres Cedex, France
Behav Pharmacol 12:575-89. 2001..The changes of mnesic state that are likely associated with excessively labile cholinergic neurotransmission may conceivably cause the complex disabilities of Alzheimer's disease... - A persistent opioid-addiction state of memoryL A Bruins Slot
Centre de Recherche Pierre Fabre, Castres Cedex, France
Behav Pharmacol 14:167-71. 2003..Thus, because tolerance did not develop to the morphine state, an increasingly large body of engrams became encoded in that state, rendering retrieval increasingly dependent... - Tolerance and inverse tolerance to the hyperalgesic and analgesic actions, respectively, of the novel analgesic, F 13640Liesbeth A Bruins Slot
Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
Eur J Pharmacol 466:271-9. 2003..Producing the mirror opposite of morphine's neuroadaptive actions, F 13640 causes an analgesia that becomes more powerful with chronic administration, and this at the expense of the initial hyperalgesia which it may also produce... - Tacrine-scopolamine interactions on state-dependent retrievalLiesbeth A Bruins Slot
Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
Psychopharmacology (Berl) 166:33-9. 2003..The data may elucidate tacrine's limited therapeutic efficacy insofar as scopolamine's mnesic actions both model human pathology and are due to scopolamine producing state-dependence...