L Bardin

Summary

Affiliation: Centre de Recherche Pierre Fabre
Country: France

Publications

  1. ncbi The complex role of serotonin and 5-HT receptors in chronic pain
    Laurent Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Behav Pharmacol 22:390-404. 2011
  2. ncbi Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies
    L Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Behav Brain Res 205:360-6. 2009
  3. ncbi Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychotics
    Laurent Bardin
    Division of Neurobiology, Pierre Fabre Research Centre, Castres, France
    Behav Pharmacol 18:103-18. 2007
  4. ncbi Antipsychotic-like vs cataleptogenic actions in mice of novel antipsychotics having D2 antagonist and 5-HT1A agonist properties
    Laurent Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Neuropsychopharmacology 31:1869-79. 2006
  5. ncbi Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats
    L Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Neurosci Res 66:135-40. 2010
  6. ncbi Dual, hyperalgesic, and analgesic effects of the high-efficacy 5-hydroxytryptamine 1A (5-HT1A) agonist F 13640 [(3-chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, fumaric acid salt]: relationship
    Laurent Bardin
    Department of General Pharmacology, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    J Pharmacol Exp Ther 312:1034-42. 2005
  7. ncbi Role of spinal 5-HT(1A) receptors in morphine analgesia and tolerance in rats
    Laurent Bardin
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, Castres Cédex F 81106, France
    Eur J Pain 8:253-61. 2004
  8. ncbi Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain
    L Bardin
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres Cedex, France
    Pharmacology 67:182-94. 2003
  9. ncbi F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. II. Activity in models of positive symptoms of schizophrenia
    R Depoortere
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Br J Pharmacol 151:253-65. 2007
  10. ncbi Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia
    F C Colpaert
    Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres Cedex, France
    Neuropharmacology 43:945-58. 2002

Detail Information

Publications20

  1. ncbi The complex role of serotonin and 5-HT receptors in chronic pain
    Laurent Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Behav Pharmacol 22:390-404. 2011
    ....
  2. ncbi Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies
    L Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Behav Brain Res 205:360-6. 2009
    ....
  3. ncbi Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychotics
    Laurent Bardin
    Division of Neurobiology, Pierre Fabre Research Centre, Castres, France
    Behav Pharmacol 18:103-18. 2007
    ....
  4. ncbi Antipsychotic-like vs cataleptogenic actions in mice of novel antipsychotics having D2 antagonist and 5-HT1A agonist properties
    Laurent Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Neuropsychopharmacology 31:1869-79. 2006
    ..Further, they indicate that the balance of affinity and/or efficacy between D2 and 5-HT1A receptors profoundly influences their pharmacological activities, and will likely impact their therapeutic profiles...
  5. ncbi Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats
    L Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Neurosci Res 66:135-40. 2010
    ..To summarize, reduction of formalin-induced paw licking/late phase might constitute a useful indicator of potential activity against inflammatory/centrally sensitized pain, as might be expressed in fibromyalgia...
  6. ncbi Dual, hyperalgesic, and analgesic effects of the high-efficacy 5-hydroxytryptamine 1A (5-HT1A) agonist F 13640 [(3-chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, fumaric acid salt]: relationship
    Laurent Bardin
    Department of General Pharmacology, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    J Pharmacol Exp Ther 312:1034-42. 2005
    ..These results demonstrate that F 13640 induces hyperalgesia and/or analgesia with a time course that parallels the occupancy of 5-HT(1A) receptors and the presence of the compound in blood and brain...
  7. ncbi Role of spinal 5-HT(1A) receptors in morphine analgesia and tolerance in rats
    Laurent Bardin
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, Castres Cédex F 81106, France
    Eur J Pain 8:253-61. 2004
    ..These findings demonstrate that 5-HT(1A) receptor agonists can act in the spinal cord to produce both hyper- and hypo-algesic effects and play a major role in the opioid analgesia and tolerance...
  8. ncbi Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain
    L Bardin
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres Cedex, France
    Pharmacology 67:182-94. 2003
    ....
  9. ncbi F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. II. Activity in models of positive symptoms of schizophrenia
    R Depoortere
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Br J Pharmacol 151:253-65. 2007
    ..Here, the profile of F15063 was evaluated in models of positive symptoms of schizophrenia and motor side-effects...
  10. ncbi Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia
    F C Colpaert
    Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres Cedex, France
    Neuropharmacology 43:945-58. 2002
    ....
  11. ncbi In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia
    L Bardin
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Cedex, Castres, France
    Eur J Pharmacol 421:109-14. 2001
    ..e., forepaw treading) of the 5-HT syndrome which 8-OH-DPAT also induces...
  12. ncbi The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain
    Ivan Kiss
    , Intensivmedizin und Schmerztherapie, Alfried Krupp Krankenhaus, 45117 Essen, Germany
    Eur J Pharmacol 523:29-39. 2005
    ..Unlike the opioid, remifentanil, F 13640 caused no hyperalgesia with ongoing postoperative pain, and should remain effective with protracted postoperative use...
  13. ncbi F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. III. Activity in models of cognition and negative symptoms
    R Depoortere
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Br J Pharmacol 151:266-77. 2007
    ..However F15063 induced neither catalepsy nor the 'serotonin syndrome'. Here, we evaluated its profile in rat models predictive of efficacy against negative symptoms/cognitive deficits of schizophrenia...
  14. ncbi 5-HT1A receptors are involved in the effects of xaliproden on G-protein activation, neurotransmitter release and nociception
    J C Martel
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Br J Pharmacol 158:232-42. 2009
    ..The present study investigated its profile on in vitro transduction, neurochemical responses and acute nociceptive pain tests in rats...
  15. ncbi Effects of antipsychotics and reference monoaminergic ligands on marble burying behavior in mice
    Liesbeth A Bruins Slot
    Department of Cellular and Molecular Biology bDivision of Neurobiology 2, Pierre Fabre Research Centre, Castres Cedex, France
    Behav Pharmacol 19:145-52. 2008
    ..Inhibition of marble burying behavior may result from the interplay of several receptor systems, including 5-HT2 receptor blockade, dopamine D2 partial agonism and serotonin 5-HT1A agonism...
  16. ncbi The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063
    Marie Bernadette Assié
    Neurobiology II Division, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    Eur J Pharmacol 592:160-6. 2008
    ....
  17. ncbi Apomorphine-induced emesis in dogs: differential sensitivity to established and novel dopamine D2/5-HT(1A) antipsychotic compounds
    Ronan Depoortere
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Eur J Pharmacol 597:34-8. 2008
    ..This model can thus be advantageously used to investigate the pharmacological activity of novel D2 receptor antagonists/partial agonists in dogs...
  18. ncbi Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors
    Ronan Depoortere
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Behav Pharmacol 20:303-11. 2009
    ..5 mg/kg). The present data do not support a major implication of either DA D3 or D4 receptors in the control of PE and YA in rats, but indicate a preponderant role of DA D2 receptors...
  19. ncbi F15599, a preferential post-synaptic 5-HT1A receptor agonist: activity in models of cognition in comparison with reference 5-HT1A receptor agonists
    Ronan Depoortere
    Neurobiology 2 Division, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Eur Neuropsychopharmacol 20:641-54. 2010
    ..This suggests that preferential activation of post-synaptic 5-HT(1A) receptors could prove useful in pathologies characterized by cognitive/memory deficiencies, such as schizophrenia and depression...
  20. ncbi F15063, a potential antipsychotic with dopamine D(2)/D(3) antagonist, 5-HT(1A) agonist and D(4) partial agonist properties: (IV) duration of brain D2-like receptor occupancy and antipsychotic-like activity versus plasma concentration in mice
    Marie Bernadette Assié
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cedex, France
    Naunyn Schmiedebergs Arch Pharmacol 375:241-50. 2007
    ..In addition, the durations of action of F15063 and haloperidol in a behavioural model of antipsychotic-like activity were closely correlated to their occupancy of central D2-like receptors, and much longer than their presence in plasma...