Research Topics
| Pierre AsfarSummaryAffiliation: Centre Hospitalier Universitaire Country: France Publications
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Detail Information
Publications
Bench-to-bedside review: circulating microparticles--a new player in sepsis?Ferhat Meziani
Service de Reanimation Medicale, Nouvel Hopital Civil, Hopitaux Universitaires de Strasbourg, F 67091 Strasbourg, France
Crit Care 14:236. 2010..Microparticles' abilities are of increasing interest in deciphering the mechanisms underlying the multiple organ dysfunction of septic shock...- Vasopressin in vasodilatory shock: is the heart in danger?Balázs Hauser
Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
Crit Care 12:132. 2008.... - Comparison of cardiac, hepatic, and renal effects of arginine vasopressin and noradrenaline during porcine fecal peritonitis: a randomized controlled trialFlorian Simon
Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik fur Anasthesiologie, Universitatsklinikum, Steinhovelstrasse 9, 89075 Ulm, Germany
Crit Care 13:R113. 2009..Therefore, we tested the hypothesis whether low-dose AVP is safe with respect to liver, kidney, and heart function and organ injury during resuscitated septic shock... - Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical careFlorian Wagner
Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik für Anästehsiologie, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
Crit Care 13:213. 2009.... - Vasopressin and ischaemic heart disease: more than coronary vasoconstriction?Pierre Asfar
Laboratoire HIFIH UPRES EA 3859, IFR 132, Universite d Angers, Département de Réanimation Médicale et Médecine Hyperbare, Centre Hospitalier Universitaire, 49933 Angers cedex 09, France
Crit Care 13:169. 2009..Consequently, the authors conclude that the use of AVP should be cautioned in patients with underlying cardiac disease... - Impact of vasopressin analogues on the gut mucosal microcirculationPierre Asfar
Laboratoire HIFIH, UPRES EA 3859, IFR 132, Universite d Angers, France
Best Pract Res Clin Anaesthesiol 22:351-8. 2008..Thus, the absence of clinically harmful effect does not exclude covert splanchnic ischaemia, which may counterbalance the beneficial systemic effects... - Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in ratsFrédérique Ganster
Laboratoire HIFIH, UPRES EA 3859, IFR 132, Universite d Angers, Rue Haute de Reculee, Angers, F 49035 France
Crit Care 14:R165. 2010.... - Clinical review: influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shockPierre Asfar
, Centre Hospitalier Universitaire, Angers, France
Crit Care 8:170-9. 2004.... - Catecholamines and vasopressin during critical illnessPierre Asfar
, Centre Hospitalier Universitaire, 4 rue Larry, 49993 Angers Cedex 9, France
Crit Care Clin 22:131-49, vii-viii. 2006..Although the evidence supporting the use of low doses of vasopressin or its analogs in vasodilatory shock is increasing, lack of data regarding mortality and morbidity prevent their implementation in critical care protocols... - Circulating microparticles from septic shock patients exert differential tissue expression of enzymes related to inflammation and oxidative stressMaria Letizia Mastronardi
INSERM, U694, Universite d Angers, Angers, France
Crit Care Med 39:1739-48. 2011..Here, we have investigated the effects of in vivo injection of microparticles from nonseptic or septic subjects on protein expression in mouse tissues... - Percutaneous radiologic gastrostomy versus nasogastric tube in critically ill patientsPierre Marie Roy
Emergency Department, Angers University Hospital, 4 rue Larrey, Angers 49033, France
Clin Nutr 24:321-5. 2005..To examine the feasibility of percutaneous radiologic gastrostomy in critically ill patients and to assess the rates of complications, esophagitis and gastroesophageal reflux when compared with nasogastric tube... - The effects of vasopressin and its analogues on the liver and its disorders in the critically illPierre Asfar
aLaboratoire HIFIH, UPRES EA 3859, IFR 132, Universite d Angers, PRES UNAM, France bDépartement de Réanimation Médicale et de Médecine Hyperbare, Centre Hospitalier Universitaire, Angers, France cSektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Klinik fur Anasthesiologie, Universitatsklinikum, Ulm, Germany dService des maladies du foie et de l appareil digestif, Centre Hospitalier Universitaire, Angers, France
Curr Opin Crit Care 16:148-52. 2010..In this review, we summarize the effects of these drugs on splanchnic hemodynamics and organ function... - Low-dose terlipressin improves systemic and splanchnic hemodynamics in fluid-challenged endotoxic ratsPierre Asfar
Laboratoire HIFIH, , France
Crit Care Med 31:215-20. 2003..CONCLUSION: Low-dose terlipressin in fluid-challenged endotoxic rats improved systemic and splanchnic hemodynamics and improved the ileal microcirculation... - Detrimental hemodynamic and inflammatory effects of microparticles originating from septic ratsSatar Mortaza
Laboratoire HIFIH UPRES EA 3859, Universite d Angers, Angers, France
Crit Care Med 37:2045-50. 2009..This study was designed to assess the effects of MPs from septic origin on the systemic hemodynamics as well as on the inflammatory, oxidative, and nitrosative stresses... - Vasopressin in vasodilatory shock: hemodynamic stabilization at the cost of the liver and the kidney?Hendrik Bracht
Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
Crit Care 11:178. 2007..Nevertheless, the findings reported by Krejci and colleagues need to be discussed in the context of the model design, the timing and dosing of AVP as well as the complex interaction between visceral organ perfusion and function... - Adenosine triphosphate-magnesium chloride: relevance for intensive careMarek Nalos
, , Ulm, Germany
Intensive Care Med 29:10-8. 2003.... - Low-dose terlipressin during long-term hyperdynamic porcine endotoxemia: effects on hepatosplanchnic perfusion, oxygen exchange, and metabolismPierre Asfar
, Ulm, Germany
Crit Care Med 33:373-80. 2005..The marked terlipressin-induced hyperlactatemia did not originate from the hepatosplanchnic organs but from extrasplanchnic tissues, possibly muscle and skin... - Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemiaAntje Pittner
, , Parkstrasse 11, 89073 Ulm, Germany
Intensive Care Med 29:312-6. 2003.... - Terlipressin in chronic hyperdynamic endotoxic shock: is it safe?Pierre Asfar
Intensive Care Med 29:154-5. 2003 - Discrepancies between perceptions by physicians and nursing staff of intensive care unit end-of-life decisionsEdouard Ferrand
Unité de Réanimation Chirurgicale et Traumatologique, Service d Anesthesie Reanimation, Hopital Henri Mondor, AP HP, 51 rue du Mal de Lattre de Tassigny, 94010 Creteil Cedex, France
Am J Respir Crit Care Med 167:1310-5. 2003..Recommendations and legislation may help to build consensus and avoid conflicts among caregivers at each step of the decision-making process... - Time out for vasopressors in increased microvascular permeability?Pierre Asfar
Intensive Care Med 33:2045-7. 2007 - Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trialJean Chastre
, , AP-HP, Paris, France
JAMA 290:2588-98. 2003..The 8-day group had less antibiotic use... - Adenosine triphosphate-magnesium dichloride during hyperdynamic porcine endotoxemia: effects on hepatosplanchnic oxygen exchange and metabolismPierre Asfar
, , Ulm, Germany
Crit Care Med 30:1826-33. 2002..Furthermore, it allowed blunting of the continuous decrease in hepatic lactate clearance, thus preserving the metabolic coupling between lactate release from the intestine and lactate utilization by the liver...