Research Topics
| Valentine BouetSummaryCountry: France Publications
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Detail Information
Publications
Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatmentValentine Bouet
Groupe Mémoire et Plasticité Comportementale GMPc, Universite de Caen Basse Normandie, EA 4259, Caen, 14032, France
Psychopharmacology (Berl) 221:329-39. 2012..Limited data are, however, available on their effects on brain development and their efficacy remains debated. Moreover, previous experimental studies are seriously hampered in their clinical relevance...
Effect of pre- versus post-weaning environmental disturbances on social behaviour in miceValentine Bouet
GMPC, Groupe Mémoire et Plasticité comportementale, Universite de Caen Basse Normandie, 5, rue Vaubénard, 14032 Caen Cedex, France
Neurosci Lett 488:221-4. 2011..Of note, social withdrawal was observed in both models suggesting that this aspect needs to be better considered in future studies, particularly in testing new treatments for schizophrenia...
Predicting sensorimotor and memory deficits after neonatal ischemic stroke with reperfusion in the ratValentine Bouet
GMPC, EA4259 Memory and Behavioural Plasticity Group, University of Caen Basse Normandie, Caen, France
Behav Brain Res 212:56-63. 2010..Based on these results, we propose here a selection of behavioural tests that should constitute meaningful tools for assessing sensory and cognitive functions after experimental neonatal ischemic stroke...
Maternal hypertension during pregnancy modifies the response of the immature brain to hypoxia-ischemia: sequential MRI and behavioral investigationsAnnelise Letourneur
CERVOxy team Hypoxia and cerebrovascular pathophysiology, UMR CI NAPS 6232, CNRS, CEA, Universite de Caen Basse Normandie, Centre Cyceron, Bd Henri Becquerel, BP5229, 14074 Caen Cedex, France
Exp Neurol 233:264-72. 2012..The data suggest that maternal hypertension causes prenatal stress that may render the immature brain more resistant to subsequent hypoxia-ischemia, related to a preconditioning phenomenon...
Behavioral deficits after distal focal cerebral ischemia in mice: Usefulness of adhesive removal testThomas Freret
UPRES EA 4259, Groupe Mémoire et Plasticité Comportementale GMPc, Universite de Caen Basse Normandie, UFR de Sciences Pharmaceutiques, Caen, France
Behav Neurosci 123:224-30. 2009..This result suggests therefore that this mouse model of ischemia is relevant to efficiently assess therapeutic strategies with histological but also behavioral analysis, provided that relevant tests are used...
The adhesive removal test: a sensitive method to assess sensorimotor deficits in miceValentine Bouet
Groupe Mémoire et Plasticité comportementale, Universite de Caen Basse Normandie, Caen, France
Nat Protoc 4:1560-4. 2009..To decrease interindividual differences, we recommend a training session (1 week, 1 trial per day) before surgical procedures so that mice to reach optimal performances...
Comparison of the effects of erythropoietin and its carbamylated derivative on behaviour and hippocampal neurogenesis in miceClaire Leconte
CERVOxy team Hypoxia and cerebrovascular pathophysiology, UMR 6232 CI NAPS, Universite de Caen Basse Normandie, Universite Paris Descartes, CNRS, CEA, Centre Cyceron, 14074 Caen, France
Neuropharmacology 60:354-64. 2011..These results suggest that CEPO is as an attractive molecule for the treatment of neuropsychiatric diseases associating memory and/or emotional disorders...
Long-term evaluation of sensorimotor and mnesic behaviour following striatal NMDA-induced unilateral excitotoxic lesion in the mouseBenoit Haelewyn
CNRS UMR 6185 CYCERON, University of Caen Basse Normandie, BP 5229, Bd H Becquerel, F 14074 Caen cedex, France
Behav Brain Res 178:235-43. 2007..Moreover, this study shows the importance of the sham group to investigate the behavioural deficits after excitotoxic lesion models in mice...
Intraluminal thread model of focal stroke in the non-human primateThomas Freret
University of Caen, CNRS UMR 6185, Cyceron, Caen, France
J Cereb Blood Flow Metab 28:786-96. 2008..This model could be suitable as an advanced screening for potential stroke therapies in which behavioural, imaging, and histologic analyses can be compared...
Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouseValentine Bouet
UMR 6185 CNRS, Neurodegenerescence models and therapeutic strategies, University of Caen Basse Normandie, Cyceron, Bd H Becquerel BP 5229, F 14074 Caen cedex, France
Exp Neurol 203:555-67. 2007....
Environmental enrichment improves recent but not remote memory in association with a modified brain metabolic activation profile in adult miceMarianne Leger
Universite de Caen Basse Normandie, Groupe Mémoire et Plasticité Comportementale GMPc, EA 4259, F 14032, Caen, France
Behav Brain Res 228:22-9. 2012..EC did not improve remote memory, and globally decreased CO activity. Our findings suggest the involvement of regions of pivotal importance during recent memory, such as the frontal cortex, in the beneficial effects of EC...
On the importance of long-term functional assessment after stroke to improve translation from bench to bedsideThomas Freret
GMPc Groupe Mémoire et Plasticité comportementale, EA4259, Universite de Caen Basse Normandie, Caen, France
Exp Transl Stroke Med 3:6. 2011..And since the ultimate goal of any stroke therapy is the restoration of normal function, an objective appraisal of the behavioral deficits should be done...
The effects of DHEA, 3beta-hydroxy-5alpha-androstane-6,17-dione, and 7-amino-DHEA analogues on short term and long term memory in the mouseMarc Antoine Bazin
Centre d Etudes et de Recherche sur le Medicament de Normandie, UFR des Sciences Pharmaceutiques, Boulevard Becquerel, 14032 Caen Cedex, France
Steroids 74:931-7. 2009..Moreover, data indicated that pharmacological modulation of DHEA as performed in this study provides derivatives giving the same mnemonic profile than reference molecule...
Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animalsValentine Bouet
GMPC, Groupe Mémoire et Plasticité comportementale, Caen, France
Mech Ageing Dev 132:240-8. 2011..Effects of 3-month continuous environmental enrichment (EE) on cognitive abilities and on theta burst-related synaptic plasticity of CA1 hippocampal neuronal networks have been assessed in 6- and 20-month old NMRI female mice...
