Research Topics
Genomes and GenesSpecies | B BorgheseSummaryCountry: France Publications
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Publications
[Endometriosis and genetics: what responsibility for the genes?]B Borghese
Service de gynécologie obstétrique 2 et médecine de la reproduction, Centre Hospitalier Universitaire Cochin Saint Vincent de Paul, Groupe Hospitalier Universitaire Ouest, AP HP, Universite Paris Descartes, 74 82, avenue Denfert Rochereau, 75014 Paris, France
J Gynecol Obstet Biol Reprod (Paris) 39:196-207. 2010..These alterations, possibly occurring during the embryonic life through epigenetic and genetic predisposition, could lead to an earlier and non-invasive diagnosis for endometriosis...
[Neurotrophins and pain in endometriosis]B Borghese
Institut Cochin, CNRS UMR 8104, Universite Paris Descartes, Paris, France
Gynecol Obstet Fertil 38:442-6. 2010....
Research resource: genome-wide profiling of methylated promoters in endometriosis reveals a subtelomeric location of hypermethylationBruno Borghese
département génétique et développement, Institut Cochin, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
Mol Endocrinol 24:1872-85. 2010..We postulated that this original observation might participate to the chromosomal stability and protect the endometriotic lesion against malignancy...
Gene expression profile for ectopic versus eutopic endometrium provides new insights into endometriosis oncogenic potentialBruno Borghese
Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Paris, France
Mol Endocrinol 22:2557-62. 2008..The study constitutes a noteworthy update of gene profiling in endometriosis, by delivering the most complete and reliable list of dysregulated genes to date...
Absence of association between a functional polymorphism of ALOX15 gene and infertility in endometriosisBruno Borghese
Service de Gynécologie Obstétrique II et Médecine de la Reproduction, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, CHU Cochin Saint Vincent de Paul, Paris, France
Fertil Steril 91:1414-6. 2009..In our study population, ALOX15 -292 C/T was not correlated either with the risk of developing an endometriosis or with the risk of infertility...
Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progressionBruno Borghese
Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Service de Gynécologie Obstétrique II, CHU Cochin Saint Vincent de Paul, Paris, France
Hum Reprod 23:1207-13. 2008..Matrix metalloproteinases (MMPs) may contribute to endometriosis. We tested whether eight functional polymorphisms of these genes could modify the risk of endometriosis...
Infertility and endometriosis: a need for global management that optimizes the indications for surgery and ARTD DE Ziegler
Department of Obstetrics and Gynecology and Reproductive Medicine, Paris Descartes University, Assistance Publique Hopitaux de Paris, CHU Cochin, Paris, France
Minerva Ginecol 63:365-73. 2011..These latter precautions prevent the adverse outcome reported in case of pre-ART use of OC when ovarian stimulation is conducted using r-FSH exclusively...
[How does peritoneal fluid flow influence anatomical distribution of endometriotic lesions?]A Bricou
Clinique Universitaire Baudelocque, CHU Cochin Saint Vincent de Paul, Assistance Publique Hopitaux de Paris AP HP, Universite Paris Descartes, 123, boulevard de Port Royal, 75014 Paris, France
Gynecol Obstet Fertil 37:325-33. 2009..The similar asymmetric distribution for all types of endometriosis (superficial lesions, ovarian endometriosis cyst, deep endometriosis) is an argument in favor of a unique origin for the different types of lesions...
Smoking habits of 411 women with histologically proven endometriosis and 567 unaffected womenCharles Chapron
Service de Gynécologie Obstétrique II et Médecine de la Reproduction, Centre Hospitalier Universitaire Cochin Saint Vincent de Paul, Groupe Hospitalier Universitaire Ouest, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Fertil Steril 94:2353-5. 2010....
Endometriosis and infertility: pathophysiology and managementDominique DE Ziegler
Universite Paris Descartes, Centre Hospitalier Universitaire Cochin, Service de Gynécologie Obstétrique II et Médecine de la Reproduction, Paris, France
Lancet 376:730-8. 2010..Weighing up the relative advantages of surgery, medical treatment and ART are the foundations for a global approach to infertility associated with endometriosis...
Complete surgery for low rectal endometriosis: long-term results of a 100-case prospective studyBertrand Dousset
Department of Digestive and Endocrine Surgery, University Hospital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Ann Surg 251:887-95. 2010....
Surgery for bladder endometriosis: long-term results and concomitant management of associated posterior deep lesionsCharles Chapron
Department of Gynecology, Obstetrics II and Reproductive Medicine, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Universitaire Ouest, Centre Hospitalier Universitaire Cochin, Saint Vincent de Paul, Pavillon Lelong, 82 avenue Denfert Rochereau, 75014 Paris, France
Hum Reprod 25:884-9. 2010..The objectives of this study are to evaluate the rate of recurrence after partial cystectomy for patients presenting with bladder DIE and to outline the surgical modalities for handling associated posterior DIE nodules...
Severe ureteral endometriosis: the intrinsic type is not so rare after complete surgical exeresis of deep endometriotic lesionsCharles Chapron
Department of Obstetrics and Gynecology II and Reproductive Medicine, Universite Paris Descartes, Assistance Publique, Hopitaux de Paris AP HP, Groupe Hospitalier Universitaire GHU Ouest, Centre Hospitalier Universitaire CHU Cochin Saint Vincent de Paul, Paris, France
Fertil Steril 93:2115-20. 2010..To evaluate the rate of intrinsic ureteral endometriosis in patients presenting with severe ureteral endometriosis...
Preoperative work-up for patients with deeply infiltrating endometriosis: transvaginal ultrasonography must definitely be the first-line imaging examinationMathilde Piketty
Department of Gynecology, Obstetrics II and Reproductive Medicine, Universite Paris Descartes, Paris, France
Hum Reprod 24:602-7. 2009..We compared the accuracy of TVUS and TRUS for diagnosing rectal wall involvement in patients presenting with histologically proved deeply infiltrating endometriosis (DIE)...
Associated ovarian endometrioma is a marker for greater severity of deeply infiltrating endometriosisCharles Chapron
Université Paris Descartes V, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Universitaire Ouest, CHU Cochin, Service de Gynécologie Obstétrique II et Médecine de la Reproduction, Paris, France
Fertil Steril 92:453-7. 2009..To investigate whether an associated ovarian endometrioma is a marker for severity of deep infiltrating endometriosis (DIE)...
Relation between severity of dysmenorrhea and endometriomaNicolas Chopin
, Paris V, Paris, France
Acta Obstet Gynecol Scand 85:1375-80. 2006..The associated deep infiltrating endometriotic lesions and in particular rectal infiltration could explain these symptoms...
Deeply infiltrating endometriosis: pathogenetic implications of the anatomical distributionCharles Chapron
Service de Gynécologie Obstérique II, Unité de chirurgie gynécologique, Institut Cochin, IFR, Universite Paris V, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Universitaire Ouest, France
Hum Reprod 21:1839-45. 2006..To investigate whether knowledge of the anatomical distribution of histologically proven deeply infiltrating endometriosis (DIE) lesions contributes to understanding the pathogenesis...
Operative management of deeply infiltrating endometriosis: results on pelvic pain symptoms according to a surgical classificationNicolas Chopin
Assistance Publique, Hopitaux de Paris, , , CHU Cochin Port-Royal, Paris, France
J Minim Invasive Gynecol 12:106-12. 2005..These results are observed whatever the main location of DIE lesions. The patients' preoperative characteristics have no significant influence on the result...
Surgical management of deeply infiltrating endometriosis: an updateCharles Chapron
Service de Chirurgie Gynecologique, Unité de Chirurgie, Clinique Universitaire Baudelocque, 123, boulevard Port Royal, CHU Cochin Saint Vincent de Paul, 75014 Paris, France
Ann N Y Acad Sci 1034:326-37. 2004..Further studies are needed to specify the place and modalities of medical treatments preoperatively and postoperatively...
