B Autran

Summary

Country: France

Publications

  1. ncbi Reconstitution of CD4+ T lymphocytes in HIV-infected individuals following antiretroviral therapy
    G Carcelain
    Laboratoire d'Immunologie Cellulaire et Tissulaire, , , , 75013, Paris, France
    Curr Opin Immunol 13:483-8. 2001
  2. ncbi Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    B Autran
    Laboratoire d Immunologie Cellulaire, URA CNRS 625, Hopital Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris, France
    Science 277:112-6. 1997
  3. ncbi T cell changes after combined nucleoside analogue therapy in HIV primary infection
    G Carcelain
    Laboratoire d Immunologie Cellulaire, CNRS UMR 7527, Hopital Pitie Salpetriere, Paris, France
    AIDS 13:1077-81. 1999
  4. ncbi Cell-mediated suppression of HIV-specific cytotoxic T lymphocytes
    P Joly
    Laboratoire d Immunologie Cellulaire et Tissulaire, UA CNRS 0186, Paris, France
    J Immunol 143:2193-201. 1989
  5. ncbi Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
    G Gorochov
    Laboratoire d Immunologie Cellulaire, CERVI, URA CNRS 625, Hopital Pitie Salpetriere, Paris, France
    Nat Med 4:215-21. 1998
  6. ncbi Markov modelling of changes in HIV-specific cytotoxic T-lymphocyte responses with time in untreated HIV-1 infected patients
    I Kousignian
    INSERM, EMI 0214, Hopital Pitie Salpetriere, Paris, France
    Stat Med 22:1675-90. 2003
  7. ncbi Dynamics of viral variants in HIV-1 Nef and specific cytotoxic T lymphocytes in vivo
    G Haas
    Laboratory of Cellular and Tissue Immunology, Hospital Pitié Salpêtrière, Paris, France
    J Immunol 157:4212-21. 1996
  8. ncbi Dynamics of HIV variants and specific cytotoxic T-cell recognition in nonprogressors and progressors
    G Haas
    Laboratoire d Immunologie Cellulaire et Tissulaire, URA CNRS 625, Hopital Pitie Salpetriere, Paris, France
    Immunol Lett 57:63-8. 1997
  9. ncbi T cell receptor gamma/delta+ lymphocyte subsets during HIV infection
    B Autran
    Laboratoire d Immunologie Cellulaire et Tissulaire, Hopital Pitie Salpetriere, Paris, France
    Clin Exp Immunol 75:206-10. 1989
  10. ncbi HIV-1 infection of lung alveolar fibroblasts and macrophages in humans
    F Plata
    , Institut Pasteur, Paris, France
    AIDS Res Hum Retroviruses 6:979-86. 1990

Detail Information

Publications29

  1. ncbi Reconstitution of CD4+ T lymphocytes in HIV-infected individuals following antiretroviral therapy
    G Carcelain
    Laboratoire d'Immunologie Cellulaire et Tissulaire, , , , 75013, Paris, France
    Curr Opin Immunol 13:483-8. 2001
    ..The optimism that has been raised by the restoration of hosts' defenses against opportunistic pathogens is, however, balanced by the poor immunity restored against HIV; thus, innovative immune interventions are required...
  2. ncbi Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    B Autran
    Laboratoire d Immunologie Cellulaire, URA CNRS 625, Hopital Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris, France
    Science 277:112-6. 1997
    ..Thus, decreasing the HIV load can reverse HIV-driven activation and CD4(+) T cell defects in advanced HIV-infected patients...
  3. ncbi T cell changes after combined nucleoside analogue therapy in HIV primary infection
    G Carcelain
    Laboratoire d Immunologie Cellulaire, CNRS UMR 7527, Hopital Pitie Salpetriere, Paris, France
    AIDS 13:1077-81. 1999
    ..To characterize the immune changes after treatment of acute HIV-1 infection with triple nucleoside analogue therapy...
  4. ncbi Cell-mediated suppression of HIV-specific cytotoxic T lymphocytes
    P Joly
    Laboratoire d Immunologie Cellulaire et Tissulaire, UA CNRS 0186, Paris, France
    J Immunol 143:2193-201. 1989
    ..They displayed the CD3, CD8, and HNK1 markers, were CD4 and CD16 negative, and lacked NK activity. The presence of Ts cells at late stages of HIV disease could thus partly explain the inefficiency of host defenses against HIV...
  5. ncbi Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
    G Gorochov
    Laboratoire d Immunologie Cellulaire, CERVI, URA CNRS 625, Hopital Pitie Salpetriere, Paris, France
    Nat Med 4:215-21. 1998
    ..These results indicate that, besides CD4+ cell count rise, an efficient control of HIV replication may allow qualitative modifications of the CD4+ repertoire balance...
  6. ncbi Markov modelling of changes in HIV-specific cytotoxic T-lymphocyte responses with time in untreated HIV-1 infected patients
    I Kousignian
    INSERM, EMI 0214, Hopital Pitie Salpetriere, Paris, France
    Stat Med 22:1675-90. 2003
    ..Indeed, these patients' T cytotoxic responses were characterized by marked individual turnover and a gradual loss of multiple protein recognition over time, this loss accelerating as viral load increased...
  7. ncbi Dynamics of viral variants in HIV-1 Nef and specific cytotoxic T lymphocytes in vivo
    G Haas
    Laboratory of Cellular and Tissue Immunology, Hospital Pitié Salpêtrière, Paris, France
    J Immunol 157:4212-21. 1996
    ..Therefore, a remarkable flexibility of the immune system allows constant adaptation of CTL to multiple HIV variants and thus elimination of HIV variant-producing cells in slow progressors...
  8. ncbi Dynamics of HIV variants and specific cytotoxic T-cell recognition in nonprogressors and progressors
    G Haas
    Laboratoire d Immunologie Cellulaire et Tissulaire, URA CNRS 625, Hopital Pitie Salpetriere, Paris, France
    Immunol Lett 57:63-8. 1997
    ....
  9. ncbi T cell receptor gamma/delta+ lymphocyte subsets during HIV infection
    B Autran
    Laboratoire d Immunologie Cellulaire et Tissulaire, Hopital Pitie Salpetriere, Paris, France
    Clin Exp Immunol 75:206-10. 1989
    ..Altogether, those data suggest a conservation of the Ti-gamma A+ subset during HIV infection, contrasting with an increase of the delta-TcS1+, Ti-gamma A- fraction in some cases...
  10. ncbi HIV-1 infection of lung alveolar fibroblasts and macrophages in humans
    F Plata
    , Institut Pasteur, Paris, France
    AIDS Res Hum Retroviruses 6:979-86. 1990
    ..Alveolar macrophages and fibroblasts thus may act as eventual HIV-1 reservoirs in vivo, and are probably involved in the induction of inflammatory reactions because they are targets for CD8 cytotoxic T lymphocytes (CTL)...
  11. ncbi Effects of antiretroviral therapy on immune reconstitution
    B Autran
    Laboratoire d Immunologie Cellulaire et Tissulaire, , Paris, France
    Antivir Ther 4:3-6. 1999
    ..These findings suggest that long-term immune recovery is feasible when HAART is given during chronic infection and might require immune intervention in addition to stable virus control...
  12. ncbi Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway
    D Cefai
    Laboratoire d Immunologie Cellulaire et Tissulaire, Group Hospitalier GH Pitié Salpétrière, Paris, France
    J Clin Invest 86:2117-24. 1990
    ....
  13. ncbi Anti-PGL-Tb1 responses as an indicator of the immune restoration syndrome in HIV-TB patients
    N Simonney
    EA3510, UFR Denis Diderot, Université Paris VII et Service de Microbiologie, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, CIB HOG, Paris, France
    Tuberculosis (Edinb) 88:453-61. 2008
    ....
  14. ncbi Acquired constitutive expression of interferon beta after gene transduction enhances human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity by a RANTES-dependent mechanism
    F Hadida
    Laboratoire d Immunologie Cellulaire, UMR 7627 CNRS, Hopital Pitie Salpetriere, Paris, France
    Hum Gene Ther 10:1803-10. 1999
    ..The efficient elimination of HIV-infected cells by IFN-beta-transduced CTL lines makes this gene therapy approach an attractive treatment for AIDS...
  15. ncbi Discontinuation of maintenance therapy for cytomegalovirus retinitis in HIV-infected patients receiving highly active antiretroviral therapy
    M Jouan
    Department of Infectious Diseases, , Paris, France
    AIDS 15:23-31. 2001
    ..CONCLUSIONS: CMV retinitis maintenance therapy may be safely discontinued in patients with CD4 cell counts above 75 x 10(6) cells/l who have been taking HAART for at least 18 months...
  16. ncbi Re-occurrence of HIV-1 drug mutations after treatment re-initiation following interruption in patients with multiple treatment failure
    C Delaugerre
    Department of Virology, , Paris, France
    AIDS 15:2189-91. 2001
    ..The outgrowth of residual wild-type virus seems not to be a true genetic reversion because drug mutations are detected rapidly at salvage therapy re-initiation...
  17. ncbi HIV-specific effector cytotoxic T lymphocytes and HIV-producing cells colocalize in white pulps and germinal centers from infected patients
    A Hosmalin
    Unité INSERM 445, Institut Cochin de Genetique Moleculaire, Paris, France
    Blood 97:2695-701. 2001
    ..This colocalization indicates that viral replication in immunocompetent structures of secondary lymphoid organs triggers anti-HIV effector CTLs to these particular locations, providing clues to target therapeutic intervention...
  18. ncbi Single-nucleotide polymorphism-defined class I and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection
    J Guergnon
    INSERM UMR S 945, Paris, France
    J Infect Dis 205:718-24. 2012
    ..The MHC LTNP-associated SNPs are ordered in ?4 linkage disequilibrium blocks; interestingly, an MHC class III linkage disequilibrium block (defined by the rs9368699 SNP) seems specific to the LTNP phenotype...
  19. ncbi Investigation of human spleen dendritic cell phenotype and distribution reveals evidence of in vivo activation in a subset of organ donors
    D McIlroy
    Laboratoire d Immunologie Cellulaire et Tissulaire URA CNRS 625, Service d Urologie, Hopital de la Pitie Salpetriere, Paris, France
    Blood 97:3470-7. 2001
    ..This activation of spleen DCs in vivo was reminiscent of the effects of experimental microbial product injection in mice, and it seemed to correlate with bacterial infection or multiple trauma. (Blood. 2001;97:3470-3477)..
  20. ncbi Evaluation of the interlaboratory concordance in quantification of human immunodeficiency virus-specific T cells with a gamma interferon enzyme-linked immunospot assay
    A Samri
    Laboratoire d'Immunologie Cellulaire et Tissulaire, AP-HP, , INSERM UMR S 543, , Paris 6, Paris, France
    Clin Vaccine Immunol 13:684-97. 2006
    ..Nonetheless, a single set of standard operating procedures should be used in multicenter trials to improve standardization...
  21. ncbi Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1
    S Faure
    Laboratoire d Immunologie Cellulaire et Tissulaire, Centre National de la Recherche Scientifique UMR 7627, Hopital Pitie Salpetriere, Paris, France
    Science 287:2274-7. 2000
    ..Functional CX3CR1 analysis showed that fractalkine binding is reduced among patients homozygous for this particular haplotype. Thus, CX3CR1-I249 M280 is a recessive genetic risk factor in HIV/AIDS...
  22. ncbi Role of treatment for depressive symptoms in relieving the impact of fatigue in HIV-HCV co-infected patients: ANRS Co13 Hepavih, France, 2006-2008
    L Michel
    INSERM U669, Paris, France
    J Viral Hepat 17:650-60. 2010
    ....
  23. ncbi Pulmonary infections associated with systemic capillary leak syndrome attacks in a patient with hypogammaglobulinemia
    K Lassoued
    Service d immuno hématologie, Hopital Saint Louis, Paris, France
    Intensive Care Med 24:981-3. 1998
    ..Both infections and attacks were successfully prevented by i.v. gammaglobulin replacement. Further evaluation is needed to assess the efficacy of i.v. gammaglobulins in patients with SCLS but without hypogammaglobulinemia...
  24. ncbi Human trophoblast cells express CD4 and are permissive for productive infection with HIV-1
    F J David
    Clinique Universitaire Baudelocque, Paris, France
    Clin Exp Immunol 88:10-6. 1992
    ..This suggests a crucial role of the CD4 receptor but an additional way of entry cannot be excluded. Such an in vitro model may be suitable for further studies concerning placental HIV transmission and its prevention...
  25. ncbi [Risk of smallpox, vaccination, bioterrorism]
    P Bossi
    Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier, Pitie Salpetriere, 47 83, Bd de l Hopital, 75013 Paris, France
    Presse Med 34:177-184. 2005
    ....
  26. ncbi Bioterrorism: management of major biological agents
    P Bossi
    Department of Infectious Diseases, Pitie Salpetriere Hospital, 47 83 Bd de l Hopital, 75013, Paris, France
    Cell Mol Life Sci 63:2196-212. 2006
    ..More than 180 pathogens have been reported to be potential agents for bioterrorism. The following is an overview of several agents that could be involved in a biological attack...
  27. ncbi [Update on smallpox vaccines]
    D Garin
    Laboratoire de Virologie, CRSSA Emile Pardé, BP 87, 38702 Grenoble cedex, France
    Med Mal Infect 34:20-7. 2004
    ..They should be replaced by a second-generation vaccine grown in cell culture and, eventually later by new and safer third-generation vaccines using non-replicative viral strains...
  28. ncbi [Vaccination: recall or second dose, semantic difference or immunologic reality?]
    B Autran
    PU-PH, Laboratoire d'Immunologie Cellulaire et Tissulaire, , 47, , 75013 Paris, France
    Arch Pediatr 12:2-4. 2005
  29. ncbi A systematic comparison of methods to measure HIV-1 specific CD8 T cells
    Y Sun
    Laboratoire d'Immunologie Cellulaire et Tissulaire, INSERM U543, , , , 75013 Paris, France
    J Immunol Methods 272:23-34. 2003
    ..These results have important implications for the choice of immunological methods to evaluate CD8 T cells responses to vaccines...