Research Topics
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Publications
Impact of vital status investigation procedures on estimates of survival in cohorts of HIV-infected patients from Sub-Saharan AfricaXavier Anglaret
INSERM U 593, Universite Victor Segalen, Bordeaux, France
J Acquir Immune Defic Syndr 35:320-3. 2004..We suggest that the percentage of deaths known through VSIPs would be a useful indicator to be added when reporting survival data from urban HIV cohort studies in sub-Saharan Africa...- [Severe opportunistic infections in HIV-positive adults in sub-Saharan Africa]X Anglaret
l Unité INSERM 593, Universite Victor Segalen Bordeaux 2, France
Med Trop (Mars) 66:343-5. 2006..The question of whether antiretroviral treatment should also be initiated "earlier" in sub-Saharan Africa than in Europe has also been raised... - [The HIV/AIDS epidemic in sub-Saharan Africa]Xavier Anglaret
INSERM U 593, Universite Victor Segalen Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux, France
Med Sci (Paris) 20:593-8. 2004..Far from being without effective tools and research tracks to fight against this plague which decimates a continent, one is above all confronted with a deficit of both mobilization and means... - Prognostic value of cross-sectional anthropometric indices on short-term risk of mortality in human immunodeficiency virus-infected adults in Abidjan, Côte d'IvoireK Castetbon
INSERM U 330, Universite Victor Segalen Bordeaux 2, 146 rue de Léo Saignat, 33076 Bordeaux Cedex, France
Am J Epidemiol 154:75-84. 2001..In Côte d'Ivoire where chemoprophylaxis of opportunistic infections has recently been recommended to be widely initiated on clinical criteria, such thresholds may help to screen patients with higher risks of mortality... - Effect of early chemoprophylaxis with co-trimoxazole on nutritional status evolution in HIV-1-infected adults in Abidjan, Côte d'IvoireK Castetbon
INSERM U.330, , Bordeaux, France
AIDS 15:869-76. 2001.... - [HIV infection in Africa. Clinical and therapeutical research]R Salamon
Unité INSERM 330, Universite Victor Segalen Bordeaux 2
Presse Med 29:146-52. 2000..Ethical issues raised by the design and conduct of clinical research in Africa need a positive thinking to face the HIV African pandemic... - CD4+ T-lymphocytes natural decrease in HAART-naïve HIV-infected adults in AbidjanJ Duvignac
INSERM U593, Bordeaux, France
HIV Clin Trials 9:26-35. 2008..To study the CD4 natural decrease and its determinants in sub-Saharan African HIV-infected adults... - Morbidity before and after HAART initiation in Sub-Saharan African HIV-infected adults: a recurrent event analysisCatherine Seyler
Programme PAC CI, Abidjan, Cote d Ivoire
AIDS Res Hum Retroviruses 23:1338-47. 2007..In HIV-infected patients on ART, the incidence of severe morbidity varied with the past history of morbidity. The past history of morbidity should be taken into account when comparing HIV morbidity rates before and after ART initiation... - HIV-1 DNA in peripheral blood mononuclear cells is strongly associated with HIV-1 disease progression in recently infected West African adultsAlbert K Minga
Programme PAC CI, Abidjan, Cote d Ivoire, France
J Acquir Immune Defic Syndr 48:350-4. 2008..To analyze the association between the HIV-1 DNA level in peripheral blood mononuclear cells (PBMCs) and disease progression in recently infected West African adults... - Scaling up antiretroviral therapy in South Africa: the impact of speed on survivalRochelle P Walensky
The Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
J Infect Dis 197:1324-32. 2008..Only 33% of eligible human immunodeficiency virus (HIV)-infected patients in South Africa receive antiretroviral therapy (ART). We sought to estimate the impact of alternative ART scale-up scenarios on patient outcomes from 2007-2012... - The independent effect of highly active antiretroviral therapy on severe opportunistic disease incidence and mortality in HIV-infected adults in Côte d'IvoireElena Losina
Department of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, MA, USA
Antivir Ther 12:543-51. 2007..Studies in developed countries have shown highly active antiretroviral therapy (HAART) decreases incidence of severe opportunistic diseases (ODs) in HIV-infected patients beyond that which is expected from changes in CD4+ T-cell count... - Prophylaxis with co-trimoxazole for HIV infected adults in AfricaXavier Anglaret
BMJ 337:a304. 2008 - Cost-effectiveness of HIV treatment in resource-poor settings--the case of Côte d'IvoireSue J Goldie
Department of Health Policy and Management, Program in Health Decision Science, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 355:1141-53. 2006..As antiretroviral therapy is increasingly used in settings with limited resources, key questions about the timing of treatment and use of diagnostic tests to guide clinical decisions must be addressed... - Incidence of neutropenia in HIV-infected African adults receiving co-trimoxazole prophylaxis: a 6-year cohort study in Abidjan, Côte d'IvoireSiaka Toure
, , , 33076 Bordeaux Cedex, France
Trans R Soc Trop Med Hyg 100:785-90. 2006..The consequences of associating co-trimoxazole with other haematotoxic drugs should be carefully assessed... - Nonantiretroviral drug consumption by CD4 cell count in HIV-infected adults: a 5-year cohort study in Côte d'IvoireNohelly Nombela
Unité INSERM U 593, Universite Victor Segalen, Bordeaux, Cedex, France
J Acquir Immune Defic Syndr 41:225-31. 2006..Meanwhile, they roughly suggest that successful antiretroviral treatment, which would stabilize the CD4 count above 500 cells/mm, could reduce by 5-fold the cost of nonantiretroviral drugs in HIV-infected adults in Abidjan... - Haematological changes in adults receiving a zidovudine-containing HAART regimen in combination with cotrimoxazole in Côte d'IvoireRaoul Moh
Programme PAC-CI, Abidjan,
Antivir Ther 10:615-24. 2005..This suggests an accentuated drug interaction between the two drugs in these sub-Saharan African individuals. Grade 3-4 anaemia was much less frequent, but remained the first cause of AZT discontinuation... - Use of a Bayesian approach to decide when to stop a therapeutic trial: the case of a chemoprophylaxis trial in human immunodeficiency virus infectionAlphonse Kpozehouen
INSERM U 593, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
Am J Epidemiol 161:595-603. 2005.... - Causes and empirical treatment of fever in HIV-infected adult outpatients, Abidjan, Côte d'IvoireXavier Anglaret
INSERM U.330, , France
AIDS 16:909-18. 2002..Reports from other African settings would be useful to compare experiences in algorithms of empirical early antibacterial and antimalarial treatments... - Pattern of bacterial diseases in a cohort of HIV-1 infected adults receiving cotrimoxazole prophylaxis in Abidjan, Côte d'IvoireXavier Anglaret
INSERM U330, , Bordeaux, France
AIDS 17:575-84. 2003..1/100 PY), serious bacterial morbidity remains the first cause of hospital admission in adults receiving cotrimoxazole in this setting... - Risk factors for active tuberculosis after antiretroviral treatment initiation in AbidjanCatherine Seyler
INSERM U593, , , 33076 Bordeaux, France
Am J Respir Crit Care Med 172:123-7. 2005..If confirmed by others, this finding could lead to assessment of new patterns of time-limited tuberculosis secondary chemoprophylaxis during the period of initiation of HAART in sub-Saharan African adults... - Medium-term survival, morbidity and immunovirological evolution in HIV-infected adults receiving antiretroviral therapy, Abidjan, Côte d'IvoireCatherine Seyler
Programme PAC-CI, Abidjan,
Antivir Ther 8:385-93. 2003..CONCLUSION: Medium-term survival under ART may be as good in Africa as in industrialized countries, provided that patients benefit from access to care for opportunistic infections, including bacterial diseases, tuberculosis and malaria... - Estimates of opportunistic infection incidence or death within specific CD4 strata in HIV-infected patients in Abidjan, Côte d'Ivoire: impact of alternative methods of CD4 count modellingSylvie Deuffic-Burban
CTRS, Unité INSERM 795, Hôpital Swynghedauw, CHRU de Lille, Lille, France
Eur J Epidemiol 22:737-44. 2007..All of the models indicate that the overall incidence of opportunistic infections under HAART in sub-Saharan Africa is high. This suggests that prophylaxis against opportunistic infections may be needed even for patients receiving HAART... - High incidence of atypical mycobacteriosis in African HIV-infected adults with low CD4 cell counts: a 6-year cohort study in Côte d'IvoireDominique Bonard
Programme PAC-CI, Abidjan, , France
AIDS 18:1961-4. 2004..In sub-Saharan Africa, where most patients start highly active antiretroviral therapy with low CD4 cell counts, improving the diagnosis of NTM may be relevant... - Incidence and determinants of mortality and morbidity following early antiretroviral therapy initiation in HIV-infected adults in West AfricaRaoul Moh
Trivacan ANRS 1269 study group, Abidjan, France
AIDS 21:2483-91. 2007..To estimate the incidence and risk factors of mortality and severe morbidity during the first months following antiretroviral therapy (ART) initiation in West African adults... - Variation of CD4 count and percentage during pregnancy and after delivery: implications for HAART initiation in resource-limited settingsDidier K Ekouevi
Programme PACCI, Abidjan, Cote d Ivoire, INSERM, Unité 593, Bordeaux, France
AIDS Res Hum Retroviruses 23:1469-74. 2007..To accurately target the most appropriate time to start HAART, the CD4 percentage could be more reliable than the absolute count in sub-Saharan African pregnant women... - Clinical impact and cost-effectiveness of co-trimoxazole prophylaxis in patients with HIV/AIDS in Côte d'Ivoire: a trial-based analysisYazdan Yazdanpanah
Service Universitaire des Maladies Infectieuses et du Voyageur, Centre Hospitalier de Tourcoing, Faculte de Medecine de Lille, France
AIDS 19:1299-308. 2005..In 2000, WHO/UNAIDS recommended co-trimoxazole prophylaxis for persons at early stages of HIV infection (WHO stage > or = 2) in sub-Saharan Africa... - HIV-1 antiretroviral drug resistance in recently infected patients in Abidjan, Côte d'Ivoire: A 4-year survey, 2002-2006Bernard Masquelier
Programme PAC CI Primo CI ANRS 1220, Abidjan, Cote d Ivoire
AIDS Res Hum Retroviruses 23:1155-60. 2007..Compared with a previous study carried out by our group in 2001-2002 in a similar population in Abidjan, our findings confirm the circulation and transmission of HIV-1 carrying key ARV drug resistance mutation... - Rapid scaling-up of antiretroviral therapy in 10,000 adults in Côte d'Ivoire: 2-year outcomes and determinantsSiaka Toure
Aconda Association, Abidjan, Cote d Ivoire
AIDS 22:873-82. 2008..To assess the rates and determinants of mortality, loss to follow-up and immunological failure in a nongovernmental organization-implemented program of access to antiretroviral treatment in Côte d'Ivoire... - Anthropometric and immunological success of antiretroviral therapy and prediction of virological success in west African adultsEugene Messou
Programme PAC, CI, Abidjan, Cote d Ivoire
Bull World Health Organ 86:435-42. 2008..We assessed the gain or loss in body mass index (BMI), alone or in combination with the gain or loss in CD4+ T-cell count (CD4), as a tool for predicting the response to ART... - Urinary pH in HIV-infected adults in Ivory Coast and in FranceEmmanuel Mortier
AIDS 17:2003-5. 2003 - Impact of genotypic drug resistance mutations on clinical and immunological outcomes in HIV-infected adults on HAART in West AfricaCatherine Seyler
INSERM U593, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
AIDS 21:1157-64. 2007..To analyse the association between the presence of resistance mutations and treatment outcomes. The impact of HIV-1 drug resistance mutations in African adults on HAART has so far never been reported... - HIV drug resistance surveillance for prioritizing treatment in resource-limited settingsRochelle P Walensky
Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
AIDS 21:973-82. 2007..Sentinel testing programs for HIV drug resistance in resource-limited settings can inform policy on antiretroviral therapy (ART) and drug sequencing... - Transfer and evaluation of an automated, low-cost real-time reverse transcription-PCR test for diagnosis and monitoring of human immunodeficiency virus type 1 infection in a West African resource-limited settingFrancois Rouet
Centre de Diagnostic et de Recherches sur le SIDA, Abidjan, Cote d Ivoire
J Clin Microbiol 43:2709-17. 2005..The TaqMan real-time PCR (12 dollars per test) is now routinely used to monitor HIV-1 infection in our laboratory. This technology should be further evaluated in limited-resource countries where strains other than CRF02 are prevalent... - Tolerance and acceptability of an efavirenz-based regimen in 740 adults (predominantly women) in West AfricaChristine Danel
Programme PAC CI, Abidjan, Cote d Ivoire, France
J Acquir Immune Defic Syndr 42:29-35. 2006.... - CD4-guided structured antiretroviral treatment interruption strategy in HIV-infected adults in west Africa (Trivacan ANRS 1269 trial): a randomised trialChristine Danel
Programme PAC-CI, Abidjan,
Lancet 367:1981-9. 2006..5-fold higher than those on CT. This difference was mainly due to high rates of common diseases in patients with CD4 count 200-500 per mm3. This CD4-guided structured treatment interruption strategy should not be recommended in Abidjan... - Risk factors for active tuberculosis in adults on highly active antiretroviral therapy in AfricaCatherine Seyler
AIDS 20:1463; author reply 1463-5. 2006 - Decreasing incidence of pregnancy by decreasing CD4 cell count in HIV-infected women in Côte d'Ivoire: a 7-year cohort studyMarc-Arthur Loko
INSERM U.593, , Bordeaux 2, Bordeaux, France
AIDS 19:443-5. 2005..This has consequences in terms of scaling-up strategies for highly active antiretroviral therapy (HAART). Women who need HAART will be less likely than those who do not to be recruited into prenatal care facilities... - Stability of ritonavir soft capsule formulation in patients with and without a refrigerator at home in Côte d'IvoireChristine Danel
Int J STD AIDS 17:784-5. 2006 - Are a past history of tuberculosis and WHO clinical stage associated with incident tuberculosis in adults receiving antiretroviral therapy?, reply to Lawn et alEric Ouattara
AIDS 21:389-90. 2007 - Lack of indinavir-associated nephrological complications in HIV-infected adults (predominantly women) with high indinavir plasma concentration in Abidjan, Côte d'IvoireChristine Danel
Programme PAC CI, Abidjan, Ccte d Ivoire
AIDS Res Hum Retroviruses 23:62-6. 2007..There was a surprising lack of nephrological side effects during the 6 months of follow-up, supporting the hypothesis that nephrological tolerance of IDV might be higher in sub-Saharan African individuals than in Americans or Europeans... - Progression to WHO criteria for antiretroviral therapy in a 7-year cohort of adult HIV-1 seroconverters in Abidjan, Côte d'IvoireAlbert Minga
Programme PAC CI, Abidjan, Cote d Ivoire
Bull World Health Organ 85:116-23. 2007..To estimate the probability of reaching the criteria for starting highly active antiretroviral therapy (HAART) in a prospective cohort of adult HIV-1 seroconverters in Abidjan, Côte d'Ivoire... - Field adherence to highly active antiretroviral therapy in HIV-infected adults in Abidjan, Côte d'IvoireSerge Paul Eholie
Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Treichville, Abidjan, Cote d Ivoire
J Acquir Immune Defic Syndr 45:355-8. 2007..To estimate adherence to highly active antiretroviral therapy (HAART) and its determinants in HIV-infected adults followed in field conditions in Abidjan... - Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countriesMartin W G Brinkhof
Institute of Social and Preventive Medicine, Bern, Switzerland
Bull World Health Organ 86:559-67. 2008..To analyse the early loss of patients to antiretroviral therapy (ART) programmes in resource-limited settings...