E Andres

..Aspergillus sp., Candida sp. etc.) and may represent important additions to the anti-infectious therapeutic arsenal...

..More than several hundred drugs, toxins, and herbs have been reported to cause blood abnormalities, and drugs account for 20 - 40% of all instances of cytopenias...

..However, given the increased life expectancy and subsequent longer exposure to drugs, as well as the development of new agents, physicians should be aware of this complication and its management...

..A relation between food-cobalamin malabsorption and pernicious anemia has been suggested, particularly in the event of food-cobalamin malabsorption related to hypochlorhydric atrophic gastritis...

..We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency...

..PROJECTS AND PERSPECTIVES: Several other molecules (rBPI, heliomicin and thanatine) are currently under development for various systemic infections. They may represent important drugs of the further anti-infectious therapeutic arsenal...

..We report a case of giant cell pulmonary arteritis revealed by acute pulmonary embolism and associated with giant cell arteritis...

..Several hundred drugs, toxins and herbs have been reported to cause blood abnormalities, and drugs account for 20 - 40% of all instances of cytopenias...

..PROSPECTS AND PROJECTS: Studies are in the way to establish the relevance of the new clinical manifestations and to validate the usefulness of oral cobalamin therapy...

..PERSPECTIVES: In the future, management of drug-induced agranulocytosis may include pre-established procedures using in critically situations, broad-spectrum antibiotic therapy and hematopoietic growth factors (G-CSF)...

..The remaining cases of nutrient-deficiency anemia are usually associated with vitamin B12, most frequently related to food-cobalamin malabsorption, and/or folate deficiency and are easily treated (nutrient-deficiency replacement)...

..This review confirms the previously reported efficacy of oral cobalamin treatment in elderly patients. Oral cobalamin treatment avoids the discomfort, inconvenience and cost of monthly injections...

..The aim of this trial was to demonstrate the efficacy of one month of oral cobalamin (vitamin B12) therapy in elderly patients with cobalamin deficiency related to food-cobalamin malabsorption (FCM)...

..PROJECTS AND PERSPECTIVES: Several other molecules (rBPI, heliomicin, and thanatine) are currently under development for various systemic infections. These will probably be important drugs for future anti-infectious therapy...

..5 x 10/l. Patients with such severe neutropenia are likely to experience life-threatening and sometimes fatal infections...

..The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment...

..We report here a case of primary hepatic anaplastic large cell Ki-1 non-Hodgkin's lymphoma in a 60 year old patient followed for hereditary hemochromatosis...

..To date, no study has documented this disorder in the elderly. There is also little information on clinical consequences...

..8+/-4 days vs. 11.6+/-5; 7.5+/-3.8 days vs. 12+/-4.5; and 7.3+/-4.8 days vs. 13+/-6.1, respectively (all p<0.05). G-CSF induced flu-like symptoms in 30% of patients, but reduced overall costs...

..In all cases, the drug responsible for causing the agranulocytosis must be discontinued and remain permanently contraindicated. The appropriate Medicines Regulatory Agency must also be notified of the adverse event...

..It is suggested that middle and inner ear can be a 'sanctuary' localization, which might sometimes require radiation therapy to achieve durable and complete remission...

..Thus, with appropriate management, the mortality rate from idiosyncratic drug-induced agranulocytosis is currently approximately 5%...

..DIA still remains a rare event. However, given the increased life expectancy and subsequent longer exposure to drugs, as well as the development of new agents, physicians should be aware of this complication and its management...

..Management of cobalamin deficiency with cobalamin injections is well codified at present, but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption...

..Liver dysfunction in adult Still's disease has been described in some case reports. The objective of this study was to analyze the pattern and the frequency of liver abnormalities in a monocenter series of adult Still's disease patients...

..Rare cases of venous thrombosis associated with celiac disease have been reported...

..Computed tomography showed multiple punched-out defects in the left iliac bone. No similar cases have been reported in the literature...

..It has been suggested that oral cobalamin (vitamin (B12)) therapy may be an effective therapy for treating cobalamin deficiencies related to food-cobalamin malabsorption. However, the duration of this treatment was not determined...

..Certain liver test abnormalities have been described in adult Still's disease. The objective of the present study was to analyze their type and frequency...

..But to date, only case reports or small series have been reported. The aim of this study was to describe the clinical characteristics of the FCM in old subjects...

..PROSPECTS AND PROJECTS: Future studies will confirm these data with the routine use of the new cobalamin assay: holotranscobalamin and validate the usefulness of oral cobalamin therapy...

..FUTURE PROSPECTS AND PROJECTS: Large-scale comparative clinical trials may clarify issues of relative efficacy in various forms of fungal infections...

....

..In this report, we review the current knowledge on the relationship between homocysteine, folate and vitamin B(12) levels and the way their disruption influences cognitive function in adults...

..Capillary leak syndrome is a rare disorder, with various clinical features, characterized by episodes of diffuse edema...

..Indeed, calcifications may be very discrete or just incidental and prevent a complete diagnostic approach...

..The aim of this study was to describe the present clinical characteristics of the pernicious anemia (PA)...

....

..This present review confirms the previously reported efficacy of oral cobalamin treatment in adult and elderly patients...

..Despite different therapeutic modalities (surgery, hormones therapy, chemotherapy), 5-year survival in patients with malignant adrenocortical carcinoma remains only 10% to 20%. Bone marrow grafts may be proposed to intensify treatment...

..the aim of this study is to determine the clinical characteristics of drug-induced agranulocytosis in rheumatology...

..Management of cobalamin deficiency with cobalamin injections is currently well codified, but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption...

..We report the case of a 50-year-old male patient, with a peculiar initial clinical presentation mimicking acute community acquired pneumonia but with an atypical evolution leading to a final diagnosis of actinomycosis...

..The authors also discuss the association of mesothelioma and FMF. Colchicine is successfully used in the treatment of FMF...

..The treatment is based on the discontinuation of the incriminated drug and on supportive measures that depend on the severity of the clinical features...

..2 micromol/l at the end of therapy. These results support the use of ABLC in the treatment of invasive fungal infections in children, including patients who have previously failed, or are intolerant of, traditional antifungal regimens...

..The aim of this study is to describe the long-term follow-up and the prognosis of a group of patients hospitalised for an inflammatory syndrome and discharged without causal diagnosis...

..Pathogenesis of the hypersensitivity syndrome is discussed. Antithyroid drugs are rarely involved in the syndrome but cases with vasculitis have been described. In our patient, the role of excessive dose is possible...

..Despite the heterogeneous presentation of this lymphoma, some clinical and biological investigations should prevail clinicians to do tissue biopsy which is required to make the diagnosis...

..The aim of this study was to determine the initial dose of oral cyanocobalamin that would correct the B12 vitamin deficiency within one week...

..The aim of this study was to determine whether oral cobalamin treatment may be an effective therapy for treating older patients with cobalamin deficiency related to nutritional deficiency and food-cobalamin malabsorption...

..We reviewed the literature and discuss the relationship between glibenclamide and haemolytic crisis and between G6PD-deficiency and diabetes...

..The aim of this study is to report personal experience of pancytopenia related to low-dose methotrexate and to review the literature...

..Studies are in the way to better characterize the food-cobalamin malabsorption in a clinical practice perspective and to validate the usefulness of oral cobalamin therapy...

..In conclusion, ES is a potentially life-threatening condition that may be associated with other underlying autoimmune or lymphoproliferative disorders...

..We review and discuss the venous prothrombic properties of CMV in immunocompetent patients...

..No renal or hepatic toxicity was observed. These results compare favourably with the results of standard treatment and suggest that ABCD combined with surgery may be a useful therapy in patients with mucormycosis...

..We studied clinical factors that may influence the duration of hematological recovery to reach neutrophil counts and thus, indirectly, the prognosis in patients with life-threatening drug-induced agranulocytosis (DIA)...

..DISCUSSION: The onset of facial palsy has been linked with Gougerot-Sjögren's syndrome. The contribution of vitamin B12 deficiency is discussed...

..This later may also be asymptomatic or lead to local inflammation or inflammatory pseudo-tumor. We report an original observation of chronic fever revealing an urachal cyst in a 21-Year-old male...

..This auscultation's school will be destined to the initial and continuous formation of the medical attendants...

..Improvement in the management of infectious complications and the use of hematopoietic growth factors in severe cases helps explain that mortality rate has fallen to less than 5%...

..Idiopathic thrombocytopenic purpura (ITP) is often diagnosed in the elderly, but no specific guidelines exist for such patients. We describe our experience with ITP management in elderly patients and analyze the therapeutic response...