Jouni T Tuomisto

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced anorexia and wasting syndrome in rats: aggravation after ventromedial hypothalamic lesion
    J T Tuomisto
    National Public Health Institute, Department of Toxicology, Kuopio, Finland
    Eur J Pharmacol 293:309-17. 1995
  2. ncbi An economic way of reducing health, environmental, and other pressures of urban traffic: a decision analysis on trip aggregation
    Jouni T Tuomisto
    Centre for Environmental Health Risk Analysis, National Public Health Institute KTL, PO Box 95, FI 70701, Finland
    BMC Public Health 5:123. 2005
  3. ncbi Soft-tissue sarcoma and dioxin: A case-control study
    Jouni T Tuomisto
    Department of Environmental Health, National Public Health Institute, PO Box 95, FIN 70701 Kuopio, Finland
    Int J Cancer 108:893-900. 2004
  4. ncbi Adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and effects on male reproductive organs in three differentially TCDD-susceptible rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Sci 81:401-7. 2004
  5. ncbi Differences in acute toxicity syndromes of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin in rats
    Marjo Niittynen
    Department of Environmental Health, National Public Health Institute, PO Box 95, FI 70701 Kuopio, Finland
    Toxicology 235:39-51. 2007
  6. ncbi Postnatal development of resistance to short-term high-dose toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in TCDD-resistant and -semiresistant rats
    Ulla Simanainen
    Laboratory of Toxicology, Department of Environmental Health, National Public Health Institute, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 196:11-9. 2004
  7. ncbi Dose-response analysis of short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in three differentially susceptible rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 187:128-36. 2003
  8. ncbi Polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in the general population in Finland
    Hannu Kiviranta
    Department of Environmental Health, National Public Health Institute, P O Box 95, FI 70701 Kuopio, Finland
    Chemosphere 60:854-69. 2005
  9. ncbi Pattern of male reproductive system effects after in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in three differentially TCDD-sensitive rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Toxicol Sci 80:101-8. 2004
  10. ncbi 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced accumulation of biliverdin and hepatic peliosis in rats
    Marjo Niittynen
    Department of Environmental Health, Laboratory of Toxicology, National Public Health Institute, Box 95, FIN 70701 Kuopio, Finland
    Toxicol Sci 71:112-23. 2003

Detail Information

Publications28

  1. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced anorexia and wasting syndrome in rats: aggravation after ventromedial hypothalamic lesion
    J T Tuomisto
    National Public Health Institute, Department of Toxicology, Kuopio, Finland
    Eur J Pharmacol 293:309-17. 1995
    ..Thus, TCDD seems to affect the same regulation chain that is involved in the lesioning of the ventromedial hypothalamus. TCDD might serve as a tool in studying different mechanisms of long-term food intake and body weight regulation...
  2. ncbi An economic way of reducing health, environmental, and other pressures of urban traffic: a decision analysis on trip aggregation
    Jouni T Tuomisto
    Centre for Environmental Health Risk Analysis, National Public Health Institute KTL, PO Box 95, FI 70701, Finland
    BMC Public Health 5:123. 2005
    ..Nonetheless, automobiles are crucial for the functions of the modern society. Most proposals for sustainable traffic solutions face major political opposition, economical consequences, or technical problems...
  3. ncbi Soft-tissue sarcoma and dioxin: A case-control study
    Jouni T Tuomisto
    Department of Environmental Health, National Public Health Institute, PO Box 95, FIN 70701 Kuopio, Finland
    Int J Cancer 108:893-900. 2004
    ..The results imply that dioxin does not increase the risk of soft-tissue sarcoma at the present population levels...
  4. ncbi Adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and effects on male reproductive organs in three differentially TCDD-susceptible rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Sci 81:401-7. 2004
    ..The fact that the influence of resistance alleles on spermatogenesis is different from that on androgenic status indicates that the effect of TCDD on sperm numbers is not fully related to decreased serum testosterone...
  5. ncbi Differences in acute toxicity syndromes of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin in rats
    Marjo Niittynen
    Department of Environmental Health, National Public Health Institute, PO Box 95, FI 70701 Kuopio, Finland
    Toxicology 235:39-51. 2007
    ....
  6. ncbi Postnatal development of resistance to short-term high-dose toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in TCDD-resistant and -semiresistant rats
    Ulla Simanainen
    Laboratory of Toxicology, Department of Environmental Health, National Public Health Institute, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 196:11-9. 2004
    ..This difference in the time course of resistance development suggests that there are basic differences in pathways mediating resistance in lines A and B rats...
  7. ncbi Dose-response analysis of short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in three differentially susceptible rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 187:128-36. 2003
    ..Both H/W-type resistance alleles also decreased the potency of TCDD. However, the potency differences in short-term toxicity seem not to explain, at least alone, the differences seen in acute lethality among the rat lines...
  8. ncbi Polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in the general population in Finland
    Hannu Kiviranta
    Department of Environmental Health, National Public Health Institute, P O Box 95, FI 70701 Kuopio, Finland
    Chemosphere 60:854-69. 2005
    ..Age, lactation, place of residence, and fish consumption frequencies were significant predictors in the models...
  9. ncbi Pattern of male reproductive system effects after in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in three differentially TCDD-sensitive rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Toxicol Sci 80:101-8. 2004
    ..Thus, the intraspecies genetic differences in C-terminal transactivation domain of AHR appear to modify the sensitivity to only certain dioxin-induced male reproductive effects...
  10. ncbi 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced accumulation of biliverdin and hepatic peliosis in rats
    Marjo Niittynen
    Department of Environmental Health, Laboratory of Toxicology, National Public Health Institute, Box 95, FIN 70701 Kuopio, Finland
    Toxicol Sci 71:112-23. 2003
    ....
  11. ncbi Parameter and model uncertainty in a life-table model for fine particles (PM2.5): a statistical modeling study
    Marko Tainio
    Centre of Excellence for Environmental Health Risk Analysis, National Public Health Institute, Kuopio, Finland
    Environ Health 6:24. 2007
    ..We studied the effects of various uncertain input variables by building a life-table model for fine particles...
  12. ncbi Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on heme oxygenase-1, biliverdin IXalpha reductase and delta-aminolevulinic acid synthetase 1 in rats with wild-type or variant AH receptor
    Marjo Niittynen
    Department of Environmental Health, National Public Health Institute, Box 95, FI 70701 Kuopio, Finland
    Toxicology 250:132-42. 2008
    ..Other factors such as the late repression of BVRA found here and possibly oxidative stress may be important contributors to biliverdin accumulation in these rats...
  13. ncbi Characterization of model error in a simulation of fine particulate matter exposure distributions of the working age population in Helsinki, Finland
    Otto O Hänninen
    Division of Environmental Health, Finnish National Public Health Institute KTL, Centre for Environmental Health Risk Analysis, Kuopio, Finland
    J Air Waste Manag Assoc 55:446-57. 2005
    ....
  14. ncbi Immediate and highly sensitive aversion response to a novel food item linked to AH receptor stimulation
    Sanna Lensu
    Department of Environmental Health, National Institute for Health and Welfare THL, P O B 95, FI 70701 Kuopio, Finland
    Toxicol Lett 203:252-7. 2011
    ....
  15. ncbi Health effects caused by primary fine particulate matter (PM2.5) emitted from buses in the Helsinki metropolitan area, Finland
    Marko Tainio
    Centre of Excellence for Environmental Health Risk Analysis, National Public Health Institute, Finland
    Risk Anal 25:151-60. 2005
    ..The dose-response relationship and the emission factors were identified as the main sources of uncertainty in the model...
  16. ncbi Characterization of the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-provoked strong and rapid aversion to unfamiliar foodstuffs in rats
    Sanna Lensu
    Department of Environmental Health, National Institute for Health and Welfare THL, P O B 95, FI 70701 Kuopio, Finland
    Toxicology 283:140-50. 2011
    ..The molecular mechanisms of this tantalizing behavioural alteration remain to be determined...
  17. ncbi Effects of epidermal growth factor receptor deficiency and 2,3,7,8-tetrachlorodibenzo-p-dioxin on fetal development in mice
    Hanna M Miettinen
    Laboratory of Toxicology, Department of Environmental Health, National Public Health Institute, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Lett 150:285-91. 2004
    ..In conclusion, EGFR signaling is not required for TCDD-induced cleft palate or hydronephrosis but TCDD appears to counteract the effect of EGFR deficiency on eye opening...
  18. ncbi Openness in participation, assessment, and policy making upon issues of environment and environmental health: a review of literature and recent project results
    Mikko V Pohjola
    National Institute for Health and Welfare, Kuopio, Finland
    Environ Health 10:58. 2011
    ....
  19. ncbi Is the fear of dioxin cancer more harmful than dioxin?
    Jouko Tuomisto
    Department of Environmental Health, National Institute for Health and Welfare THL, P O Box 95, FI 70701 Kuopio, Finland
    Toxicol Lett 210:338-44. 2012
    ..This could pose indirect nutritional risks, in fact being more harmful than even the worst case predictions of the putative cancer risks attributable to dioxins...
  20. ncbi Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains
    Ulla Simanainen
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Toxicol Appl Pharmacol 181:38-47. 2002
    ..Type I effects are similar in both strains, and type II effects show decreased efficacy of toxic response in relation with the altered H/W-type AHR...
  21. ncbi Human dietary intake of organochlorines from Baltic herring: implications of individual fish variability and fisheries management
    Mikko Kiljunen
    Department of Biological and Environmental Science, University of Jyvaskyla, Finland
    Ambio 36:257-64. 2007
    ..Increased fishing would only slightly decrease organochlorine concentrations of herring in the Finnish fish market...
  22. ncbi A probabilistic characterization of the relationship between fine particulate matter and mortality: elicitation of European experts
    Roger M Cooke
    Delft University of Technology, Delft, The Netherlands
    Environ Sci Technol 41:6598-605. 2007
    ..By providing quantitative estimates of the uncertainty in current estimates of PM2.5 mortality risks, the study facilitates structured analysis of the value of further research on PM2.5 and its impacts...
  23. ncbi Comparative risk analysis of dioxins in fish and fine particles from heavy-duty vehicles
    Olli Leino
    National Public Health Institute of Finland
    Risk Anal 28:127-40. 2008
    ..In addition, the benefits of fish consumption due to omega-3 exposure were notably higher than the potential dioxin cancer risk. Both regulations were instigated as ways of promoting public health...
  24. ncbi Response of the incisor tooth to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a dioxin-resistant and a dioxin-sensitive rat strain
    Anu Kiukkonen
    Department of Pedodontics and Orthodontics, Institute of Dentistry, Mannerheimintie 172, FIN-00014 University of Helsinki, Finland
    Toxicol Sci 69:482-9. 2002
    ..Similar responses in both strains implied that the impaired formation of the incisor tooth, at least of its mesenchymal elements, is not associated with the differential resistance of H/W and L-E rats to TCDD acute lethality...
  25. ncbi Altered retinoid metabolism in female Long-Evans and Han/Wistar rats following long-term 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treatment
    Nick Fletcher
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Toxicol Sci 86:264-72. 2005
    ..Furthermore, 9-cis-4-oxo-13,14-dihydro-RA was identified as a novel and sensitive indicator of TCDD exposure, in a resistant and sensitive rat strain, thereby extending the database of low-dose TCDD effects...
  26. ncbi Risk-benefit analysis of eating farmed salmon
    Jouni T Tuomisto
    Science 305:476-7; author reply 476-7. 2004
  27. ncbi Closing the gap between science and policy on air pollution and health
    Leendert van Bree
    Netherlands Environmental Assessment Agency MNP, Bilthoven, The Netherlands
    J Toxicol Environ Health A 70:377-81. 2007
    ....
  28. ncbi Assessing environmental health risks or net health benefits?
    Jouni T Tuomisto
    Scand J Public Health 33:162-3. 2005