Jaakko Parkkinen

Summary

Affiliation: Finnish Red Cross Blood Service
Country: Finland

Publications

  1. ncbi A modified caprylic acid method for manufacturing immunoglobulin G from human plasma with high yield and efficient virus clearance
    J Parkkinen
    Finnish Red Cross Blood Service, Helsinki, Finland
    Vox Sang 90:97-104. 2006
  2. ncbi Function and therapeutic development of apotransferrin
    Jaakko Parkkinen
    Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    Vox Sang 83:321-6. 2002
  3. ncbi Erratum to "Apotransferrin administration prevents growth of Staphylococcus epidermidis in serum of stem cell transplant patients by binding of free iron". [FEMS Immunol. Med Microbiol. 37 (2003) 45-51]
    Leni von Bonsdorff
    Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    FEMS Immunol Med Microbiol 40:173-80. 2004
  4. ncbi Non-transferrin-bound iron in haematological patients during chemotherapy and conditioning for autologous stem cell transplantation
    Leila Sahlstedt
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Haematol 83:455-9. 2009
  5. ncbi Effect of repeated apotransferrin administrations on serum iron parameters in patients undergoing myeloablative conditioning and allogeneic stem cell transplantation
    Jaakko Parkkinen
    Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    Br J Haematol 135:228-34. 2006
  6. ncbi Apotransferrin administration prevents growth of Staphylococcus epidermidis in serum of stem cell transplant patients by binding of free iron
    Leni von Bonsdorff
    Finnish Red Cross Blood Transfusion Service, Kivihaantie 7, 00310 Helsinki, Finland
    FEMS Immunol Med Microbiol 37:45-51. 2003
  7. ncbi Non-transferrin-bound iron in platelet concentrates promotes the growth of Staphylococcus epidermidis
    Sanna Matinaho
    Finnish Red Cross Blood Service, Helsinki, Finland
    Transfusion 45:927-33. 2005
  8. ncbi Inhibition of erythroid and granulocyte-macrophage colony formation by non-transferrin-bound iron in vitro: protective effect of apotransferrin
    Eeva Juvonen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Haematol 79:126-31. 2007
  9. ncbi Bicarbonate inhibits the growth of Staphylococcus epidermidis in platelet concentrates by lowering the level of non-transferrin-bound iron
    Sanna Matinaho
    Finnish Red Cross Blood Service, Helsinki
    Transfusion 45:1768-73. 2005
  10. ncbi Identification of alpha-1 acid glycoprotein as a lysophospholipid binding protein: a complementary role to albumin in the scavenging of lysophosphatidylcholine
    Pauli J Ojala
    Finnish Red Cross Blood Service, Kivihaantie 7, FI 00310 Helsinki, Finland
    Biochemistry 45:14021-31. 2006

Collaborators

  • Leni von Bonsdorff
  • Freja Ebeling
  • Eeva Juvonen
  • Pauli J Ojala
  • T Ruutu
  • J Jolkkonen
  • Leila Sahlstedt
  • Sanna Matinaho
  • Bart de Vries
  • Diethard Monbaliu
  • Janne Heikkinen
  • Sarah J Walter
  • Wim A Buurman
  • Tim G A M Wolfs
  • Katrien Vekemans
  • Jean Olivier Defraigne
  • Jean-Olivier Defraigne
  • Joel Pincemail
  • Tina Crabbé
  • Joanne Greenwood
  • Rita De Vos
  • Jacques Pirenne
  • Marcel Zeegers
  • Johan Fevery
  • Jos van Pelt
  • Peter Heeringa
  • Fausto Biancari
  • Jarkko Räbinä
  • Jorma Hirvonen
  • Claude Libert
  • Kai Kiviluoma
  • Juha Koskenkari
  • Tino Hochepied
  • Timo Kaakinen
  • Tatu Juvonen
  • Sebastian Dahlbacka
  • L W Ernest van Heurn

Detail Information

Publications17

  1. ncbi A modified caprylic acid method for manufacturing immunoglobulin G from human plasma with high yield and efficient virus clearance
    J Parkkinen
    Finnish Red Cross Blood Service, Helsinki, Finland
    Vox Sang 90:97-104. 2006
    ..Here, we describe a new IVIG production process resulting in a high yield of IgG and effective reduction of physico-chemically resistant viruses...
  2. ncbi Function and therapeutic development of apotransferrin
    Jaakko Parkkinen
    Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    Vox Sang 83:321-6. 2002
  3. ncbi Erratum to "Apotransferrin administration prevents growth of Staphylococcus epidermidis in serum of stem cell transplant patients by binding of free iron". [FEMS Immunol. Med Microbiol. 37 (2003) 45-51]
    Leni von Bonsdorff
    Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    FEMS Immunol Med Microbiol 40:173-80. 2004
    ..The results suggest that exogenous apotransferrin might protect stem cell transplant patients against infections by S. epidermidis and possibly other opportunistic pathogens...
  4. ncbi Non-transferrin-bound iron in haematological patients during chemotherapy and conditioning for autologous stem cell transplantation
    Leila Sahlstedt
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Haematol 83:455-9. 2009
    ....
  5. ncbi Effect of repeated apotransferrin administrations on serum iron parameters in patients undergoing myeloablative conditioning and allogeneic stem cell transplantation
    Jaakko Parkkinen
    Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    Br J Haematol 135:228-34. 2006
    ..Complete iron binding with apotransferrin would apparently require very high apotransferrin doses...
  6. ncbi Apotransferrin administration prevents growth of Staphylococcus epidermidis in serum of stem cell transplant patients by binding of free iron
    Leni von Bonsdorff
    Finnish Red Cross Blood Transfusion Service, Kivihaantie 7, 00310 Helsinki, Finland
    FEMS Immunol Med Microbiol 37:45-51. 2003
    ..The results suggest that exogenous apotransferrin might protect stem cell transplant patients against infections by S. epidermidis and possibly other opportunistic pathogens...
  7. ncbi Non-transferrin-bound iron in platelet concentrates promotes the growth of Staphylococcus epidermidis
    Sanna Matinaho
    Finnish Red Cross Blood Service, Helsinki, Finland
    Transfusion 45:927-33. 2005
    ..CONCLUSIONS: PCs stored in plasma or AS contain a low level of NTBI because of the displacement of iron from plasma-derived transferrin by citrate. NTBI in the PC medium supports the growth of S. epidermidis...
  8. ncbi Inhibition of erythroid and granulocyte-macrophage colony formation by non-transferrin-bound iron in vitro: protective effect of apotransferrin
    Eeva Juvonen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Haematol 79:126-31. 2007
    ..The aim of the study was to investigate in vitro the effect of free iron on erythroid and granulocyte-macrophage colony formation and the effect of binding free iron with apotransferrin...
  9. ncbi Bicarbonate inhibits the growth of Staphylococcus epidermidis in platelet concentrates by lowering the level of non-transferrin-bound iron
    Sanna Matinaho
    Finnish Red Cross Blood Service, Helsinki
    Transfusion 45:1768-73. 2005
    ..To achieve the same beneficial effect in blood banking, other more practical ways to bind NTBI in a harmless form should be developed...
  10. ncbi Identification of alpha-1 acid glycoprotein as a lysophospholipid binding protein: a complementary role to albumin in the scavenging of lysophosphatidylcholine
    Pauli J Ojala
    Finnish Red Cross Blood Service, Kivihaantie 7, FI 00310 Helsinki, Finland
    Biochemistry 45:14021-31. 2006
    ..The results suggest that AGP complements albumin as a lysophospholipid scavenging protein, particularly in inflammatory conditions when the capacity of albumin to sequester LPC becomes impaired...
  11. ncbi Bleomycin-detectable iron assay for non-transferrin-bound iron in hematologic malignancies
    Leni von Bonsdorff
    Finnish Red Cross Blood Transfusion Service, Kivihaantie 7, FIN 00310 Helsinki, Finland
    Clin Chem 48:307-14. 2002
    ..A microwell modification of the bleomycin assay for determining non-transferrin-bound iron (NTBI) was evaluated and compared with a chelation method...
  12. ncbi Effective binding of free iron by a single intravenous dose of human apotransferrin in haematological stem cell transplant patients
    Leila Sahlstedt
    Department of Medicine, Helsinki University Central Hospital, Finland
    Br J Haematol 119:547-53. 2002
    ..Repeated apotransferrin infusions might completely eliminate NTBI and iron-induced toxicity during myeloablative therapy...
  13. ncbi Reduction of circulating redox-active iron by apotransferrin protects against renal ischemia-reperfusion injury
    Bart de Vries
    Department of Surgery, Nutrition and Toxicology Research Institute Maastricht, Academic Hospital Maastricht, Maastricht, The Netherlands
    Transplantation 77:669-75. 2004
    ..Apotransferrin could be used in the treatment of acute renal failure, as seen after transplantation of ischemically damaged organs...
  14. ncbi Apotransferrin, C1-esterase inhibitor, and alpha 1-acid glycoprotein for cerebral protection during experimental hypothermic circulatory arrest
    Janne Heikkinen
    Department of Surgery, University of Oulu and Oulu University Hospital, Oulu, Finland
    Scand Cardiovasc J 38:178-86. 2004
    ....
  15. ncbi Molecular mechanisms underlying neuroprotective effects of albumin after ischemic stroke
    Jaakko Parkkinen
    Stroke 38:255; author reply 256. 2007
  16. ncbi Primary graft nonfunction and Kupffer cell activation after liver transplantation from non-heart-beating donors in pigs
    Diethard Monbaliu
    Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    Liver Transpl 13:239-47. 2007
    ..A no-flow phenomenon is eventually observed in these failing grafts...
  17. ncbi Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis
    Bart de Vries
    Department of Surgery, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Academic Hospital Maastricht and Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands
    Transplantation 78:1116-24. 2004
    ..However, the precise mechanism of protection remains to be established. We therefore studied the effects of exogenous human AGP (hAGP) in a mouse model of ischemic acute renal failure...