Predictors of asymptomatic malaria in pregnancyS T Balogun
Niger J Physiol Sci 26:179-83. 2011
..035). In conclusion, parasitaemic pregnant women resident in hyper- or holo-endemic malaria region are likely to be symptomatic with increasing density of the parasitaemia...
- Exposure to anti-malarial drugs and monitoring of adverse drug reactions using toll-free mobile phone calls in private retail sector in Sagamu, Nigeria: implications for pharmacovigilance
Ahmed A Adedeji
Communicable Disease Research Unit, Olabisi Onabanjo University Teaching Hospilal Sagamu, PMB 2002, Nigeria
Malar J 10:230. 2011
..The exposure to anti-malarial and use of mobile phone technology to report ADRs following drug exposures were investigated in Sagamu--a peri-urban community in Southwest Nigeria...
- Comparative efficacy of chloroquine and cotrimoxazole in the treatment of acute uncomplicated falciparum malaria in Nigerian children
F A Fehintola
Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria
Cent Afr J Med 48:101-5. 2002
..To evaluate the efficacy of two dosing regimens of cotrimoxazole in the treatment of falciparum malaria and compare the efficacy with that of chloroquine, the first-line antimalaria drug in the area of study...
- Effects of artesunate-cotrimoxazole and amodiaquine-artesunate against asexual and sexual stages of Plasmodium falciparum malaria in Nigerian children
Fatai A Fehintola
Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria
J Infect Chemother 14:188-94. 2008
..Reduction of gametocyte carriage by these two treatment regimens may reduce transmissibility in P. falciparum malaria, and this reduction is presumed to be related to the accelerated clearance of the asexual forms of the parasite...
- Malaria: passive case detection and healthcare providers' choices of chemotherapy
F A Fehintola
Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria
Afr J Med Med Sci 39:49-54. 2010
..In conclusion, there appears to be over-diagnosis of malaria considering that only about a third of the clinical malaria cases were confirmed by microscopy. There is need for large epidemiological studies and possible policy review...
- Cotrimoxazole, clinical uses and malaria chemotherapy
F A Fehintola
Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria
Afr J Med Med Sci 39:63-8. 2010
..Specific experiences of the author in the application of cotrimoxazole in the treatment of acute uncomplicated falciparum malaria were highlighted and suggestions on how to optimize the use of this drug were made...
- Comparative study of efficacy of artesunate plus cotrimoxazole and artesunate plus chloroquine in the treatment of malaria in Nigerian children: a preliminary report
F A Fehintola
Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan
J Vector Borne Dis 47:145-50. 2010
....
- Intermittent preventive treatment during pregnancy with sulphadoxine-pyrimethamine may promote Plasmodium falciparum gametocytogenesis
F A Fehintola
Department of Clinical Pharmacology and Therapeutics, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria
Med Princ Pract 21:63-7. 2012
..To determine the incidence of gametocytes and the propensity of sulphadoxine-pyrimethamine to promote gametocytogenesis when used as intermittent preventive treatment in pregnancy...
- Open randomized study of artesunate-amodiaquine vs. chloroquine-pyrimethamine-sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children
A Sowunmi
Department of Pharmacology and Therapeutics, Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria
Trop Med Int Health 10:1161-70. 2005
..We assessed the safety, treatment efficacy and effects on gametocyte carriage of the combination of artesunate plus amodiaquine and chloroquine plus pyrimethamine-sulfadoxine in children...
- Predictors of the failure of treatment with chloroquine in children with acute, uncomplicated, Plasmodium falciparum malaria, in an area with high and increasing incidences of chloroquine resistance
A Sowunmi
Department of Pharmacology, Institute for Medical Research and Training, University of Ibadan, Nigeria
Ann Trop Med Parasitol 99:535-44. 2005
..Together, these findings may have implications for malaria-control efforts in all areas of sub-Saharan Africa where treatment of malaria depends almost entirely on antimalarial monotherapy...
- Effects of antifolates--co-trimoxazole and pyrimethamine-sulfadoxine--on gametocytes in children with acute, symptomatic, uncomplicated, Plasmodium falciparum malaria
A Sowunmi
Department of Pharmacology and Therapeutics, Institute for Medical Research and Training, Ibadan, Nigeria
Mem Inst Oswaldo Cruz 100:451-5. 2005
....
- Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children
A Sowunmi
Department of Pharmacology and Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria
Parasitology 129:255-62. 2004
..These findings may have implications for malaria control efforts in sub-Saharan Africa where control of the disease depends almost entirely on chemotherapy...
- Predictors of the failure of treatment with chloroquine plus chlorpheniramine, in children with acute, uncomplicated, Plasmodium falciparum malaria
A Sowunmi
Department of Pharmacology and Therapeutics and Malaria Research Group, Institute for Medical Research and Training, University of Ibadan, Nigeria
Ann Trop Med Parasitol 99:331-8. 2005
..In resource-poor communities using chloroquine plus chlorpheniramine, the easily identifiable predictors of treatment failure might be used to identify children requiring alternative antimalarial drugs...
- Comparative efficacy of chloroquine plus chlorpheniramine alone and in a sequential combination with sulfadoxine-pyrimethamine, for the treatment of acute, uncomplicated, falciparum malaria in children
A Sowunmi
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria
Ann Trop Med Parasitol 94:209-17. 2000
..Treatment with a CQ-CP combination (CQ and CP for 3 days and then CP alone for another 4 days) is also effective but requires continuing administration after the signs and symptoms of acute malaria have disappeared...
- Comparative effects of pyrimethamine-sulfadoxine, with and without probenecid, on Plasmodium falciparum gametocytes in children with acute, uncomplicated malaria
A Sowunmi
Department of Pharmacology and Therapeutics, and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria
Ann Trop Med Parasitol 98:873-8. 2004
- Plasmodium falciparum: evaluation of lactate dehydrogenase in monitoring therapeutic responses to standard antimalarial drugs in Nigeria
A M Oduola
Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Nigeria
Exp Parasitol 87:283-9. 1997
..Further development of the procedure will enhance its valuable application in clinical management of drug-resistant malaria in the endemic areas...
- Plasmodium falciparum malaria in Nigerian children during high and low transmission seasons: gametocyte carriage and response to oral chloroquine
A A Adedeji
Department of Pharmacology and Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria
J Trop Pediatr 51:288-94. 2005
..These findings may be important in our understanding of P. falciparum transmission sustenance, response to chloroquine therapy and contribution of chloroquine to gametocyte carriage as seasonal changes occur...
- Comparative efficacy of chloroquine plus chlorpheniramine and halofantrine in acute uncomplicated falciparum malaria in Nigerian children
A Sowunmi
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria
Trans R Soc Trop Med Hyg 92:441-5. 1998
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- Cardiac effects of halofantrine in children suffering from acute uncomplicated falciparum malaria
A Sowunmi
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria
Trans R Soc Trop Med Hyg 92:446-8. 1998
..Despite the ECG abnormalities, there was no clinical symptom. These findings indicate that, in children, the currently recommended dose of halofantrine for the treatment of falciparum malaria may produce serious cardiac side effects...
- Comparative cardiac effects of halofantrine and chloroquine plus chlorpheniramine in children with acute uncomplicated falciparum malaria
A Sowunmi
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria
Trans R Soc Trop Med Hyg 93:78-83. 1999
..The addition of CP to CQ does not significantly amplify the cardiac effects of CQ in children with acute uncomplicated falciparum malaria...
- Open randomized study of pyrimethamine-sulphadoxine vs. pyrimethamine-sulphadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children
A Sowunmi
Department of Pharmacology and Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria
Trop Med Int Health 9:606-14. 2004
..falciparum to pyrimethamine and sulphadoxine in vitro, but the clinical significance is unclear. We assessed the safety, treatment efficacy, and effects on gametocyte carriage of adding probenecid to pyrimethamine-sulphadoxine...
- Activities of artesunate and amodiaquine against intestinal helminth in children with Plasmodium falciparum malaria in endemic areas
A A Adedeji
Department of Pharmacology and Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria
Eur J Clin Microbiol Infect Dis 27:627-9. 2008
- Intravascular haemolysis following treatment of malaria with halofantrine: case report
F A Fehintola
Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria
Niger J Clin Pract 9:174-5. 2006
- Pattern of chloroquine-induced pruritus in antenatal patients at the University College Hospital, Ibadan
O Olayemi
Department of Obstetrics and Gynaecology, College of Medicine, University College Hospital, Ibadan, Nigeria
J Obstet Gynaecol 23:490-5. 2003
..Among the indices of severity, the frequency of itching with chloroquine use was the only factor that correlated with continuation of use (P < 0.01)...
- Therapeutic monitoring of chloroquine in pregnant women with malaria
T O Fakeye
Department of Pharmaceutical Microbiology and Clinical Pharmacy, College of Medicine, University of Ibadan, Nigeria
West Afr J Med 21:286-7. 2002
..5 hours while peak plasma concentrations, (Cp(max)) were obtained at 2, 28, and 52 hours with values of 204. 36, 343.51 and 257.04 ng/ml respectively. There was total parasitaemia clearance before the end of 96 hours in all the subjects...
- Cerebral malaria in pregnancy
M A Okunlola
Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria
J Obstet Gynaecol 26:561. 2006
- The effect of anti-hypertensive therapy on urinary albumin excretion in Nigerian hypertensives
B L Salako
Department of Medicine, University of College Hospital, Ibadan, Oyo State, Nigeria
West Afr J Med 18:170-4. 1999
..This study has shown that control of blood pressure can reduce or reverse urinary albumin excretion in Nigerian hypertensives...
- Haematological profile of healthy pregnant women in Ibadan, south-western Nigeria
T S Akingbola
Department of Haematology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Oyo State, Nigeria
J Obstet Gynaecol 26:763-9. 2006
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