Women and autoimmune diseasesDelisa Fairweather
Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21205, USA
Emerg Infect Dis 10:2005-11. 2004
..Sex hormones may further amplify this hyperimmune response to infection in susceptible persons, which leads to an increased prevalence of autoimmune diseases in women...
- Cutting edge: cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease
Sylvia Frisancho-Kiss
Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health and School of Medicine, Baltimore, MD 21205, USA
J Immunol 178:6710-4. 2007
..Cross-regulation of TLR4 and Tim-3 occurs during the innate and adaptive immune response. This novel mechanism may help explain why inflammatory heart disease is more severe in males...
- Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity
Sylvia Frisancho-Kiss
Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
J Immunol 176:6411-5. 2006
..These results indicate that regulation of inflammation in the heart begins during innate immunity and that Tim-3 signaling on cells of the innate immune system critically influences regulation of the adaptive immune response...
- Sex differences in coxsackievirus B3-induced myocarditis: IL-12Rbeta1 signaling and IFN-gamma increase inflammation in males independent from STAT4
Sylvia Frisancho-Kiss
Department of Pathology, Johns Hopkins University, School of Medicine, 728 Rutland Avenue, Baltimore, MD 21205, USA
Brain Res 1126:139-47. 2006
..Thus, IFN-gamma increases inflammation in males independent from STAT4. These results demonstrate that sex differences greatly influence viral replication and the severity of acute CVB3-induced myocarditis...
- Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart
Delisa Fairweather
Department of Environmental Health Sciences, Johns Hopkins University and Bloomberg School of Public Health, 615 North Wolfe Street, Rm E7628, Baltimore, MD 21205, USA
J Immunol 176:3516-24. 2006
..These results show that expression of CR1/2 is not necessary for effective clearance of CVB3 infection, but prevents immune-mediated damage to the heart...
- Sex differences in a murine model of Sjögren's syndrome
Daniela Cihakova
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ann N Y Acad Sci 1173:378-83. 2009
..Thus, sex has a strong impact on the severity of murine Sjögren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation...
- Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart
Delisa Fairweather
Department of Pathology, Johns Hopkins Medical Institutions, 720 Rutland Ave, Baltimore, MD 21205, USA
Am J Pathol 165:1883-94. 2004
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- Th2 regulation of viral myocarditis in mice: different roles for TLR3 versus TRIF in progression to chronic disease
Eric D Abston
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Clin Dev Immunol 2012:129486. 2012
..We show for the first time that TLR3 versus TRIF deficiency results in different Th2 responses that uniquely influence the progression to chronic myocarditis...
- Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation
Daniela Cihakova
Johns Hopkins University, Department of Pathology, Division of Immunology, Ross 648, 720 Rutland Ave, Baltimore, MD 21205, USA
Am J Pathol 172:1195-208. 2008
..IL-13 KO mice had increased caspase-1 activation, leading to increased production of both IL-1beta and IL-18. Therefore, IL-13 protects against myocarditis by modulating monocyte/macrophage populations and by regulating their function...
- Gonadectomy of male BALB/c mice increases Tim-3(+) alternatively activated M2 macrophages, Tim-3(+) T cells, Th2 cells and Treg in the heart during acute coxsackievirus-induced myocarditis
Sylvia Frisancho-Kiss
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Brain Behav Immun 23:649-57. 2009
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- IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heart
Delisa Fairweather
Department of Pathology, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
J Immunol 174:261-9. 2005
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- Mast cells and innate cytokines are associated with susceptibility to autoimmune heart disease following coxsackievirus B3 infection
Delisa Fairweather
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Autoimmunity 37:131-45. 2004
..Thus, susceptibility to autoimmune heart disease can be determined as early as 6 h following viral infection in susceptible strains of mice...
- Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity
Delisa Fairweather
Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
Methods 41:118-22. 2007
..An improved understanding of the interaction between environmental exposures and the development of heart disease represents a clear challenge for immunotoxicologists...
- Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure
Marina Afanasyeva
Department of Pathology, The Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 102:180-5. 2005
..An exaggerated inflammatory response in IFN-gamma KO mice causes cardiac dysfunction, leading to dilated cardiomyopathy and heart failure...
- A novel model of drug hapten-induced hepatitis with increased mast cells in the BALB/c mouse
Dolores B Njoku
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Blalock 906A, 600 North Wolfe Street, Baltimore, MD 21287, USA
Exp Mol Pathol 78:87-100. 2005
..This is the first report, to our knowledge, of a hapten-induced model of hepatitis with immune and autoimmune features...
- Mast cells and inflammatory heart disease: potential drug targets
Delisa Fairweather
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Cardiovasc Hematol Disord Drug Targets 8:80-90. 2008
..An improved understanding of the role of MCs in regulating inflammation and fibrosis will enable researchers and clinicians to better treat heart disease...
- Novel model of constrictive pericarditis associated with autoimmune heart disease in interferon-gamma-knockout mice
Marina Afanasyeva
Department of Pathology, Johns Hopkins Medical Intitutions, Baltimore, MD, USA
Circulation 110:2910-7. 2004
..Constrictive pericarditis represents a serious hemodynamic syndrome that may lead to heart failure. Studies of its pathophysiological mechanisms have been impeded by the lack of an animal model...
- Viruses as adjuvants for autoimmunity: evidence from Coxsackievirus-induced myocarditis
Delisa Fairweather
The Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Rev Med Virol 15:17-27. 2005
..Recent findings suggest that mast cell activation by viruses or adjuvants may be important in initiating autoimmune disease...
- Alternatively activated macrophages in infection and autoimmunity
Delisa Fairweather
Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Autoimmun 33:222-30. 2009
..Thus, women may be at an increased risk of M2-mediated autoimmunity due to estrogen's ability to increase Th2 responses...
- Low-dose inorganic mercury increases severity and frequency of chronic coxsackievirus-induced autoimmune myocarditis in mice
Jennifer F Nyland
Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29209, USA
Toxicol Sci 125:134-43. 2012
..IL-17 levels were also significantly increased in the spleen during chronic disease. Thus, we show for the first time that low-dose Hg exposure increases chronic myocarditis and DCM in a murine model...
- Sex differences in autoimmune disease from a pathological perspective
Delisa Fairweather
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe St, Room E7628, Baltimore, MD 21205, USA
Am J Pathol 173:600-9. 2008
..Th17 responses increase neutrophil inflammation and chronic fibrosis. This distinction between acute and chronic pathology has primarily been overlooked, but greatly impacts our understanding of sex differences in autoimmune disease...
- The innate immune response to coxsackievirus B3 predicts progression to cardiovascular disease and heart failure in male mice
Jennifer A Onyimba
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Biol Sex Differ 2:2. 2011
..abstract:..
- Autoimmune heart disease: role of sex hormones and autoantibodies in disease pathogenesis
Delisa Fairweather
Johns Hopkins University Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 N Wolfe Street, Baltimore, MD 21205, USA
Expert Rev Clin Immunol 8:269-84. 2012
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- IL-12 receptor beta 1 and Toll-like receptor 4 increase IL-1 beta- and IL-18-associated myocarditis and coxsackievirus replication
Delisa Fairweather
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Immunol 170:4731-7. 2003
..These findings have important implications not only for the pathogenesis of myocarditis, but for other autoimmune diseases triggered by viral infections...
- Infectious etiologies of chronic diseases: focus on women
Delisa Fairweather
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 10:2028-9. 2004
- Characterisation of murine cytomegalovirus myocarditis: cellular infiltration of the heart and virus persistence
Jason C Lenzo
Department of Microbiology, The University of Western Australia, Australia
J Mol Cell Cardiol 34:629-40. 2002
..Our findings suggest that maintenance of the chronic phase of myocarditis involving post-viral immunological responses can occur in the presence of little infectious virus replication in the heart...
- Type 1 diabetes: virus infection or autoimmune disease?
Delisa Fairweather
Nat Immunol 3:338-40. 2002
