High gene expression of inflammatory markers and IL-17A correlates with severity of injection site reactions of Atlantic salmon vaccinated with oil-adjuvanted vaccinesStephen Mutoloki
Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Sciences, Oslo, Norway
BMC Genomics 11:336. 2010
..qPCR was also used to examine the expression of additional genes known to be important in the adaptive immune response...
- Cardiomyopathy syndrome of atlantic salmon (Salmo salar L.) is caused by a double-stranded RNA virus of the Totiviridae family
Oyvind Haugland
Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
J Virol 85:5275-86. 2011
..The identification of the causative agent for CMS is important for improved disease surveillance and disease control and will serve as a basis for vaccine development against the disease...
- A comparative immunopathological study of injection site reactions in salmonids following intraperitoneal injection with oil-adjuvanted vaccines
Stephen Mutoloki
Norwegian School of Veterinary Science, Institute of Basic Science and Aquatic Medicine, P.O. Box 8146 Dep, Ullevaalsveien 72, N-0033 Oslo, Norway
Vaccine 24:578-88. 2006
..The strong onset in rainbow trout leads to rapid breakdown and removal of antigens resulting in early resolution...
- Time-course study of injection site inflammatory reactions following intraperitoneal injection of Atlantic cod (Gadus morhua L.) with oil-adjuvanted vaccines
Stephen Mutoloki
Department of Basic Science and Aquatic Medicine, Norwegian School of Veterinary Science, P O Box 8146 Dep, N 0033 Oslo, Norway
Fish Shellfish Immunol 24:386-93. 2008
..Oil-adjuvanted vaccines appear to be well-tolerated by this species and show promise as a possible approach for disease control...
- Expression profiles of inflammatory and immune-related genes in Atlantic salmon (Salmo salar L.) at early time post vaccination
Oyvind Haugland
Department of Pathology, National Veterinary Institute, Oslo, Norway
Vaccine 23:5488-99. 2005
..By day 19, immune-related genes like immunoglobulin and T cell-receptor genes, comprised a higher proportion of the up-regulated genes than at earlier time points...
- Differential expression profiles and gene structure of two tumor necrosis factor-alpha variants in Atlantic salmon (Salmo salar L.)
Oyvind Haugland
Department of Pathology, National Veterinary Institute, Oslo, Norway
Mol Immunol 44:1652-63. 2007
..A shift from TNF-alpha2 to TNF-alpha1 was however seen, and from day 12 the TNF-alpha1 was most abundant transcript. Implications of variant specific gene-expression are discussed...
- The contribution of Aeromonas salmonicida extracellular products to the induction of inflammation in Atlantic salmon (Salmo salar L.) following vaccination with oil-based vaccines
Stephen Mutoloki
Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
Fish Shellfish Immunol 20:1-11. 2006
..It is also documented that the combination of antigens with oil adjuvants, and not the adjuvants alone, is the inducer of strong inflammatory reactions in Atlantic salmon...
