Screening for beta-thalassaemia carriers in Egypt: significance of the osmotic fragility testA el-Beshlawy
Department of Paediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
East Mediterr Health J 13:780-6. 2007
..For the one-tube osmotic fragility test, sensitivity was 87.0% and specificity 34.1%; the test has limited use for a mass screening programme in Egypt, where iron deficiency is prevalent...
- Fetal globin induction in beta-thalassemia
Amal El-Beshlawy
Pediatric Hematology Department, Cairo University Hospital, Cairo, Egypt
Hemoglobin 33:S197-203. 2009
..Induction of HbF in beta-thalassemia patients is expected to be crucial for developing countries unable to sustain the high cost of clinical management of beta-thalassemia patients...
- Improvement of cardiac function in thalassemia major treated with L-carnitine
Amal El-Beshlawy
Hematology Clinic, New Cairo University Children Hospital, Cairo, Egypt
Acta Haematol 111:143-8. 2004
..Chronic anemia and the tissue hypoxia it induces impair free fatty acid oxidation and ATP production in myocardial cells. The use of L-carnitine, a butyric acid derivative, may help overcome some of these defects...
- Diastolic dysfunction and pulmonary hypertension in sickle cell anemia: is there a role for L-carnitine treatment?
A el-Beshlawy
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
Acta Haematol 115:91-6. 2006
..Therefore, L-carnitine deserves a rigorous large-scale randomized clinical trial to evaluate its potential benefits as treatment for SCD patients with cardiac complications...
- Prevention of hemoglobinopathies in Egypt
Amal El-Beshlawy
Pediatric Hematology Department, Cairo University, Cairo, Egypt
Hemoglobin 33:S14-20. 2009
..Our objectives were to provide an in-depth analysis of the current status of hemoglobinopathies in Egypt and what we need for prevention of these diseases...
- Pulmonary hypertension in beta-thalassemia major and the role of L-carnitine therapy
Amal El-Beshlawy
Pediatric Department, Cairo University, Cairo, Egypt
Pediatr Hematol Oncol 25:734-43. 2008
..No clinical predictors were identified. Oral administration of L-carnitine appears to significantly improve PASP...
- Iron chelation in thalassemia: combined or monotherapy? The Egyptian experience
Amal El-Beshlawy
Faculty of Medicine, Cairo University, 32 Falaky Street, Bab El Louk, Cairo, Egypt
Ann Hematol 87:545-50. 2008
..Toxicity of DFP was mild to moderate and acceptable; most commonly, transient arthropathy and nausea/vomiting were observed. Thus, combination therapy has shown to be effective in reducing iron overload in thalassemia patients...
- The safety, tolerability, and efficacy of a liquid formulation of deferiprone in young children with transfusional iron overload
Moshen S ElAlfy
Thalassemia Center, Children Hospital, Ain Shams University, Heliopolis, Cairo, Egypt
J Pediatr Hematol Oncol 32:601-5. 2010
..0005). The results of this study show a favorable benefit/risk ratio of deferiprone oral solution for the treatment of young children with transfusional iron overload...
- Skin iron concentration: a simple, highly sensitive method for iron stores evaluation in thalassemia patients
Ilham Youssry
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
Hemoglobin 31:357-65. 2007
..2 mg/g dry liver weight with a standard error of 4.07. Biochemical assay of the skin iron concentration is a reliable quantitative indicator of the body iron stores in patients with thalassemia major...
- Correction of aberrant pre-mRNA splicing by antisense oligonucleotides in beta-thalassemia Egyptian patients with IVSI-110 mutation
Amal El-Beshlawy
Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt
J Pediatr Hematol Oncol 30:281-4. 2008
..In conclusion, ASON can restore correct splicing of beta-globin pre-mRNA leading to correct gene product in cultured erythropoietic cells. These results suggest the applicability of ASON for the treatment of thalassemia...
- Effect of L-carnitine on the physical fitness of thalassemic patients
Amal El Beshlawy
Department of Pediatrics, New Children Hospital, Cairo University, Cairo, Egypt
Ann Hematol 86:31-4. 2007
..It improves their cardiac performance and physical fitness. The younger the patients are, the higher is the degree of improvement in their exercise parameters...
- Study of beta-Thalassemia mutations using the polymerase chain reaction-amplification refractory mutation system and direct DNA sequencing techniques in a group of Egyptian Thalassemia patients
Somaia El Gawhary
Department of Clinical Pathology, Cairo University Hospitals, Kasre El Eini Hospital, Cairo, Egypt
Hemoglobin 31:63-9. 2007
..Direct DNA sequencing is an additional way to allow a full characterization of beta-thal patients in the Egyptian population...
- Molecular diagnosis of spinal muscular atrophy in Egyptians
R M Shawky
Department of Genetics, University of Ain Shams, Cairo, Egypt
East Mediterr Health J 7:229-37. 2001
..There may therefore be 5q-unlinked SMA or SMA due to other mutations. Detection of deletions of SMA exons 7 and 8 is a powerful diagnostic test in patients with SMA, but other mutations among Egyptians must also be sought...
- Study of 22 Egyptian patients with Diamond-Blackfan anemia, corticosteroids, and cyclosporin therapy results
Amal El-Beshlawy
Hematology Clinic, Laboratory in the New Cairo University Children's Hospital, Cairo, Egypt
Pediatrics 110:e44. 2002
..CONCLUSION: CSA therapy should be tried in steroid-resistant Diamond-Blackfan anemia patients before blood transfusion or corticosteroid therapy complications are instituted...
