Role of IL-1beta in type 2 diabetesCharles A Dinarello
Department of Medicine, University of Colorado, Aurora, Colorado 80045, USA
Curr Opin Endocrinol Diabetes Obes 17:314-21. 2010
..To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta...
- Blocking interleukin-1? in acute and chronic autoinflammatory diseases
C A Dinarello
Department of Medicine, University of Colorado, Aurora, CO, USA
J Intern Med 269:16-28. 2011
..Flares of gout, type 2 diabetes, heart failure and smouldering multiple myeloma are examples of seemingly unrelated diseases, which are uniquely responsive to IL 1? neutralization...
- Histone deacetylase inhibitors for treating a spectrum of diseases not related to cancer
Charles A Dinarello
Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado 80045, USA
Mol Med 17:333-52. 2011
..The data suggest the use of HDACi's in treating autoimmune as well as chronic inflammatory diseases...
- Why not treat human cancer with interleukin-1 blockade?
Charles A Dinarello
Department of Medicine, University of Colorado, 12700 East 19th Ave, B168, Aurora, CO 80045, USA
Cancer Metastasis Rev 29:317-29. 2010
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- Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation
Charles A Dinarello
Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Semin Dial 22:256-9. 2009
..Hence a possible link of high salt intake, inflammation, and atherogenesis may be one molecular mechanism for the association of high salt intake and cardiovascular events...
- Historical insights into cytokines
Charles A Dinarello
University of Colorado Health Sciences Center, 4200 East Ninth Ave, B168, Denver, CO 80262, USA
Eur J Immunol 37:S34-45. 2007
..A recent advance in the field has been that of differential cytokine production, which can be used to classify human disease as being "autoimmune" or "autoinflammatory" thus impacting on therapeutic interventions...
- A signal for the caspase-1 inflammasome free of TLR
Charles A Dinarello
Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue B168, Denver, CO 80262, USA
Immunity 26:383-5. 2007
..However, Kanneganti et al. (2007) find that bacteria can use pore-forming mechanisms to activate caspase-1 for the production of IL-1beta precursor independently of TLRs...
- IL-32, a novel cytokine with a possible role in disease
C A Dinarello
University of Colorado, Health Science Center, 4200 East Ninth Avenue, 80262 Denver, CO, USA
Ann Rheum Dis 65:iii61-4. 2006
..Thus, IL-32 exhibits many properties of proinflammatory cytokines and associations with disease severity...
- The paradox of pro-inflammatory cytokines in cancer
Charles A Dinarello
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Ave, B168, Denver, CO 80262, USA
Cancer Metastasis Rev 25:307-13. 2006
..However, blocking cytokines will not kill tumor cells nor prevent carcinogenesis. Blocking cytokines is best as an adjunct therapy together with tumorocidal drugs...
- Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process
Charles A Dinarello
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Clin Nutr 83:447S-455S. 2006
..From human and animal studies, one may conclude that IL-1beta and IL-18 participate in fundamental inflammatory processes that increase during the aging process...
- Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed
Charles A Dinarello
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Endotoxin Res 10:201-22. 2004
..Thus, fever is the result of either cytokine receptor or TLR triggering; in autoimmune diseases, fever is mostly cytokine mediated whereas both cytokine and TLR account for fever during infection...
- Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation
Charles A Dinarello
University of Colorado Health Sciences Center, Division of Infectious Diseases, B168, 4200 East Ninth Ave, Denver, Colorado 80262, USA
Curr Opin Pharmacol 4:378-85. 2004
....
- Blocking IL-1 in systemic inflammation
Charles A Dinarello
Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Exp Med 201:1355-9. 2005
..Loss of control of the secretion of IL-1beta might be a common mechanism explaining the aberrant activity of IL-1 in these diseases...
- IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma
L L Reznikov
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 97:2174-9. 2000
..These studies demonstrate that IL-18BP decreases endogenous IL-18 activity by reducing IFN-gamma-mediated responses...
- Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice
G Fantuzzi
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Blood 91:2118-25. 1998
..Our results show that IL-18 is an IL-12-independent regulator of IFNgamma production and of cell proliferation induced by microbial stimuli. However, ICE-dependent processing of IL-18 is not needed for response to mitogens or antigens...
- Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain
S H Kim
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 166:148-54. 2001
..The synergism of IL-18 plus IL-12 for IFN-gamma production is, in part, due to IL-12 up-regulation of both IL-18R alpha and IL-18R beta chains, although postreceptor events likely contribute to IFN-gamma production...
- Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase
M Knotek
Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Kidney Int 59:2243-9. 2001
..The present study tested the hypothesis that the role of TNF in endotoxic renal failure is mediated by iNOS-derived NO...
- Differential roles of interleukin-18 (IL-18) and IL12 for induction of gamma interferon by staphylococcal cell wall components and superantigens
R J Stuyt
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
Infect Immun 69:5025-30. 2001
..In contrast to its role in the interactions between staphylococci and host cells, IL-18 does not appear to play a major role in superantigen-induced IFN-gamma...
- Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
B Siegmund
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
Am J Physiol Regul Integr Comp Physiol 281:R1264-73. 2001
..The stimulation of lamina propria mononuclear cells by IL-18 and IL-12 resulted in a synergistic increase in IFN-gamma synthesis. These findings suggest that IL-18 is a pivotal mediator in experimental colitis...
- Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein
S H Kim
University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 98:3304-9. 2001
..The identification of E42 and K89 in the mature IL-18 peptide is consistent with previous modeling studies of IL-18 binding to IL-18BP and explains the unusually high affinity of IL-18BP for IL-18...
- Liposomal delivery of purified inhibitory-kappaBalpha inhibits tumor necrosis factor-alpha-induced human vascular smooth muscle proliferation
C H Selzman
Department of Surgery, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
Circ Res 84:867-75. 1999
..Furthermore, liposomal delivery of endogenous inhibitory proteins may represent a novel, therapeutically accessible method for selective transcriptional suppression in the response to vascular injury...
- Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia
M G Netea
Departments ofMedicine and Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 164:2644-9. 2000
..coli LPS) or TNF (S. typhimurium LPS) synthesis by anti-IL-18 treatment may also be involved...
- Physiological and cytokine responses in IL-1 beta-deficient mice after zymosan-induced inflammation
G Fantuzzi
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA
Am J Physiol 273:R400-6. 1997
..Our results demonstrate that IL-1 beta plays a significant, although not exclusive, role in the physiological and cytokine responses to zymosan-mediated inflammation...
- Response to local inflammation of IL-1 beta-converting enzyme- deficient mice
G Fantuzzi
Department of Medicine, Tufts University School of Medicine and New England Medical Center, Boston, MA 02111, USA
J Immunol 158:1818-24. 1997
..Our results demonstrate that in turpentine-induced tissue necrosis, precursor IL-1 beta is processed by non-ICE proteases, but in complement-mediated inflammation, ICE participates in the processing of the IL-1 beta precursor...
- Utilization of endoscopic inoculation in a mouse model of intrauterine infection-induced preterm birth: role of interleukin 1beta
L L Reznikov
Division of Infectious Diseases, University of Colorado Health SciencesCenter, Denver 80262, USA
Biol Reprod 60:1231-8. 1999
..This model using direct intracervical bacterial or LPS inoculation is useful for studying preterm pregnancy loss in genetically altered mice in order to develop novel interventions for infection-associated preterm labor...
- IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation
B Siegmund
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 98:13249-54. 2001
..We conclude that inhibition of ICE represents a novel anti-inflammatory strategy for intestinal inflammation...
- Novel targets for interleukin 18 binding protein
C A Dinarello
Department of Medicine, University Colorado Health Sciences Centre, Denver 80262, USA
Ann Rheum Dis 60:iii18-24. 2001
..IL18BP binds IL18 with a high affinity (Kd of 400 pM) and, at equimolar ratios, inhibits 50-70% of IL18; at twofold molar excess, IL18BP neutralises nearly all IL18 activity...
- TNF receptor I is required for induction of macrophage heat shock protein 70
J K Heimbach
Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA
Am J Physiol Cell Physiol 281:C241-7. 2001
..These studies demonstrate that TNFR-I is required for the synthesis of HSP70 in stressed Mphi by a TNF-independent mechanism and support an intracellular role for TNFR-I...
- Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure
V Y Melnikov
Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
J Clin Invest 107:1145-52. 2001
..Finally, we confirmed histologically that caspase-1(-/-) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration...
- The IL-1 family and inflammatory diseases
C A Dinarello
Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, B168, Denver, CO 80262, USA
Clin Exp Rheumatol 20:S1-13. 2002
..This property, of IL-1 is not observed in the responses to TNFalpha. Furthermore, in animal models of destructive rheumatoid arthritis, IL-1 is necessary but TNFalpha is not...
- Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta
B J Pomerantz
Department of Surgery, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 98:2871-6. 2001
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- IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor
G Fantuzzi
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Clin Invest 104:761-7. 1999
..Furthermore, administration of IL-12 significantly increased liver-associated IL-18 levels. These data demonstrate that endogenous, ICE-cleaved IL-18 significantly contributes to induction of IFN-gamma by IL-12...
- Interleukin-1beta deficiency results in reduced NF-kappaB levels in pregnant mice
L L Reznikov
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Physiol Regul Integr Comp Physiol 278:R263-70. 2000
..This suppression was 25% greater in IL-1beta(-/-) than in IL-1beta(+/+) mice. These data suggest that constitutive NF-kappaB p65 protein synthesis is regulated by IL-1beta, particularly during pregnancy...
- Inflammatory markers and the risk of Alzheimer disease: the Framingham Study
Z S Tan
Department of Medicine, Institute for Aging Research, Hebrew Senior Life, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02131, USA
Neurology 68:1902-8. 2007
..To examine whether serum cytokines and spontaneous production of peripheral blood mononuclear cell (PBMC) cytokines are associated with the risk of incident Alzheimer disease (AD)...
- Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells
L L Reznikov
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Clin Nephrol 61:324-36. 2004
..In patients receiving hemodialysis, AGE are thought to contribute to the inflammatory components of the therapy, particularly in diabetic patients...
- Role of interferon regulatory factor-1 in the regulation of IL-18 production and activity
G Fantuzzi
Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
Eur J Immunol 31:369-75. 2001
..In conclusion, IRF-1 regulates IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP. In addition, IRF-1 participates in the induction of IFN-gamma by IL-18...
- Modulation of muramyl dipeptide stimulation of cytokine production by blood components
J H M van der Meer
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80602, USA
Clin Exp Immunol 156:428-33. 2009
..The inhibition of MDP stimulation was dependent upon cellular components, with erythrocyte-derived haemoglobin and neutrophils collaborating in the inhibition of MDP effects in whole blood...
- Targeting interleukin 18 with interleukin 18 binding protein
C A Dinarello
University of Colorado Health Sciences Center, Division Infectious Diseases, B168, 4200 East Ninth Avenue, Denver, CO 80262, USA
Ann Rheum Dis 59:i17-20. 2000
..It is likely that preferential secretion of high affinity functional and non-functional isoforms of IL18BP affect the immune response and the outcome of disease...
- Differences in signaling pathways by IL-1beta and IL-18
Jae-Kwon Lee
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 101:8815-20. 2004
..We conclude that in epithelial cells, IL-18 signal transduction is primarily via the MAPK p38 pathway rather than NF-kappaB, which may explain the absence of COX-2 and the failure of IL-18 to cause fever...
- Effect of endotoxin in IL-1 beta-deficient mice
G Fantuzzi
Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
J Immunol 157:291-6. 1996
..In summary, our results suggest that either IL-1 beta is not essential for the in vivo systemic response to LPS or that its role can be fulfilled by other cytokines with overlapping activities...
- Measurement of soluble and membrane-bound interleukin 1 using a fibroblast bioassay
C A Dinarello
University of Colorado Health Sciences Center, Denver, Colorado, USA
Curr Protoc Immunol . 2001
..Also listed are sources of commercially available kits (ELISAs, immunoassays) to measure IL-1, and antibodies useful in setting up these assays...
- Elevated circulating levels of soluble interleukin-1 receptor type II during interleukin-2 immunotherapy
E Vannier
Department of Medicine, Division of Geographic Medicine and Infectious Diseases, New England Medical Center and Tufts University School of Medicine, Boston, MA, USA
Eur Cytokine Netw 10:37-42. 1999
..IL-1sRI levels did not increase during immunotherapy with IL-2 or IL-6. Our results indicate that IL-1sRII, unlike IL-1Ra, remains a modest, natural, anti-inflammatory mechanism triggered by immunotherapy with IL-2, but not with IL-6...
- Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages
A Vazquez-Torres
Department of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 98:2561-5. 2001
..TNFalpha-TNFRp55 signaling plays a critical role in the immediate innate immune response to an intracellular pathogen by optimizing the delivery of toxic reactive oxygen species to the phagosome...
- Macrophage inflammatory protein-1 alpha production in lipopolysaccharide-stimulated human adherent blood mononuclear cells is inhibited by the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine
H Muhl
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA
J Immunol 159:5063-9. 1997
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- Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness
Christian Taube
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 30:837-43. 2004
..The effects of inhibiting p38 MAPK in decreasing AHR indicate activities independent of its prevention of neutrophil accumulation...
- Interleukin-18 and the treatment of rheumatoid arthritis
Charles A Dinarello
Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B168, Denver, CO 80262, USA
Rheum Dis Clin North Am 30:417-34, ix. 2004
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- Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
Mihai G Netea
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
PLoS Med 3:e277. 2006
..Interleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system...
- Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18
S H Kim
University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 97:1190-5. 2000
..It is likely that preferential secretion of functional and nonfunctional isoforms of IL-18BP affect the immune response...
- Proinflammatory cytokines in heart disease
C A Dinarello
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Blood Purif 19:314-21. 2001
..Two orally effective agents, the IL-1beta-converting enzyme inhibitor and the mitogen-activating protein kinase p38 inhibitor, are currently being investigated in clinical trials...
- The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice
G Fantuzzi
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
J Leukoc Biol 59:489-93. 1996
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- Interleukin-18 inhibits human immunodeficiency virus type 1 production in peripheral blood mononuclear cells
H J Choi
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Infect Dis 184:560-8. 2001
..Furthermore, inhibition was present during the early stages of viral infection and was associated with reduced HIV-1 receptor expression...
- Interleukin-32: a cytokine and inducer of TNFalpha
Soo Hyun Kim
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Immunity 22:131-42. 2005
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- Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice
Wei Wang
Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Physiol Renal Physiol 288:F997-1004. 2005
..Neutralization of IL-1beta and IL-18 is not functionally protective. The role of the intracellular proinflammatory cytokine IL-1alpha in endotoxemic ARF merits further study...
- Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone
Jung Won Park
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 30:830-6. 2004
..In summary, acute exposure to O(3) induces AHR, neutrophilic inflammation, epithelial damage, and IL-1. An IL-1Ra effectively prevents the development of altered airway function, inflammation, and structural damage...
- Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation
Charles A Dinarello
University Colorado Health Sciences Center, Division of Infectious Diseases, B168, 4200 East Ninth Avenue, Denver, CO 80262, USA
Immunity 20:243-4. 2004
..Blocking IL-1 receptors arrests inflammation in humans with the mutation...
- Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF
Rogier J L Stuyt
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
Cytokine 21:65-73. 2003
..In conclusion, S. epidermidis stimulates IFN-gamma which is IL-18, IL-12 and TNF-dependent, but IL-1 independent...
- The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures
Mihai G Netea
Department of Medicine and Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Infect Dis 185:963-70. 2002
..Blocking the biologic activities of IL-18, IL-12, and IL-1beta in patients (e.g., for treatment of autoimmune diseases) may result in increased susceptibility to C. albicans infection...
- Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction
Christopher D Raeburn
Department of Surgery, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Box C 320, Denver, CO 80262, USA
Am J Physiol Heart Circ Physiol 283:H650-7. 2002
..In conclusion, neutralization of IL-18 protects against LPS-induced myocardial dysfunction. IL-18 may mediate endotoxemic myocardial dysfunction through induction of and/or synergy with IL-1beta, ICAM-1, and VCAM-1...
- Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation
Travis H Wyman
Bonfils Blood Center, Denver, CO 80230, USA
J Leukoc Biol 72:401-9. 2002
..We conclude that IL-18, at physiologic concentrations, is an effective PMN priming agent that requires p38 MAP kinase activity...
- Immunological and inflammatory functions of the interleukin-1 family
Charles A Dinarello
Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado 80045, USA
Annu Rev Immunol 27:519-50. 2009
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- Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide
Philip Bufler
Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA
Biochem J 381:503-10. 2004
..These results indicate that both IL-1F7b and IL-18 mRNA contain functional instability determinants within their coding region, which influence mRNA decay as a novel mechanism to regulate the expression of IL-1 family members...
- Anti-cytokine therapies in response to systemic infection
C A Dinarello
Department of Medicine, Division Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA
J Investig Dermatol Symp Proc 6:244-50. 2001
..It appears that systemic inflammation of sepsis requires more than anticytokine monotherapy to significantly reduce mortality...
- Differential expression of interleukin-32 in chronic rhinosinusitis with and without nasal polyps
A Keswani
Division of Allergy Immunology, Northwestern University Feinberg School of Medicine, 240 E Huron, Chicago, IL 60611, USA
Allergy 67:25-32. 2012
..However, the mechanism of inflammation in CRS has still not been fully elucidated. The aim of the study was to investigate the role of interleukin-32 (IL-32), a recently discovered proinflammatory cytokine, in CRS...
- Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta
Miyako Okamoto
Department of Dermatology, University of Colorado Denver, Aurora, Colorado 80045, USA
J Biol Chem 285:6477-88. 2010
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- Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin
Joseph A Sennello
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Endocrinology 146:2157-64. 2005
..In conclusion, although leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNF alpha-induced death...
- IL-1: discoveries, controversies and future directions
Charles A Dinarello
Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
Eur J Immunol 40:599-606. 2010
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- Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils
Christopher C Silliman
Research Dept, Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
Am J Physiol Cell Physiol 298:C714-24. 2010
..Extracellular IL-18 participates in TNF-alpha priming of the PMN oxidase as demonstrated by inhibition with the IL-18 binding protein...
- Interleukin-18 and the pathogenesis of inflammatory diseases
Charles A Dinarello
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO, USA
Semin Nephrol 27:98-114. 2007
..Other options for reducing IL-18 activities are inhibitors of caspase-1, human monoclonal antibodies to IL-18, soluble IL-18 receptors, and anti-IL-18 receptor monoclonal antibodies...
- Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury
Charles L Edelstein
University of Colorado Health Science Center, Department of Internal Medicine, Denver, CO 80262, USA, and Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Taiwan
Nephrol Dial Transplant 22:1052-61. 2007
..The role of caspase-1 in hypoxia-induced membrane injury of proximal tubules (PT) in vitro is unknown...
- Interleukin-1beta
Charles A Dinarello
University of Colorado Health Sciences Center, Denver, CO, USA
Crit Care Med 33:S460-2. 2005
- Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
Mihai G Netea
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
Blood 113:2324-35. 2009
..We conclude that IL-1beta production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation...
- Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors
Mihai G Netea
Division of Infectious Diseases, B168 University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Leukoc Biol 80:1454-61. 2006
..This latter finding supports the concept that TREM-1 provides optimal amplification of cytokine-induced inflammation during the initiation of host defense...
- IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia
Casey M Calkins
Department of Surgery, University of Colorado Health Sciences Center and Veterans Affairs Hospital, 4200 East 9th Avenue, Box C-313, Denver, CO 80262, USA
J Endotoxin Res 8:59-67. 2002
..These data suggest that IL-1 regulates tissue chemokine expression and neutrophil accumulation after LPS...
- Generation and characterization of mice transgenic for human IL-18-binding protein isoform a
Giamila Fantuzzi
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Leukoc Biol 74:889-96. 2003
..These results indicate that high endogenous levels of IL-18BP in trangenic mice effectively neutralize IL-18 and are protective in response to different inflammatory stimuli...
- Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney
Sarah Faubel
Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Box C281, 4200 E 9th Ave, Denver, CO 80262, USA
J Pharmacol Exp Ther 322:8-15. 2007
..However, inhibition of IL-1beta, IL-18, and IL-6 or neutrophil infiltration in the kidney is not sufficient to prevent cisplatin-induced ARF...
- Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein
Nirmal K Banda
Division of Rheumatology, Health Sciences Center, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Immunol 170:2100-5. 2003
..The mechanisms of mIL-18BP inhibition of CIA include reductions in cell-mediated and humoral immunity to collagen as well as decreases in production of proinflammatory cytokines in the spleen and joints...
- Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling
Claudia A Nold-Petry
Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
J Biol Chem 284:25900-11. 2009
....
- Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways
Milene T Saavedra
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
Am J Respir Cell Mol Biol 38:679-88. 2008
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- The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma
Leonid L Reznikov
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Interferon Cytokine Res 22:593-601. 2002
..These studies reveal that the combination of the ligand-binding and the nonligand-binding extracellular domains of IL-18R is needed to inhibit IL-18, whereas IL-18BP neutralizes at equimolar concentration...
- Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor
Eli C Lewis
Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 103:16852-7. 2006
..Importantly, discrepancies between IL-18- and IL-18R-deficient cells suggest that IL-18Ralpha chain is used by an inflammation-suppressing signal...
- Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex
Tania Azam
University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 171:6574-80. 2003
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- A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
Philip Bufler
University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 99:13723-8. 2002
..We propose that after binding to IL-18BP, IL-1F7b forms a complex with IL-18Rbeta, depriving the beta-chain of forming a functional receptor complex with IL-18Ralpha and thus inhibiting IL-18 activity...
- alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice
Eli C Lewis
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 105:16236-41. 2008
..Because AAT treatment in humans is safe, its use during human islet transplantation may be considered...
- IL-32-dependent effects of IL-1beta on endothelial cell functions
Claudia A Nold-Petry
Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 106:3883-8. 2009
..This study introduces IL-32 as a critical regulator of endothelial function, expanding the properties of this cytokine relevant to coagulation, endothelial inflammation, and atherosclerosis...
- Effect of a four-week course of interleukin-10 on cytokine production in a placebo-controlled study of HIV-1-infected subjects
Gregory B Pott
Department of Medicine, Division of Infectious Diseases, University of Colorado at Denver and Health Sciences Center, 4200 E 9th Ave Box B168, Denver, CO 80262, USA
Eur Cytokine Netw 18:49-58. 2007
....
- Interleukin-18 and host defense against infection
Charles A Dinarello
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Infect Dis 187:S370-84. 2003
..Thus, blockade of IL-18 appears to be a viable clinical target to combat the pathologic consequences of sepsis via IFN-gamma mechanisms...
- Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis
Xianzhong Meng
Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado, USA
Am J Physiol Cell Physiol 294:C29-35. 2008
..These results suggest that TLR2 and TLR4 may play a role in aortic valve inflammation and stenosis...
- Anti-cytokine therapeutics and infections
Charles A Dinarello
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Vaccine 21:S24-34. 2003
....
- Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury
Zhibin He
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Physiol Renal Physiol 295:F1414-21. 2008
..In conclusion, protection against ischemic AKI in IL-18BP Tg mice is associated with less macrophage infiltration and less production of CXCL1 in the kidney...
- Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis
Sarah Faubel
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
Kidney Int 66:2202-13. 2004
..Although well studied in vitro, caspases have not been previously studied in cisplatin-induced acute renal failure (ARF) in vivo...
- Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
Mihai G Netea
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 105:3515-20. 2008
..Thus, IL-32 not only contributes to host responses through the induction of proinflammatory cytokines but also directly affects specific immunity by differentiating monocytes into macrophage-like cells...
- Alveolar type II cells inhibit fibroblast proliferation: role of IL-1alpha
Joshua Portnoy
Dept. of Medicine, National Jewish Medical and Research Center, and Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80206, USA
Am J Physiol Lung Cell Mol Physiol 290:L307-16. 2006
..In addition, these studies demonstrate that KGF enhances ATII cell PGE2 production through an IL-1alpha-independent pathway...
- Differences between anti-tumor necrosis factor-alpha monoclonal antibodies and soluble TNF receptors in host defense impairment
Charles A Dinarello
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Rheumatol Suppl 74:40-7. 2005
....
- Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice
Eli C Lewis
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 102:12153-8. 2005
..In light of the established safety record and the nondiabetogenic potential of AAT, these data suggest that AAT may be beneficial as adjunctive therapy in patients undergoing islet transplantation...
- IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism
Mihai G Netea
Divisions of Infectious Diseases and Pulmonary Science and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 102:16309-14. 2005
..The modulation of intracellular NOD2 pathways by IL-32, but not cell-surface TLRs, and the marked expression of IL-32 in colon mucosa suggest a role of IL-32 in the pathogenesis of Crohn's disease...
- An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor
Charles A Dinarello
University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Immunity 23:461-2. 2005
..IL-33 recapitulates much of the existing data that ST2 promotes T(H)2-type responses. The caspase-1 processing of precursor IL-33 provides a therapeutic target to control allergic diseases...
- Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1
Catharina W Wieland
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Infect Immun 70:1352-8. 2002
..These data indicate that different virulence factors from P. aeruginosa induce pulmonary inflammation in vivo and that IRF-1 is involved in some of the cytokine responses to LPS and ETA...
- Anti-inflammatory Agents: Present and Future
Charles A Dinarello
Department of Medicine, University of Colorado, Aurora, 80045, USA
Cell 140:935-50. 2010
..This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics...
- Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans
Edward Abraham
Division of Pulmonary Sciences and Critical Care Medicine and Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, 80262, USA
J Immunol 176:7753-60. 2006
..049 for TNFRII. These results demonstrate that stable patterns in the response of peripheral blood neutrophils to LPS exist in the human population and correlate with inflammatory response following direct exposure to LPS in the lung...
- High cytokine levels at admission are associated with fatal outcome in patients with necrotizing fasciitis
Kathrin Lungstras-Bufler
University of Colorado, Health Sciences Center, Denver, CO 80262, USA
Eur Cytokine Netw 15:135-8. 2004
..The measurement of proinflammatory cytokines and IL-1Ra may help to establish early diagnosis of life-threatening necrotizing fasciitis and thus to initiate aggressive treatment...
- T cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alpha
Alison M Morris
Division of Endocrinology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Metabolism 55:555-9. 2006
..These findings indicate that inflammation-induced TNF-alpha is a critical mediator of adipose-tissue-derived adiponectin in vivo...
