p53 Exon 4 (codon 72) Polymorphism and Exon 7 (codon 249) Mutation in Breast Cancer Patients in Southern Region (Madurai) of Tamil NaduKiruthiga Perumal Vijayaraman
Department of Biotechnology, Alagappa University, Karaikudi, Tamil Nadu, India E mail
Asian Pac J Cancer Prev 13:511-6. 2012
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Eugenol (an essential oil of clove) acts as an antibacterial agent against Salmonella typhi by disrupting the cellular membraneK Pandima Devi
Department of Biotechnology, Alagappa University, Karaikudi 630 003, Tamil Nadu, India
J Ethnopharmacol 130:107-15. 2010
..To evaluate the antibacterial activity of eugenol and its mechanism of bactericidal action against Salmonella typhi...
Study of p53 codon 72 polymorphism and codon 249 mutations in Southern India in relation to age, alcohol drinking and smoking habitsK Pandima Devi
Department of Biotechnology, Alagappa University, Karaikudi, Tamil Nadu, India
Hum Exp Toxicol 29:451-8. 2010
..No mutation was detected in both smokers and nonsmokers in p53 codon 249. From the worldwide scenario, it can be speculated that the smokers, with Arg/Pro genotype are more prone for lung cancer or to other types of cancer...
Bioprotective properties of seaweeds: in vitro evaluation of antioxidant activity and antimicrobial activity against food borne bacteria in relation to polyphenolic contentKasi Pandima Devi
Department of Biotechnology, Alagappa University, Karaikudi 630 003, Tamil Nadu, India
BMC Complement Altern Med 8:38. 2008
..The present study was carried out to evaluate the antimicrobial and antioxidant activity of methanolic extracts of seaweeds, with a view to developing safer food preservatives...
Olive oil protects rat liver microsomes against benzo(a)pyrene-induced oxidative damages: an in vitro studyKasi Pandima Devi
Department of Biotechnology, Alagappa University, Tamil Nadu, India
Mol Nutr Food Res 52:S95-102. 2008
..Further, no B(a)P metabolites (3-OH B(a)P and B(a)P 7,8-dihydrodiol) were identified in HPLC during B(a)P + OO exposure. The results prove the protective role of OO against B(a)P-induced oxidative damage...
Protective effect of Premna tomentosa extract (L. verbanacae) on acetaminophen-induced mitochondrial dysfunction in ratsK Pandima Devi
Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India
Mol Cell Biochem 272:171-7. 2005
..Presence of anti-oxidant compound D-limonene (58%) in P. tomentosa leaves, which is known to enhance conjugation of toxic metabolites by maintaining liver GSH concentrations may explain the hepatoprotective property of the extract...
Immunomodulatory effects of Premna tomentosa extract against Cr (VI) induced toxicity in splenic lymphocytes--an in vitro studyK Pandima Devi
Department of Biochemistry and Molecular Biology, University of, Guindy Campus, Chennai 600 025, Madras, India
Biomed Pharmacother 57:105-8. 2003
..The results indicated that the leaf extract of P. tomentosa has cytoprotective and immunomodulatory activities...
Antinociceptive and hypnotic effects of Premna tomentosa L. (Verbenaceae) in experimental animalsK Pandima Devi
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India
Pharmacol Biochem Behav 75:261-4. 2003
..The responses were dose-dependent. On the basis of the present finding, we can conclude that PT possesses antinociceptive and hypnotic activities...
Protective effect of Premna tomentosa (L. Verbenaceae) extract on membrane-bound phosphatases and inorganic cations transport in acetaminophen-induced hepatotoxicity ratsK Pandima Devi
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu, India
J Ethnopharmacol 93:371-5. 2004
..The potential of the plant might be credited to the presence of antioxidant compound limonene in the plant...
Immunomodulatory effects of Premna tomentosa (L. Verbenaceae) extract in J 779 macrophage cell cultures under chromate (VI)-induced immunosuppressionKasi Pandima Devi
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India
J Altern Complement Med 10:535-9. 2004
..In the present study, the immunomodulatory effects of Premna tomentosa extract against chromate (VI)-induced toxicity was assessed in J 779 macrophage cell line...
Assessment of the protective potential of Premna tomentosa (L. Verbenaceae) extract on lipid profile and lipid-metabolizing enzymes in acetaminophen-intoxicated ratsKasi Pandima Devi
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India
J Altern Complement Med 10:540-6. 2004
..Because injury to the liver can promote a variety of reactions with consequent effect on lipids, the present study was designed to elucidate the hypolipidemic effect of PT extract in acetaminophen (AA)-induced hepatotoxicity in rats...
Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro studyP V Kiruthiga
Department of Biotechnology, Alagappa University, Karaikudi 630003, Tamil Nadu, India
Toxicol Appl Pharmacol 247:116-28. 2010
..The results suggest that silymarin exhibits multiple protections and it should be considered as a potential protective agent for environmental contaminant induced immunotoxicity...
Silymarin protection against major reactive oxygen species released by environmental toxins: exogenous H2O2 exposure in erythrocytesP V Kiruthiga
Department of Biotechnology, Alagappa University, Tamil Nadu, India
Basic Clin Pharmacol Toxicol 100:414-9. 2007
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Protective effect of silymarin on erythrocyte haemolysate against benzo(a)pyrene and exogenous reactive oxygen species (H2O2) induced oxidative stressP V Kiruthiga
Department of Biotechnology, Alagappa University, Karaikudi 630 003, Tamil Nadu, India
Chemosphere 68:1511-8. 2007
..From the results of our study, it was suggested that silymarin possess substantial protective effect and free radical scavenging mechanism against environmental contaminants induced oxidative stress damages...
CYP1A1 gene polymorphisms: lack of association with breast cancer susceptibility in the southern region (Madurai) of IndiaP V Kiruthiga
Department of Biotechnology, Alagappa University, Karaikudi, Tamil Nadu, India
Asian Pac J Cancer Prev 12:2133-8. 2011
..720, CI-95% (0.606-0.856)]. Our results suggest that there is no significant correlation between CYP1A1 M1/ CYP1A1 M2 polymorphism and occurrence of breast cancer in South Indian women...
Synergistic effect of hydroxypropyl-beta-cyclodextrin encapsulated soluble ferrocene and the gold nanocomposite modified glassy carbon electrode for the estimation of NO in biological systemsS Varatharajan
Central Electrochemical Research Institute CECRI Council of Scientific and Industrial Research CSIR, Karaikudi 630006, Tamil Nadu, India
Analyst 135:2348-54. 2010
..Analysis of NO has been carried out in real samples like liver extract, peripheral blood mononuclear cells (PBMCs) and miconazole nitrate ointment and the values obtained are comparable with that obtained by Griess analysis...