Helle M Sickmann

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis
    Helle M Sickmann
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Cereb Blood Flow Metab 30:1527-37. 2010
  2. ncbi Functional significance of brain glycogen in sustaining glutamatergic neurotransmission
    Helle M Sickmann
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Neurochem 109:80-6. 2009
  3. ncbi Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient
    Arne Schousboe
    Faculty of Pharmaceutical Sciences, Department of Pharmacology and Pharmacotherapy, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark
    Neurotox Res 18:94-9. 2010
  4. ncbi Energy substrates to support glutamatergic and GABAergic synaptic function: role of glycogen, glucose and lactate
    Arne Schousboe
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Neurotox Res 12:263-8. 2007
  5. ncbi Characterization of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity
    Anne B Walls
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Neurochem 105:1462-70. 2008
  6. ncbi Compartmentation of lactate originating from glycogen and glucose in cultured astrocytes
    Helle M Sickmann
    Department of Pharmacology and Pharmacotherapy, Danish University of Pharmaceutical Sciences, DK-2100 Copenhagen, Denmark
    Neurochem Res 30:1295-304. 2005

Collaborators

Detail Information

Publications6

  1. ncbi Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis
    Helle M Sickmann
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Cereb Blood Flow Metab 30:1527-37. 2010
    ..Glucose metabolism through the TCA cycle was more decreased than glycolytic activity. Furthermore, reduced glutamate-glutamine cycling was also observed in the obese and type 2 diabetic states...
  2. ncbi Functional significance of brain glycogen in sustaining glutamatergic neurotransmission
    Helle M Sickmann
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Neurochem 109:80-6. 2009
    ..Neurotransmitter release was affected by the presence of d-lactate indicating that glycogen derived energy is important not only in the astrocytic but also in the neuronal compartment...
  3. ncbi Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient
    Arne Schousboe
    Faculty of Pharmaceutical Sciences, Department of Pharmacology and Pharmacotherapy, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark
    Neurotox Res 18:94-9. 2010
    ..It is argued that glycolytically derived energy in the form of ATP may be of particular functional importance in this context...
  4. ncbi Energy substrates to support glutamatergic and GABAergic synaptic function: role of glycogen, glucose and lactate
    Arne Schousboe
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Neurotox Res 12:263-8. 2007
    ..Moreover, it should be noted that the amino acid neurotransmitters can be used as metabolic substrates. This requires pyruvate recycling, a process that is discussed as well...
  5. ncbi Characterization of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity
    Anne B Walls
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Neurochem 105:1462-70. 2008
    ..Based on the experimental findings, DAB can be used to evaluate glycogen shunt activity and its functional importance in intact brain tissue and cells at a concentration of 300-1000 muM and a pre-incubation period of 1 h...
  6. ncbi Compartmentation of lactate originating from glycogen and glucose in cultured astrocytes
    Helle M Sickmann
    Department of Pharmacology and Pharmacotherapy, Danish University of Pharmaceutical Sciences, DK-2100 Copenhagen, Denmark
    Neurochem Res 30:1295-304. 2005
    ..Moreover, it was found that lactate originating from glycogen is compartmentalized from that derived from glucose, which lends further support to a compartmentalized metabolism in astrocytes...